CN101181368A - Compound prescription for defending and protecting hepar as well as preparation technique thereof - Google Patents
Compound prescription for defending and protecting hepar as well as preparation technique thereof Download PDFInfo
- Publication number
- CN101181368A CN101181368A CNA2007101777667A CN200710177766A CN101181368A CN 101181368 A CN101181368 A CN 101181368A CN A2007101777667 A CNA2007101777667 A CN A2007101777667A CN 200710177766 A CN200710177766 A CN 200710177766A CN 101181368 A CN101181368 A CN 101181368A
- Authority
- CN
- China
- Prior art keywords
- parts
- extract
- hours
- fructus schisandrae
- liver
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a composite formula used for protecting liver, which is prepared by fructus schisandrae sphenantherae extract, white paeony root extract and Milk Thistle extract and adding with certain supplementary materials, wherein, the extraction preparation technologies of the Chinese traditional medicine include: the fructus schisandrae sphenantherae is crushed into rough powder; the rough power is heated, refluxed and extracted by 60 to 80 percent of alcohol in the quantity of 6 folds for 3 times with 1.5 hours for one time; the extracting solution is combined, the alcohol are filtered and recycled; the filtered solution is concentrated into an extract with relative density of 1.30 to 1.35 (thermally measuring in 50 to 60 DEG C); the extract is dried in vacuum, ground and screened with 80 meshes. The Milk Thistle and the white paeony root are boiled for three times in water of 8 to 10 folds, the lasting time respectively is 2 hours, 1.5 hours and 1 hour; then the boiled solution is filtered, and the filtering solution is concentrated into an extract with relative density of 1.15 to 1.20 (thermally measuring in 50 to 60 DEG C), and the extract is sprayed and dried. The formula has the major effects of protecting liver, preventing fatty liver, having curing and health effect on the chemical liver injury (including poisoning, and overdrink of alcohol, etc.), having adjuvant treatment on the virus hepatitis, alleviating the deterioration of chronic hepatitis and liver cirrhosis.
Description
Technical field
The present invention relates to a kind of compound prescription that is used for hepatoprotective, belong to the functional health care food technical field.
Background technology
Fatty liver is meant because the pathological changes of the interior fatty overheap of the hepatocyte that a variety of causes causes.Because a variety of causes makes liver fat metabolic function generation obstacle, the dynamic unbalance that causes lipid material, excess fats is accumulated in hepatocyte, if fat (mainly the being triglyceride) content of accumulating surpasses 5% of liver weight in wet base, or 50% above hepatocyte fatization is arranged on the histology, promptly be called fatty liver.It is a kind of prognosis disease preferably, but the concurrent hepatic fibrosis of long-term fatty liver (especially alcoholic fatty liver) meeting, even develop into liver cirrhosis, therefore eliminating fatty liver is to prolong the time that forms liver cirrhosis, thereby avoids taking place liver failure and threat to life.
Along with China's rapid economy development, the raising of national life level, the adjustment of dietary structure, pathogenesis of fatty liver presents increasing sign, becomes the second largest hepatopathy that is only second to viral hepatitis.The sickness rate of China's fatty liver is about 10%, and in some professional population (taxi driver, company's white collar, government official, individual proprietor, high level intellectual etc.), the pathogenesis of fatty liver rate can be up to 25%.
The medicine that some hepatoprotective, treatment hepatitis are also arranged at present, but these medicines exist many deficiencies, are not suitable for non-hepatitis and take for a long time, are difficult to satisfy the health care needs of body health of people.In recent years, some prepare health food and come hepatoprotective, as " functional food for protecting liver made from Fructus Ligustri Lucidi and Pupa bombycis and preparation method thereof " that the CN1460435 patent application proposes, it is the functional food that the enzymolysis dry powder that makes of the oleanolic acid that extracted by Fructus Ligustri Lucidi and Pupa bombycis etc. is prepared." health food of a kind of hepatoprotective and blood lipid regulation and preparation method thereof " that the CN1466990 patent application proposes is by Radix Salviae Miltiorrhizae, Semen Persicae, Herb Gynostemmae Pentaphylli, fermented Cordyceps powder, the preparation of preparation of raw material such as chitosan.Different prescriptions, the preparation effect that makes is also different.
Summary of the invention
The object of the present invention is to provide a kind of compound prescription that is used for hepatoprotective.
The present invention also provides the preparation technology of this compound recipe prescription.
Compound recipe of the present invention has mainly acted on: the liver protecting, prevention fatty liver; Chemical liver injury (comprising poisoning, insobriety etc.) there is therapeuticing and health effect; The effect of auxiliary treatment viral hepatitis is arranged; Slow down the deterioration of chronic hepatitis, liver cirrhosis.
Compound prescription of the present invention is prepared from by the following weight parts proportion raw material:
250～750 parts of 200～600 parts of Herba Silybi marianis of 600～1600 portions of Radix Paeoniae Albas of Fructus Schisandrae Sphenantherae
8～25 parts of adjuvants
Compound prescription of the present invention is prepared from by following preferred weight part proportion raw material:
400～600 parts of 300～500 parts of Herba Silybi marianis of 800～1300 portions of Radix Paeoniae Albas of Fructus Schisandrae Sphenantherae
10～20 parts of adjuvants
Compound prescription of the present invention is prepared from by following optimum weight part proportion raw material:
15 parts of 500 parts of adjuvants of 400 parts of Herba Silybi marianis of 1050 portions of Radix Paeoniae Albas of Fructus Schisandrae Sphenantherae
Compound prescription of the present invention can form by following prepared:
1, Fructus Schisandrae Sphenantherae is ground into coarser powder, extracts each 1.5 hours 3 times with 6 times of amount alcohol heating reflux of 60～80%, merge extractive liquid, filters, and reclaims ethanol, being concentrated into relative density is 1.30～1.35 extractum (50～60 ℃ of heat are surveyed), and vacuum drying was pulverized 80 mesh sieves.Standby.
2, Herba Silybi mariani, the Radix Paeoniae Alba decoct three times with 8～10 times of water gagings, be followed successively by 2 hours, and 1.5 hours, 1 hour, filter, it is 1.15～1.20 extractum (50～60 ℃ of heat are surveyed) that filtrate is concentrated into relative density, spray drying.
3, above two kinds of medicated powder are pressed formula proportion adding adjuvant, mix homogeneously.
4, take a morsel encapsulatedly, survey disintegration, should be in 20 minutes.
5, the check hygiology is surveyed moisture.Qualified back packing.
Fructus Schisandrae Chinensis has comprehensive liver-protective effect in the prescription, and it is always plain that its effective ingredient is mainly Fructus Schisandrae Chinensis, schisandrin, pure second, ester first, ester the second grade composition.Fructus Schisandrae Chinensis is to the protective effect of hepatic injury; not only show and reduce serum GPT; can also promote hepatic glycogen and protein synthesis; give sufficient protection to the hepatocyte form; it also has antioxidation simultaneously; can improve hepatomicrosome cytochrome P-450 content, thereby strengthen the function of detoxification of liver poisonous substance and chemical carcinogen.
Chinese medicine thinks that the Radix Paeoniae Alba is sour sweet yin fluid astringing, the product of easing the affected liver to relieve pain, and in the clinical practice in thousands of years, treatment through being usually used in hepatopathy and protection.The modern science experiment shows that Radix Paeoniae Alba total glucosides can obviously make blood plasma or serum SGPT and blood plasma LDH reduce, and the change that the hepatopathy reason is organized also has certain protective role.
Herba Silybi mariani is a kind of plant amedica in American-European extensive use, has the hepatic cholagogic function.Cure mainly acute and chronic hepatitis, hepatitis interstitialis chronica, fatty liver, toxic liver injury etc.Experiment showed, the main component silibinin of Herba Silybi mariani seed extract, the hepatic injury that multiple hepatotoxic agent caused is had significant protective effect, and the liver regeneration ability is had facilitation, and the liver drug metabolism enzyme activity is had protective effect.
The present invention is on probation through the crowd, to 138 routine Patients with Fatty Liver continuous 2 months take tracing observation, the result shows that effective percentage is 90.58%.Do not meet quick in the use and other untoward reaction.Show that this contrivance hepatoprotective effect is remarkable, have no side effect.
The specific embodiment
Embodiment 1
Fructus Schisandrae Sphenantherae 800kg Radix Paeoniae Alba 300kg Herba Silybi mariani 400kg corn starch 10kg
Fructus Schisandrae Sphenantherae is ground into coarser powder, extracts 3 times with 6 times of amount alcohol heating reflux of 80%, and each 1.5 hours, merge extractive liquid, filtered, and reclaims ethanol, and being concentrated into relative density is 1.30～1.35 extractum (50～60 ℃ of heat are surveyed), and vacuum drying was pulverized 80 mesh sieves.Standby.Herba Silybi mariani, the Radix Paeoniae Alba decoct three times with 8～10 times of water gagings, be followed successively by 2 hours, and 1.5 hours, 1 hour, filter, it is 1.15～1.20 extractum (50～60 ℃ of heat are surveyed) that filtrate is concentrated into relative density, spray drying.More than two kinds of medicated powder press formula proportion and add corn starch, mix homogeneously.It is encapsulated to take a morsel, and surveys disintegration, should be in 20 minutes.The check hygiology is surveyed moisture.Qualified back packing.
Embodiment 2
500 parts of Herba Silybi mariani 600kg of Fructus Schisandrae Sphenantherae 1300kg Radix Paeoniae Alba corn starch 20kg
Fructus Schisandrae Sphenantherae is ground into coarser powder, extracts 3 times with 6 times of amount alcohol heating reflux of 80%, and each 1.5 hours, merge extractive liquid, filtered, and reclaims ethanol, and being concentrated into relative density is 1.30～1.35 extractum (50～60 ℃ of heat are surveyed), and vacuum drying was pulverized 80 mesh sieves.Standby.Herba Silybi mariani, the Radix Paeoniae Alba decoct three times with 8～10 times of water gagings, be followed successively by 2 hours, and 1.5 hours, 1 hour, filter, it is 1.15～1.20 extractum (50～60 ℃ of heat are surveyed) that filtrate is concentrated into relative density, spray drying.More than two kinds of medicated powder press formula proportion and add corn starch, mix homogeneously.It is encapsulated to take a morsel, and surveys disintegration, should be in 20 minutes.The check hygiology is surveyed moisture.Qualified back packing.
Embodiment 3
Fructus Schisandrae Sphenantherae 1050kg Radix Paeoniae Alba 400kg Herba Silybi mariani 500kg corn starch 15kg
Fructus Schisandrae Sphenantherae is ground into coarser powder, extracts 3 times with 6 times of amount alcohol heating reflux of 80%, and each 1.5 hours, merge extractive liquid, filtered, and reclaims ethanol, and being concentrated into relative density is 1.30～1.35 extractum (50～60 ℃ of heat are surveyed), and vacuum drying was pulverized 80 mesh sieves.Standby.Herba Silybi mariani, the Radix Paeoniae Alba decoct three times with 8～10 times of water gagings, be followed successively by 2 hours, and 1.5 hours, 1 hour, filter, it is 1.15～1.20 extractum (50～60 ℃ of heat are surveyed) that filtrate is concentrated into relative density, spray drying.More than two kinds of medicated powder press formula proportion and add corn starch, mix homogeneously.It is encapsulated to take a morsel, and surveys disintegration, should be in 20 minutes.The check hygiology is surveyed moisture.Qualified back packing.
Claims (4)
1. one kind is used for the hepatoprotective compound prescription, it is characterized in that containing the raw material of following weight portion: 600～1600 parts of Fructus Schisandrae Sphenantheraes, 200～600 parts of the Radix Paeoniae Albas, 250～750 parts of Herba Silybi marianis, 8～25 parts of adjuvants.
2. require described a kind of hepatoprotective compound prescription that is used for according to right 1, it is characterized in that containing the raw material of following weight portion: 800～130 parts of Fructus Schisandrae Sphenantheraes, 300～500 parts of the Radix Paeoniae Albas, 400～600 parts of Herba Silybi marianis, 10～20 parts of adjuvants.
3. require described a kind of hepatoprotective compound prescription that is used for according to right 1,2, it is characterized in that the optimised quantity of each raw material is: 1050 parts of Fructus Schisandrae Sphenantheraes, 400 parts of the Radix Paeoniae Albas, 500 parts of Herba Silybi marianis, 15 parts of adjuvants.
4. require described raw material according to right 3, its processing technology is:
(1) Fructus Schisandrae Sphenantherae is ground into coarser powder, extracts each 1.5 hours 3 times with 6 times of amount alcohol heating reflux of 60～80%, merge extractive liquid, filters, and reclaims ethanol, being concentrated into relative density is 1.30～1.35 extractum (50～60 ℃ of heat are surveyed), and vacuum drying was pulverized 80 mesh sieves.Standby.
(2) Herba Silybi mariani, the Radix Paeoniae Alba decoct three times with 8～10 times of water gagings, be followed successively by 2 hours, and 1.5 hours, 1 hour, filter, it is 1.15～1.20 extractum (50～60 ℃ of heat are surveyed) that filtrate is concentrated into relative density, spray drying.
(3) above two kinds of medicated powder are pressed formula proportion adding adjuvant, mix homogeneously.
(4) take a morsel encapsulatedly, survey disintegration, should be in 20 minutes.
(5) the check hygiology is surveyed moisture.Qualified back packing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007101777667A CN101181368A (en) | 2007-11-21 | 2007-11-21 | Compound prescription for defending and protecting hepar as well as preparation technique thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007101777667A CN101181368A (en) | 2007-11-21 | 2007-11-21 | Compound prescription for defending and protecting hepar as well as preparation technique thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101181368A true CN101181368A (en) | 2008-05-21 |
Family
ID=39446879
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2007101777667A Pending CN101181368A (en) | 2007-11-21 | 2007-11-21 | Compound prescription for defending and protecting hepar as well as preparation technique thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101181368A (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102499411A (en) * | 2011-11-03 | 2012-06-20 | 南昌大学 | Liver nourishing/protecting beverage and preparation method thereof |
| CN102641469A (en) * | 2011-02-22 | 2012-08-22 | 北京中医药大学东方医院 | Medicinal composition for preventing or treating nonalcoholic steatohepatitis |
| CN103181940A (en) * | 2011-12-31 | 2013-07-03 | 瑞普（天津）生物药业有限公司 | Liver protection tablet with delicious taste used for pets |
| CN104147214A (en) * | 2014-08-27 | 2014-11-19 | 河南科技大学第一附属医院 | Kidney-tonifying and liver-nourishing traditional Chinese medicine composition and preparation method thereof |
| CN105687743A (en) * | 2016-03-17 | 2016-06-22 | 南京多宝生物科技有限公司 | Herba cistanches health care product |
| CN113332356A (en) * | 2021-06-28 | 2021-09-03 | 成都农业科技职业学院 | Chinese herbal medicine preparation for preventing and treating liver and gall diseases of aquatic animals and preparation and using method thereof |
-
2007
- 2007-11-21 CN CNA2007101777667A patent/CN101181368A/en active Pending
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102641469A (en) * | 2011-02-22 | 2012-08-22 | 北京中医药大学东方医院 | Medicinal composition for preventing or treating nonalcoholic steatohepatitis |
| CN102641469B (en) * | 2011-02-22 | 2014-07-02 | 北京中医药大学东方医院 | Medicinal composition for preventing or treating nonalcoholic steatohepatitis |
| CN102499411A (en) * | 2011-11-03 | 2012-06-20 | 南昌大学 | Liver nourishing/protecting beverage and preparation method thereof |
| CN103181940A (en) * | 2011-12-31 | 2013-07-03 | 瑞普（天津）生物药业有限公司 | Liver protection tablet with delicious taste used for pets |
| CN103181940B (en) * | 2011-12-31 | 2015-01-07 | 瑞普（天津）生物药业有限公司 | Liver protection tablet with delicious taste used for pets |
| CN104147214A (en) * | 2014-08-27 | 2014-11-19 | 河南科技大学第一附属医院 | Kidney-tonifying and liver-nourishing traditional Chinese medicine composition and preparation method thereof |
| CN104147214B (en) * | 2014-08-27 | 2016-09-21 | 河南科技大学第一附属医院 | A kind of Chinese medicine composition of tonifying kidney and nourishing liver and preparation method thereof |
| CN105687743A (en) * | 2016-03-17 | 2016-06-22 | 南京多宝生物科技有限公司 | Herba cistanches health care product |
| CN113332356A (en) * | 2021-06-28 | 2021-09-03 | 成都农业科技职业学院 | Chinese herbal medicine preparation for preventing and treating liver and gall diseases of aquatic animals and preparation and using method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1286513C (en) | Chinese medicine composition for treating dermatosis and its preparing method | |
| CN105169118A (en) | Dendrobium officinale compound health buccal tablet and preparation method thereof | |
| CN101181368A (en) | Compound prescription for defending and protecting hepar as well as preparation technique thereof | |
| CN104997878A (en) | Auxiliary blood pressure and blood fat reducing health product and preparation process thereof | |
| CN104083727A (en) | Traditional Chinese medicine composition for nourishing and protecting liver | |
| CN101933973B (en) | Medicament composition for preventing and treating liver damage | |
| CN103223069A (en) | Traditional Chinese medicine composition for treating hepatitis | |
| CN1069542C (en) | Medicine for treating chronic hepatism and its preparing process | |
| CN101537160B (en) | Health product for toxicant elimination and beauty maintenance | |
| CN102846879B (en) | Composition for depressing blood fat | |
| CN102579658A (en) | Traditional Chinese medicinal composition for curing hyperuricacidemia, gout and urinary retention | |
| CN101390970B (en) | Traditional Chinese medicine for treating hepatitis B and preparation method thereof | |
| CN101347605A (en) | Chinese medicinal composition for treating gout and preparation method and application thereof | |
| CN110876772A (en) | Preparation method and application of traditional Chinese medicine preparation with liver protection function | |
| CN103690832B (en) | A kind of Chinese medicine composition for the treatment of viral myocarditis | |
| CN102139006A (en) | Compound picrorhiza rhizome composition for treating hepatic injury and preparation method and application thereof | |
| CN100455300C (en) | Compound wild kiwi tablet and its preparing method | |
| CN111671792B (en) | Traditional Chinese medicine composition for preventing and treating liver injury and preparation method thereof | |
| CN101987188B (en) | Biological Chinese patent drug for preventing and treating hyperlipoidemia | |
| CN104547026A (en) | Preparation method and application of salvia miltiorrhiza leave and panax pseudo-ginseng extract | |
| CN107468825A (en) | A kind of Chinese medicine composition of ganoderma lucidum protecting and nourishing liver and preparation method thereof | |
| CN104547027B (en) | Preparation method and application of salvia miltiorrhiza leave and panax notoginseng leaf extract | |
| CN102920765A (en) | Method for extracting total flavone of active parts of China ixeris | |
| CN1559523A (en) | Naodesheng soft capsule and its preparation method | |
| CN102327369B (en) | Pharmaceutical composition and medicine for treating hepatic injury, and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Open date: 20080521 |