CN117377682A - 使用溶瘤病毒递送正交il-2选择性刺激实体瘤中的t细胞 - Google Patents

使用溶瘤病毒递送正交il-2选择性刺激实体瘤中的t细胞 Download PDF

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Publication number
CN117377682A
CN117377682A CN202280033752.0A CN202280033752A CN117377682A CN 117377682 A CN117377682 A CN 117377682A CN 202280033752 A CN202280033752 A CN 202280033752A CN 117377682 A CN117377682 A CN 117377682A
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cells
cell
domain
receptor
orthogonal
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CN202280033752.0A
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English (en)
Chinese (zh)
Inventor
M·西乌拉
C·H·祝恩
A·波西
A·里巴斯
A·卡尔巴西
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University of Pennsylvania Penn
University of California San Diego UCSD
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University of Pennsylvania Penn
University of California San Diego UCSD
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/32—T-cell receptors [TCR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
    • A61K40/4214—Receptors for cytokines
    • A61K40/4217—Receptors for interleukins [IL]
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4254—Adhesion molecules, e.g. NRCAM, EpCAM or cadherins
    • A61K40/4255—Mesothelin [MSLN]
    • A—HUMAN NECESSITIES
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    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4267—Cancer testis antigens, e.g. SSX, BAGE, GAGE or SAGE
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CN202280033752.0A 2021-03-09 2022-03-09 使用溶瘤病毒递送正交il-2选择性刺激实体瘤中的t细胞 Pending CN117377682A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163158671P 2021-03-09 2021-03-09
US63/158,671 2021-03-09
PCT/US2022/019479 WO2022192346A1 (en) 2021-03-09 2022-03-09 Selective stimulation of t cells in solid tumors using oncolytic viral delivery of orthogonal il-2

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CN117377682A true CN117377682A (zh) 2024-01-09

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CN202280033752.0A Pending CN117377682A (zh) 2021-03-09 2022-03-09 使用溶瘤病毒递送正交il-2选择性刺激实体瘤中的t细胞

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US (1) US20240299541A1 (https=)
EP (1) EP4305054A4 (https=)
JP (1) JP2024509917A (https=)
CN (1) CN117377682A (https=)
WO (1) WO2022192346A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023044457A1 (en) 2021-09-17 2023-03-23 Parker Institute For Cancer Immunotherapy Switch receptors using il-9 signaling domains
US20230265147A1 (en) * 2021-09-17 2023-08-24 The Trustees Of The University Of Pennsylvania Interleukin-9 Signaling in Chimeric Antigen Receptor (CAR) Immune Cells
EP4554611A1 (en) * 2022-07-15 2025-05-21 The Regents Of The University Of California Il-9r signaling compositions and methods
CN120225568A (zh) * 2022-12-27 2025-06-27 广州瑞风生物科技有限公司 一种融合蛋白及其应用
WO2025085721A1 (en) * 2023-10-18 2025-04-24 Memorial Sloan-Kettering Cancer Center Chimeric receptors and uses thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102739782B1 (ko) * 2015-09-11 2024-12-09 더 보드 오브 트러스티스 오브 더 리랜드 스탠포드 쥬니어 유니버시티 생물학적으로 관련된 직교 사이토카인/수용체 쌍
EP3746116A1 (en) * 2018-01-31 2020-12-09 Novartis AG Combination therapy using a chimeric antigen receptor
AU2020219246A1 (en) * 2019-02-08 2021-08-19 Seattle Children's Hospital (dba Seattle Children's Research Institute) Chimeric cytokine receptors
CN115996746A (zh) * 2020-04-06 2023-04-21 辛德凯因股份有限公司 经基因组修饰以表达正交受体的人免疫细胞

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EP4305054A1 (en) 2024-01-17
EP4305054A4 (en) 2025-03-19
JP2024509917A (ja) 2024-03-05
US20240299541A1 (en) 2024-09-12
WO2022192346A1 (en) 2022-09-15

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