CN117398441A - 一种利用多糖和三萜类物质辅助放化疗的组合物 - Google Patents
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Abstract
本发明公开了一种利用多糖和三萜类物质辅助放化疗的组合物，涉及医药技术领域。一种利用多糖和三萜类物质辅助放化疗的组合物包括以下重量份原料：灵芝孢子粉1‑100份、米斛1‑80份、灰树花1‑80份；或灵芝孢子油10‑100份、米斛1‑60份、灰树花1‑60份。本发明采用上述的一种利用多糖和三萜类物质辅助放化疗的组合物，能够缓解肿瘤放化疗过程中对人体的伤害，提高身体的免疫力和抵抗力。
Description
技术领域
本发明涉及医药技术领域，尤其是涉及一种利用多糖和三萜类物质辅助放化疗的组合物。
背景技术
目前，临床上对肿瘤常用的三大治疗手段：化疗、放疗及手术，它们对肿瘤的治疗效果是确切的、明显的。但是，化疗和放疗在对肿瘤细胞杀伤的同时无选择地伤害了正常健康的细胞，而手术治疗只能切除可见的病灶，术后容易发生肿瘤细胞的转移。而无论是化疗、放疗还是手术给患者带来的精神及经济上的压力都是难以承受的，尤其是身体上的伤害，使患者很难承受。
灵芝孢子粉具有增强免疫力、降血压、抗炎镇痛、促进新陈代谢等作用。灵芝孢子粉的主要成分是灵芝多糖、灵芝三萜、腺嘌呤核苷，还有10多种碱，以及油酸、纤维素、氨基酸、微量元素等等，其中的灵芝多糖可以增强免疫力，加速血液微循环，提高血液供氧能力，降低机体静止状态下的无效耗氧量，消除体内自由基，提高机体细胞膜的封闭度，抗放射，提高肝脏、骨髓、血液合成DNA，RNA，蛋白质的能力，延长寿命等。灵芝三萜也是灵芝重要的药理成分，三萜类化合物有抗炎、镇痛、镇静、抗衰老等作用。灵芝孢子粉还含有一种天然的有机酯，可以增强人体的血液供应，促进新陈代谢、消除自由基，可以防止细胞的老化，还可以抑制癌细胞恶化和扩散。因此提供一种利用多糖和三萜类物质辅助放化疗的组合物，能够缓解肿瘤放化疗过程中对人体的伤害，缓解放化疗的副作用，提高身体的免疫力和抵抗力。
发明内容
本发明的目的是提供一种利用多糖和三萜类物质辅助放化疗的组合物，能够缓解肿瘤放化疗过程中对人体的伤害，缓解放化疗的副作用，提高身体的免疫力和抵抗力。
为实现上述目的，本发明提供了一种利用多糖和三萜类物质辅助放化疗的组合物，包括以下重量份原料：灵芝孢子粉1-100份、米斛1-80份、灰树花1-80份；
或灵芝孢子油10-100份、米斛1-60份、灰树花1-60份。
进一步地，包括以下重量份原料：灵芝孢子粉15-80份、米斛10-70份、灰树花10-70份；
或灵芝孢子油20-80份、米斛10-50份、灰树花10-50份。
进一步地，包括以下重量份原料：灵芝孢子粉50份、米斛45份、灰树花40份；
或灵芝孢子油40份、米斛30份、灰树花35份。
进一步地，还包括辅料10-20份，辅料包括蜂蜜、甘草、蔗糖中的一种或几种的组合。
本发明还提供了上述的组合物的制备方法，包括以下步骤：
S1、将米斛、灰树花洗净、沥干、切段，低温冷冻后干燥，然后用粉碎机超细粉碎，得到冻干粉，备用；
S2、按照重量份称取灵芝孢子粉或灵芝孢子油、米斛冻干粉、灰树花冻干粉、辅料，备用；
S3、将步骤S1和S2中的原料混合，按混合物的总重量加5-10倍量的水，80-110℃煎煮1-3h，煎煮1-3次，合并煎煮液，过滤，得到滤液，备用；
S4、将步骤S3得到的滤液，浓缩至膏状，得到稠膏，备用；
S5、将步骤S4得到的稠膏，60℃条件下干燥2-4小时，破碎分散后制成组合物。
进一步地，步骤S3中按混合物的总重量加10倍量的水，100℃煎煮2.5h，煎煮3次；步骤S5中破碎分散后制成颗粒或片剂或口服液，或者将颗粒填充进胶囊中制成胶囊剂。
本发明还提供了上述的组合物在制备辅助肿瘤放化疗药物或食品中的应用。
进一步地，所述的药物或食品包括活性成分灵芝多糖、灵芝三萜、米斛三萜、灰树花三萜。
本发明所述的一种利用多糖和三萜类物质辅助放化疗的组合物的优点和积极效果是：
1、本发明在中药材选择和配伍上符合中医辨证理论，给药简单、方便；能够有效缓解肿瘤放化疗过程中对人体的伤害，缓解放化疗的副作用。
2、本发明中的组合物能够有效抑制、抗肿瘤，且无毒副作用，达到了中药配伍中相辅相成的目的。
下面通过附图和实施例，对本发明的技术方案做进一步的详细描述。
附图说明
图1为本发明一种利用多糖和三萜类物质辅助放化疗的组合物的实施例的效果验证结果。
具体实施方式
以下通过附图和实施例对本发明的技术方案作进一步说明。
除非另外定义，本发明使用的技术术语或者科学术语应当为本发明所属领域内具有一般技能的人士所理解的通常意义。
实施例1
一种利用多糖和三萜类物质辅助放化疗的组合物的制备方法，包括以下步骤：
S1、将米斛、灰树花洗净、沥干、切段，低温冷冻后干燥，然后用粉碎机超细粉碎，得到冻干粉，备用；
S2、按照重量份称取灵芝孢子粉15份、米斛冻干粉50份、灰树花冻干粉50份、辅料10份，备用；
S3、将步骤S1和S2中的原料混合，按混合物的总重量加10倍量的水，100℃煎煮2.5h，煎煮3次，合并煎煮液，过滤，得到滤液，备用；
S4、将步骤S3得到的滤液，浓缩至膏状，得到稠膏，备用；
S5、将步骤S4得到的稠膏，60℃条件下干燥2-4小时，破碎分散后制成颗粒组合物A。
实施例2
按照重量份称取灵芝孢子粉50份、米斛冻干粉45份、灰树花冻干粉40份、辅料10份，其余步骤与实施例1相同，制成颗粒组合物B。
实施例3
按照重量份称取灵芝孢子粉80份、米斛冻干粉10份、灰树花冻干粉10份、辅料10份，其余步骤与实施例1相同，制成颗粒组合物C。
实施例4
按照重量份称取灵芝孢子油20份、米斛冻干粉50份、灰树花冻干粉40份、辅料10份，其余步骤与实施例1相同，制成颗粒组合物D。
实施例5
按照重量份称取灵芝孢子油40份、米斛冻干粉30份、灰树花冻干粉35份、辅料10份，其余步骤与实施例1相同，制成颗粒组合物E。
实施例6
按照重量份称取灵芝孢子油80份、米斛冻干粉20份、灰树花冻干粉25份、辅料10份，其余步骤与实施例1相同，制成颗粒组合物F。
效果验证
对实施例1-6制得的组合物进行效果验证，随机选600名志愿者(正在接受放疗或化疗的肿瘤患者)，分为6组(实施例1-6每组100人)，每组志愿者每人每天开水冲泡3g，一日2次，服用60天。统计缓解脱发、缓解肠胃不适、提高免疫力和抵抗力的人数及比例，如表1和图1所示。
表1
| 缓解脱发 | 缓解肠胃不适 | 提高免疫力和抵抗力 | |
| 实施例1 | 62 | 67 | 72 |
| 实施例2 | 85 | 89 | 89 |
| 实施例3 | 75 | 75 | 80 |
| 实施例4 | 82 | 73 | 78 |
| 实施例5 | 88 | 89 | 95 |
| 实施例6 | 85 | 80 | 84 |
由图1和表1可知，本发明实施例1-6制备的组合物均可以有效缓解放化疗引起的脱发、肠胃不适、免疫力和抵抗力较低的问题。并且实施例4-6制备的组合物的整体效果优于实施例1-3，说明灵芝孢子油的效果明显优于灵芝孢子粉的效果。另外实施例5和实施例2制备的组合物的效果相比，实施例5制备的组合物的效果明显更好，说明本发明制备的组合物，能够缓解肿瘤放化疗过程中对人体的伤害，提高身体的免疫力和抵抗力。
因此，本发明采用上述的一种利用多糖和三萜类物质辅助放化疗的组合物，能够缓解肿瘤放化疗过程中对人体的伤害，提高身体的免疫力和抵抗力。
最后应说明的是：以上实施例仅用以说明本发明的技术方案而非对其进行限制，尽管参照较佳实施例对本发明进行了详细的说明，本领域的普通技术人员应当理解：其依然可以对本发明的技术方案进行修改或者等同替换，而这些修改或者等同替换亦不能使修改后的技术方案脱离本发明技术方案的精神和范围。
Claims (8)
1.一种利用多糖和三萜类物质辅助放化疗的组合物，其特征在于，包括以下重量份原料：灵芝孢子粉1-100份、米斛1-80份、灰树花1-80份；
或灵芝孢子油10-100份、米斛1-60份、灰树花1-60份。
2.根据权利要求1所述的一种利用多糖和三萜类物质辅助放化疗的组合物，其特征在于，包括以下重量份原料：灵芝孢子粉15-80份、米斛10-70份、灰树花10-70份；
或灵芝孢子油20-80份、米斛10-50份、灰树花10-50份。
3.根据权利要求1所述的一种利用多糖和三萜类物质辅助放化疗的组合物，其特征在于，包括以下重量份原料：灵芝孢子粉50份、米斛45份、灰树花40份；
或灵芝孢子油40份、米斛30份、灰树花35份。
4.根据权利要求1所述的一种利用多糖和三萜类物质辅助放化疗的组合物，其特征在于：还包括辅料10-20份，辅料包括蜂蜜、甘草、蔗糖中的一种或几种的组合。
5.权利要求1-4任一项所述的组合物的制备方法，其特征在于，包括以下步骤：
S1、将米斛、灰树花洗净、沥干、切段，低温冷冻后干燥，然后用粉碎机超细粉碎，得到冻干粉，备用；
S2、按照重量份称取灵芝孢子粉或灵芝孢子油、米斛冻干粉、灰树花冻干粉、辅料，备用；
S3、将步骤S1和S2中的原料混合，按混合物的总重量加5-10倍量的水，80-110℃煎煮1-3h，煎煮1-3次，合并煎煮液，过滤，得到滤液，备用；
S4、将步骤S3得到的滤液，浓缩至膏状，得到稠膏，备用；
S5、将步骤S4得到的稠膏，60℃条件下干燥2-4小时，破碎分散后制成组合物。
6.根据权利要求5所述的制备方法，其特征在于：步骤S3中按混合物的总重量加10倍量的水，100℃煎煮2.5h，煎煮3次；步骤S5中破碎分散后制成颗粒或片剂或口服液，或者将颗粒填充进胶囊中制成胶囊剂。
7.权利要求1-4任一项所述的组合物在制备辅助肿瘤放化疗药物或食品中的应用。
8.根据权利要求7所述的应用，其特征在于：所述的药物或食品包括活性成分灵芝多糖、灵芝三萜、米斛三萜、灰树花三萜。
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