CN1049354C - Paralysis recovering pill and preparing process thereof - Google Patents

Abstract

The present invention discloses a paralysis-recovering pill for treating cerebrovascular diseases and cardiovascular diseases, especially apoplexy, and a preparing method thereof. The pill uses astragalus root, american ginseng, prepared rhizome of rehmannia, cassia twig, angelica, hemlock parsley, peony, cinnabar, etc. as raw materials. According to different medicine properties, the materials are respectively dried, ground and filtered at different temperatures, and then are mixed with refined honey for preparing pills. The pill prepared by the prescription not only has the synthetic curative effects on a patient with apoplexy, but also has the unique curative effects on some symptoms.

Description

Paralysis recovering pill and preparation method thereof

The present invention relates to a kind of medicine for the treatment of cardiovascular and cerebrovascular disease, specifically it is to be the Chinese patent medicine of feedstock production with Chinese medicine, the invention still further relates to the preparation method of this medicine.

It is more to suffer from the cardiovascular and cerebrovascular disease number at present, often causes sequela such as paralysis, aphasia after the morbidity, causes patient can't take care of oneself, and brings secular misery to them.

Many for this reason medical personnels devote oneself to treat the research of cardiovascular and cerebrovascular vessel medicine, and this sick Chinese patent medicine of treatment that has gone on the market at present is existing several, and these drug uses are convenient, have certain curative effect, but combined therapy effect are not good enough.For this reason, application number is to have disclosed a kind of treatment Chinese Traditional Medicines in 59117933.0 the patent application, this name of patent application is " a compound recipe hemiplegia recovery ball ", this medicine is applicable to the treatment that cerebral thrombosis, cerebral hemorrhage, cerebral embolism etc. are sick, though combined therapy effect is better, but its medicine component is too many, and processing is complicated, and can not show special therapeutic effect to some symptoms of patient.

The medicine that the purpose of this invention is to provide a kind of treatment cardiovascular and cerebrovascular disease with Chinese medicine preparation, be particularly useful for apoplexy, cerebral infarction, apoplexy sequela are had outside the Comprehensive Treatment effect, and collapse from physical exhaustion at the treatment limbs, there is significant curative effect aspects such as blood viscosity lowering and blood fat reducing; Another object of the present invention also is to provide the preparation method of this medicine.

Technical scheme of the present invention is based on theory and the principle of China's medical science to the treatment cardiovascular and cerebrovascular disease, the present invention analyzes the composition and the performance of medicine with scientific methods, filter out and have benefiting QI for activating blood circulation, eliminating blood stasis and smoothing collaterals, endogenous wind stopping relieves the pain, the eliminating phlegm of having one's ideas straightened out, tranquilizing mind, the medicine of the eliminating stagnation of inducing sweat effect are that feedstock production forms.

The present invention makes (consumption is a weight portion) by following component

Radix Astragali 30-40 part Radix Panacis Quinquefolii 8-12 part

Radix Rehmanniae Preparata 30-40 part Ramulus Cinnamomi 8-12 part

Radix Angelicae Sinensis 8-12 part Rhizoma Chuanxiong 12-18 part

Bungarus Parvus 12-18 part Gekko Swinhonis 8-12 part

Semen Strychni (processed) 20-28 part Herba Spirodelae 3-7 part

Radix Notoginseng 8-13 part Scorpio 8-12 part

Rhizoma Acori Graminei 3-7 part Radix Paeoniae 8-12 part

Cinnabaris 0.7-1.2 part Mel 115.8-193.3 part

The preferred weight ratio range of preparation medicine of the present invention is:

10 parts of 35 parts of Radix Panacis Quinquefoliis of the Radix Astragali

10 parts of 35 parts of Ramulus Cinnamomi of Radix Rehmanniae Preparata

15 parts of 10 parts of Rhizoma Chuanxiongs of Radix Angelicae Sinensis

10 parts of 15 parts of Gekko Swinhonis of Bungarus Parvus

5 parts of 24 parts of Herba Spirodelae of Semen Strychni (processed)

10 parts of 11 parts of Scorpio of Radix Notoginseng

10 parts of 5 portions of Radix Paeoniaes of Rhizoma Acori Graminei

153.8 parts of 1.2 parts of Mel of Cinnabaris

Above-mentioned each component is made medicine production method of the present invention is:

1, selecting for use the above-mentioned medical material that meets national pharmaceutical grades then Radix Rehmanniae Preparata to be washed with yellow wine steams three times; Bungarus Parvus is brushed away scurf, remove end to end, dry after the reuse yellow wine soaks into; The Semen Strychni (processed) unhairing.

2, the Radix Astragali, Radix Panacis Quinquefolii, Radix Notoginseng, Rhizoma Acori Graminei, Semen Strychni (processed), Radix Paeoniae are dried or dry under 20 ℃ of-60 ℃ of temperature; Radix Rehmanniae Preparata, Scorpio are dried for 33 ℃ at constant temperature, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Ramulus Cinnamomi, dry under 30 ℃～40 ℃ temperature, prevent the volatilization of active ingredient.

3, the above-mentioned medicines such as Gekko Swinhonis, Herba Spirodelae that reach after each step process are prepared by deal, pulverize, cross 100 purpose sieves, add refined honey, stir, make and be slightly less than 9 grammes per square metre pills.

4, put in the greenhouse, its temperature is to appoint between 10-40 ℃ to get.Place after 4 hours and take out, the Cinnabaris that rolls outward after water flies is clothing.

5, with Waxpaper bag ball, the cured shell of packing into heals up, and paraffin wax is stained with in the outside.The manufacturing of pill should meet the requirement of pill preparation in the Pharmacopoeia of People's Republic of China (the 5th edition).

In the medicine that the present invention relates to:

Rhizoma Chuanxiong: property and flavor of peppery and warm, contain lipid in the Rhizoma Chuanxiong, compositions such as ferulic acid, alkaloid, it can suppress its spontaneous activity to the center nervous system, and smooth muscle is had the spasmolytic effect, has the effect of blood circulation promoting and blood stasis dispelling.

Radix Rehmanniae Preparata: sweet in flavor and warm in property, contain catalpol, rehmanin, vitamin A sample material and polysaccharide and lysine, histidine, case propylhomoserin, glutamic acid, leucine, phosphoric acid etc. have nourishing the liver and kidney, the effect of tonifying blood and regulating menstruation.

Radix Angelicae Sinensis: nature and flavor Gan Xinwen, contain volatile oil, Main Ingredients and Appearance is a n-butene skin lactone, contains fatty oil in addition, Palmic acid reaches a paddy and stays alcohol and cetylate, vitamin B12, vitamin Es etc. have and enrich blood, invigorate blood circulation, pain relieving, purging and intestine lubricating action.

Radix Paeoniae: the cold of nature and flavor picric acid, contain Radix Paeoniae, B-paddy stays alcohol, tannin, a small amount of volatile oil, benzoic acid, resin, starch, fatty oil, benzoic acid calcium etc., and nervus centralis is had inhibitory action, can reduce spontaneous activity.Coronary vessel disease and extremity vascular there is dilating effect.

Semen Strychni: the nature and flavor bitter cold, contain alkaloid, it is mainly strychnine, it mainly contains excited spinal reflex function, impel neural impulse between nerve, to conduct, improve skeletal muscle, the tension force of smooth muscle, especially can enhances skeletal muscle tonus degree, change unable state, also have excited cerebration, cause the sensitivity of various sensory organ functions, impel the patient of inhibitory state to revive, and can regulate the process of inhibition of corticocerebral excitement.

The Radix Astragali: sweet in flavor and warm in property, contain 2 ', 4 ' dihydroxy-5,6-, dimethyl flavone, choline, aminoacid, sucrose, glucose, aldehydic acid and micro-folic acid, and a paddy stays alcohol, linoleic acid and linolenic acid.Make the expansion of whole body peripheral vessel, improve the peripheral blood circulation, be beneficial to paralyzed limbs and recover.

Ramulus Cinnamomi: property acrid-sweet flavor temperature, contain volatile oil, be mainly cinnamic aldehyde.The effect of central and tip blood vessel dilating is arranged, can improve blood circulation, warming the meridian for promoting the flow of YANG QI has the effect that restores menstrual flow and invigorates blood circulation with Radix Angelicae Sinensis, Rhizoma Chuanxiong with using.

Gekko Swinhonis: nature and flavor are salty-cold, and are slightly poisonous, and the treatment paralysis due to windstroke is arranged, brothers' erectile problem or scrofula joint wind and wind-phlegm infantile convulsion, and accumulation of blood becomes effects such as painful abdominal mass.

Scorpio, nature and flavor are hot flat, contain charybdotoxin.It is the toxic protein of elements such as a secondary carbon containing, hydrogen, oxygen, ammonia, sulfur, and contains trimethylamine etc., and it has certain anticonvulsant action, and the energy blood vessel dilating, lowers adrenergic resistance to compression effect.To apoplexy, hemiplegia, facial hemiparalysis has the endogenous wind stopping relieving convulsion, the detoxicating and resolving stagnation of pathogens effect.

Bungarus Parvus: the property sweet-salty, contain the thrombin-like material, esterase and three kinds of anticoagulative substances have wind-damp dispelling, and the effect of saturating muscles and bones can be treated the rheumatism paralysis, joint pain, facial hemiparalysis, numb limbs and tense tendons, hemiplegia.

Cinnabaris: sweet in flavor and cold in property, Containing Sulfur hydrargyrum, energy tranquilizing mind, heat-clearing and toxic substances removing.

Herba Spirodelae: property and flavor of peppery and cold.Contain orientin, vitexin, apiose, reseda flavin.And contain potassium acetate, potassium chloride, iodine etc., to excessive in the rheumatism, erectile problem person is effective in cure in paralysis.

Radix Panacis Quinquefolii: the property bitter but slightly sweet taste is cold, mainly contains the ginsenoside, contains volatile oil, resin etc. again, can subsidize edema caused by disorder of QI, and can the tonification blood system.

Rhizoma Acori Graminei: property and flavor of peppery and warm, contain volatile oil, effect such as causing resuscitation with aromatic drugs is arranged, reduce phlegm, calm the nerves, and effective in cure to coma after the apoplexy and aphasia.

Mel: nature and flavor are sweet to be slightly cold, and contains a large amount of glucoses and fructose mixture, and contains micro-pantothenic acid, Yan acid, acetylcholine and vitamin A, D, E etc.

Radix Notoginseng: property sweet and slightly bitter taste, temperature, it has hemostasis, dissipating blood stasis, the effect of subduing swelling and relieving pain.

The patent medicine that said medicine is made removes effective in cure to cardiovascular and cerebrovascular disease, especially the cerebral infarction of apoplexy, the sequela of cerebral hemorrhage there is comprehensive therapeutic effect, again because medicine such as the Radix Astragali, Ramulus Cinnamomi, Semen Strychni, Gekko Swinhonis, Radix Rehmanniae Preparata, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Notoginseng, Radix Paeoniae that are adopted among the present invention and appropriate compatibility between them, make this medicine have more activating qi and collateral, the effect of the paralysis that shakes, Conclusion Decreasing, viscosity reduction, blood fat reducing.The flavour of a drug that the present invention adopts are less, and manufacturing process is simpler, the corresponding cost that also reduced.

For showing the therapeutic effect of this medicine to cerebrovascular, the present invention carries out clinical treatment observation to 300 routine cerebrovascular patients, among the 300 routine patients, male's 208 examples, women's 92 examples, 35-40 year 10 examples wherein, 41-50 year 43 examples, 51-60 year 109 examples, 138 examples more than 61 years old, case midbrain hemorrhage 84 examples, cerebral thrombosis 212 examples, cerebral embolism 4 examples are apoplexy, apoplex involving the channels and collaterals by tcm diagnosis, extreme hyperactivity of the liver-yang wherein, disturb disease person 30 examples on the wind-fire, wind-phlegm blood resistance venation disease person 108 examples are held together disease person 20 examples on the real wind-phlegm of the hot internal organs of expectorant, blood stasis due to qi deficiency disease person 106 examples, stirring of wind due to deficiency of YIN disease person 36 examples.All cases are by at random being divided into treatment group and matched group at 2: 1, and two groups all have comparability at aspects such as age, sex, the course of disease, clinical settings, check P＞0.05 through X.

Treatment group: take medicine of the present invention promptly: paralysis recovering pill, instructions of taking is: each oral ball, every ball 9 grams, the next day once, be a course of treatment around serveing on.

Matched group: take Beijing Changcheng Pharmaceutical Factory and produce, lot number is that the accurate word [85] of medicine is defended No. 291 in the capital, and this medicine by specification is introduced identical with orientation treatment of the present invention.Patient's method of administration is: each oral one, and every 10ML, serveing on for 4 weeks 3 times every day is a course of treatment.

At period in a medicine, all can handle for two groups at patient's complication, can give the depressor treatment as the hyperpietic, the concurrent infection person can give antibiotic therapy, but the Chinese medicine of not handy other any treatment apoplexies or Western medicine.

After a course of therapy, evaluate according to the criterion of therapeutical effect in " the clinical research guideline of new Chinese medicine treatment apoplexy " of Ministry of Health of the People's Republic of China's formulation in 1993, two groups of therapeutic outcomes relatively are: treatment group total effective rate 83%, the matched group total effective rate is 70%, through X ²Check, P＜0.05.

Cure-remarkable-effectiveness rate compares: the treatment group is 53%, and matched group is 30%, through X ²Check, P＜0.05.

Distinguish disease classification therapy effect according to the traditional Chinese medical science: two groups of comparable situation see Table 1

Table 1

Treatment group matched group

Pattern of syndrome

Routine base shows the basic apparent total effect that has of total effect example

Number is more imitated to be had the % number more to imitate the % extreme hyperactivity of the liver-yang is arranged, disturb 20 002 10.00 10 001 10.00 wind-phlegm blood stasis on the wind-fire, the hot internal organs of numbness resistance venation 72 12 32 28 100.00 36 38 18 80.55 expectorant is real, disturbs 14 007 50.00 6002 33.33 blood stasis due to qi deficiency, 70 16 46 8 100.00 36 7 12 17 100.00 stirring of wind due to deficiency of YIN 24 00 15 62.50 12 002 16.66 on the wind-phlegm

Can find out from this comparison sheet: paralysis recovering pill is low to the inclined to one side muscular tension of cerebrovascular, and it is comparatively satisfied to show as the person's of collapsing from physical exhaustion curative effect.

In observed drug: 108 routine patients have been carried out the inspection that hemorheology is learned, and wherein 70 examples are organized in treatment, matched group 38 examples, and it the results are shown in Table 2.

Table 2 liang group whole blood viscosity variation (X ± SE)

High speed shear rate (1/S) low speed shear rate (1/S) treatment group preceding 5.44 ± 0.20 29.78 ± 1.30

Back 3.90 ± 0.22**, 23.56 ± 1.10** matched group preceding 5.36 ± 0.63 29.41 ± 3.06

Annotate back 5.01 ± 0.63 27.94 ± 1.82: compare P＜0.05 between * * group

Obvious reduction whole blood viscosity effect (P＜0.01) self is relatively arranged behind the medicine of treatment group as can be known from Table 2, the prodrug.Compare, notable difference is arranged for two groups.

Before and after 106 routine patient treatments, the Blood Lipid situation is observed: wherein, 106 people are organized in treatment, matched group 50 people, and its control case sees Table 3

Before the treatment of table 3 group always there be treatment back produce effects enabledisable

((efficient TC treatment group 1067.78 ± 1.67 5.76 ± 1.56 64 (60.37) 32 (30.18) 10 (9.43) 90.56TC control groups 507.68 ± 2.15 6.53 ± 1.87 12 (24.00) 18 (36.00) 20 (40.00) 60.00TC treatment groups 1063.33 ± 1.98 2.06 ± 1.52 43 (40.56) 52 (49.05) 11 (10.37) 89.62TC control group 502.73 ± 1.48 2.21 ± 1.26 13 (26.00) 20 (40.00) 17 (34.00) 66.00 of X ± s) of X ± s)

As seen from Table 3, relatively treatment group reduces TC obvious effective rate and total effective rate between group, obviously is better than matched group (P＜0.01), reduces TC obvious effective rate total effective rate and is better than matched group (P＜0.05).

In treatment was observed, by to patient, blood, urine, just routine test and the heart, liver, kidney function test were not found any untoward reaction and toxic and side effects.

Embodiment 1

Take by weighing raw material by following proportioning:

2.75 kilograms of 9.5 kilograms of Radix Panacis Quinquefoliis of the Radix Astragali

2.75 kilograms of 9.5 kilograms of Ramulus Cinnamomi of Radix Rehmanniae Preparata

4.25 kilograms of 2.5 kilograms of Rhizoma Chuanxiongs of Radix Angelicae Sinensis

2.25 kilograms of 4 kilograms of Gekko Swinhonis of Bungarus Parvus

1.5 kilograms of 5.75 kilograms of Herba Spirodelae of Semen Strychni (processed)

2.75 kilograms of 3 kilograms of Scorpio of Radix Notoginseng

2.75 kilograms of 1.5 kilograms of Radix Paeoniaes of Rhizoma Acori Graminei

35.025 kilograms of 0.225 kilogram of Mel of Cinnabaris

Production method is as follows: above-mentioned each raw material should be selected for use and meet pharmaceutical grades, concocts by rule then, Radix Rehmanniae Preparata is washed with yellow wine steamed three times; Bungarus Parvus is brushed away scurf, decaptitate and truncate, after soaking into, dries the reuse yellow wine, the Semen Strychni (processed) unhairing, with Rhizoma Chuanxiong, Radix Angelicae Sinensis, Ramulus Cinnamomi is dry in 30 ℃ of temperature, the Radix Astragali, Radix Panacis Quinquefolii, Radix Notoginseng, Rhizoma Acori Graminei, Semen Strychni (processed), Radix Paeoniae is dried Radix Rehmanniae Preparata under 30 ℃ of situations, Scorpio is dried under 33 ℃ of situations, the raw material pulverize separately except that Mel and Cinnabaris, and mistake 100 purpose sieves, the back raw material that will sieve mixes and stirs, and back refined honey adds above-mentioned raw materials in the honey of refining again, stir well, make the ball that is slightly less than 9 grammes per square metres,, take out the indoor placement of 20 ℃～25 ℃ of temperature 4 hours, the Cinnabaris that appearance rolls on after water flies is clothing, then with Waxpaper bag ball, the cured shell of packing into heals up, and paraffin wax is glued in the outside.

Embodiment 2

Present embodiment is to take by weighing raw material by following proportioning:

2.5 kilograms of 8.75 kilograms of Radix Panacis Quinquefoliis of the Radix Astragali

2.5 kilograms of 8.75 kilograms of Ramulus Cinnamomi of Radix Rehmanniae Preparata

3.75 kilograms of 2.5 kilograms of Rhizoma Chuanxiongs of Radix Angelicae Sinensis

2.5 kilograms of 3.75 kilograms of Gekko Swinhonis of Bungarus Parvus

1.25 kilograms of 6 kilograms of Herba Spirodelae of Semen Strychni (processed)

2.5 kilograms of 2.75 kilograms of Scorpio of Radix Notoginseng

2.5 kilograms of 1.25 kilograms of Radix Paeoniaes of Rhizoma Acori Graminei

38.45 kilograms of 0.3 kilogram of Mel of Cinnabaris

In this embodiment

The Radix Astragali adopts Radix Rehmanniae Preparata that produce the Inner Mongol to adopt the Wuzhi to produce

Radix Angelicae Sinensis adopts Gansu institute pan money Agkistrodon to adopt Zhejiang to produce

It is that produce in Sichuan that Radix Paeoniae is adopted Rhizoma Acori Graminei that produce in Hangzhou and Rhizoma Chuanxiong

Ramulus Cinnamomi is that Guangxi product Cinnabaris is that produce in the Hunan.

In process for making, Radix Rehmanniae Preparata is used yellow the steaming and is given a baby a bath on the third day after its birth time, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Ramulus Cinnamomi are dry under 30 ℃ of temperature, the Radix Astragali, Radix Panacis Quinquefolii, Radix Notoginseng, Rhizoma Acori Graminei, Semen Strychni (processed), Radix Paeoniae are dried under 40 ℃ of temperature, the pill of making is in 30 ℃～35 ℃ indoor placement 4 hours, other operational approach, process and temperature required identical with embodiment 1.

Claims (5)

1, a kind of paralysis recovering pill for the treatment of cardiovascular and cerebrovascular disease is characterized in that it is to be made by following medicine and weight proportion thereof:

Radix Astragali 30-40 part Radix Panacis Quinquefolii 8-12 part

Radix Rehmanniae Preparata 30-40 part Ramulus Cinnamomi 8-12 part

Radix Angelicae Sinensis 8-12 part Rhizoma Chuanxiong 12-18 part

Bungarus Parvus 12-18 part Gekko Swinhonis 8-12 part

Semen Strychni (processed) 20-28 part Herba Spirodelae 3-7 part

Radix Notoginseng 8-13 part Scorpio 8-12 part

Rhizoma Acori Graminei 3-7 part Radix Paeoniae 8-12 part

Cinnabaris 0.7-1.2 part Mel 115.8-193.3 part

2, paralysis recovering pill according to claim 1 is characterized in that: the weight proportion of contained each raw material is:

10 parts of 35 parts of Radix Panacis Quinquefoliis of the Radix Astragali

10 parts of 35 parts of Ramulus Cinnamomi of Radix Rehmanniae Preparata

15 parts of 10 parts of Rhizoma Chuanxiongs of Radix Angelicae Sinensis

10 parts of 15 parts of Gekko Swinhonis of Bungarus Parvus

5 parts of 24 parts of Herba Spirodelae of Semen Strychni (processed)

10 parts of 11 parts of Scorpio of Radix Notoginseng

10 parts of 5 portions of Radix Paeoniaes of Rhizoma Acori Graminei

153.8 parts of 1.2 parts of Mel of Cinnabaris

3, paralysis recovering pill according to claim 2 is characterized in that: in the described raw material

The Radix Astragali adopts Radix Rehmanniae Preparata that produce the Inner Mongol to adopt the Wuzhi to produce

Radix Angelicae Sinensis adopts Gansu institute pan money Agkistrodon to adopt Zhejiang to produce

It is that produce in Sichuan that Radix Paeoniae is adopted Rhizoma Acori Graminei that produce in Hangzhou and Rhizoma Chuanxiong

Ramulus Cinnamomi is that Guangxi product Cinnabaris is that produce in the Hunan.

4, the preparation method of paralysis recovering pill according to claim 1 and 2 is characterized in that:

Radix Rehmanniae Preparata is washed steaming three times with yellow wine, Bungarus Parvus brushes away scurf, remove end to end, after soaking into, dries the reuse yellow wine, the Semen Strychni (processed) unhairing, the Radix Astragali, Radix Panacis Quinquefolii, Radix Notoginseng, Rhizoma Acori Graminei, Semen Strychni (processed), Radix Paeoniae are dried under 20 ℃ of-60 ℃ of temperature, and Rhizoma Chuanxiong, Radix Angelicae Sinensis, Ramulus Cinnamomi are dried under 30 ℃ of-40 ℃ of temperature; Radix Rehmanniae Preparata, Scorpio are dried for 33 ℃ at constant temperature, then pulverize, and cross 100 order square-bottomed bamboo baskets, stir well the back and add in the refined honey, and restir is even, makes ball, take out after putting into temperature and be 20 ℃-40 ℃ indoor 4 hours, and every pill product are clothing with the Cinnabaris after flying through water.

5, the preparation method of paralysis recovering pill according to claim 4 is characterized in that the every ball of this medicine weighs 9 grams, and pill wraps Waxpaper by hand, and adorns heal up back outside of cured shell and speckle with paraffin wax.