CN1173711C - Doukey-hide gelatin capsule - Google Patents
Doukey-hide gelatin capsule Download PDFInfo
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- CN1173711C CN1173711C CNB001112015A CN00111201A CN1173711C CN 1173711 C CN1173711 C CN 1173711C CN B001112015 A CNB001112015 A CN B001112015A CN 00111201 A CN00111201 A CN 00111201A CN 1173711 C CN1173711 C CN 1173711C
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Abstract
The present invention relates to a doukey-hide gelatin soft capsule which is prepared by using donkey-hide gelatin as base materials. The present invention is characterized in that the capsule is prepared by processing the raw materials of donkey-hide gelatin, salad oil, soybean phospholipid, vitamin E, beeswax, etc. The formula is established under the guide of traditional Chinese medical science principles and on the basis of a lot of tests and selection by sifting. The content of the soft capsule prepared according to the formula has the advantages of stability, uniformity, good fluidity, etc. and can not be easily delaminated. Tests prove that the formula has extensive and stable nourishing efficiency and has the advantages of no toxic effect, side effect, or unhealthy smell, and easy oral administration.
Description
The present invention relates to a kind of health care, nourishing capsule, particularly a kind of soft capsule that utilizes Colla Corii Asini to be made for base material.
Along with the development of society, people begin to pay attention to the nutrition and health care of health, for adapting to this situation, have occurred diversified health care, nutriment in recent years in the society, and quality and difference on effect are very big.The treasure that the Colla Corii Asini conduct is enriched blood, nourished blood, and 2000 years of development history are arranged, be subjected to people's popular welcome from ancient times, be described as excellent tonic product, therefore be that the health product of raw material are also more with the Colla Corii Asini.As notification number is the application for a patent for invention of CN1133719, and donkey-hide gelatin and Chinese angelica root health liquid, application number are 95110715, mainly form by Colla Corii Asini, Radix Angelicae Sinensis, Fructus Jujubae, Tong Fructus Tribuli, Fructus Setariae Germinatus and hydromel, sucrose water, taking convenience, the sweet perfume (or spice) of taste has health-care effects such as YIN nourishing is good for the stomach, invigorating the liver and kidney.But it is unreasonable to be somebody's turn to do the product composition proportion, can not effectively bring into play the comprehensive function of all compositions, causes making a low multiple use of effective ingredient, makes complicated simultaneously.
The object of the present invention is to provide the Doukey-hide gelatin capsule that can significantly improve content of hemoglobin, enhancing human body immunity power, not only have antioxidation but also have the effect of skin maintenance.
The invention provides two kinds of technical schemes for this reason:
A kind of Doukey-hide gelatin capsule is characterized in that it is the soft capsule that is formed through processing and fabricating by the following weight proportion raw material: Colla Corii Asini 15-30, salad oil 49-65, soybean phospholipid 3-5, vitamin E 1-3, Cera Flava 2-4.
Another kind of Doukey-hide gelatin capsule is characterized in that it is the soft capsule that is formed through processing and fabricating by the following weight proportion raw material: Colla Corii Asini 15-30, soybean phospholipid 30-50, vitamin E 1-3, Cera Flava 2-4, safflower oil 45-55.
Above-mentioned prescription is by consulting a large amount of lists of references, under the guidance of theory of Chinese medical science, sets up on the basis of a large amount of experiment sievings, and the soft capsule content of making according to this prescription has stable uniform, good fluidity, be difficult for advantage such as layering.Evidence, this prescription have extensive and stable nourishing effects, have no side effect, and do not have bad abnormal smells from the patient, are easy to take.
It is the major function raw material that the present invention adopts Colla Corii Asini, and Colla Corii Asini is of high nutritive value, main with its contained protein, aminoacid with trace element is relevant in a large number.From the Colla Corii Asini composition as can be known, contain rich in protein, peptide material, aminoacid in the Colla Corii Asini, total amount can reach 75%; Wherein contain 8 kinds of amino acid/11s, comprise needed by human and self can not synthetic aminoacid 8 kinds, account for 20.3% of total amino acids amount; And glycine wherein is to promote the synthetic important substance of hemoglobin, other arginine, tryptophan, valine, leucine, threonine, lysine all have the function that promotes medulla hematopoietic system, can significantly improve content of hemoglobin, the enhancing human body immunity function.Contain 27 kinds of trace element in addition in the Colla Corii Asini, wherein 9 kinds is human essential elements.In vivo, aminoacid and trace element interact, and mutually combine, and generate plurality of enzymes, hormone, protein and nucleic acid raw material material etc., regulate body physiological function by constituting these life active compounds, improve the organism metabolism balance.Also add vitamin E in the prescription in addition, promptly had the effect that antioxidation has skin maintenance again.
The invention will be further described below in conjunction with embodiment.
Embodiment 1, gets Colla Corii Asini 15 gram, adds that water is an amount of, heating is dissolved, and makes relative density reach 1.10, places then to make glue temperature naturally cool to 90 ℃; Utilize spray dryer to make the Colla Corii Asini powder again, the spray drying temperature is 180-200 ℃.Getting total amount again is the salad oil of 49 grams, utilize wherein 2/3 promptly 32.7 grams with after above-mentioned Colla Corii Asini powder fully mixes, add soybean phospholipid 3 grams again, reach auxiliary material, auxiliary material is edible calcium carbonate 30 grams in this prescription, stir into uniform pasty state liquid after the mixing gently as first liquid, standby.Get Cera Flava 2 gram again and be heated to 80 ℃, after dissolving again with remaining 1/3 salad oil promptly 16.3 grams mix, Cera Flava is dissolved in the salad oil as second liquid, standby.To heat after above-mentioned first liquid and second liquid mixing, be heated to 60-70 ℃ and get final product, the two is uniformly mixed into suspension; After being cooled to 40 ℃, add liquid vitamin e1 gram again, after being uniformly mixed into suspension, again this suspension is crossed colloid mill, carry out evacuation, the processing of compacting soft capsule, can form soft capsule, the film temperature is 60-65 ℃, and the sprinkler body temperature is 47-48 ℃, 2.6 rev/mins of mould rotating speeds, the soft capsule that makes was dried dry 2 hours, dry and to pack warehouse-in.For ease of taking, the content that soft capsule is every is designed to 1 gram.Instructions of taking is secondary every day, each 2.The effect of this prescription: bone density improving is applicable to the calcium deficiency crowd.Promote absorbing of calcium because of Colla Corii Asini has, can promote calcium balance and positive nitrogen balance.Contained lysine, the arginine of Colla Corii Asini is its functional component that promotes calcium absorption, states clearly absorption and the storage that Colla Corii Asini can promote calcium under " Chinese medicine voluminous dictionary " Colla Corii Asini item, is effective Chinese medicine of prevention and treatment osteoporosis.The edible calcium carbonate calcium content just can satisfy the Ca supply amount up to 40% with very low dose of in addition, and it can very fast digest and decompose be ionized calcium in gastrointestinal, is convenient to amino acid whose combination and absorption by human body utilization.More than two flavor components mutual compatibilities, can improve osteoporosis fast.
After testing, each functional component and quality index content are in this product:
| Project | Calcium | Vitamin E | Protein | Moisture | Acid value | Peroxide value | Disintegration time |
| Data | 90g/kg | 9.4×10 4mg/kg | 270g/kg | 3.6％ | 3.25 | ＜0.1 | 28 |
This product has been carried out following animal experiment by Shanghai City preventive medicine academy:
1, laboratory animal: ablactation wistar rat, male, the 50-60 gram.
2, normal feedstuff prescription: casein containing protein 15 grams in per 100 gram normal feedstuff, rice meal 30 grams, corn starch 32 grams, analysis for soybean powder 10 grams, Oleum Arachidis hypogaeae semen 5 grams, salt-mixture 3.5 grams.
3, dosage design:
(1), this laboratory sample is established basic, normal, high three dosage groups:
Low dose group: normal feedstuff adds sample, to calcium content 1500mg/kg
Middle dosage group: normal feedstuff adds sample, to calcium content 3000mg/kg
High dose group: normal feedstuff adds sample, to calcium content 5000mg/kg
(2) matched group is provided with three:
Low calcium matched group: be the normal feedstuff group, feed calcium content is 600mg/kg
Middle calcium matched group: be that normal feedstuff adds calcium carbonate, feed calcium content is 3000mg/kg
The high calcium matched group: for normal feedstuff adds calcium carbonate, feed calcium content is 5000mg/kg
4, experimental technique: 60 of ablactation rats, after the one week adaptation of normal diet feed, weigh, be divided into 6 groups at random, 10 every group, single cage is raised, respectively the above 6 kinds of feedstuffs of feed; Animal feeding to 12 adopts QDR-4000 type borne densitometers to measure rat femur mid point and femur metaphysis bone density after week, puts to death rat then, peels off the left side femur, with the length of vernier caliper measurement femur, femur is dried to constant weight, and weighing is key heavy.
Result of the test sees the following form:
Table 1, laboratory sample are to the influence of rat body weight
Group number of animals body weight (g) weight increase (g/12w)
After testing before (only) experiment
Low calcium matched group 10 71.8 329.8 258
Middle calcium matched group 10 74.0 341.0 273
High calcium matched group 10 74.8 347.8 280.0
Low dose group 10 72.0 335.2 263.2
(brought forward)
Middle dosage group 10 71.2 352.6 281.4
High dose group 10 73.6 363.8 290.2
By table 1 as seen, sample high dose group body weight is significantly higher than the high calcium matched group, in, low dose group body weight and corresponding matched group relatively, no significant difference; The weight increase high dose group is for the highest, but each dosage group and corresponding matched group are relatively, no significant difference.
Table 2, sample are to the influence of rat height
Group number of animals height (cm) height increases (cm/12w)
After testing before (only) experiment
Low calcium matched group 10 14.9 23.8 8.45
Middle calcium matched group 10 15.2 24.8 9.71
High calcium matched group 10 15.1 24.9 10.1
Low dose group 10 15.0 23.9 8.96
Middle dosage group 10 15.0 25.1 9.90
High dose group 10 15.1 25.4 1.029
By table 2 as seen, before the experiment, height does not have significant difference between each group, and after the experiment, high, medium and low each dosage group height, height increase and corresponding matched group does not relatively have significant difference.
Table 3, sample are to the influence of length, weight and the bone density of rat femur
Group number of animals femur length femur weight femur metaphysis femur mid point
(only) be (g) bone density bone density (cm)
(g/cm
2) (g/cm
2)
Low calcium matched group 10 3.09 0.78 0.289 0.307
Middle calcium matched group 10 3.17 0.81 0.297 0.319
High calcium matched group 10 3.18 0.82 0.323 0.340
Low dose group 10 3.17 0.79 0.294 0.317
Middle dosage group 10 3.19 0.82 0.304 0.321
High dose group 10 3.20 0.82 0.332 0.341
By table 3 as seen, the length of femur, high, medium and low group all significantly greater than low calcium matched group; The weight of femur, femoral shaft epiphysis bone density, femur mid point bone density, high, middle dosage group are all significantly greater than low calcium matched group.
Embodiment 2, get Colla Corii Asini 15 gram, soybean phospholipid 3 grams, vitamin e1 gram, Cera Flava 2 grams, salad oil 54 grams, and Radix Panacis Quinquefolii 25 grams are as auxiliary material, and manufacture method is also made the soft capsule of 1 gram with embodiment 1, and instructions of taking also is secondary every day, each 2.The effect of this prescription: resisting fatigue is applicable to the fatiguability crowd.In this prescription, Colla Corii Asini contains rich nutrient substances, and each nutritional labeling can interact in vivo, mutually combine, and generates plurality of enzymes, hormone, protein and nucleic acid raw material material etc., regulate body physiological function by constituting these life active compounds, improve the organism metabolism balance.Colla Corii Asini has significant blood tonification effect in addition, can provide abundant prescribing adequate nutrition material for histoorgan, strengthens the conveying function of blood oxygen.Radix Panacis Quinquefolii is that the QI invigorating that people use always is set upright, nourishing and fit keeping function, antifatigue treasure, and the ginsenoside is its main functional component, and content is about 6%, wherein-Rb
2,-Re ,-Rg has the obvious anti-fatigue effect.Radix Panacis Quinquefolii has the moderate excitation to nervus centralis in addition, and Radix Panacis Quinquefolii has regulating action to carbohydrate metabolism, and blood sugar concentration can raise.More than two medicines complement each other, qi and blood tonifying makes the gas promoting the circulation of blood smooth, the blood circulation of qi promoting is prosperous, plays the antifatigue health-care effect altogether.
After testing, each functional component and quality index content are in this product: Radix Ginseng total saponins 0.72g/100g, protein 13.5%.
This product has been carried out following animal experiment by Shandong Prov. Sanitation and Antiepidemic Station:
1, laboratory animal: ablactation rat;
2, dosage design: basic, normal, high three dosage groups are established in this experiment, are respectively 0.33g/kgb.w, 0.66g/kgb.w, 2g/kgb.w.Matched group is irritated and is fed distilled water
3, experimental technique: (1) carries out the serum urea nitrogen determination with diacetyl-oxime method; (2) carrying out hepatic glycogen with anthrone method measures; (3) carrying out lactic acid with the lactic acid analyser measures.
4, experimental result sees the following form:
Table 4, the influence of serum urea nitrogen during to mouse movement
Group number of animals serum urea nitrogen P value
(only) (mgdl)
Contrast 15 27.58
Low dosage 14 25.63＜0.05
Middle dosage 15 25.66
High dose 15 24.88＜0.05
By table 4 as seen, per os gives this product 30 days of mice various dose, serum urea nitrogen level in the time of obviously reducing mouse movement, and low, high dose group is compared with matched group, has significant difference.
The influence of table 5, this product hepatic glycogen consumption during to mouse movement
Group number of animals hepatic glycogen (g/100g hepatic tissue)
Contrast 13 5.26
Low dosage 13 5.35
Middle dosage 14 5.88
High dose 13 4.60
By table 5 as seen, this product can not increase the deposit of hepatic glycogen.
Table 6, this product are to the influence of mouse movement bleeding from anus lactic acid rising speed
Group number of animals blood lactic acid (mmol/l)
Back 0 minute difference P value of experiment before (only) experiment
Contrast 15 2.00 6.16 4.16
Low dosage 15 1.70 4.68 2.98＜0.01
Middle dosage 15 1.66 4.74 3.08
High dose 15 1.88 4.96 3.03＜0.05
By table 6 as seen, per os gives this product 30 days of mice various dose, blood lactic acid rising speed in the time of reducing mouse movement.The difference of the blood lactic acid that sampling records before high dose group motion post-sampling and the motion has been compared significant difference with matched group; And low dose group has utmost point significant difference.
Embodiment 3, get Colla Corii Asini 20 gram, soybean phospholipid 3 grams, vitamin e1 gram, Cera Flava 2 grams, salad oil 49 grams, and Semen Ziziphi Spinosae 25 grams are as auxiliary material, manufacture method is also made the soft capsule of 1 gram with embodiment 1, and instructions of taking also is secondary every day, each 2.The effect of this prescription: improve sleep, be applicable to the insomnia crowd.In this prescription, Colla Corii Asini, Semen Ziziphi Spinosae matter lubricant nature are mended, and have the effect of the blood that nourishes heart, tranquilizing mind, are used for the fidgets due to deficiency insomnia, severe palpitation due to heart-liver blood deficiency, the lack of preservation of spirit, the deficient syndrome of malaise such as forgetful.Colla Corii Asini contains rich in protein, aminoacid and a large amount of trace element, and nutritive value is enriched comprehensively, is used for nourishing the heart to keep a sound mind by its vigorous reinforcing the heart blood.Semen Ziziphi Spinosae has the effect of " tranquilizing by nourishing the heart ", is used for neurasthenia aypnia clinically, and no matter single medicinal material or compatibility use all better curative effect.Experimental results show that Semen Ziziphi Spinosae has significant sedation to various animals, even take very heavy dose of animal generation anesthesia that also can not make.Semen Ziziphi Spinosae can suppress the mice defensive conditionedreflex, suppresses diffusion in causing, makes defensive unconditioned reflex prolongation of latency, and its inhibitory action and tranquilizer to nervus centralis has similar effect.Colla Corii Asini and Semen Ziziphi Spinosae compatibility use in this prescription, have strengthened the blood that nourishes heart, and the effect of tranquilizing mind especially has significant effect to neurasthenia aypnia.
Embodiment 4, get Colla Corii Asini 30 gram, soybean phospholipid 2 grams, vitamin e1 gram, Cera Flava 1 gram, salad oil 65 grams, and ferrous lactate 1 gram is as auxiliary material, and manufacture method is also made the soft capsule of 1 gram with embodiment 1, and instructions of taking also is secondary every day, each 2.The effect of this prescription: improve nutritional anemia, be applicable to the anemia that malnutrition causes.In this prescription, Colla Corii Asini contains aminoacid and multiple macroelement and a large amount of trace element of rich in protein, needed by human body, aminoacid and trace element interact, mutually combine in vivo, generate plurality of enzymes, hormone, vitamin, constitute the basic material of human body hemopoietic.Current medical evidence Colla Corii Asini contains and acts on the further induced differentiation material of early stage bone marrow stem cell, and promotes human body hemopoietic by improving the human body hematopoieticmicroenviron-ment.In addition with regard to erythrocytic generation, hemoglobin is the main composition of erythrocyte, it is a kind of conjugated protein, its prothetic group partly is a haemachrome, protein portion is a globin, ferrous ion is to constitute the requisite material of haemachrome, when ferrum element unbalanced when the human body meals or that take in is on the low side, nutritional anemia (also comprising iron deficiency anemia) will take place.Ferrous lactate in this prescription not only safety is good and be organic ferrum, and its absorbance does not more have the side effect such as gastrointestinal reaction of inorganic iron apparently higher than inorganic iron, is a kind of iron supplement agent commonly used.Above-mentioned all medicine compatibilities are promptly consolidated the speed of enriching blood soon again.Colla Corii Asini improves hematopoieticmicroenviron-ment, and the hemopoietic material is provided, thereby promotes the absorption and the utilization of ferrum; Ferrous lactate can remedy relatively slowly problem of the speed of enriching blood that Colla Corii Asini causes owing to the deficiency of chalybeate in improving human body anemia process, it is more perfect to make Colla Corii Asini improve the health-care effect of nutritional anemia on the whole.
Embodiment 5, get Colla Corii Asini 10 gram, soybean phospholipid 3 grams, vitamin e1 gram, Cera Flava 2 grams, salad oil 54 grams, and Pericarpium Citri Reticulatae 10 grams, Radix Codonopsis 20 grams are as auxiliary material, manufacture method is with embodiment 1, also make the soft capsule of 1 gram, instructions of taking also is secondary every day, each 2.The effect of this prescription: the protection gastric mucosa is applicable to the injured crowd of gastric mucosa.Pericarpium Citri Reticulatae is the spleen invigorating key medicine of regulating the flow of vital energy, and fragrance is good for the stomach, and the therapeutic method to keep the adverse QI flowing downwards of dispeling the wind is also alleviated stagnation of QI in spleen and stomach, can treat abdominal distention.Peptic Ulcers is many to be lost due to the fortuneization by incoordination between the spleen and stomach, retention of damp-heat in the interior or irritability stasis, spleen, show the gastral cavilty distending pain is arranged, acid regurgitation, disease such as noisy.The effective ingredient of Pericarpium Citri Reticulatae is a hesperidin, can obviously suppress the generation of mice ulcer, and can increase by disease-resistant rational gastric secretion, uses vitamin E as merging, and effect is strengthened.Radix Codonopsis is the medicine that strengthens the spleen and stomach, and studies show that Radix Codonopsis has tangible anti-experimental character gastric ulcer and gastric mucosa injury effect; This extract can be secreted by gastric acid inhibitory, promotes gastric mucosa synthetic, strengthens gastric mucus---bicarbonate barrier action and suppress ulcer, the protection gastric mucosa.Think after deliberation: Radix Codonopsis polysaccharide is the main effective ingredient of Radix Codonopsis antiulcer and gastric mucosa injury.Colla Corii Asini contains rich in protein, peptide material and trace element, has nutrition organs, regulates immunization; for tissue repair provides competent protein substance and trace element; mutually promote with above two flavor medicines, combined effect can be protected the stomach film better in ulcer surface.
Embodiment 6, get Colla Corii Asini 15 gram, soybean phospholipid 2 grams, vitamin e1 gram, Cera Flava 1 gram, salad oil 61 grams, and Rhizoma Chuanxiong 10 grams, the Radix Angelicae Dahuricae 10 grams are as auxiliary material, manufacture method is with embodiment 1, also make the soft capsule of 1 gram, instructions of taking also is secondary every day, each 2.The effect of this prescription: beautification function.The moistening of blood supported effect and can be reflected from aspects such as complexion, muscle, skins, show as have rosy cheeks, skin is smooth, flexible.Support when weakening and moisten, body except that organ function lowly, lustreless complexion or sallow, scaly dry skin just can appear.Colla Corii Asini is familiar with by people as a kind of treasure of enriching blood, and can replenish the human body rich nutrient substances again except that having blood tonification effect.The Radix Angelicae Dahuricae in this prescription is a kind of natural cosmetic material in addition, just thinks the Radix Angelicae Dahuricae skin of moistening in Shennong's Herbal, thinks in " Bencao Jingshu ", and " fragrance and hot is so can moisten for the Radix Angelicae Dahuricae." modern medicine study proves; the activity that the volatile oil in the Radix Angelicae Dahuricae can restraint of tyrosinase; tryrosinase can be transformed into two hydroxypropyl ammonia by catalysis butyric acid; and the Radix Angelicae Dahuricae enzymatic inhibition by effective ingredient just; reducing melanin forms; and be applicable to the various speckle of treatment, have good result antibiotic and the maintenance skin of face simultaneously.Rhizoma Chuanxiong applying frequency on China's beauty treatment history is also quite a lot of, Rhizoma Chuanxiong has good Accommodation to microcirculation, it is very high that its infusion suppresses activity to some pathogenic dermatophytes, the effect that has vitamin antagonist E to lack, and Rhizoma Chuanxiong also has the active effect of restraint of tyrosinase simultaneously.The mutual compatibility of above-mentioned all medicines can suppress the generation of chloasma, the effect of playing spot-eliminating beauty treatment altogether together.
Embodiment 7, get Colla Corii Asini 20 gram, soybean phospholipid 3 grams, vitamin e1 gram, Cera Flava 2 grams, salad oil 54 grams, and Fructus Schisandrae Chinensis 20 grams are as auxiliary material, and manufacture method is also made the soft capsule of 1 gram with embodiment 1, and instructions of taking also is secondary every day, each 2.The effect of this prescription: the protective effect to chemical liver injury is applicable to hepatitis patient.Fructus Schisandrae Chinensis extrat preparation in this prescription, clinical practice have and significantly fall enzyme and hepatoprotective effect.Experiment showed, that falling enzyme mechanism is to make the various to external world impairment factors of hepatocyte have defence, resistant function.Schizandrol (schisandra chinensis ethyl hydrate extract) and other seven kinds of effective ingredient (deoxyschizandrin, second element, third element, pure first, pure second, ester first and ester second) all have protective effect to drug-induced animal liver damage.The mechanism that fall enzyme, protects the liver is as follows: promote hepatocyte to repair or the inhibition liver cell lesion; Make liver plasma membrane that certain function take place and sexually revise, membrane permeability is reduced; Promote hepatocyte internal protein anabolism; Promote adrenal cortex function, the hepatocyte inflammation is alleviated; Antioxidation makes the hepatocyte lipid peroxidation injury that poisonous substance is caused produce protective effect (also helping pre-anti-aging and the tumor generation); Hepatomicrosome enzyme there is inducing action, can improves detoxification ability poisonous substance and carcinogen.With Fructus Schisandrae Chinensis powder all kinds hepatitis being reduced SGPT has significant curative effect, but can recur, and GPT has rebound phenomenon.Colla Corii Asini synthetic and hormone in vivo for the hepatocyte internal protein synthetic provides abundant raw material, can improve body's immunological function comprehensively, reduce the glutamate pyruvate transaminase rebound phenomenon, strengthen the effect of the anti-hepatocyte inflammation of Fructus Schisandrae Chinensis, with the Fructus Schisandrae Chinensis synergism, strengthen hepatoprotective effect.
Embodiment 8, get Colla Corii Asini 10 gram, soybean phospholipid 3 grams, vitamin e1 gram, Cera Flava 2 grams, salad oil 54 grams, and Poria 10 grams, Polyporus 10 grams, Radix Et Caulis Acanthopanacis Senticosi 10 grams are as auxiliary material, manufacture method is with embodiment 1, also make the soft capsule of 1 gram, instructions of taking also is secondary every day, each 2.The effect of this prescription: auxiliary function of tumor inhibition is applicable to tumour patient.The Poria antitumor action is relevant with the raising body immune function in this prescription.Pachyman has immunological enhancement, shows as: 1, significantly improve laboratory animal peritoneal macrophage phagocytic percentage and phagocytic index, and energy antagonism immunosuppressant prednisoni acetas is to the inhibitory action of macrophage function.2, make thymus, lymph node weightening finish.3, alleviate
60Murine interleukin due to the Co radiation gamma reduces.4, strengthen cell immune response.The pachyman lumbar injection can suppress mice S
180The growth of solid tumor in the extract of the Poria mycelium that deep layer is cultivated, is found to exist S
180Strong anti-tumor activity polysaccharide is arranged, wherein H
11To S in the body
180The suppression ratio of tumor is 94%.Polyporus extract can suppress murine sarcoma 180 and hepatocarcinoma.Its anticancer mechanism is: 1, suppress the synthetic of the interior DNA of oncocyte, thereby influence tumor cell proliferation.2, improve cAMP content in the oncocyte.3, Poria is a kind of non-specific immunostimulating agents, can significantly improve the tumor-bearing mice peritoneal macrophage and engulf vigor, improves lymhocyte transformation rate.4, pachyman has the effect of the former state of adaptation, can make ascitic type liver cancer H
22The hyperfunction cortex effect of tumor-bearing mice is recovered, and the hepatic glycogen accumulation increases, and the glyconeogenesis enzymatic activity strengthens, and this improvement to the tumor animal allomeric function has positive role, also is a pharmacological basis of its treatment tumor.The contained effective ingredient Radix Acanthopanacis Senticosi of Radix Et Caulis Acanthopanacis Senticosi polysaccharide has the effect of the anti-nonspecific stimulation of enhancing body; Blood middle leukocytes sum and multinuclear leucocyte digital display work is increased; But the activating macrophage phagocytic function has the good restraining effect to oncocyte.Find also that in addition it can suppress the synthetic of the interior DNA of oncocyte, can influence the division growth of oncocyte.Colla Corii Asini has the function that promotes medulla hematopoietic system, can significantly improve immunity of organisms, the growth of tumor cell is had suppress and lethal effect.The common compatibility of above medicine replenishes mutually, mutually promotes, and has strengthened suppressing the effect of tumor.
Embodiment 9, get Colla Corii Asini 10 gram, soybean phospholipid 3 grams, vitamin e1 gram, Cera Flava 2 grams, salad oil 54 grams, and Radix Polygoni Multiflori 15 grams, the Radix Astragali 15 grams are as auxiliary material, manufacture method is with embodiment 1, also make the soft capsule of 1 gram, instructions of taking also is secondary every day, each 2.The effect of this prescription: immunoregulation effect is applicable to the hypoimmunity crowd.In this prescription, Radix Polygoni Multiflori contains a large amount of phospholipid substances and inorganic elements calcium, ferrum, zinc, manganese, copper, strontium, nickel etc., has invigorating the liver and kidney, benefiting essence-blood, black beard and hair, the effect of bone and muscle strengthening.Obviously mouse thymus degeneration atrophy after the delay maturation, increase thymus and spleen weight, improve spleen plaque forming cells quantity, significantly increase inductive thymus of ConA and spleen lymphocyte breeder reaction, improve the macrophage phagocytic ability, activate dried lymhocyte transformation rate, inducement interferon.Immunity is subjected to press down mice to be had more obvious promotion cellular immunization and regulates the effect of humoral immunization.Studies show that: Radix Polygoni Multiflori mainly by protection thymus, increase to rely on thymus cell function and enhance immunity, resistance against diseases, this and its kidney invigorating and essence nourishing, training revisal qigong effect matches.The Radix Astragali contains Polysaccharide A, B, C, D, contains aminoacid and reaches 25 kinds, and total amount is about 1.26%, and protein, choline, betanin, folic acid etc. also contain alkaloid, trace element silicon, cobalt, selenium, molybdenum etc.Have invigorating QI to consolidate the body surface resistance, the diuresis poison holding is arranged the merit of dense granulation promoting.Can significantly increase nonspecific immunity and specific immunity.To the nonspecific immunity effect, the Radix Astragali can make blood middle leukocytes sum and multinuclear leucocyte digital display work increase, and can activate macrophage phagocytosis of mice, and the phagocytic function of liver spleen fixed macrophage and abdominal cavity wandering macrophage is all had stronger facilitation; The Radix Astragali can strengthen NKT (NK) cell activity; Can improve the ability of body inducement interferon.To the specific immunity effect, the Radix Astragali can significantly improve lymphocyte function; Can improve humoral immunization.Colla Corii Asini contains rich nutrient substances, and medulla hematopoietic system is had facilitation, can improve body specificity and non-specific immunity.Above drug regimen has been strengthened the immunomodulating effect together.Show that by functional experiment this product has significant raising immunization to the rat of hypoimmunity.
Embodiment 10, get Colla Corii Asini 15 grams, soybean phospholipid 30 grams, vitamin e1 gram, Cera Flava 2 grams, reach safflower oil 52 grams as auxiliary material, and manufacture method is also made the soft capsule of 1 gram with embodiment 1, and instructions of taking also is secondary every day, each 2.The effect of this prescription: blood lipid regulation is applicable to the higher crowd of blood fat.Colla Corii Asini contains rich in protein in the Yin Ben prescription, can be combined into the bigger protein-lipid complex of dissolubility with blood fat and is turned round by blood.Show that by zoopery Colla Corii Asini has the effect that improves blood microcirculation in addition, can promote that the operation of blood is unimpeded, the obstruction that too much causes for accumulation has the mediation effect.Soybean phospholipid is called as a jinx of cholesterol, can stop deposition and the removing part deposit of cholesterol at blood vessel, improves the absorption and the utilization of blood fat simultaneously, the effect with excellent prevention cardiovascular disease.Safflower oil contains up to the linoleic acid more than 70%, because linoleic acid can form cholesterol ester with cholesterol, than cholesterol ester easier running, metabolism and the drainage of satisfied fatty acid with cholesterol formation, and promotes it to be transformed into cholic acid and discharges.The safflower oil zoopery shows that it can not only obviously reduce serum cholesterol and triglyceride levels, and sclerosis has positive effect to prevention of arterial medicated porridge shape, is first-selected blood fat reducing oils.The mutual compatibility of above component is mutually promoted, and disappears to settle accounts the effect that amounts to finishing blood lipid regulation.
After testing, each functional component and quality index content are in this product:
| Project | Phospholipid | Linoleic acid | Vitamin E | Protein | Fat | Moisture | Disintegration time |
| Data | 10.19g/100g | 41.74g/100g | 9.1×10 3 | 312.4g/kg | 646g/kg | 4.4％ | 54 |
This product has also been carried out following animal experiment by Shanghai City preventive medicine academy:
1, laboratory animal: ablactation rat;
2, dosage design: basic, normal, high three dosage groups are established in this experiment, are respectively 0.33g/kg, 0.66g/kg, 2g/kg, and matched group gives vegetable oil;
3, experimental technique: get 40 of rat, after 5 days, get tail blood with the normal diet feed, survey the normal value of serum triglycerides, cholesterol, high density lipoprotein, according to basic blood lipid level rat is divided into four groups at random then, every group 10, be respectively sample three dosage group and matched groups, design according to dosage gives sample, respectively organize simultaneously equal feed high lipid food, feed after 28 days continuously, weigh, get rathole blood and survey every blood lipids index.
Experimental result sees the following form:
Table 7, to suppressing the effect that rat fat raises
Group number of animals cholesterol triglyceride high density lipoprotein
(only) (mmol/l) (mmol/l) (mmol/l)
After preceding experiment is tested in the experiment back before testing after the experiment before the experiment
Contrast 10 1.87 3.07 1.01 2.83 0.56 0.71
Low dose group 10 1.99 2.83 1.05 2.78 0.53 0.74
Middle dosage group 10 1.95 2.84 1.10 2.76 0.52 0.75
High dose group 10 1.95 2.27 1.19 2.28 0.55 1.09
By table 7 as seen, for the rat of the high nutrient fodder of the high fat of feed, per os gives the sample of various dose simultaneously, can suppress the rising of cholesterol and triglyceride, high density lipoprotein increasing; By analysis, sample high dose group cholesterol, triglyceride and high density lipoprotein are compared with matched group, and significant difference is all arranged.
Table 8, to the influence of rat fat level
Group number of animals cholesterol triglyceride high density lipoprotein
(only) (%) (%) (mmol/l)
Contrast 10------
Low dose group 10-7.8-1.8+0.03
Middle dosage group 10-7.5-2.5+0.04
High dose group 10-26.1-19.4+0.38
By table 8 as seen, sample high dose group cholesterol and triglyceride have descended 26.1% and 19.4% respectively, the high density lipoprotein 0.38mmol/l (14.7mg/dl) that risen.
Claims (8)
1, a kind of Doukey-hide gelatin capsule, it is characterized in that this capsule is the capsule that is formed by following materials of weight proportions processing and fabricating: Colla Corii Asini 15-30 part, salad oil 49-65 part, soybean phospholipid 3-5 part, vitamin e1-3 part, Cera Flava 2-4 part, Radix Panacis Quinquefolii 20-30 part.
2, Doukey-hide gelatin capsule as claimed in claim 1 is characterized in that, wherein Colla Corii Asini 15 weight portions, salad oil 54 weight portions, soybean phospholipid 3 weight portions, vitamin e1 weight portion, Cera Flava 2 weight portions, Radix Panacis Quinquefolii 25 weight portions.
3, a kind of method for preparing Doukey-hide gelatin capsule, described Doukey-hide gelatin capsule is formed by following materials of weight proportions processing and fabricating, Colla Corii Asini 15-30 part, salad oil 49-65 part, soybean phospholipid 3-5 part, vitamin e1-3 part, Cera Flava 2-4 part, Radix Panacis Quinquefolii 20-30 part, this method may further comprise the steps:
A. take by weighing above-mentioned raw materials respectively in proportion;
B. Colla Corii Asini is added the water post-heating and dissolve, then but, make the Colla Corii Asini powder with spray dryer with the Colla Corii Asini liquid cooling;
C. get salad oil weight 2/3 with after above-mentioned Colla Corii Asini powder mixes, add soybean phospholipid and Radix Panacis Quinquefolii, stir after the mixing, the pasty state liquid that obtains is as first liquid, and is standby;
D. get the Cera Flava heat fused, mix with the salad oil of remaining 1/3 weight, as second liquid, standby;
E. with first liquid and the second liquid mixing post-heating, make uniform suspension, suspension cooling back is added vitamin E, mix homogeneously is crossed colloid mill with suspension again, evacuation, is pressed into soft capsule.
4, a kind of method for preparing Doukey-hide gelatin capsule, described Doukey-hide gelatin capsule is formed by following materials of weight proportions processing and fabricating, 15 parts in Colla Corii Asini, 54 parts of salad oils, 3 parts of soybean phospholipids, vitamin e1 part, 2 parts in Cera Flava, 25 parts of Radix Panacis Quinquefoliis is characterized in that this method may further comprise the steps:
A. take by weighing above-mentioned raw materials respectively in proportion;
B. Colla Corii Asini is added the water post-heating and dissolve, then but, make the Colla Corii Asini powder with spray dryer with the Colla Corii Asini liquid cooling;
C. get salad oil weight 2/3 with after above-mentioned Colla Corii Asini powder mixes, add soybean phospholipid and Radix Panacis Quinquefolii, stir after the mixing, the pasty state liquid that obtains is as first liquid, and is standby;
D. get the Cera Flava heat fused, mix with the salad oil of remaining 1/3 weight, as second liquid, standby;
E. with first liquid and the second liquid mixing post-heating, make uniform suspension, suspension cooling back is added vitamin E, mix homogeneously is crossed colloid mill with suspension again, evacuation, is pressed into soft capsule.
5, as the preparation method of the Doukey-hide gelatin capsule of claim 3 or 4, it is characterized in that among the step b Colla Corii Asini liquid is cooled to 90 ℃, spray-dired temperature is 180-200 ℃.
6, as the preparation method of the Doukey-hide gelatin capsule of claim 3 or 4, it is characterized in that, in the steps d, is 80 ℃ with the temperature of Cera Flava heat fused.
7, as the preparation method of the Doukey-hide gelatin capsule of claim 3 or 4, it is characterized in that, among the step e, described first liquid and the second liquid mixing post-heating temperature are 60-70 ℃, the chilling temperature that described cooling back adds vitamin E is 40 ℃, the film temperature is 60-65 ℃ during described compacting soft capsule, and the sprinkler body temperature is 47-48 ℃, and the mould rotating speed is 2.6 rev/mins.
8, as the preparation method of the Doukey-hide gelatin capsule of claim 3 or 4, it is characterized in that, also comprise obtained soft capsule drying, airing, packing warehouse-in.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB001112015A CN1173711C (en) | 2000-07-10 | 2000-07-10 | Doukey-hide gelatin capsule |
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| Application Number | Priority Date | Filing Date | Title |
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| CNB001112015A CN1173711C (en) | 2000-07-10 | 2000-07-10 | Doukey-hide gelatin capsule |
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| CN1287836A CN1287836A (en) | 2001-03-21 |
| CN1173711C true CN1173711C (en) | 2004-11-03 |
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Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1593461B (en) * | 2004-07-08 | 2010-04-28 | 王健柏 | Manufacture method of nutrient oral liquor of ass hide glue flavone |
| CN1593460B (en) * | 2004-07-08 | 2010-12-01 | 王健柏 | Nutrient capsule of ass hide glue flavone |
| CN1323721C (en) * | 2005-04-25 | 2007-07-04 | 郑启英 | Capsule covering containing ass-hide gelatin component and its prepn process and application |
| CN101822366B (en) * | 2009-03-05 | 2012-12-19 | 成仲阳 | Donkey-glue calcium particle |
| CN101810340A (en) * | 2010-04-23 | 2010-08-25 | 陈显刚 | Angelica keiskei soft capsule |
| CN102526106B (en) * | 2010-12-31 | 2014-06-18 | 山东东阿阿胶股份有限公司 | Donkey-hide gelatine raw powder and preparation method thereof |
| CN102210783B (en) * | 2011-05-30 | 2012-08-29 | 广东如来医药进出口有限公司 | Composition preparation of donkey-hide glue, and preparation method thereof |
| CN102273625B (en) * | 2011-06-20 | 2012-08-29 | 山东东阿古胶阿胶系列产品有限公司 | Sugar-free American ginseng donkey-hide gelatin sheet and production technology thereof |
| CN104305167B (en) * | 2014-07-08 | 2016-04-13 | 浙江越溪胶丸有限公司 | A kind of Doukey-hide gelatin capsule and preparation method thereof |
| CN104758549B (en) * | 2015-02-09 | 2018-02-02 | 绍兴文理学院元培学院 | A kind of compound safflower sugar free granule |
| CN105030830A (en) * | 2015-06-24 | 2015-11-11 | 山东圣海保健品有限公司 | Sheep embryo and vitamin E soft capsule |
| CN108042595B (en) * | 2018-01-23 | 2021-01-15 | 康美（北京）药物研究院有限公司 | Composition with health care function and preparation method and application thereof |
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2000
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