CN1172658C - 蛋白质制剂 - Google Patents

蛋白质制剂 Download PDF

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Publication number
CN1172658C
CN1172658C CNB998073628A CN99807362A CN1172658C CN 1172658 C CN1172658 C CN 1172658C CN B998073628 A CNB998073628 A CN B998073628A CN 99807362 A CN99807362 A CN 99807362A CN 1172658 C CN1172658 C CN 1172658C
Authority
CN
China
Prior art keywords
pharmaceutical preparation
pth
parathyroid hormone
preparation
concentration
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CNB998073628A
Other languages
English (en)
Chinese (zh)
Other versions
CN1319003A (zh
Inventor
马丁·比尔格
3
迈克尔·布鲁尔斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shire NPS Pharmaceuticals Inc
Original Assignee
NPS ALLELIX Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by NPS ALLELIX Inc filed Critical NPS ALLELIX Inc
Publication of CN1319003A publication Critical patent/CN1319003A/zh
Application granted granted Critical
Publication of CN1172658C publication Critical patent/CN1172658C/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/29—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Endocrinology (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
CNB998073628A 1998-04-28 1999-04-26 蛋白质制剂 Expired - Lifetime CN1172658C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE98014954 1998-04-28
SE9801495A SE9801495D0 (sv) 1998-04-28 1998-04-28 Protein formulationa

Publications (2)

Publication Number Publication Date
CN1319003A CN1319003A (zh) 2001-10-24
CN1172658C true CN1172658C (zh) 2004-10-27

Family

ID=20411122

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB998073628A Expired - Lifetime CN1172658C (zh) 1998-04-28 1999-04-26 蛋白质制剂

Country Status (24)

Country Link
US (1) US20050209144A1 (enExample)
EP (1) EP1079803B1 (enExample)
JP (2) JP4733267B2 (enExample)
KR (1) KR100579872B1 (enExample)
CN (1) CN1172658C (enExample)
AT (1) ATE273693T1 (enExample)
AU (2) AU766514B2 (enExample)
BR (1) BR9909958A (enExample)
CA (1) CA2329800C (enExample)
CY (1) CY2006006I1 (enExample)
DE (3) DE69919533T2 (enExample)
DK (1) DK1079803T3 (enExample)
ES (1) ES2224637T3 (enExample)
FR (1) FR06C0032I2 (enExample)
HK (1) HK1041218B (enExample)
IL (1) IL139320A (enExample)
LU (1) LU91281I2 (enExample)
NL (1) NL300243I2 (enExample)
NZ (1) NZ508269A (enExample)
PT (1) PT1079803E (enExample)
SE (1) SE9801495D0 (enExample)
SI (1) SI1079803T1 (enExample)
WO (1) WO1999055353A2 (enExample)
ZA (1) ZA200006040B (enExample)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6770623B1 (en) 1997-12-09 2004-08-03 Eli Lilly And Company Stabilized teriparatide solutions
SE9801495D0 (sv) * 1998-04-28 1998-04-28 Astra Ab Protein formulationa
US20050032698A1 (en) * 2003-07-14 2005-02-10 Nps Allelix Corp. Stabilized formulation of parathyroid hormone
BRPI0618469A2 (pt) * 2005-11-10 2011-08-30 Univ Michigan Tech hormÈnio paratiróide de urso preto e métodos de uso de hormÈnio paratiróide de urso preto
US7803770B2 (en) 2006-10-03 2010-09-28 Radius Health, Inc. Method of treating osteoporosis comprising administration of PTHrP analog
USRE49444E1 (en) 2006-10-03 2023-03-07 Radius Health, Inc. Method of treating osteoporosis comprising administration of PTHrP analog
JP5375611B2 (ja) 2006-10-03 2013-12-25 ラジウス ヘルス，インコーポレイテッド 骨同化作用を有するタンパク質のための薬物送達方法
FR2925333B1 (fr) * 2007-12-19 2012-04-13 Farid Bennis Compositions pharmaceutiques renfermant au moins un principe actif proteinique protege des enzymes digestives
JP2009091363A (ja) * 2008-11-21 2009-04-30 Asahi Kasei Pharma Kk Ｐｔｈの安定化水溶液注射剤
EP2509996A1 (en) 2009-12-07 2012-10-17 Michigan Technological University Black bear parathyroid hormone and methods of using black bear parathyroid hormone
ES2833277T3 (es) * 2011-06-07 2021-06-14 Asahi Kasei Pharma Corp Preparación liofilizada que contiene PTH de alta pureza y método para producirla
CN103301058A (zh) * 2013-06-17 2013-09-18 深圳翰宇药业股份有限公司 一种特立帕肽注射用组合物及其制备方法和制剂
PT3122426T (pt) 2014-03-28 2023-02-28 Univ Duke Tratamento de cancro da mama utilizando moduladores seletivos do recetor de estrogénio
EP3288383A4 (en) 2015-04-29 2019-01-23 Radius Pharmaceuticals, Inc. METHOD FOR THE TREATMENT OF CANCER
CN106309358A (zh) * 2015-06-29 2017-01-11 成都金凯生物技术有限公司 含有人甲状旁腺激素的药物组合物及其制备方法与用途
ES2981967T3 (es) 2017-01-05 2024-10-14 Radius Pharmaceuticals Inc Formas polimórficas de RAD1901-2HCl
CN108333360A (zh) * 2017-01-19 2018-07-27 深圳市新产业生物医学工程股份有限公司 胃泌素释放肽前体稀释液及其应用和试剂盒
US10996208B2 (en) 2017-04-28 2021-05-04 Radius Health, Inc. Abaloparatide formulations and methods of testing, storing, modifying, and using same
JP6577683B2 (ja) * 2017-09-22 2019-09-18 旭化成ファーマ株式会社 安定性に優れるテリパラチド含有液状医薬組成物
CN108159404B (zh) * 2018-01-05 2019-08-27 北京博康健基因科技有限公司 重组人甲状旁腺激素制剂及其制备方法
JP7473486B2 (ja) 2018-07-04 2024-04-23 ラジウス ファーマシューティカルズ，インコーポレイテッド Ｒａｄ１９０１－２ｈｃｌの多形形態
JOP20210218A1 (ar) 2019-02-12 2023-01-30 Radius Pharmaceuticals Inc عمليات ومركبات

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5981485A (en) * 1997-07-14 1999-11-09 Genentech, Inc. Human growth hormone aqueous formulation
DE3935738A1 (de) * 1989-10-27 1991-05-08 Forssmann Wolf Georg Arzneimittel, enthaltend das humane parathormon-fragment (1-37) als aktiven wirkstoff
US5744444A (en) * 1989-10-27 1998-04-28 Haemopep Pharma Gmbh HPTH-fragment-(1-37), the preparation thereof, medicaments containing same and the use thereof
US5547939A (en) * 1991-06-14 1996-08-20 The Regents Of The University Of California Broad spectrum antimicrobial compounds and methods of use
JP2662842B2 (ja) * 1991-12-09 1997-10-15 旭化成工業株式会社 パラサイロイドホルモンの安定化組成物
US5563122A (en) * 1991-12-09 1996-10-08 Asahi Kasei Kogyo Kabushiki Kaisha Stabilized parathyroid hormone composition
KR100291620B1 (ko) * 1992-09-29 2001-10-24 추후제출 부갑상선호르몬의활성단편의폐를통한전달방법
US5496801A (en) * 1993-12-23 1996-03-05 Allelix Biopharmaceuticals Inc. Parathyroid hormone formulation
JPH09157294A (ja) * 1995-06-15 1997-06-17 Takeda Chem Ind Ltd 副甲状腺ホルモン誘導体
DE19538687A1 (de) * 1995-10-17 1997-04-24 Boehringer Mannheim Gmbh Stabile pharmazeutische Darreichungsformen enthaltend Parathormon
JP4053107B2 (ja) * 1996-02-01 2008-02-27 中外製薬株式会社 血小板減少症の予防剤および治療剤
US5964807A (en) * 1996-08-08 1999-10-12 Trustees Of The University Of Pennsylvania Compositions and methods for intervertebral disc reformation
DE19733651A1 (de) * 1997-08-04 1999-02-18 Boehringer Ingelheim Pharma Wässrige Aerosolzubereitungen enthaltend biologisch aktive Markomoleküle und Verfahren zur Erzeugung entsprechender Aerosole
SE9801495D0 (sv) * 1998-04-28 1998-04-28 Astra Ab Protein formulationa

Also Published As

Publication number Publication date
LU91281I2 (fr) 2006-12-19
DE69919533D1 (de) 2004-09-23
CA2329800A1 (en) 1999-11-04
FR06C0032I2 (fr) 2007-04-27
FR06C0032I1 (enExample) 2006-11-24
WO1999055353A3 (en) 2000-01-13
KR20010052276A (ko) 2001-06-25
NL300243I2 (nl) 2007-02-01
ZA200006040B (en) 2002-01-28
AU2004200156A1 (en) 2004-02-12
AU2004200156B2 (en) 2005-12-15
CN1319003A (zh) 2001-10-24
SI1079803T1 (en) 2005-02-28
DE122006000057I2 (de) 2009-11-05
JP4733267B2 (ja) 2011-07-27
AU766514B2 (en) 2003-10-16
KR100579872B1 (ko) 2006-05-12
AU3591699A (en) 1999-11-16
SE9801495D0 (sv) 1998-04-28
EP1079803A2 (en) 2001-03-07
DE69919533T2 (de) 2005-09-08
EP1079803B1 (en) 2004-08-18
HK1041218A1 (en) 2002-07-05
BR9909958A (pt) 2000-12-26
CY2006006I2 (el) 2009-11-04
NL300243I1 (nl) 2006-12-01
DK1079803T3 (da) 2004-11-22
JP2002512973A (ja) 2002-05-08
IL139320A0 (en) 2001-11-25
DE122006000057I1 (de) 2007-01-04
CA2329800C (en) 2004-06-15
ES2224637T3 (es) 2005-03-01
HK1041218B (zh) 2005-03-18
PT1079803E (pt) 2004-11-30
CY2006006I1 (el) 2009-11-04
JP5753692B2 (ja) 2015-07-22
IL139320A (en) 2007-06-17
WO1999055353A2 (en) 1999-11-04
NZ508269A (en) 2003-12-19
ATE273693T1 (de) 2004-09-15
JP2011105739A (ja) 2011-06-02
US20050209144A1 (en) 2005-09-22

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Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
ASS Succession or assignment of patent right

Owner name: NPS PHARMACEUTICALS, INC.

Free format text: FORMER OWNER: NPS ALLIQUES COMPANY

Effective date: 20090904

C41 Transfer of patent application or patent right or utility model
TR01 Transfer of patent right

Effective date of registration: 20090904

Address after: new jersey

Patentee after: NPS Pharmaceuticals, Inc.

Address before: Ontario

Patentee before: NPS Allelix Inc.

CX01 Expiry of patent term

Granted publication date: 20041027

CX01 Expiry of patent term