CN117205210A - 含有阿托品的水性组合物 - Google Patents

含有阿托品的水性组合物 Download PDF

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Publication number
CN117205210A
CN117205210A CN202311240197.1A CN202311240197A CN117205210A CN 117205210 A CN117205210 A CN 117205210A CN 202311240197 A CN202311240197 A CN 202311240197A CN 117205210 A CN117205210 A CN 117205210A
Authority
CN
China
Prior art keywords
buffer
aqueous composition
composition according
atropine
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202311240197.1A
Other languages
English (en)
Chinese (zh)
Inventor
D·谭
R·波尔曼
浅田博之
高桥恭平
阪中浩二
森本隆司
藤泽丰实
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Santen Pharmaceutical Co Ltd
Nanyang Technological University
Singapore Health Services Pte Ltd
Original Assignee
Santen Pharmaceutical Co Ltd
Nanyang Technological University
Singapore Health Services Pte Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=60411416&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN117205210(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Santen Pharmaceutical Co Ltd, Nanyang Technological University, Singapore Health Services Pte Ltd filed Critical Santen Pharmaceutical Co Ltd
Publication of CN117205210A publication Critical patent/CN117205210A/zh
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/186—Quaternary ammonium compounds, e.g. benzalkonium chloride or cetrimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/08—Mydriatics or cycloplegics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/10—Ophthalmic agents for accommodation disorders, e.g. myopia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Ophthalmology & Optometry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Inorganic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Emergency Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Materials For Photolithography (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
CN202311240197.1A 2016-05-25 2017-05-24 含有阿托品的水性组合物 Pending CN117205210A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
SG10201604200P 2016-05-25
SG10201604200P 2016-05-25
CN201780031738.6A CN109310687B (zh) 2016-05-25 2017-05-24 含有阿托品的水性组合物
PCT/JP2017/019423 WO2017204262A1 (en) 2016-05-25 2017-05-24 Atropine-containing aqueous composition

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201780031738.6A Division CN109310687B (zh) 2016-05-25 2017-05-24 含有阿托品的水性组合物

Publications (1)

Publication Number Publication Date
CN117205210A true CN117205210A (zh) 2023-12-12

Family

ID=60411416

Family Applications (3)

Application Number Title Priority Date Filing Date
CN202311240197.1A Pending CN117205210A (zh) 2016-05-25 2017-05-24 含有阿托品的水性组合物
CN201780031738.6A Active CN109310687B (zh) 2016-05-25 2017-05-24 含有阿托品的水性组合物
CN202311238651.XA Pending CN117205209A (zh) 2016-05-25 2017-05-24 含有阿托品的水性组合物

Family Applications After (2)

Application Number Title Priority Date Filing Date
CN201780031738.6A Active CN109310687B (zh) 2016-05-25 2017-05-24 含有阿托品的水性组合物
CN202311238651.XA Pending CN117205209A (zh) 2016-05-25 2017-05-24 含有阿托品的水性组合物

Country Status (15)

Country Link
US (3) US20210267885A1 (cg-RX-API-DMAC7.html)
EP (2) EP3463360B2 (cg-RX-API-DMAC7.html)
JP (6) JP6590860B2 (cg-RX-API-DMAC7.html)
KR (4) KR102804061B1 (cg-RX-API-DMAC7.html)
CN (3) CN117205210A (cg-RX-API-DMAC7.html)
AR (1) AR108591A1 (cg-RX-API-DMAC7.html)
CA (1) CA3023149C (cg-RX-API-DMAC7.html)
EA (1) EA201892703A1 (cg-RX-API-DMAC7.html)
ES (1) ES2929368T3 (cg-RX-API-DMAC7.html)
MY (1) MY189774A (cg-RX-API-DMAC7.html)
PH (1) PH12018502421A1 (cg-RX-API-DMAC7.html)
SG (1) SG11201809822SA (cg-RX-API-DMAC7.html)
TW (3) TWI849355B (cg-RX-API-DMAC7.html)
UA (1) UA126195C2 (cg-RX-API-DMAC7.html)
WO (1) WO2017204262A1 (cg-RX-API-DMAC7.html)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9421199B2 (en) 2014-06-24 2016-08-23 Sydnexis, Inc. Ophthalmic composition
WO2016172712A2 (en) * 2015-04-23 2016-10-27 Sydnexis, Inc. Ophthalmic composition
US11052094B2 (en) 2015-05-29 2021-07-06 Sydnexis, Inc. D2O stabilized pharmaceutical formulations
EP3585386A4 (en) 2017-02-21 2020-12-30 Singapore Health Services PTE Ltd COMPOSITION AND PROCESS FOR PREVENTING OR DELAYING THE ONCE OF MYOPIA INCLUDING ATROPINE
EP3970694A1 (en) 2017-05-11 2022-03-23 Vyluma Inc. Atropine pharmaceutical compositions
CN110934869B (zh) * 2018-09-25 2023-07-04 沈阳兴齐眼药股份有限公司 一种阿托品药物组合物和药盒产品
CN114533652B (zh) * 2018-09-25 2024-12-13 沈阳兴齐眼药股份有限公司 药物组合物、其制备方法和用途
MA52857A (fr) 2019-03-01 2021-04-21 Medivis S R L Formulations ophtalmiques à base d'atropine
CA3189821A1 (en) 2020-08-04 2022-02-10 Santen Pharmaceutical Co., Ltd. Agent for treating myopia, preventing myopia and/or suppressing myopia progression
KR20230087514A (ko) * 2020-10-14 2023-06-16 산텐 세이야꾸 가부시키가이샤 안정한 의약 조성물
PE20231656A1 (es) 2020-11-02 2023-10-17 Trethera Corp Formas cristalinas de un inhibidor de cinasa de desoxicitidina y sus usos
WO2022130337A1 (en) * 2020-12-17 2022-06-23 Sun Pharmaceutical Industries Limited An aqueous sterile solution of atropine for ophthalmic use
EP4088713A1 (en) 2021-05-10 2022-11-16 Warszawskie Zaklady Farmaceutyczne Polfa S.A. Ophthalmic pharmaceutical composition comprising atropine
EP4088714A1 (en) 2021-05-10 2022-11-16 Warszawskie Zaklady Farmaceutyczne Polfa S.A. Ophthalmic pharmaceutical composition comprising atropine
US20230120997A1 (en) * 2021-10-18 2023-04-20 Ocular Science, Inc. Compositions and methods for myopia control and orthokeratology lenses treatment
CN114129511A (zh) * 2021-12-07 2022-03-04 河南润弘制药股份有限公司 一种具有改进稳定性的硫酸阿托品注射液
JP7884090B2 (ja) * 2022-09-11 2026-07-02 アルコン インク． ベンジルアトロピンを含む水性医薬組成物及びその使用
WO2025018419A1 (ja) 2023-07-20 2025-01-23 センジュ ユーエスエー、インコーポレイテッド 水性液剤
JP7665073B1 (ja) 2024-04-05 2025-04-18 ロート製薬株式会社 容器に収容してなる眼科用組成物
JP7723851B1 (ja) 2024-11-22 2025-08-14 参天製薬株式会社 アトロピン含有水性医薬組成物

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01203320A (ja) * 1988-02-05 1989-08-16 Eisai Co Ltd 安定なジフェンヒドラミン含有水溶液
WO2015200361A1 (en) * 2014-06-24 2015-12-30 Sydnexis, Inc. Ophthalmic composition

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US5612027A (en) * 1995-04-18 1997-03-18 Galin; Miles A. Controlled release of miotic and mydriatic drugs in the anterior chamber
JP3166002B2 (ja) * 1997-01-27 2001-05-14 日本車輌製造株式会社 自動車の洗浄装置
US20030096831A1 (en) 2000-01-18 2003-05-22 Stone Richard A. Ocular growth and nicotinic antagonists
CN1509172A (zh) * 2001-05-25 2004-06-30 ά����ҩ��˾ 哌仑西平眼用凝胶剂
US20070254914A1 (en) * 2006-05-01 2007-11-01 Non-Profit Organization Chang Gung Memorial Hospital Low-concentration atropine solution for preventing myopia progression and preparing method thereof
JP2007308398A (ja) * 2006-05-17 2007-11-29 Chang Gung Memorial Hospital 目薬、及びその製造方法
JP2010528010A (ja) * 2007-05-21 2010-08-19 ニューロプティックス コーポレイション アミロイドβ造影剤の眼用製剤およびその使用の方法
CN101327216A (zh) * 2007-06-22 2008-12-24 肖正连 一种硫酸阿托品眼用即型凝胶
WO2012161655A1 (en) * 2011-05-23 2012-11-29 Singapore Health Services Pte Ltd Composition and/or method for reducing and/or preventing myopia progression comprising atropine
US20160009705A1 (en) * 2014-06-24 2016-01-14 Sydnexis, Inc. Ophthalmic composition
CN104983739B (zh) * 2015-06-25 2018-01-16 成都乾坤动物药业股份有限公司 一种多功能药物组合及其制备方法和应用
JP2017102939A (ja) * 2016-12-26 2017-06-08 株式会社プロフィールド オーサリング装置、オーサリング方法、およびプログラム
EP3970694A1 (en) * 2017-05-11 2022-03-23 Vyluma Inc. Atropine pharmaceutical compositions

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01203320A (ja) * 1988-02-05 1989-08-16 Eisai Co Ltd 安定なジフェンヒドラミン含有水溶液
WO2015200361A1 (en) * 2014-06-24 2015-12-30 Sydnexis, Inc. Ophthalmic composition

Also Published As

Publication number Publication date
KR102804061B1 (ko) 2025-05-07
JP2018021007A (ja) 2018-02-08
EA201892703A1 (ru) 2019-04-30
KR20230141882A (ko) 2023-10-10
JP2023058574A (ja) 2023-04-25
CA3023149C (en) 2024-07-02
EP3463360B1 (en) 2022-08-31
KR20220154842A (ko) 2022-11-22
CN117205209A (zh) 2023-12-12
TW201808289A (zh) 2018-03-16
JP2020007356A (ja) 2020-01-16
JP2025084921A (ja) 2025-06-03
JP2021120404A (ja) 2021-08-19
KR102580933B1 (ko) 2023-09-19
TW202206070A (zh) 2022-02-16
UA126195C2 (uk) 2022-08-31
KR20250067951A (ko) 2025-05-15
JP7224390B2 (ja) 2023-02-17
JP2025176149A (ja) 2025-12-03
EP3463360B2 (en) 2026-07-15
TWI791438B (zh) 2023-02-11
WO2017204262A1 (en) 2017-11-30
PH12018502421A1 (en) 2019-09-30
EP4112055A1 (en) 2023-01-04
JP6886502B2 (ja) 2021-06-16
SG11201809822SA (en) 2018-12-28
US20210267885A1 (en) 2021-09-02
MY189774A (en) 2022-03-04
CA3023149A1 (en) 2017-11-30
CN109310687B (zh) 2023-10-20
TW202325296A (zh) 2023-07-01
EP3463360A1 (en) 2019-04-10
AR108591A1 (es) 2018-09-05
TWI849355B (zh) 2024-07-21
ES2929368T3 (es) 2022-11-28
EP3463360A4 (en) 2020-01-29
US20260183235A1 (en) 2026-07-02
KR20190013877A (ko) 2019-02-11
US20240307305A1 (en) 2024-09-19
JP6590860B2 (ja) 2019-10-16
TWI874894B (zh) 2025-03-01
CN109310687A (zh) 2019-02-05

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