CN1171959A - Traditional Chinese medicine preparation for curing osteoproliferation disease and its preparing technology - Google Patents

Abstract

The present invention relates to a Chinese patent medicine preparation for curing osteoproliferation and its preparation method. It is formed from the Chinese medicinal materials of drynaria root, achyranthes root, dipsacus root, eucommia bark, Chinese angelica root, millettia root and stem, small gleditsia fruit, mollissima, asarum, tianxiong, aconite tuber, ground pine, krait/agkistrodon, scorpion, centipede, wingless cockroach, nux vomica and hornet's nest. Said medicine preparation can be used for curing various osteoproliferations, and possesses the advantages of short course of treatment, quickly-obtaining result, high cure rate and low recurrence rate.

Description

A kind of Chinese medicine preparation and preparation technology thereof who treats hyperosteogeny

The present invention relates to a kind of Chinese patent medicine preparation and preparation technology thereof, particularly a kind of Chinese medicine preparation and preparation technology thereof who treats hyperosteogeny.

Hyperosteogeny is the most common osteoarthritis of middle-aged and elderly people, and China and countries in the world sickness rate are all very high.According to the study, hyperosteogeny phenomenon is in various degree all arranged more than 90% among the crowd more than 40 years old, and the sickness rate more than 50 years old that produces clinical symptoms is about the crowd who accounts for more than 13～15%, 60 years old 50%, 70% or more the clinical symptoms of different degrees generation is all arranged more than 70%.The mechanism of its morbidity is: aging takes place in the mankind along with the hypertrophy at age, the old and feeble regression of skeleton is a whole old and feeble part, this also is the rule of not avoided, Just because of this, because in the productive labor and life activity of people in secular life course, human synovial is mainly this class weight-bearing joint of cervical vertebra, lumbar vertebra, hip knee joint and heel, under the situation of bearing gravity and load for a long time, turn round, make joint wearing and tearing and the damage of long-pending base property, the outer of cartilage fragment that the destruction of articular cartilage, disintegrate come off moves; At vertebra owing to push away the atrophy and the degeneration of intercalated disc, vertebra is asked that the bulging of dish is outstanding or is deviate from, joint space narrow, at this moment body is to set up the stability that new balancing increases the joint,,, ossified gradually at the joint epiphysis owing to ossification takes place osteoblastic participating in under the cartilage fragment and partial blood stasis situation that enclose, around making epiphysis the change of lip sample taking place, and then forms bony spur even bone bridge and joint fusion.Combination proliferation that outgrowth bony spur and on every side soft tissue form and then extruding, stimulate, involve and adhesion muscle, tendon, synovial membrane and joint capsule around it, and nerve, blood vessel, spinal cord and the salty nerve fiber of friendship etc., thereby very complicated clinical symptoms takes place.

It is documented, the method of treatment hyperosteogeny is a lot of at present, as acupuncture, physical therapy, decline, massage, traction, small needle knife, hyperosteogeny treating machine, the qigong, cupping jar, sand therapy, mud therapy, wax therapy, hot wax, medicinal liquid immersion, steam, fumigation and wash method, mineral spring, ultrasonic, magnetic therapy, infrared, refined light, medicine ion penetrate, sealing, kanlisha coarse sand granules, medicated wine, liniment, plaster, bamboo branch therapy, occupational therapy, banting, psychotherapy, Western medicine analgesic for oral administration, various Chinese medicine decoction, pill, powder, tablet, electuary and surgical operation etc.Over 1993, the Chinese medicine preparation of State Patent Office's published application patent also reaches 30 and plants etc.But at present, because each family remains in problems such as the certain limitation and the degree of depth, so above-mentioned various Therapeutic Method all still can not fundamentally reverse the pathological change of primary disease with understanding on angle and the layer the pathogenetic awareness of primary disease.According to the study, any Therapeutic Method except that operation all can not be eliminated or softening bony spur, the sort of eliminate or any idea and the saying of softening bony spur all are unpractical, also can not be with unnecessary, also can grow again behind the excision, simultaneously, operation back symptom can not eliminated fully yet, and function can not be recovered fully.And in fact the hyperosteogeny patient more than 95% treats with non-operative treatment.But various non-operative treatment are all because of itself intrinsic weakness or deficiency, general all fail the damage of on the pathology angle, promptly repairing joint and cartilage, change the Combination proliferation and to the extruding of surrounding tissue, stimulate, involve with adhesion also thereby the clinical symptoms of the complexity that causes.As external pharmacological action and penetrance problem, to the stimulation of skin and allergic problem etc.The pharmacological action of oral medicine does not find as yet so far that aspect Western medicine any medicine has the effect of complexity like this.Chinese medicine for oral administration is also many at certain a bit or work on a certain level or a certain link.Though block therapy has short run effect to some people, to the serious destruction of articular cartilage as for harmful no profit etc.Therefore, the new active drug of exploitation is very necessary.

Think according to research at present; hyperosteogeny itself is the protection mechanism of skeleton self-regeneration; increase the stability in joint for the new balance of joint foundation; all absolutely not hyperosteogenys all cause clinical symptoms; simultaneously size and the clinical symptoms of bony spur are not proportional, even hyperosteogeny very seriously and its people does not still have any discomfort.The purpose of treatment neither be softened or the bony spur that disappears, but eliminates or alleviate extruding, the stimulation of Combination proliferation to surrounding tissue, adhesion and the pathological change that involves and produce therefrom and the recovery of corresponding symptoms and function.

Chinese medicine is " rheumatism involving the bone " in the primary disease ownership " arthromyodynia " and " muscular rheumatism " category, and " (element is asked the numbness opinion " said: " numbness is that bone is then heavy, is arteries and veins then blood is puckery not flow, and is that muscle is then bent not stretch, and all numbness and so on is filled in then worm (bitterly), meets heat then to indulge." " (element is asked thorn joint opinion " say: " sick at bone, unable to raise the limbs due to heaviness of the bones, spinal cord is ached, and cold extremely is called rheumatism involving the bone." " element ask air pocket opinion) " says: " accumulated cold staying in the body, the Wei Buju of battalion roll up the meat muscle that contracts, and the rib elbow must not be stretched, and interior is rheumatism involving the bone, is outward unfavorable." and think, kidney governing bones, liver governing tendons is because people's naturally-aged; Liver and kidney is all empty, and muscles and bones mistake is supported, add " prolonged standing injuring bones; " " prolonged walking injuring tendons " (" element is asked and declared five gas opinion " causes osteoarticular long-pending base property damage, the destruction of articular cartilage, coming off of cartilage fragment, the invasion and attack of wind-cold damp pathogen, blockage of main and collateral channels, stagnation of QI-blood accumulates in the course of time and does not go, and it is turbid to turn to expectorant, with the blood stasis gluing, numbness resistance bone joint forms the muscles and bones arthromyodynia.This medicine utilizes the advantage of Chinese medicine, at pathogenesis, and reasonable recipe, the monarch compatibility is suitable, and technological process is reasonable, has invigorating the liver and kidney, bone and muscle strengthening, expelling wind and cold, blood stasis dispelling is active, the clearing away phlegm softening the hard mass, and the worm ant is searched the merit of picking, can improve the Nutrition and Metabolism in joint, improve and promote the benign cycle of blood, repair the osteoarthrosis of infringement, reverse pathological change, eliminate the cause of disease and focus, promote the recovery of function, thereby reach the purpose of clinical cure.

The object of the present invention is to provide and a kind ofly can avoid operative treatment, good effect, instant effect, short treating period is difficult for the Chinese medicine preparation of recurrence.

The present invention also aims to provide a kind of above-mentioned preparation preparation method.

The present invention is achieved by the following technical solutions:

(1) medicine of the present invention is formed (by weight) by following crude drug:

Rhizoma Drynariae 40～80, Radix Achyranthis Bidentatae 40～80, Radix Dipsaci 40～80, Cortex Eucommiae (parched) 20～60, Radix Angelicae Sinensis 40～80, Caulis Spatholobi 60～120, Fructus Gleditsiae Abnormalis (Fructus Gleditsia) 130, Herba Aristolochiae Mollissimae 20～60, Herba Asari 10～30, Radix Aconiti 60～100, Herba Lycopodii 100～200, Agkistrodon 10～40, Scorpio 10～50, Scolopendra 10～40, Eupolyphaga Seu Steleophaga 40～80, Semen Strychni (processed) 10～40, Nidus Vespae 10～40.

(2) said medicine is by following processing step processing

(1) takes by weighing the crude drug of required dosage.

(2) it is standby Radix Angelicae Sinensis, Herba Asari to be added water distillation and extraction volatile oil; Then that the medicinal residues medicinal liquid is standby.

(3) earlier with the pre-decoction of Radix Aconiti two hours, standby.

(4) with Rhizoma Drynariae, Radix Achyranthis Bidentatae, Radix Dipsaci, Fructus Gleditsiae Abnormalis, Herba Aristolochiae Mollissimae, the Cortex Eucommiae, Caulis Spatholobi, Herba Lycopodii together with the medicinal residues medicinal liquid in (1) (2) with fry in shallow oil, steaming and decocting three times, add 5,4,3.5 times of water gagings at every turn respectively, respectively fried in shallow oil 40 minutes, get filtrate respectively three times, merge 3 times filtrate, be condensed into the thick paste shape.

(5) with Eupolyphaga Seu Steleophaga 1/2 amount system coarse powder, after 4 hours, add 2.5 times of amounts of 60% ethanol, soaked 3 days, constantly stir with the infiltration of 60% ethanol, receive filtrate, will remain medicinal residues again and add 2 times of amount 60% ethanol, soaked 3 days, stir, receive filtrate, merge 2 times filtrate, reclaim ethanol, simmer down to thick paste shape.

(6) water is carried the condensed cream of gained and the condensed cream mixing that alcohol extraction gets, the stand flakiness rolls into fine powder after the conventional cold drying, and it is standby to cross 80 mesh sieves.

(7) institute is surplused 1/2 amount Eupolyphaga Seu Steleophaga and Scorpio, Scolopendra, Semen Strychni (processed), Nidus Vespae system fine powder, mistake 80～100 mesh sieves, it is standby to sterilize.

(8) with each medicated powder mix homogeneously in (6), (7), spray 85% ethanol, stir into soft material, cross 16～18 mesh sieves, make wet grain, granulate adds the volatile oil that step (2) obtains at last and mixes thoroughly.

(9) acceptable clinically all dosage forms are made in medicine-feeding.

The present invention, be adapted to the caused joints of position hyperosteogeny such as cervical vertebra, lumbar vertebra hip and knee and heel and reach limbs pain, numb aching and tired up and down, ankylosis, swelling distortion, joint crunch, limitation of activity and limb muscle atrophy, function and sensory disturbance, for a long time more not or outbreak repeatedly, or the microtrauma and the humidity of catching cold, dizziness etc. during severe pain or the rotary head suddenly of tired back.

Over more than 30 year, the Clinical Application surplus ten thousand person-time facts have proved that the present invention is effective in cure good, instant effect, and short treating period, the cure rate height, relapse rate is low, taking convenience does not have obvious toxic-side effects, the cheap painless advantage of waiting bitterly for.Welcome by extensive patients, enjoy very high prestige.Patient's clinical practice also obtains splendid effect through Australia.

Sum up 1988-1993 and control data is comparatively complete among the patient 1900 examples and wherein 883 routine treatment of cervical spondylopathy results, 1698 examples are arranged among the 1900 routine patients, and once footpath acupuncture, physical therapy, massage, massage, traction, hyperosteogeny treating machine, tcm herbal ion penetrated respectively, one or more methods such as the multiple plaster of external application, various Pharmaceuticalss for oral administration or GUXIAN PIAN, bony spur tablet, hypertrophy ball, JINGFUKANG treat because of unsatisfactory curative effect and use this product instead.The present adds up as follows with therapeutic outcome:

Subordinate list 1,2:

Table 1 1900 routine hyperosteogeny therapeutic outcome statistical tables

Site of pathological change example number clinical cure (%) produce effects (%) is (%) invalid (%) effectively

Cervical spondylosis 883 749 74 47 13

Lumbar vertebra hyperosteogeny sick 651 513 67 50 21

Knee joint hyperosteogeny sick 131 67 31 27 6

Calcanean spur 200 168 24 80

Elbow hyperosteogeny sick 19 14 320

Hip joint hyperosteogeny 11 8210

Shoulder joint hyperosteogeny 52111

Amount to 1900 (100) 1521 (80) 202 (10.6) 136 (7) 41 (2.2)

Table 2 883 routine treatment of cervical spondylopathy are statistical table as a result

Type example number clinical cure (%) produce effects (%) is (%) invalid (%) effectively

Spondylotic radiculopathy 644 585 36 23 0

Vertebral artery type 74 41 20 11 2

Adrenergic type 15 5334

Myeloid form 40013

Mixed type 146 118 15 94

Amount to 883 (100) 749 (84.8) 74 (8.4) 47 (5.3) 13 (1.5)

1859 examples are effective among the 1900 routine various hyperosteogeny patients as can be seen from Table 1, total effective rate 97.7%; Clinical cure 1521 examples, total cure rate 80%.Wherein 883 routine cervical spondylosis patient's 870 examples effectively; Total effective rate 98.5%, 749 routine clinical cure has 1718 examples to take medicine for 1 course of treatment among cure rate 84.8%, the 1900 routine patient, and 166 examples were taken medicine for 2 courses of treatment, and 16 examples were taken medicine for 3 courses of treatment.

Embodiment:

With Rhizoma Drynariae 60 grams, Radix Achyranthis Bidentatae 60 grams, Radix Dipsaci 60 grams, the Cortex Eucommiae 40 grams, Radix Angelicae Sinensis 60 grams, Caulis Spatholobi 100 grams, Fructus Gleditsiae Abnormalis 130 grams, Herba Aristolochiae Mollissimae 40 grams, Herba Asari 20 grams, Radix Aconiti 80 grams, Herba Lycopodii 150 grams, Agkistrodon 30 grams, Scorpio 30 grams, Scolopendra 30 grams, Eupolyphaga Seu Steleophaga 60 grams, Semen Strychni (processed) 30 grams, Nidus Vespae 30 grams, process by following technology:

Elder generation is standby with Radix Angelicae Sinensis, the conventional extraction of Herba Asari volatile oil; Radix Aconiti was fried in shallow oil 2 hours in advance, Radix Angelicae Sinensis, Herba Asari medicinal residues are mixed decoction three times together with medicinal liquid, Radix Aconiti and decocting liquid thereof with Rhizoma Drynariae, Radix Achyranthis Bidentatae, Radix Dipsaci, Fructus Gleditsiae Abnormalis, Herba Aristolochiae Mollissimae, the Cortex Eucommiae, Caulis Spatholobi, Herba Lycopodii, each amount of water is respectively 5,4,3.5 times, respectively fried in shallow oil 40 minutes, and got respectively and be condensed into the thick paste shape after 3 filtrates merge.Other gets 1/2 Eupolyphaga Seu Steleophaga system coarse powder, adds 2.5 times of 60% ethanol, soaks 3 days, receives filtrate, reclaims ethanol; Again medicinal residues are added 2 times of 60% ethanol, soaked 3 days, receive filtrate, merge secondary filtrate, the simmer down to thick paste; Then two kinds of thick pastes are mixed, it is standby to roll powder after low temperature (conventional method) drying.Again surplus 1/2 Eupolyphaga Seu Steleophaga and Scolopendra, Scorpio, Semen Strychni (processed), Nidus Vespae powder process are crossed the sterilization of 80-100 mesh sieve, merge each medicated powder and spray an amount of 85% ethanol, make soft material, cross the 16-18 mesh sieve, the wet grain of system, add the Radix Angelicae Sinensis, the Herba Asari volatile oil that extract at last and make 1000, sugar coating, label is pasted in packing, be finished product, preserve in shady and cool dry place.

Claims (4)

1, a kind of Chinese medicine preparation for the treatment of hyperosteogeny is characterized in that said preparation (by weight) composed of the following components:

Rhizoma Drynariae 40～80 Radix Achyranthis Bidentataes 40～80 Radix Dipsacis 40～80

Cortex Eucommiae (parched) 20～60 Radix Angelicae Sinensis 40～80 Caulis Spatholobis 60～120

Process Fructus Gleditsiae Abnormalis 80～150 Herba Aristolochiae Mollissimaes 20～60 Herba Asaris 10～30

Radix Aconiti 60～100 Herba Lycopodiis 100～200 Agkistrodons 10～40

Scorpio 10～50 Scolopendras 10～40 Eupolyphaga Seu Steleophagas 40～80

Semen Strychni (processed) 10～40 Nidus Vespaes 10～40

2, Chinese medicine preparation as claimed in claim 1 is characterized in that the component of said preparation is:

Rhizoma Drynariae 60 Radix Achyranthis Bidentataes 60 Radix Dipsacis 60

Cortex Eucommiae (parched) 60 Radix Angelicae Sinensis 60 Caulis Spatholobis 60

Process Fructus Gleditsiae Abnormalis 130 Herba Aristolochiae Mollissimaes 40 Herba Asaris 20

Radix Aconiti 80 Herba Lycopodiis 150 Agkistrodons 30

Scorpio 30 Scolopendras 30 Eupolyphaga Seu Steleophagas 60

Semen Strychni (processed) 30 Nidus Vespaes 30

3, the preparation method of Chinese medicine preparation as claimed in claim 1 or 2, it is characterized by technological process has following steps:

(1) Radix Angelicae Sinensis, Herba Asari being added the water distillation, to extract volatile oil standby;

(2) earlier with Radix Aconiti pre-decoct 2 hours standby;

(3) with Rhizoma Drynariae, Radix Achyranthis Bidentatae, Radix Dipsaci, Fructus Gleditsiae Abnormalis, Herba Aristolochiae Mollissimae, the Cortex Eucommiae, Caulis Spatholobi, Herba Lycopodii, together with the medicines such as Radix Aconiti decocting liquid in Radix Angelicae Sinensis medicinal liquid, medicinal residues and the step (2) in the step (1) with boiling, boil altogether three times, add 5,4,3.5 times of water gagings respectively at every turn, respectively fried in shallow oil 40 minutes, get filtrate, merge 3 times filtrate, the simmer down to thick paste;

(4) 1/2 amount Eupolyphaga Seu Steleophaga system coarse powder is added the infiltration of 60% ethanol after 4 hours, add 60% ethanol of 2.5 times of amounts again, soaked 3 days, constantly stir, get filtrate; Medicinal residues were added 2 times of amount 60% soak with ethanol 3 days again, stir, receive filtrate, it is standby to merge 2 filtrate simmer down to thick paste shapes;

(5) above-mentioned two kinds of ointment are mixed, the stand flakiness, cold drying, the system fine powder is crossed 80～100 mesh sieves;

(6) institute is surplused 1/2 amount Eupolyphaga Seu Steleophaga and Scorpio, Scolopendra, Semen Strychni (processed), Nidus Vespae and make fine powder and cross 80～100 mesh sieves, sterilize;

(7) (5), (6) two kinds of medicated powder mixing are mixed thoroughly, spray 85% ethanol, stir into soft material, Radix Angelicae Sinensis, Herba Asari volatile oil that the wet grain back adding step of system (1) is proposed;

(8) required dosage form is made in medicine-feeding.

4, preparation method as claimed in claim 3 is characterized in that its dosage form can be tablet, capsule, patch, pill, powder.