CN117377522A - 用于捕集流体中的颗粒的声流体装置和方法 - Google Patents

用于捕集流体中的颗粒的声流体装置和方法 Download PDF

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Publication number
CN117377522A
CN117377522A CN202280033395.8A CN202280033395A CN117377522A CN 117377522 A CN117377522 A CN 117377522A CN 202280033395 A CN202280033395 A CN 202280033395A CN 117377522 A CN117377522 A CN 117377522A
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CN
China
Prior art keywords
channel
acoustic
fluid
particles
substrate
Prior art date
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Pending
Application number
CN202280033395.8A
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English (en)
Chinese (zh)
Inventor
迈克尔·塞巴斯蒂安·格尔特
彼得·鲁彭
于尔格·杜阿利
斯文·潘克
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eidgenoessische Technische Hochschule Zurich ETHZ
Original Assignee
Eidgenoessische Technische Hochschule Zurich ETHZ
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Application filed by Eidgenoessische Technische Hochschule Zurich ETHZ filed Critical Eidgenoessische Technische Hochschule Zurich ETHZ
Publication of CN117377522A publication Critical patent/CN117377522A/zh
Pending legal-status Critical Current

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads or physically stretching molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D21/00—Separation of suspended solid particles from liquids by sedimentation
    • B01D21/28—Mechanical auxiliary equipment for acceleration of sedimentation, e.g. by vibrators or the like
    • B01D21/283—Settling tanks provided with vibrators
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1404—Handling flow, e.g. hydrodynamic focusing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2221/00—Applications of separation devices
    • B01D2221/10—Separation devices for use in medical, pharmaceutical or laboratory applications, e.g. separating amalgam from dental treatment residues
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2259/00—Type of treatment
    • B01D2259/80—Employing electric, magnetic, electromagnetic or wave energy, or particle radiation
    • B01D2259/816—Sonic or ultrasonic vibration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0668—Trapping microscopic beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/12—Specific details about manufacturing devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0433—Moving fluids with specific forces or mechanical means specific forces vibrational forces
    • B01L2400/0436—Moving fluids with specific forces or mechanical means specific forces vibrational forces acoustic forces, e.g. surface acoustic waves [SAW]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40—Concentrating samples
    • G01N1/4077—Concentrating samples by other techniques involving separation of suspended solids
    • G01N2001/4094—Concentrating samples by other techniques involving separation of suspended solids using ultrasound

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Fluid Mechanics (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Micromachines (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
CN202280033395.8A 2021-05-06 2022-05-03 用于捕集流体中的颗粒的声流体装置和方法 Pending CN117377522A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP21172430.7 2021-05-06
EP21172430.7A EP4085982A1 (en) 2021-05-06 2021-05-06 Acoustofluidic device and method for trapping particles in a fluid
PCT/EP2022/061881 WO2022233893A1 (en) 2021-05-06 2022-05-03 Acoustofluidic device and method for trapping particles in a fluid

Publications (1)

Publication Number Publication Date
CN117377522A true CN117377522A (zh) 2024-01-09

Family

ID=76034419

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202280033395.8A Pending CN117377522A (zh) 2021-05-06 2022-05-03 用于捕集流体中的颗粒的声流体装置和方法

Country Status (7)

Country Link
US (1) US20240253039A1 (enExample)
EP (2) EP4085982A1 (enExample)
JP (1) JP2024518382A (enExample)
KR (1) KR20240006602A (enExample)
CN (1) CN117377522A (enExample)
AU (1) AU2022268583A1 (enExample)
WO (1) WO2022233893A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2026006856A1 (en) * 2024-06-25 2026-01-02 The Regents Of The University Of Colorado A Body Corporate High-throughput gravity-based multichannel separation assembly
WO2026011041A1 (en) * 2024-07-02 2026-01-08 The Charles Stark Draper Laboratory, Inc. Acoustic concentration of cells or particles in blood products

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4523682A (en) * 1982-05-19 1985-06-18 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Acoustic particle separation
US20080245709A1 (en) * 2007-04-09 2008-10-09 Gregory Kaduchak Apparatus for separating particles utilizing engineered acoustic contrast capture particles
US20130043170A1 (en) * 2011-08-16 2013-02-21 Klint A. Rose Microfluidic ultrasonic particle separators with engineered node locations and geometries
US20140011240A1 (en) * 2012-03-15 2014-01-09 Flodesign Sonics, Inc. Acoustophoretic separation technology using multi-dimensional standing waves
CN103667051A (zh) * 2013-12-20 2014-03-26 河南省医药科学研究院 用于肿瘤细胞分离的表面声波微流控芯片
CN112076808A (zh) * 2019-06-13 2020-12-15 安行生物技术有限公司 利用超高频声波控制溶液中的微粒移动的方法及设备
CN114308157A (zh) * 2021-12-27 2022-04-12 南京航空航天大学 一种基于局域谐振腔的动态可调声镊装置及其使用方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3488732B2 (ja) * 1992-12-02 2004-01-19 株式会社日立製作所 超音波処理装置
JP2700058B2 (ja) 1996-01-23 1998-01-19 工業技術院長 超音波を用いた非接触マイクロマニピュレーション方法
US7837040B2 (en) 2007-04-09 2010-11-23 Los Alamos National Security, Llc Acoustic concentration of particles in fluid flow
ES2326109B1 (es) * 2007-12-05 2010-06-25 Consejo Superior De Investigaciones Cientificas Microdispositivo de separacion y extraccion selectiva y no invasiva de particulas en suspensiones polidispersas, procedimiento de fabricacion y sus aplicaciones.
JP2012202789A (ja) * 2011-03-25 2012-10-22 Fujifilm Corp 測定装置
US9457302B2 (en) * 2014-05-08 2016-10-04 Flodesign Sonics, Inc. Acoustophoretic device with piezoelectric transducer array
WO2014178782A1 (en) 2013-04-30 2014-11-06 Acousort Ab Microsystem and method to focus cells or particles using acoustophoresis
US10161926B2 (en) * 2015-06-11 2018-12-25 Flodesign Sonics, Inc. Acoustic methods for separation of cells and pathogens
SG11201811220UA (en) * 2016-07-01 2019-01-30 Life Technologies Corp Methods, systems and devices for concentration of particles
EP3844261A2 (en) 2018-08-31 2021-07-07 The Charles Stark Draper Laboratory, Inc. Method and apparatus for high throughput high efficiency transfection of cells

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4523682A (en) * 1982-05-19 1985-06-18 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Acoustic particle separation
US20080245709A1 (en) * 2007-04-09 2008-10-09 Gregory Kaduchak Apparatus for separating particles utilizing engineered acoustic contrast capture particles
US20130043170A1 (en) * 2011-08-16 2013-02-21 Klint A. Rose Microfluidic ultrasonic particle separators with engineered node locations and geometries
US20140011240A1 (en) * 2012-03-15 2014-01-09 Flodesign Sonics, Inc. Acoustophoretic separation technology using multi-dimensional standing waves
CN103667051A (zh) * 2013-12-20 2014-03-26 河南省医药科学研究院 用于肿瘤细胞分离的表面声波微流控芯片
CN112076808A (zh) * 2019-06-13 2020-12-15 安行生物技术有限公司 利用超高频声波控制溶液中的微粒移动的方法及设备
CN114308157A (zh) * 2021-12-27 2022-04-12 南京航空航天大学 一种基于局域谐振腔的动态可调声镊装置及其使用方法

Also Published As

Publication number Publication date
AU2022268583A1 (en) 2023-11-23
US20240253039A1 (en) 2024-08-01
EP4334011A1 (en) 2024-03-13
KR20240006602A (ko) 2024-01-15
JP2024518382A (ja) 2024-05-01
EP4334011B1 (en) 2025-11-26
WO2022233893A1 (en) 2022-11-10
EP4085982A1 (en) 2022-11-09
EP4334011C0 (en) 2025-11-26

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