CN117296857A - Pesticide composition for preventing and treating nematodes - Google Patents
Pesticide composition for preventing and treating nematodes Download PDFInfo
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- CN117296857A CN117296857A CN202311160799.6A CN202311160799A CN117296857A CN 117296857 A CN117296857 A CN 117296857A CN 202311160799 A CN202311160799 A CN 202311160799A CN 117296857 A CN117296857 A CN 117296857A
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- Prior art keywords
- ethylicin
- avermectin
- preventing
- root
- nematodes
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- 239000000575 pesticide Substances 0.000 title claims abstract description 26
- 239000000203 mixture Substances 0.000 title claims abstract description 25
- 241000244206 Nematoda Species 0.000 title claims abstract description 22
- OICGFSUWXCJLCO-UHFFFAOYSA-N 1-ethylsulfonylsulfanylethane Chemical compound CCSS(=O)(=O)CC OICGFSUWXCJLCO-UHFFFAOYSA-N 0.000 claims abstract description 41
- 239000005660 Abamectin Substances 0.000 claims abstract description 37
- RRZXIRBKKLTSOM-XPNPUAGNSA-N avermectin B1a Chemical compound C1=C[C@H](C)[C@@H]([C@@H](C)CC)O[C@]11O[C@H](C\C=C(C)\[C@@H](O[C@@H]2O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](OC)C3)[C@@H](OC)C2)[C@@H](C)\C=C\C=C/2[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\2)O)C[C@H]4C1 RRZXIRBKKLTSOM-XPNPUAGNSA-N 0.000 claims abstract description 30
- 238000002360 preparation method Methods 0.000 claims abstract description 8
- 239000000839 emulsion Substances 0.000 claims description 18
- 239000003094 microcapsule Substances 0.000 claims description 11
- 239000000725 suspension Substances 0.000 claims description 7
- 239000004495 emulsifiable concentrate Substances 0.000 claims description 5
- 239000004530 micro-emulsion Substances 0.000 claims description 2
- 230000000361 pesticidal effect Effects 0.000 claims 5
- 238000009472 formulation Methods 0.000 claims 1
- 241000243785 Meloidogyne javanica Species 0.000 abstract description 14
- 230000000694 effects Effects 0.000 abstract description 12
- 239000003814 drug Substances 0.000 abstract description 10
- 229940079593 drug Drugs 0.000 abstract description 8
- 241000196324 Embryophyta Species 0.000 abstract description 7
- 206010059866 Drug resistance Diseases 0.000 abstract description 5
- 230000002195 synergetic effect Effects 0.000 abstract description 5
- 150000001875 compounds Chemical class 0.000 abstract description 4
- 235000013311 vegetables Nutrition 0.000 abstract description 4
- 241000219104 Cucurbitaceae Species 0.000 abstract description 3
- 230000007246 mechanism Effects 0.000 abstract description 3
- 235000003228 Lactuca sativa Nutrition 0.000 abstract description 2
- 230000009471 action Effects 0.000 abstract description 2
- 241000208822 Lactuca Species 0.000 abstract 1
- 230000005923 long-lasting effect Effects 0.000 abstract 1
- 239000003995 emulsifying agent Substances 0.000 description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 16
- 239000012071 phase Substances 0.000 description 15
- 201000010099 disease Diseases 0.000 description 13
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 13
- 238000002156 mixing Methods 0.000 description 13
- JHIVVAPYMSGYDF-UHFFFAOYSA-N cyclohexanone Chemical compound O=C1CCCCC1 JHIVVAPYMSGYDF-UHFFFAOYSA-N 0.000 description 12
- 239000002245 particle Substances 0.000 description 10
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 9
- 239000003921 oil Substances 0.000 description 9
- -1 polyoxypropylene Polymers 0.000 description 8
- IBSREHMXUMOFBB-JFUDTMANSA-N 5u8924t11h Chemical compound O1[C@@H](C)[C@H](O)[C@@H](OC)C[C@@H]1O[C@@H]1[C@@H](OC)C[C@H](O[C@@H]2C(=C/C[C@@H]3C[C@@H](C[C@@]4(O3)C=C[C@H](C)[C@@H](C(C)C)O4)OC(=O)[C@@H]3C=C(C)[C@@H](O)[C@H]4OC\C([C@@]34O)=C/C=C/[C@@H]2C)/C)O[C@H]1C.C1=C[C@H](C)[C@@H]([C@@H](C)CC)O[C@]11O[C@H](C\C=C(C)\[C@@H](O[C@@H]2O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](OC)C3)[C@@H](OC)C2)[C@@H](C)\C=C\C=C/2[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\2)O)C[C@H]4C1 IBSREHMXUMOFBB-JFUDTMANSA-N 0.000 description 7
- 229950008167 abamectin Drugs 0.000 description 7
- 239000002904 solvent Substances 0.000 description 7
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 5
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 5
- 229920000053 polysorbate 80 Polymers 0.000 description 5
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 4
- 241000607479 Yersinia pestis Species 0.000 description 4
- 239000004480 active ingredient Substances 0.000 description 4
- 230000001276 controlling effect Effects 0.000 description 4
- 239000002552 dosage form Substances 0.000 description 4
- 229920000642 polymer Polymers 0.000 description 4
- 229920001451 polypropylene glycol Polymers 0.000 description 4
- 239000002689 soil Substances 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- ABPYVNPDRFJZEU-UHFFFAOYSA-N 2-(2,2,2-triphenylethyl)phenol Chemical compound OC1=CC=CC=C1CC(C=1C=CC=CC=1)(C=1C=CC=CC=1)C1=CC=CC=C1 ABPYVNPDRFJZEU-UHFFFAOYSA-N 0.000 description 3
- 241000283070 Equus zebra Species 0.000 description 3
- 239000004359 castor oil Substances 0.000 description 3
- 235000019438 castor oil Nutrition 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 230000000295 complement effect Effects 0.000 description 3
- 239000013530 defoamer Substances 0.000 description 3
- 238000009826 distribution Methods 0.000 description 3
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 3
- 230000000749 insecticidal effect Effects 0.000 description 3
- 229940051841 polyoxyethylene ether Drugs 0.000 description 3
- 229920000056 polyoxyethylene ether Polymers 0.000 description 3
- 230000002265 prevention Effects 0.000 description 3
- 239000002994 raw material Substances 0.000 description 3
- 238000010008 shearing Methods 0.000 description 3
- 244000305550 Streptopus amplexifolius Species 0.000 description 2
- 235000001231 Streptopus amplexifolius Nutrition 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 239000002518 antifoaming agent Substances 0.000 description 2
- 239000008346 aqueous phase Substances 0.000 description 2
- 239000012752 auxiliary agent Substances 0.000 description 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 239000008367 deionised water Substances 0.000 description 2
- 229910021641 deionized water Inorganic materials 0.000 description 2
- 230000018109 developmental process Effects 0.000 description 2
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 description 2
- 230000035784 germination Effects 0.000 description 2
- 238000011835 investigation Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 229920001296 polysiloxane Polymers 0.000 description 2
- 238000005507 spraying Methods 0.000 description 2
- 239000000375 suspending agent Substances 0.000 description 2
- IWOUTIHKEQOMCY-UHFFFAOYSA-N 2-ethyl-3,4,5-triphenylphenol Chemical compound C1(=CC=CC=C1)C=1C(=C(C(=C(C1)O)CC)C1=CC=CC=C1)C1=CC=CC=C1 IWOUTIHKEQOMCY-UHFFFAOYSA-N 0.000 description 1
- 240000002234 Allium sativum Species 0.000 description 1
- 108010062745 Chloride Channels Proteins 0.000 description 1
- 102000011045 Chloride Channels Human genes 0.000 description 1
- 206010018498 Goitre Diseases 0.000 description 1
- 229910021578 Iron(III) chloride Inorganic materials 0.000 description 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 1
- 240000008415 Lactuca sativa Species 0.000 description 1
- 208000000291 Nematode infections Diseases 0.000 description 1
- 206010033799 Paralysis Diseases 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 241000208292 Solanaceae Species 0.000 description 1
- 241000187747 Streptomyces Species 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- 230000000895 acaricidal effect Effects 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 230000008484 agonism Effects 0.000 description 1
- 238000012271 agricultural production Methods 0.000 description 1
- 229940124277 aminobutyric acid Drugs 0.000 description 1
- 230000002528 anti-freeze Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- JBIROUFYLSSYDX-UHFFFAOYSA-M benzododecinium chloride Chemical compound [Cl-].CCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 JBIROUFYLSSYDX-UHFFFAOYSA-M 0.000 description 1
- 229920005551 calcium lignosulfonate Polymers 0.000 description 1
- OOCMUZJPDXYRFD-UHFFFAOYSA-L calcium;2-dodecylbenzenesulfonate Chemical compound [Ca+2].CCCCCCCCCCCCC1=CC=CC=C1S([O-])(=O)=O.CCCCCCCCCCCCC1=CC=CC=C1S([O-])(=O)=O OOCMUZJPDXYRFD-UHFFFAOYSA-L 0.000 description 1
- RYAGRZNBULDMBW-UHFFFAOYSA-L calcium;3-(2-hydroxy-3-methoxyphenyl)-2-[2-methoxy-4-(3-sulfonatopropyl)phenoxy]propane-1-sulfonate Chemical compound [Ca+2].COC1=CC=CC(CC(CS([O-])(=O)=O)OC=2C(=CC(CCCS([O-])(=O)=O)=CC=2)OC)=C1O RYAGRZNBULDMBW-UHFFFAOYSA-L 0.000 description 1
- 239000012876 carrier material Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 239000002270 dispersing agent Substances 0.000 description 1
- GVGUFUZHNYFZLC-UHFFFAOYSA-N dodecyl benzenesulfonate;sodium Chemical compound [Na].CCCCCCCCCCCCOS(=O)(=O)C1=CC=CC=C1 GVGUFUZHNYFZLC-UHFFFAOYSA-N 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 229960003692 gamma aminobutyric acid Drugs 0.000 description 1
- 235000004611 garlic Nutrition 0.000 description 1
- 229930195712 glutamate Natural products 0.000 description 1
- 201000003872 goiter Diseases 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- RBTARNINKXHZNM-UHFFFAOYSA-K iron trichloride Chemical compound Cl[Fe](Cl)Cl RBTARNINKXHZNM-UHFFFAOYSA-K 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 239000003120 macrolide antibiotic agent Substances 0.000 description 1
- 238000003760 magnetic stirring Methods 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 230000001069 nematicidal effect Effects 0.000 description 1
- 239000011664 nicotinic acid Substances 0.000 description 1
- 239000007764 o/w emulsion Substances 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 230000005080 plant death Effects 0.000 description 1
- 230000008635 plant growth Effects 0.000 description 1
- 230000001863 plant nutrition Effects 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 229940080264 sodium dodecylbenzenesulfonate Drugs 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 230000001502 supplementing effect Effects 0.000 description 1
- 239000004548 suspo-emulsion Substances 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000820 toxicity test Toxicity 0.000 description 1
- 230000001018 virulence Effects 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N41/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a sulfur atom bound to a hetero atom
- A01N41/02—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a sulfur atom bound to a hetero atom containing a sulfur-to-oxygen double bond
- A01N41/04—Sulfonic acids; Derivatives thereof
- A01N41/08—Sulfonic acid halides; alpha-Hydroxy-sulfonic acids; Amino-sulfonic acids; Thiosulfonic acids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
- A01P5/00—Nematocides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Plant Pathology (AREA)
- Environmental Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pest Control & Pesticides (AREA)
- General Health & Medical Sciences (AREA)
- Dentistry (AREA)
- Agronomy & Crop Science (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention belongs to the technical field of pesticides, and relates to a pesticide composition for preventing and treating nematodes. The effective components are avermectin and ethylicin, and the mass ratio of the avermectin to ethylicin is 1:5-1:29. The invention uses avermectin and ethylicin as effective components to compound, has obvious synergistic effect on preventing root-knot nematode from infecting plant root systems, and the effect has not been reported yet. The preparation product containing the composition can improve the control effect on the root-knot nematode and has development potential. The avermectin and ethylicin have different action mechanisms, have long lasting period, can reduce the times of medication, and can delay the generation of drug resistance. Is mainly used for preventing and controlling nematodes of solanaceous vegetables, cucurbitaceae vegetables, lettuce and other crops.
Description
Technical Field
The invention belongs to the technical field of pesticides, and relates to a pesticide composition for preventing and treating nematodes.
Background
Root knot nematode disease is one of the main diseases of crops such as Solanaceae, cucurbitaceae and the like, and especially in facility agriculture, crops which are easy to be infected by nematodes are planted throughout the year, so that the root knot nematode disease commonly occurs and serious economic loss is caused. At present, the active ingredient varieties registered for preventing and controlling plant root-knot nematodes are few, chemical pesticides are mainly used, and continuous administration for many years is easy to induce pests to generate drug resistance, so that the development of safe and efficient medicaments including biological pesticides is urgently needed in agricultural production.
Ethylicin (English name: ethylicin) is an ethylicin homolog of plant pesticide garlicin, and has chemical formula C 4 H 10 O 2 S 2 Colorless or yellowish oily liquid with garlic odor. Ethylicin is a high-efficiency pollution-free broad-spectrum bionic bactericide, has the plant growth regulating effect, can promote germination, increase germination rate, increase yield and improve quality, and is a preferred raw material of a compound pesticide preparation. Ethylicin can be used for preventing and treating various diseases, and acts with sulfur-containing substances in thallus to inhibit normal metabolism of thallus. No report of controlling root knot nematode disease by ethylicin exists at present.
Avermectin is a hexadecanoid macrolide compound with bactericidal, insecticidal, acaricidal and nematicidal activity, and is prepared from Streptomyces avermitilisStreptomyces avermitilisThe fermentation is produced, and has the characteristics of broad spectrum, high efficiency, low toxicity and the like. The insecticidal mechanism of avermectin is paraγ-an agonism of aminobutyric acid (GABA) and a change of the chloride channel opening pattern controlled by glutamate, resulting in paralysis and mortality of the pests.
The reasonable blending of the pesticide has the advantages of improving the control effect, delaying the drug resistance and the drug resistance of pests, reducing the medication cost, expanding the insecticidal spectrum and the like. The invention combines abamectin and ethylicin, and has obvious synergy.
Disclosure of Invention
The invention provides a novel pesticide composition for preventing and treating nematodes, aiming at the problems that the traditional pesticide composition for preventing and treating nematode diseases has few selectable pesticide varieties and is easy to cause pesticide resistance of pests.
In order to achieve the above purpose, the invention is realized by adopting the following technical scheme:
the pesticide composition for preventing and treating the nematodes comprises the effective components of abamectin and ethylicin, wherein the mass ratio of the abamectin to the ethylicin is 1:5-1:29.
Preferably, the pesticide composition for preventing and treating nematodes has a mass ratio of abamectin to ethylicin of 1:8-1:19.
Preferably, the pesticide composition for preventing and treating nematodes has a mass ratio of abamectin to ethylicin of 1:9.
Preferably, the pesticide composition for preventing and treating nematodes comprises 3-50% of the effective components of avermectin and ethylicin by mass percent.
The pesticide composition for preventing and treating the nematodes is any one of emulsifiable concentrate, suspoemulsion, aqueous emulsion, microemulsion, microcapsule and microcapsule suspension. Besides the effective components, the pesticide composition also comprises auxiliary components which are allowed to be used and accepted in the pesticide. The pesticide auxiliary agent comprises one or more of solvent, wetting agent, dispersing agent, stabilizer, antifreezing agent, preservative, filler, carrier material, adhesive and the like. The use of the auxiliary agent is selected according to the dosage form.
The invention provides application of the pesticide composition in preparation of a preparation for preventing and treating nematodes.
Compared with the prior art, the invention has the advantages and positive effects that:
the invention uses avermectin and ethylicin as effective components to compound, has obvious synergistic effect on preventing root-knot nematode from infecting plant root systems, and the effect has not been reported yet. The preparation product containing the composition can improve the control effect on the root-knot nematode and has development potential.
In addition, the avermectin and ethylicin have different action mechanisms, so that the administration times can be reduced, and the generation of drug resistance can be delayed. Is mainly used for preventing and controlling nematodes of solanaceous vegetables, cucurbitaceae vegetables, lettuce and other crops.
Detailed Description
In order that the above objects, features and advantages of the invention will be more clearly understood, a further description of the invention will be provided with reference to specific examples. It should be noted that, in the case of no conflict, the embodiments of the present application and the features in the embodiments may be combined with each other.
In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present invention, however, the present invention may be practiced otherwise than as described herein, and therefore the present invention is not limited to the specific embodiments of the disclosure that follow.
The percentages mentioned in the examples below are percentages by mass, unless otherwise indicated.
Example 1
5% avermectin ethylicin aqueous emulsion (1:9).
95% avermectin (zebra): 0.5 percent,
95% ethylicin original drug (folded hundred): 4.5 percent,
cyclohexanone (solvent): 5 percent,
polyoxyethylene sorbitan monooleate (emulsifier): 1 percent,
triphenylethyl phenol polyoxypropylene polyoxyethylene block polymer (emulsifier): 4 percent,
castor oil polyoxyethylene ether (emulsifier): 1 percent,
silicone defoamer: 0.1 percent,
ethylene glycol (antifreeze): 2 percent,
water: the complement is 100 percent.
Uniformly mixing the active components and the solvent to prepare an oil phase; uniformly mixing an emulsifying agent, a defoaming agent, an antifreezing agent and water to prepare a water phase; mixing the oil phase and the water phase, and shearing at high speed of 10000 r/min for 20 min to reach the required particle size (average particle size of 1-2 μm or less) to obtain 5% avermectin-ethylicin aqueous emulsion.
Example 2
3% avermectin-ethylicin aqueous emulsion (1:5).
95% avermectin (zebra): 0.5 The%;
95% ethylicin original drug (folded hundred): 2.5%;
cyclohexanone (solvent): 5%;
polyoxyethylene sorbitan monooleate (emulsifier): 1%;
triphenylethyl phenol polyoxypropylene polyoxyethylene block polymer (emulsifier): 4%;
castor oil polyoxyethylene ether (emulsifier): 1%;
silicone defoamer: 0.1%;
ethylene glycol: 2%;
water: the complement is 100 percent.
Uniformly mixing the active components and the solvent to prepare an oil phase; uniformly mixing an emulsifying agent, a defoaming agent, an antifreezing agent and water to prepare a water phase; mixing the oil phase and the water phase, and shearing at high speed of 10000 r/min for 20 min to reach the required particle size (average particle size of 1-2 μm or less) to obtain 3% avermectin-ethylicin aqueous emulsion.
Example 3
5% avermectin ethylicin microcapsule suspension emulsion (1:9).
1.09g of avermectin raw material (92%) is dissolved in 10 g cyclohexanone, and then 4g of polyoxyethylene sorbitan monooleate (emulsifier) is added as an oil phase; 0.3 g polyvinyl alcohol, 0.5 g sodium dodecylbenzenesulfonate, and 2.5g calcium lignosulfonate were dissolved in deionized water to form an aqueous phase. Adding the aqueous phase to the oil phase under magnetic stirring at 400 rpm to form an oil-in-water emulsion; then adding 2.5g of dodecyl dimethyl benzyl ammonium chloride into the emulsion slowly, and stirring for 20 minutes; adding 0.2g of 10% ferric chloride aqueous solution under stirring; stirring for 20 minutes; the deionized water is used for supplementing 100g; the 1% avermectin microcapsule suspending agent is prepared.
Uniformly mixing 9.47 and g ethylicin raw material (95 percent) and 5g cyclohexanone to prepare an oil phase; 1g of polyoxyethylene sorbitan monooleate (emulsifier), 4g of triphenyl ethylphenol polyoxypropylene polyoxyethylene block polymer (emulsifier), 1g of castor oil polyoxyethylene ether (emulsifier) emulsifier, 0.1g of organosilicon defoamer, 2g ethylene glycol and water are uniformly mixed to prepare a water phase; mixing the oil phase and the water phase, and shearing at high speed of 10000 r/min for 20 minutes until the particle size reaches the required particle size to obtain the 9% ethylicin aqueous emulsion.
1% avermectin microcapsule suspending agent and 9% ethylicin aqueous emulsion are mixed according to the following ratio of 1:1, mixing and stirring for half an hour to prepare the 5% avermectin ethylicin microcapsule suspension emulsion. Through detection, the particle size distribution D of the drug particles in the preparation 50 Value 225 nm, D 90 The value is 820 nm.
Example 4
5% avermectin-ethylicin emulsifiable concentrate.
95% avermectin (zebra): 0.5 Percent (a),
95% ethylicin original drug (folded hundred): 4.5 percent,
cyclohexanone (solvent): 5 percent,
polyoxyethylene sorbitan monooleate (emulsifier): 2 percent,
triphenylethyl phenol polyoxypropylene polyoxyethylene block polymer (emulsifier): 4 percent,
calcium dodecylbenzenesulfonate (emulsifier): 4 percent,
benzoate (solvent): the complement is 100 percent.
After dissolving cyclohexanone which is the raw avermectin, adding the raw ethylicin, an emulsifier and benzoate, and uniformly mixing to form a uniform and transparent oil phase preparation, namely the 5% avermectin ethylicin emulsifiable concentrate.
Field efficacy test example.
The field efficacy tests of 5% avermectin-ethylicin aqueous emulsion (example 1), 3% avermectin-ethylicin aqueous emulsion (example 2) and 5% avermectin-ethylicin microcapsule suspension emulsion (example 3) on root-knot nematodes were carried out. Adopting a soil surface spraying, mixing and applying technology, diluting a test reagent with water conventionally, uniformly spraying the diluted test reagent onto the soil surface of a test cell, and then ridging and planting seedlings by using a 15-20 cm soil layer in a rotary cultivator rotary root cell. The control area, sprayed with clear water, and other operations were consistent with the cells treated with the medication. Each treatment was repeated 3 times. The cells are arranged in random groups, and the cultivation conditions are uniform. After treatment, 90 d, the plant root system is slowly taken out for cleaning, and the disease condition is recorded.
The root knot grading criteria are as follows:
level 0: the root system is healthy and has no root knot; stage 1: a very small number of root knots can be found by careful examination; 2. stage: root imaging is level 1 in size but slightly larger in number; 3. stage: a large number of small root knots are long together, and the root function is not damaged; 4. stage: a large number of small root knots, some large root knots, most of the roots still have functions; 5. stage: 25% of root systems are severely galled and disabled; 6. stage: 50% of root systems are severely galled and lose function; 7. stage: 75% of root systems are severely galled and lose functions; 8. stage: no healthy root, plant nutrition interruption; 9. stage: root system all goiter and rot, plant death; 10. stage: the plants and root systems die.
Disease index% = Σ (number of disease plants at each stage×relative number)/(total number of investigation×highest index of investigation grade) ×100;
control effect (%) = [1- (treated disease index/control disease index) ]×100.
TABLE 1 results of field efficacy test for controlling root knot nematode disease
As can be seen from table 1:
when the dosage of the active ingredients is the same, the control effect of the composition compounded by the avermectin and the ethylicin is higher than that of the two medicaments which are independently used, and the control effect of the embodiment 1 (avermectin: ethylicin=1:9) is higher than that of the embodiment 2 (avermectin: ethylicin=1:5), which proves that the composition with the highest synergy ratio has application value. Meanwhile, the dosage form factors have influence on the prevention effect, and the prevention effect of the embodiment 3 is obviously higher than that of the embodiment 1, probably because the particle size distribution of the drug carrying particles in the embodiment 3 is in the nanometer range, the mobility and the distribution range of the active ingredients in the soil are improved, the root system is more effectively protected, and the prevention effect is improved. Meanwhile, the aqueous emulsion and the microcapsule suspension emulsion developed by the invention are water-based dosage forms, and compared with an emulsifiable concentrate dosage form, the aqueous emulsion and the microcapsule suspension emulsion have low cost and good environmental compatibility. The application and popularization of the invention are beneficial to improving the control effect on the root knot nematode disease of crops, and will produce larger economic value.
Example 5
The embodiment provides a combined toxicity test for mixing different active ingredients, and the combined toxicity of the pharmaceutical composition for inhibiting 2-year-old root-knot nematodes from infecting cucumber root systems is examined. The results are shown in Table 2, and show that the abamectin and ethylicin mixed in a certain proportion range have obvious synergistic effect on the control of nematodes. More preferably, the weight ratio of the avermectin to the ethylicin is 1:9-1:15.
Table 2 combined virulence of abamectin and ethylicin to inhibit root-knot nematode infection of cucumber root system
The avermectin and ethylicin are mixed according to the weight ratio of 1:5, 1:9, 1:15, 1:19 and 1:29, a flat plate infection test is carried out on two-instar larvae of root knot nematodes, the results are shown in table 2, the ratio of 1:9 and 1:15 are synergistic effects, and when the ratio is 1:9, the co-toxicity coefficient is highest, namely the synergistic effect is most obvious, and the experimental results also correspond to the experimental results in table 1.
The present invention is not limited to the above-mentioned embodiments, and any equivalent embodiments which can be changed or modified by the technical content disclosed above can be applied to other fields, but any simple modification, equivalent changes and modification made to the above-mentioned embodiments according to the technical substance of the present invention without departing from the technical content of the present invention still belong to the protection scope of the technical solution of the present invention.
Claims (6)
1. A pesticide composition for controlling nematodes, characterized in that: the effective components are avermectin and ethylicin, and the mass ratio of the avermectin to ethylicin is 1:5-1:29.
2. A pesticidal composition for controlling nematodes as claimed in claim 1, in which: the mass ratio of the avermectin to the ethylicin is 1:8-1:19.
3. A pesticidal composition for controlling nematodes as claimed in claim 1, in which: the mass ratio of the avermectin to the ethylicin is 1:9.
4. A pesticidal composition for controlling nematodes as claimed in claim 1, in which: the mass fraction of the effective components avermectin and ethylicin in the pesticide composition is 3-50%.
5. A pesticidal composition for controlling nematodes according to any of claims 1 to 4, in the form of any of emulsifiable concentrates, suspoemulsions, aqueous emulsions, microemulsions, microcapsules, microcapsule suspensions.
6. Use of a pesticidal composition according to any one of claims 1 to 4 in the preparation of a formulation for controlling nematodes.
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