CN1255126C

CN1255126C - Medicinal prescription for treating aseptic necrosis of femur head

Info

Publication number: CN1255126C
Application number: CN 200410037612
Authority: CN
Inventors: 武英
Original assignee: Individual
Current assignee: Individual
Priority date: 2004-04-27
Filing date: 2004-04-27
Publication date: 2006-05-10
Anticipated expiration: 2024-04-27
Also published as: CN1569199A

Abstract

The present invention relates to a medicine for treating ischemic necrosis of a femoral head, which is characterized in that the present invention is composed of traditional Chinese medicines, such as epimedium, drynaria, Chinese teasel roots, herba pyrolae, astragalus roots, Chinese angelica roots, red sage roots, corydalis tuber, cyathula roots, etc. Impurities are removed so that the traditional Chinese medicines are cleanly cleaned; the traditional Chinese medicines are ground into fine powder separately filled in capsules, the weight of each capsule is 0.5g, and the capsules are taken for three times every day with plain boiled water. The medicine prepared by the present invention is adopted to perform the action of obvious bone growth promotion, blood capillary osmosis enhancement, bone cell generation activation, sclerotin reparation promotion and acceleration, and no toxic side effect. The present invention prepared by using natural medicines has the functions of vigor enhancement, marrow benefit, blood circulation activation, stasis dispelling, meridian and collateral clearing, bone strengthening, pain alleviation, blood nourishment, bone generation and necrosis treatment.

Description

A kind of medicine for the treatment of aseptic necrosis of femoral head

One, technical field:

The present invention relates to a kind of medicine for the treatment of femur head necrosis.

Two, background technology:

Ischemic necrosis of femoral head be since wound or non-wound factors disrupt the femoral head blood supply, hip joint intermittence or constant pain appear clinically at first, and aggravation gradually, finally cause the hip joint limitation of activity, and it is normal to occur bone density on the X linear light sheet, a series of performances such as bone density lowers, and cystis degeneration and typical " meniscus sign " femoral head flatten, and the joint space is narrow.At present, operative treatment is all adopted in treatment both at home and abroad, and this artificial femoral head replacement's infectious-related complication is difficult to overcome, and occurs infecting, loosening, joint stiffness, pain etc., and patient can cause disability, and needs the people to take care of, the serious patient's lifelong disability that causes.Own painful, bring burden also for family, society.At present, though the medicine of some Chinese medicine proved recipe treatment ischemic necrosis of femoral head, these prescriptions or pill are arranged, though strengthening the body resistance is arranged, the function of analgesic antidotal or QI invigorating, healthy energy, nourishing YIN, YANG invigorating is not to be treating the poisonous disease with poisonous drugs targetedly, the method of effecting a permanent cure of block up of loosing of assaulting fortified position, general effect is very poor.The sign of ischemic necrosis of femoral head is that osteocyte disappears in lacuna, rather than the fractureing of bone structure, after it regains blood supply, then area of new bone can borrow bone trabecula to grow into gradually, make downright bad femoral head healing, therefore, in the diagnoses and treatment, emphasize that early diagnosis prevents that actively collapse of the femoral head from being crucial.

Three, technology contents:

The object of the present invention is to provide a kind of medicine that utilizes the treatment Avascular Necrosis Of Femur Head of traditional Chinese medicine development.

The present invention realizes in the following manner:

Form by weight ratio by following component: Herba Epimedii 15-20 part, Rhizoma Drynariae 15-50 part, Radix Dipsaci 20-50 part, Herba Pyrolae 20-30 part, Radix Astragali 20-50 part, Radix Angelicae Sinensis 16-30 part, Radix Salviae Miltiorrhizae 16-20 part, Rhizoma Corydalis 16-20 part, river cattle sunset 16-30 part.

Decontamination makes it cleaning totally then, grinds to form smalls, in the dried capsule of packing.Every 0.5g, day clothes three times, boiled water send down.

The present invention treats the nearly over thousands of example of this type of patient with this medicine so far from establishment in 1988, the satisfaction of producing effects, and it is to be formed by the natural drug compatibility, has sperm adding and marrow healthing, activating blood circulation to dissipate blood stasis, dredge the meridian passage, reducing swelling and alleviating pain, the bone growth promoting that nourishes blood improves necrotic lesion.Now be summarized as follows:

1, clinical data

1.1 selection case

This is organized 5 examples and is femur head necrosis I, II phase patient, wherein male 3 examples, women 2 examples, minimum 8 years old of age, maximum 18 years old, the shortest 2 weeks of the course of disease, the longest 1 year, treatment time is the longest 2 years, the shortest February, about half a year mean treatment time, about 70% of the concurrent femur head necrosis of fracture of femoral neck, be 6% after the dislocation of hip joint, taking hormone for a long time is 11%, and ethylism is 10%, and other factors account for 3%.

1.2 function cures mainly

Liver and kidney tonifying, promoting blood circulation to remove obstruction in the collateral, be used for that the aseptic femoral head is bad, ischemia give birth to downright bad, various osteoporosis, cure mainly give birth to strong, but early stage blood circulation promoting and blood stasis dispelling, dredge the meridian passage, promoting tissue regeneration by removing blood stasis.Instructions of taking: every day three times, each 4, take after the meal, generally need 1-3 month, indivedual case half a year answer periodic review to clap the X-ray sheet in the treatment, show the bony union walking of could bearing a heavy burden.Seriously row trouble limb traction is to alleviate the heavy burden of femoral head pressurized simultaneously in bed as the hip arthralgia, and routine is taken the medicine of the present invention's preparation, but early stage activating blood circulation to dissipate blood stasis, dredge the meridian passage promotes blood fortune, the silt tissue regeneration promoting of dispelling, reunion of fractured tendons and bones, liver and kidney tonifying, strong muscles and bones, every day three times, each 4, take after the meal, generally need 2-3 week, answer periodic review to clap the X-ray sheet in the treatment, the walking of could bearing a heavy burden of healing fully.

1.3 criterion of therapeutical effect

Therapeutic outcome

After treatment June cure rate 85%, effective percentage reach 10%, inefficiency 5%.

2, discuss

Applicable to the teenager patient, with teen-age growth promoter, femoral head can obtain new life about the conservative treatment of femur head necrosis, obtains satisfactory result.Adult's pathological changes belongs to I, II phase, especially old people, and to merge organic illness can not the person of undergoing surgery excellent, and the medicine that adopts the present invention to make has the effect of obvious promote osteogenesis, increase the blood capillary infiltration, it is active that osteocyte is generated, and promotes and quicken the reparation of sclerotin, has no side effect.Its evolution process is divided into downright bad phase, reparation phase, collapse of the femoral head phase behind the ischemic femoral head, after ischemia 12-24 hour except that cartilage, the necrotic area osteocyte is all dead, after 4 days about 60%, osteocyte lacuna inanition, the reparation phase started from about 2 weeks, 8-12 after week new bone and blood capillary proliferation can spread all over the big portion zone of necrotic area, fashion into sophisticated bone trabecula through " creeping substitution " again, may subside when femoral head suffers acetabular bone pressure in whole repair process, by Ficat ischemic necrosis of femoral head was divided into for 6 phases at present:

0 phase: osteonecrosis is arranged, but do not have clinical findings, X line and bone scanning are all normal.

1 phase: clinical symptoms and sign are arranged, but X line and bone scanning are all normal.

2 phases: existing bone density lowers cystis degeneration, performances such as osteosclerosis on the X line.

3 phases: visible " meniscus sign " subchondral bone subsides on the X line, but femoral head does not flatten.

4 phases: visible femoral head flattens on the X line, but the joint space keeps normal.

5 phases: visible joint space is narrow on the X line, and variable the change arranged in the acetabular bone.

When ischemic necrosis of femoral head is treated by my institute, after giving this medicine, advise patient's strictness to avoid bearing a heavy burden walking when promoting the sclerotin repair medicine to improve cure rate.

Four, the specific embodiment:

Embodiment 1:

Select for use every part of following Chinese herbal medicine to form by 122 gram weight proportionings: Herba Epimedii 16 grams, Rhizoma Drynariae 16 grams, Radix Dipsaci 30 grams, Herba Pyrolae 30 grams, the Radix Astragali 30 grams, Radix Angelicae Sinensis 25 grams, Radix Salviae Miltiorrhizae 25 grams, Rhizoma Corydalis 25 grams, river cattle sunset 25 gram.

Decontamination makes it cleaning totally then, grinds to form smalls, be sub-packed in the capsule, and every 0.5g, day clothes three times, boiled water send down.

Embodiment 2:

Select for use every part of following Chinese herbal medicine to form by 182 gram weight proportionings: Herba Epimedii 16 grams, Rhizoma Drynariae 35 grams, Radix Dipsaci 21 grams, Herba Pyrolae 21 grams, the Radix Astragali 21 grams, Radix Angelicae Sinensis 17 grams, Radix Salviae Miltiorrhizae 17 grams, Rhizoma Corydalis 17 grams, river cattle sunset 17 gram.

Embodiment 3:

Select for use every part of following Chinese herbal medicine to form by 175 gram weight proportionings: Herba Epimedii 17 grams, Rhizoma Drynariae 20 grams, Radix Dipsaci 22 grams, Herba Pyrolae 22 grams, the Radix Astragali 22 grams, Radix Angelicae Sinensis 18 grams, Radix Salviae Miltiorrhizae 18 grams, Rhizoma Corydalis 18 grams, river cattle sunset 18 gram.

Embodiment 4:

Select for use every part of following Chinese herbal medicine to form by 183 gram weight proportionings: Herba Epimedii 18 grams, Rhizoma Drynariae 18 grams, Radix Dipsaci 25 grams, Herba Pyrolae 23 grams, the Radix Astragali 23 grams, Radix Angelicae Sinensis 19 grams, Radix Salviae Miltiorrhizae 19 grams, Rhizoma Corydalis 19 grams, river cattle sunset 19 gram.

Embodiment 5:

Select for use every part of following Chinese herbal medicine to form by 207 gram weight proportionings: Herba Epimedii 19 grams, Rhizoma Drynariae 30 grams, Radix Dipsaci 30 grams, Herba Pyrolae 24 grams, the Radix Astragali 24 grams, Radix Angelicae Sinensis 20 grams, Radix Salviae Miltiorrhizae 20 grams, Rhizoma Corydalis 20 grams, river cattle sunset 20 gram.

Embodiment 6:

Select for use every part of following Chinese herbal medicine to form by 249 gram weight proportionings: Herba Epimedii 17 grams, Rhizoma Drynariae 25 grams, Radix Dipsaci 35 grams, Herba Pyrolae 29 grams, the Radix Astragali 35 grams, Radix Angelicae Sinensis 27 grams, Radix Salviae Miltiorrhizae 27 grams, Rhizoma Corydalis 27 grams, river cattle sunset 27 gram.

Embodiment 7:

Select for use every part of following Chinese herbal medicine to form by 278 gram weight proportionings: Herba Epimedii 18 grams, Rhizoma Drynariae 40 grams, Radix Dipsaci 40 grams, Herba Pyrolae 28 grams, the Radix Astragali 40 grams, Radix Angelicae Sinensis 28 grams, Radix Salviae Miltiorrhizae 28 grams, Rhizoma Corydalis 28 grams, river cattle sunset 28 gram.

Embodiment 8:

Select for use every part of following Chinese herbal medicine to form by 284 gram weight proportionings: Herba Epimedii 16 grams, Rhizoma Drynariae 45 grams, Radix Dipsaci 45 grams, Herba Pyrolae 27 grams, the Radix Astragali 45 grams, Radix Angelicae Sinensis 29 grams, Radix Salviae Miltiorrhizae 29 grams, Rhizoma Corydalis 29 grams, river cattle sunset 29 gram.

This type of patient has 100 examples, now lifts following 3 examples:

Model case 1:

Patient Duan Jingrong, woman 31 years old, admission number 0399, main cause " left three weeks of hip pain " was gone to a doctor in my institute on August 25th, 1999, improve coherence check after being admitted to hospital, the X-ray sheet shows: fl head density lowers, do not see obvious cystis degeneration, the inquiry medical history: this patient suffered from " nephrotic syndrome " and accepts hormone therapy half a year in pool, natural pond hospital before 2 years, every day, consumption was not quite clear, diagnosis " fl head ischemic necrosis I phase " is now suffered from limb traction after being admitted to hospital, take medicine of the present invention after, every day three times each 4 oral, subjective symptoms obviously disappears after January, left side hip percussion pain () hip joint activity is normal substantially, no obvious clinical symptoms after February, and the X-ray sheet: fl head density is normal substantially.Be as good as with examining left lower extremity heavy burden walking after 1 year, bone trabecula passes through normally in the fl head, return visit after 2 years, and the state of an illness does not have recurrence.

Case 2:

Patient Lv Jincui, woman 56 years old, admission number 8102 is because of " no obvious inducement sense left side hip pain before half a year " went to a doctor in my institute in March, 1996, human health screening, left side hip percussion pain (+), adductor tenderness (+), hip is crossed pain when bending, " 4 " word test (+) hip joint CT sheet shows: visible two folliculus shape low-density shadow in the fl head, bone does not have and subsides, and gives the left lower extremity traction, takes this medicine every day three times, each 4 oral, continuous 15 days of 5%g300ml+ Radix Salviae Miltiorrhizae 16ml intravenous drip, once a day through and anti-inflammatory treatment, January, future trouble limb pain was clearly better, check X-ray sheet art, performance is the same, and no hip pain can be held up and be turned walking after half a year, check X-ray sheet art, bone density lowers in the fl head, no cystis degeneration, and further consultation in year left side hip is movable normal, find when adhering to taking medicine to 2 years, fl skull density is with strong side, and the return visit daily life can be taken care of oneself in 5 years, and activity freely.

Model case 3:

Patient Zhang Yongfeng, man 56 years old, admission number 0512, main cause " right femoral head fracture of cervical vertebra " postoperative 3 years takes out behind the internal fixation in eight months right hip pain limitation of activity April and goes to a doctor, the X-ray sheet shows: former right fracture of femoral neck heading line off, collodiaphyseal angle is normal, see that in right femoral head several cryptomeres sexually revise, the little joint space of bone density is normal substantially, diagnosis " ischemic necrosis of femoral head after the right fracture of femoral neck " after being admitted to hospital, the patient suffered from " coronary heart disease (angina pectoris) " 7 years, from the thing control of taking medicine, the preceding fraud foot of the sense heart is vexed, nervous in the time of recently, suggestion row conservative treatment after being admitted to hospital, suffer from limb bone traction 6Kg weight and keep, obey this medicine every day three times, each oral 4, and coronary dilating Drug therapy, the limb pain relief is suffered from the back private prosecution of three weeks, during March, suffers from limb pain and disappears substantially, during half a year, subjective symptoms complete obiteration, check are clapped the X sheet and are shown: be dispersed in three cryptomere low-density shadow in the right femoral head, remove the bone traction, intermittently give skin traction, begin to hold up and turn walking, the right femoral head of film making does not see that obvious cryptomere changes after 1 year, and the strong side of density is lower slightly, right hip joint activity is normal substantially, at present still in return visit.

Claims

1, a kind of medicine for the treatment of aseptic necrosis of femoral head is characterized in that: be made up of by weight ratio following component: Herba Epimedii 15-20 part, Rhizoma Drynariae 15-50 part, Radix Dipsaci 20-50 part, Herba Pyrolae 20-30 part, Radix Astragali 20-50 part, Radix Angelicae Sinensis 16-30 part, Radix Salviae Miltiorrhizae 16-20 part, Rhizoma Corydalis 16-20 part, river cattle sunset 16-30 part.