CN117379519A - 一种生血中药组合物及其制备方法 - Google Patents
一种生血中药组合物及其制备方法 Download PDFInfo
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- CN117379519A CN117379519A CN202211730038.5A CN202211730038A CN117379519A CN 117379519 A CN117379519 A CN 117379519A CN 202211730038 A CN202211730038 A CN 202211730038A CN 117379519 A CN117379519 A CN 117379519A
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Abstract
本发明公开一种生血中药组合物及其制备方法,其由生地黄、山萸肉、山药、太子参、党参、麦冬、北沙参、人参须、天冬、五味子、肉桂、白芍、甘草、浮小麦、大枣、女贞子、墨旱莲、生姜组成,本发明以机体正气亏虚是恶性肿瘤为病机,诸药协同作用,共奏健脾补肾、补气生血、调和营卫之功效,以对恶性肿瘤进行有效的防治。
Description
技术领域
本发明涉及中药物技术领域,尤其涉及一种生血中药组合物及其制备方法。
背景技术
恶性肿瘤是威胁人类生存和健康的严重疾病。近年来,恶性肿瘤的患病率逐年上升,已成为继心脑血管疾病之后的人类健康的重要疾病。药物化疗是治疗恶性肿瘤的主要方法之一。
目前,虽然可以利用的癌症治疗药物的数目呈指数级增长,但抗肿瘤的药物研究和开发仍面临巨大挑战,如抗肿瘤药物多为细胞毒药物,其副作用明显,患者长期使用会对身体和心理上都会产生较大的损害,导致患者的生活质量较差,不利于积极地与病魔抗争,高品质地延长寿命。与现行常用的癌症治疗药物相比,中医药治疗是我国独特的治疗手段,在综合治疗中发挥了重要作用,深受广大患者的欢迎。
恶性肿瘤的证候在祖国医学早期文献中就曾有过描述,如《内经》的“肠覃”、“石瘕”、“膈中”,《难经》的“积聚”,《诸病源候论》的“症瘕”、“石疽”、“石痈”及后世所说的“失荣”、“石疔”、“肾岩”,有的属于胃肠、子宫、肝、胰等脏器和体表的肿瘤。在病理因素上,历代医家大多归因瘀滞痰湿、毒邪,而其中机体正气亏虚是恶性肿瘤发生发展的根本原因。
发明内容
因此,基于以上背景,本发明对传统的中医药方进行不断改进,最终形成本发明的技术方案,一种生血中药组合物及其制备方法,诸药并用,共凑补肾填精生髓,健脾益气生血之效,以达补血养血,扶正固本,提高机体免疫力。
本发明提供的技术方案为:
一种生血中药组合物,按重量计,其由以下药物组成:
生地黄5-100份、山萸肉5-100份、山药5-100份、太子参5-100份、党参5-100份、麦冬5-100份、北沙参5-100份、人参须5-100份、天冬5-100份、五味子5-100份、肉桂5-100份、白芍5-100份、甘草5-100份、浮小麦5-100份、大枣5-100份、女贞子5-100份、墨旱莲5-100份、生姜5-100份。
优选地,按重量计,其由以下药物组成:
生地黄12份、山萸肉30份、山药10份、太子参15份、党参15份、麦冬15份、北沙参15份、人参须15份、天冬15份、五味子6份、肉桂6份、白芍20份、甘草20份、浮小麦30份、大枣20份、女贞子20份、墨旱莲20份、生姜10份。
优选地,其可加入常规辅剂制成口服制剂。
优选地,其为颗粒制剂。
优选地,其制备方法包括如下步骤:
S1:按比例取原料药物;
S2:加8倍水,煎煮1h后,过滤;
S3:将药渣加6倍水,煎煮1h,过滤;
S4:将步骤S2和S3的煎煮液合并,减压浓缩至相对密度为1.01-1.05g/cm3,喷雾干燥即可制取颗粒剂。
本发明中生地黄滋阴润燥、凉血止血;
山萸肉补益肝肾、涩精固脱、固经止血;
山药健脾养胃、补肾涩精、润肺止咳;
太子参补气益肺、健脾生津、健胃消食;
党参补中益气、健脾益肺、养血生津;
麦冬养阴生津、润肺止咳;
北沙参养阴清肺、益胃生津;
人参须生津益气、潜阳降火、止渴;
天冬滋阴润燥、清肺降火;
五味子收敛固涩、益气生津、补肾宁心;
肉桂镇静镇痛、补火壮阳、活血通经;
白芍养血调经、敛阴止汗、柔肝止痛;
甘草补脾益气、祛痰止咳、止痛;
浮小麦益气、除热、止汗;
大枣补中益气、养血安神;
女贞子滋补肝肾、明目乌发;
墨旱莲滋阴益肾、凉血止血;
生姜解表散寒、温中止呕、温肺止咳。
一般人们所说的“癌症”习惯上泛指所有恶性肿瘤。癌症具有细胞分化和增殖异常、生长失去控制、浸润性和转移性等生物学特征,其发生是一个多因子、多步骤的复杂过程,分为致癌、促癌、演进三个过程,认为与吸烟、感染、职业暴露、环境污染、不合理膳食、遗传因素密切相关。专家们根据《医宗必读》中“积之成者正气不足而后邪气踞之。”的记载,指出正虚是恶性肿瘤发生、发展的根本原因。正虚的实质是脏腑气血功能失调,与西医之机体自身免疫功能低下导致肿瘤发生、发展的免疫学说不谋而合,而邪气不仅指六淫、疫毒、饮食劳倦,更是包括正虚之后产生的痰结、湿聚、气阻、血瘀、郁热等病理变化。肿瘤的生长只有在机体阴阳失调,正气亏虚的情况下才能发病,即所谓“邪之所凑,其气必虚。”而癌细胞及其导致的感染、出血等反过来又影响脏腑气血功能,使正气更虚,出现恶性循环,这正是恶性肿瘤难以治愈且容易复发的原因所在。
如《外科医案汇编》云:“正虚则为岩”,现代研究也证实,正虚不仅是肿瘤形成的决定因素,并且贯穿于肿瘤发生、发展的始终,表现为不同程度的机体免疫功能低下。专家们结合文献及临床所见,邪气又可导致或加重肿瘤发生、发展。临床许多患者虽然表现为癥瘕、积聚、发热、腹胀、呕血、咳、喘等实证,这只能是“至虚有盛候”的临床表现,正虚始终为主要矛盾。此时若一味破血散结、苦害攻下、清热泻火,不仅不能解决标实,而且易伤正,使正气更虚,病情恶化。据此确立本发明针对恶性肿瘤的防治以健脾补肾、补气生血、调和营卫的主则。
本发明中以机体正气亏虚是恶性肿瘤发生发展的根本原因,即机体正气亏虚是恶性肿瘤的病机,故发明中以党参、太子参、人参须、北沙参配合甘草、白芍、大枣、生姜为君药,以健脾益气生血;生地黄、山萸肉、山药为臣要,其为经典六味地黄汤之三补,取补肾填精生髓之意;女贞子、旱莲草滋补肝肾;党麦冬、五味子、肉桂佐助君药,益气养阴以助精血之生;甘草、大枣、浮小麦、天冬为使药,养心安神,心神安则血安。诸药并用,共凑补肾填精生髓,健脾益气生血之效。
采用本发明可实现的有益效果如下:
本发明以机体正气亏虚是恶性肿瘤为病机,诸药协同作用,共奏健脾补肾、补气生血、调和营卫之功效,以对恶性肿瘤进行有效的防治。
本发明还可作为恶性肿瘤治疗的辅助用药。
具体实施方式
现将详细地提供本发明实施方式的参考,其一个或多个实例描述于下文。提供每一实例作为解释而非限制本发明。实际上,对本领域技术人员而言,显而易见的是,可以对本发明进行多种修改和变化而不背离本发明的范围或精神。例如,作为一个实施方式的部分而说明或描述的特征可以用于另一实施方式中,来产生更进一步的实施方式。
因此,旨在本发明覆盖落入所附权利要求的范围及其等同范围中的此类修改和变化。本发明的其它对象、特征和方面公开于以下详细描述中或从中是显而易见的。本领域普通技术人员应理解本讨论仅是示例性实施方式的描述,而非意在限制本发明更广阔的方面。下面结合实施例对本发明做进一步说明。
实施例1:一种生血中药组合物,按重量计,其由以下药物组成:
生地黄12份、山萸肉30份、山药10份、太子参15份、党参15份、麦冬15份、北沙参15份、人参须15份、天冬15份、五味子6份、肉桂6份、白芍20份、甘草20份、浮小麦30份、大枣20份、女贞子20份、墨旱莲20份、生姜10份。
本实施例的生血中药组合物为颗粒剂,其制备方法包括如下步骤:
S1:按比例取原料药物;
S2:加8倍水,煎煮1h后,过滤;
S3:将药渣加6倍水,煎煮1h,过滤;
S4:将步骤S2和S3的煎煮液合并,减压浓缩至相对密度为1.01-1.05g/cm3(55℃-60℃测定),喷雾干燥即可制取颗粒剂。
本发明的中药组合物所制备的颗粒剂命名为生血颗粒。
实施例2:临床疗效
选自2006年至2014年来院就诊的确诊患有恶性肿瘤的采用本发明进行治疗的患者,共100例,其中男性58例,女性52例,年龄在28-74岁。
上述的患者的采用本发明的生血颗粒进行治疗,其给药方式为:
1日2次,一次1袋,一袋15克,饭后半小时温开水送服,以30天为基础疗程。
对本实施例的100例病人按疗程治疗后随诊观察,临床有效93例,显效3例,无效4例,有效率为96%,疗效显著。
治疗标准:
根据临床症状改善效果分为显效、有效、无效、3个等级;
显效:临床症状、体征基本消失或显著改善;
有效:临床症状及体征又算缓解或好转;
无效:临床症状、体征无明显改善或病情加重。
以上所述实施例的各技术特征可以进行任意的组合,为使描述简洁,未对上述实施例中的各个技术特征所有可能的组合都进行描述,然而,只要这些技术特征的组合不存在矛盾,都应当认为是本说明书记载的范围。
Claims (5)
1.一种生血中药组合物,其特征在于,按重量计,其由以下药物组成:
生地黄5-100份、山萸肉5-100份、山药5-100份、太子参5-100份、党参5-100份、麦冬5-100份、北沙参5-100份、人参须5-100份、天冬5-100份、五味子5-100份、肉桂5-100份、白芍5-100份、甘草5-100份、浮小麦5-100份、大枣5-100份、女贞子5-100份、墨旱莲5-100份、生姜5-100份。
2.根据权利要求1所述的一种生血中药组合物,其特征在于,按重量计,其由以下药物组成:
生地黄12份、山萸肉30份、山药10份、太子参15份、党参15份、麦冬15份、北沙参15份、人参须15份、天冬15份、五味子6份、肉桂6份、白芍20份、甘草20份、浮小麦30份、大枣20份、女贞子20份、墨旱莲20份、生姜10份。
3.根据权利要求1或2所述的一种生血中药组合物,其特征在于,其可加入常规辅剂制成口服制剂。
4.根据权利要求3所述的一种生血中药组合物,其特征在于,其为颗粒制剂。
5.根据权利要求4所述的一种生血中药组合物,其特征在于,其制备方法包括如下步骤:
S1:按比例取原料药物;
S2:加8倍水,煎煮1h后,过滤;
S3:将药渣加6倍水,煎煮1h,过滤;
S4:将步骤S2和S3的煎煮液合并,减压浓缩至相对密度为1.01-1.05g/cm3,喷雾干燥即可制取颗粒剂。
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