CN117338860A - Preparation method of extract for promoting glycolysis and application of extract - Google Patents
Preparation method of extract for promoting glycolysis and application of extract Download PDFInfo
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- CN117338860A CN117338860A CN202311499641.1A CN202311499641A CN117338860A CN 117338860 A CN117338860 A CN 117338860A CN 202311499641 A CN202311499641 A CN 202311499641A CN 117338860 A CN117338860 A CN 117338860A
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- extract
- promoting
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Classifications
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Abstract
The invention belongs to the technical field of medicines, and particularly relates to a preparation method of an extract for promoting ethanol decomposition and application of the extract. The effective substances in the milk thistle herb, the vine tea and the liquorice are extracted through the steps of raw material selection, coarse crushing, heat extraction, concentration, resin purification and the like, so that the content of active ingredients is greatly increased, the triglyceride content in the liver is effectively reduced, and the ethanol decomposition is promoted, so that the alcoholic fatty liver is inhibited, and the liver function is protected. The milk thistle herb, vine tea and liquorice extracts are prepared into medicines, health products, foods and the like, so that the milk thistle herb, vine tea and liquorice extracts can be widely applied to medicines, health products and foods, and have wide future development and application prospects.
Description
Technical Field
The invention belongs to the technical field of medicines, and particularly relates to a preparation method of an extract for promoting ethanol decomposition and application of the extract.
Background
At present, a plurality of fatty liver patients caused by domestic drinking, but no good medicine, health care product or food for treating and protecting alcoholic fatty liver disease exist. The traditional anti-alcoholic drugs for promoting alcoholism are mostly chemical preparations, and have the main effect of relieving alcoholism symptoms, but can generate side effects such as liver injury, gastrointestinal discomfort, respiratory system inhibition, dependency and the like. Long-term abuse of anti-hangover drugs may impair liver function, leading to liver diseases and even liver failure. Therefore, how to select the extracts of the medicinal and edible plants to prepare the preparation for promoting the alcoholism becomes the research direction in the technical field of modern medicine.
Through researches, milk thistle, namely Silybum marianum (L.) Gaertn, has the effects of resisting liver injury, atherosclerosis, cerebral ischemia, platelet aggregation, tumor and the like. Licorice, (Glycyrrhiza uralensis Fisch.) licorice belongs to the genus Glycyrrhiza of the family Leguminosae, and has brown root bark, pale yellow inside, and sweet taste. Liquorice is distributed in northeast China, north China, shanxi China, gansu China, qinghai China, xinjiang China, shandong China and other areas. Licorice was recorded in the national major protection wild plant directory, 2021, 9, which is a national class ii protection plant. Licorice is recorded in books of Chinese calendar generation, and is not only a good medicine, but also a good name of Zhongzhiwang, and the licorice has the effects of tonifying spleen and replenishing qi, moistening lung and relieving cough, clearing heat and detoxicating, harmonizing medicines and the like, and is also used for symptoms such as sore throat, deficiency-cold of spleen and stomach, peptic ulcer, poisoning and the like. Therefore, licorice is called as "Jiucao" in ten medicines. Ampelopsis grossedentata (Ampelopsis grossedentata) is a plant of Vitaceae, is wild in natural environment protection area with altitude of 400-1300 m and diffuse dense fog, and is a very precious pure wild edible and medicinal plant. Vine tea has been drunk for over 600 years since ancient times, and it is said that people in Guizhou have been in the age of no doctor to prevent and treat hypertension, heart disease, cerebrovascular disease, throat swelling, constipation, etc. by taking vine tea. The vine tea has bitter and astringent taste, sweet aftertaste, and effects of promoting salivary secretion, quenching thirst, relieving fever, removing toxic substances, resisting bacteria, diminishing inflammation, strengthening tendons and bones, lowering blood pressure and cholesterol value, and protecting liver. Therefore, how to apply the medical and edible plants containing silymarin, dihydromyricetin, glycyrrhizic acid and glycyrrhetinic acid to medical services is a research direction.
Disclosure of Invention
The invention aims to provide a preparation method of milk thistle herb, vine tea and liquorice extracts which are extracted from plants and can reduce triglyceride content in livers and promote ethanol decomposition and application of the extracts.
In order to solve the problems existing in the prior art, the invention adopts the following technical scheme:
a method for preparing an extract for promoting glycolysis, comprising the steps of:
(1) Preparing raw materials: screening milk thistle herb, vine tea and liquorice with good quality, and drying;
(2) Coarse crushing: pulverizing dried herba Cephalanoploris, ampelopsis Grossdentata, and Glycyrrhrizae radix with pulverizing device, filtering with 5 mesh sieve to obtain coarse powder, soaking the coarse powder in purified water for 30min;
(3) And (3) heat extraction: reflux-extracting the coarse powder soaked for 30min for 2 times to obtain extractive solution;
(4) Concentrating and filtering: filtering the extractive solution, and vacuum concentrating the filtrate under reduced pressure;
(5) Purifying: eluting the concentrated solution with fixed resin column with ethanol of different concentrations, concentrating, evaporating, and pulverizing to obtain extract powder.
The preparation method of the extract for promoting ethanol decomposition comprises the step (2) of adding purified water 10-20 times of the weight of the coarse powder of milk thistle herb, vine tea and liquorice.
The reflux extraction temperature in the step (3) is 80-100 ℃.
The reflux extraction time in the step (3) is 120min each time.
The preparation method of the extract for promoting ethanol decomposition comprises the step (4) of filtering and using a filter cloth of 100 meshes.
The preparation method of the extract for promoting ethanol decomposition comprises the step (4) that the concentration temperature of the filtrate is 50-60 ℃ and the pressure is less than-0.1 MPa.
The preparation method of the extract for promoting ethanol decomposition comprises the step (4) of concentrating to obtain a solid content of 30-60%.
The preparation method of the extract for promoting ethanol decomposition comprises the step (5), wherein the extract powder comprises 10-30% of silymarin, 20-60% of dihydromyricetin, 10-30% of glycyrrhizic acid and 5-20% of glycyrrhetinic acid.
The extract for promoting glycolysis is applied to medicines, health products or compound preparations.
The application of the extract for promoting glycolysis comprises the following components: 30-50 parts of extract powder, 35-40 parts of microcrystalline cellulose, 2-4 parts of pregelatinized starch, 4-6 parts of hydroxypropyl methylcellulose, 5-8 parts of povidone, 1-2 parts of colloidal silicon dioxide and 3-6 parts of magnesium stearate.
Compared with the prior art, the invention has the following beneficial effects:
the invention develops a method for preparing extracts of milk thistle herb, vine tea and liquorice, which is proved by experiments of mice to use the extracts of milk thistle herb, vine tea and liquorice to prove that dihydromyricetin in the extracts of milk thistle herb, vine tea and liquorice can effectively reduce the content of triglyceride in liver, promote glycolysis so as to inhibit alcoholic fatty liver and protect liver function. The extract can be prepared into medicines, health products, foods and the like, can be widely applied to the aspects of medicines, health products and foods, and has wide future development and application prospects.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings that are needed in the description of the embodiments will be briefly described below, it being obvious that the drawings in the following description are only some embodiments of the present invention, and that other drawings may be obtained according to these drawings without inventive effort for a person skilled in the art.
FIG. 1 is a technical roadmap of the invention.
FIG. 2 is a graph showing comparison of alcohol content in serum of mice extracted with the extract of the present invention.
FIG. 3 is a graph showing comparison of GOT glutamic oxaloacetic transaminase and GPT glutamic pyruvic transaminase contents in serum of mice extracted with the method.
FIG. 4 is a graph showing comparison of triglyceride content in liver of mice extracted according to the present invention.
Detailed Description
In order that the above-recited objects, features and advantages of the present invention will become more apparent, a more particular description of the invention will be rendered by reference to specific embodiments thereof which are illustrated in the appended drawings.
In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present invention, but the present invention may be practiced in other ways other than those described herein, and persons skilled in the art will readily appreciate that the present invention is not limited to the specific embodiments disclosed below.
Further, reference herein to "one embodiment" or "an embodiment" means that a particular feature, structure, or characteristic can be included in at least one implementation of the invention. The appearances of the phrase "in one embodiment" in various places in the specification are not necessarily all referring to the same embodiment, nor are separate or alternative embodiments mutually exclusive of other embodiments.
Unless otherwise indicated, all starting materials used in the examples were commercially available.
Example 1
Referring to fig. 1, the present embodiment provides a method for preparing an extract for promoting ethanol decomposition, which specifically includes the following steps:
(1) Preparing raw materials: screening a certain amount of milk thistle herb, vine tea and liquorice with good quality, and drying;
(2) Coarse crushing: pulverizing dried herba Cephalanoploris, ampelopsis Grossdentata, and Glycyrrhrizae radix with pulverizing device, filtering with 5 mesh filter screen to obtain coarse powder, weighing coarse powder, adding purified water 10 times of the coarse powder, and soaking for 30min;
(3) And (3) heat extraction: reflux-extracting the coarse powder after soaking for 30min for 2 times to obtain extractive solution at 100deg.C for 120min each time;
(4) Concentrating and filtering: filtering the extract with 100 mesh filter cloth to obtain filtrate, concentrating the filtrate under reduced pressure at 60deg.C under-0.15 MPa to obtain concentrated solid with concentration of 60%;
(5) Purifying: eluting the concentrated solution with fixed resin column with 60% ethanol, eluting with anhydrous ethanol, concentrating, evaporating, and pulverizing to obtain extract powder containing silymarin 10%, dihydromyricetin 60%, glycyrrhizic acid 25% and glycyrrhetinic acid 5%.
Example 2
The difference between this example and example 1 is that a certain weight of coarse powder is weighed, purified water is added into the coarse powder, and the adding amount of the purified water is 12 times of the weight of the coarse powder of milk thistle herb, vine tea and liquorice; during heat extraction, the reflux extraction temperature is 90 ℃, and the reflux extraction time is 120min each time; concentrating and filtering at 55deg.C under vacuum degree of-0.2 MPa, and concentrating to obtain solid substance with concentration of 58%; eluting with 30% ethanol, and eluting with anhydrous ethanol, wherein the purified extract powder contains silymarin 30%, dihydromyricetin 20%, glycyrrhizic acid 30% and glycyrrhetinic acid 20%.
Example 3
The difference between this example and example 1 is that a certain weight of coarse powder is weighed, purified water is added into the coarse powder, and the adding amount of the purified water is 20 times of the weight of the coarse powder of milk thistle herb, vine tea and liquorice; during heat extraction, the reflux extraction temperature is 80 ℃, and the reflux extraction time is 120min each time; concentrating and filtering at 50deg.C under vacuum degree of-0.1 MPa, and concentrating to obtain solid content of 30%; eluting with 10% ethanol, and eluting with anhydrous ethanol, wherein the purified extract powder contains silymarin 25%, dihydromyricetin 55%, glycyrrhizic acid 10% and glycyrrhetinic acid 10%.
The extract of the invention is evaluated in mice experiments as follows:
all mice (6 week old C57BL/6 mice) were randomly divided into 4 groups, the normal group was fed a non-alcoholic diet, the remaining groups were fed a liquid diet with 5% alcohol and the last day of alcoholic gavage. Samples of the extract (250 mg/kg), 98% samples of curcumin (200 mg/kg) were orally administered once daily for 11 days. The mice were then anesthetized with isoflurane, the abdominal aorta was sampled, and the alcohol, GOT, GPT content in the blood was rapidly determined using the kit. The rat livers were simultaneously harvested and rapidly stored at-80 degrees celsius for subsequent triglyceride determination (kit).
The measurement results are shown in FIGS. 2 to 4:
alcohol content in serum of each group: mean ± SE (n=5-6). Where p <0.05, < p <0.01.
GOT glutamic oxaloacetic transaminase, GPT glutamic pyruvic transaminase content in serum of each group: mean ± SE (n=5-6). Where p <0.05, < p <0.01.
Content of triglycerides in each group of livers: mean ± SE (n=5-6). Where p <0.05, < p <0.01.
In the invention, the content of active ingredients is greatly increased through the steps of raw material selection, coarse crushing, heat extraction, concentration, resin purification and the like. The liver protecting and lipid lowering activity of each extract was evaluated by a C57BL/6 mouse model, liquid ethanol feed feeding, 1 day 1 return administration experiment of each extract. The results show that each extract can reduce the concentration of ethanol in the blood of mice, promote the metabolism of ethanol in vivo, reduce the accumulation of fat in liver cells, thereby reducing the damage to the liver cells, inhibiting alcoholic fatty liver and protecting liver function.
Example 4
The embodiment provides an application formula of a health care product capsule for promoting ethanol decomposition of extracts of milk thistle herb, vine tea and liquorice. The composition comprises the following components: 30 parts of the extract powder obtained in the example 1, 35 parts of microcrystalline cellulose, 4 parts of pregelatinized starch, 6 parts of hydroxypropyl methylcellulose, 90 parts of povidone K, 2 parts of colloidal silicon dioxide, 6 parts of magnesium stearate and the balance of auxiliary materials are selected according to weight percentage.
Example 5
This example differs from example 4 in that a tablet application formulation of a compound preparation of milk thistle herb, vine tea, licorice extract for promoting ethanol decomposition is provided. The composition comprises the following components: the extract powder obtained in the example 2 is selected from 40 parts by weight, 40 parts by weight of microcrystalline cellulose, 2.5 parts by weight of pregelatinized starch, 5 parts by weight of hydroxypropyl methylcellulose, 7.5 parts by weight of povidone K90, 1 part by weight of colloidal silicon dioxide, 4 parts by weight of magnesium stearate and the balance of auxiliary materials.
Example 6
This example differs from example 4 in that a granule application formulation of a drug for promoting ethanolysis of milk thistle, vine tea, licorice extract is provided, comprising the following components: 50 parts of the extract powder obtained in the example 3, 38 parts of microcrystalline cellulose, 2 parts of pregelatinized starch, 4 parts of hydroxypropyl methylcellulose, 90 parts of povidone K, 1.5 parts of colloidal silicon dioxide, 3 parts of magnesium stearate and the balance of auxiliary materials are selected according to weight percentage.
The application experiment of the invention verifies that the medicines, health products and foods containing the dihydromyricetin extracted from milk thistle herb, vine tea and liquorice have certain protection effect on fatty liver caused by alcohol. Has positive effects in promoting glycolysis, reducing injury to liver cells, inhibiting alcoholic fatty liver and protecting liver function, and has wide application prospect.
It should be noted that the above embodiments are only for illustrating the technical solution of the present invention and not for limiting the same, and although the present invention has been described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that the technical solution of the present invention may be modified or substituted without departing from the spirit and scope of the technical solution of the present invention, which is intended to be covered in the scope of the claims of the present invention.
Claims (10)
1. A process for the preparation of an extract for promoting ethanolysis, comprising the steps of:
(1) Preparing raw materials: screening milk thistle herb, vine tea and liquorice with good quality, and drying;
(2) Coarse crushing: pulverizing dried herba Cephalanoploris, ampelopsis Grossdentata, and Glycyrrhrizae radix with pulverizing device, filtering with 5 mesh sieve to obtain coarse powder, soaking the coarse powder in purified water for 30min;
(3) And (3) heat extraction: reflux-extracting the coarse powder soaked for 30min for 2 times to obtain extractive solution;
(4) Concentrating and filtering: filtering the extractive solution, and vacuum concentrating the filtrate under reduced pressure;
(5) Purifying: eluting the concentrated solution with fixed resin column with ethanol of different concentrations, concentrating, evaporating, and pulverizing to obtain extract powder.
2. The method for preparing an extract for promoting glycolysis according to claim 1, wherein the purified water is added in an amount of 10-20 times the weight of the raw powder of milk thistle herb, vine tea, licorice in step (2).
3. The method for preparing an extract for promoting ethanol decomposition according to claim 1, wherein the reflux extraction temperature in said step (3) is 80-100 ℃.
4. The method for preparing an extract for promoting ethanol decomposition according to claim 1, wherein the reflux extraction time in said step (3) is 120min each time.
5. The method for preparing an extract for promoting glycolysis according to claim 1, wherein the filter cloth used for filtering in the step (4) is 100 mesh.
6. The method for preparing an extract for promoting glycolysis according to claim 1, wherein the concentration temperature of the filtrate obtained in step (4) is 50-60 ℃ and the pressure is less than-0.1 MPa.
7. The method for preparing an extract for promoting glycolysis according to claim 1 wherein the concentration of solids after concentration in step (4) is 30-60%.
8. The method for preparing an extract for promoting glycolysis according to claim 1, wherein in the step (5), the extract powder comprises silymarin 10-30%, dihydromyricetin 20-60%, glycyrrhizic acid 10-30% and glycyrrhetinic acid 5-20%.
9. The use of an extract for promoting glycolysis according to claims 1-8 in medicine, health care products or compound preparations.
10. The use of an extract for promoting glycolysis according to claim 9, wherein the pharmaceutical, nutraceutical, or compound formulation comprises the following components: 30-50 parts of extract powder, 35-40 parts of microcrystalline cellulose, 2-4 parts of pregelatinized starch, 4-6 parts of hydroxypropyl methylcellulose, 5-8 parts of povidone, 1-2 parts of colloidal silicon dioxide and 3-6 parts of magnesium stearate.
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Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102160637A (en) * | 2011-01-07 | 2011-08-24 | 上海黄金搭档生物科技有限公司 | Composition with auxiliary protection effect on chemical hepatic injury and alcoholic hepatic injury and health care food thereof |
CN109568538A (en) * | 2017-09-29 | 2019-04-05 | 海维尔D&H有限公司 | Resolution composition of being still drank after a night comprising milk thistle, turmeric, Radix Glycyrrhizae and cassia seed |
CN114424824A (en) * | 2022-01-27 | 2022-05-03 | 湖北省农业科学院中药材研究所 | Ampelopsis grossedentata extract, preparation method thereof and application thereof in preparation of lipid-lowering and liver-protecting medicines or foods |
-
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Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102160637A (en) * | 2011-01-07 | 2011-08-24 | 上海黄金搭档生物科技有限公司 | Composition with auxiliary protection effect on chemical hepatic injury and alcoholic hepatic injury and health care food thereof |
CN109568538A (en) * | 2017-09-29 | 2019-04-05 | 海维尔D&H有限公司 | Resolution composition of being still drank after a night comprising milk thistle, turmeric, Radix Glycyrrhizae and cassia seed |
CN114424824A (en) * | 2022-01-27 | 2022-05-03 | 湖北省农业科学院中药材研究所 | Ampelopsis grossedentata extract, preparation method thereof and application thereof in preparation of lipid-lowering and liver-protecting medicines or foods |
Non-Patent Citations (3)
Title |
---|
北青网: "每天吃点它养肝降血脂 可加快酒精排出体外", pages 1, Retrieved from the Internet <URL:https://www.sohu.com/a/444700156_255783> * |
张霞;程富胜;: "甘草提取物对酒精性肝损伤的防治作用研究", 中兽医医药杂志, no. 06, 10 December 2013 (2013-12-10), pages 10 - 14 * |
茶派: "藤茶小百科-酒后的护肝茶", pages 2, Retrieved from the Internet <URL:https://zhuanlan.zhihu.com/p/621046029> * |
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