CN117138000A - 一种用于预防和治疗脂溢性脱发的中药组合物及其中药发用洗剂、制备方法 - Google Patents

一种用于预防和治疗脂溢性脱发的中药组合物及其中药发用洗剂、制备方法 Download PDF

Info

Publication number
CN117138000A
CN117138000A CN202311100054.0A CN202311100054A CN117138000A CN 117138000 A CN117138000 A CN 117138000A CN 202311100054 A CN202311100054 A CN 202311100054A CN 117138000 A CN117138000 A CN 117138000A
Authority
CN
China
Prior art keywords
parts
chinese medicine
traditional chinese
root
seborrheic alopecia
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CN202311100054.0A
Other languages
English (en)
Other versions
CN117138000B (zh
Inventor
庞艳阳
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hainan Medical College
Original Assignee
Hainan Medical College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hainan Medical College filed Critical Hainan Medical College
Priority to CN202311100054.0A priority Critical patent/CN117138000B/zh
Priority claimed from CN202311100054.0A external-priority patent/CN117138000B/zh
Publication of CN117138000A publication Critical patent/CN117138000A/zh
Application granted granted Critical
Publication of CN117138000B publication Critical patent/CN117138000B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/483—Gleditsia (locust)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/13—Coniferophyta (gymnosperms)
    • A61K36/14—Cupressaceae (Cypress family), e.g. juniper or cypress
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/17—Gnetophyta, e.g. Ephedraceae (Mormon-tea family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/236—Ligusticum (licorice-root)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258—Panax (ginseng)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/26—Aristolochiaceae (Birthwort family), e.g. heartleaf
    • A61K36/268—Asarum (wild ginger)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/287—Chrysanthemum, e.g. daisy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/534—Mentha (mint)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/537—Salvia (sage)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/538—Schizonepeta
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
    • A61K36/605—Morus (mulberry)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/704—Polygonum, e.g. knotweed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/718—Coptis (goldthread)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/74—Rubiaceae (Madder family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/758—Zanthoxylum, e.g. pricklyash
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/77—Sapindaceae (Soapberry family), e.g. lychee or soapberry
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/80—Scrophulariaceae (Figwort family)
    • A61K36/808—Scrophularia (figwort)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8964—Anemarrhena
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/08—Antiseborrheics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

本发明提出了一种用于预防和治疗脂溢性脱发的中药组合物及其中药发用洗剂、制备方法，包括如下重量份原料：皂角20～30份、无患子20～30份、浮萍20～30份、灯芯草20～30份、首乌藤20～30份、茜草15～25份、透骨草20～30份、知母20～30份、侧柏叶20～30份、白芷22～28份、桑叶20～38份、花椒10～18份、当归20～30份、川芎20～30份、细辛25～30份、桂枝25～30份、丹参25～30份、黄连40～50份、玄参40～50份、薄荷10～18份、人参40～55份、竹茹40～55份、火麻仁40～55份、麻黄40～55份、荆芥穗45～65份、菊花35～55份、赤芍35～55份、牡丹皮35～55份、竹叶心35～55份和淡豆豉35～45份。本发明提供的中药发用洗剂，对人永生化表皮细胞(HaCat细胞)具有增殖作用，可提高脂溢性脱发小鼠的平均毛发长度、重量，加速毛囊的发育，对脂溢性脱发的毛发生长具有促进作用。

Description

一种用于预防和治疗脂溢性脱发的中药组合物及其中药发用 洗剂、制备方法
技术领域
本发明涉及中药组合物技术领域，特别涉及一种用于预防和治疗脂溢性脱发的中药组合物及其中药发用洗剂、制备方法。
背景技术
脂溢性脱发(Seborrheic alopecia,SA)，又称为早秃、雄性激素性脱发(Androgeneic alopecia,AGA)，为临床上最常见的脱发类型。脂溢性脱发诊断容易治疗难，以头部皮肤油腻、瘙痒、脱屑为主要症状，并伴有头部毛发细软、呈进行性减少，女性症状较轻，极少发生顶部全秃。中医认为，脱发的病机归结为气血不足、肝肾不足、湿热等有关，不能容润毛发所致。中医运用辩证法，将补益气血等药材制成中药洗剂、膏剂、酊剂等剂型，用于治疗雄激素性脱发。中药剂型较为丰富，疗效也较好，通常患者接受度高。依据中医理论，开发用于预防和治疗脂溢性脱发的生发、固发产品，作为日常使用，在治疗脂溢性脱发的同时，起到预防的作用，则有效提高脂溢性脱发的治疗效果。
发明内容
鉴于此，本发明的目的在于提出一种用于预防和治疗脂溢性脱发的中药组合物及其中药发用洗剂、制备方法。
本发明的技术方案是这样实现的：
本发明的目的之一在于提供一种用于预防和治疗脂溢性脱发的中药组合物，包括如下重量份原料：皂角(Gleditsia sinensis)20～30份、无患子(Sapindus mukorossiGaertn.)20～30份、浮萍(Lemna minor L.)20～30份、灯芯草(Juncus effusus L.)20～30份、首乌藤[为蓼科植物何首乌Fallopia multiflora(Thunb.)Harald的干燥藤茎]20～30份、茜草(Rubia cordifolia Linn.)15～25份、透骨草[Phryma leptostachyaL.subsp.asiatica(Hara)Kitamura]20～30份、知母(Anemarrhena asphodeloides Bunge)20～30份、侧柏叶[为柏科植物侧柏PLatycladus orientalis(L.)Franco的干燥枝梢和叶]20～30份、白芷(Angelica dahurica(Fisch.ex Hoffm.)Benth.et Hook.f.ex Franch.etSav)22～28份、桑叶(Folium Mori)20～38份、花椒(Zanthoxylum bungeanum Maxim.)10～18份、当归(Angelica sinensis)20～30份、川芎(Ligusticum chuanxiong hort)20～30份、细辛(Asarum sieboldii Miq.)25～30份、桂枝(Cinnamomum cassia Presl)25～30份、丹参(Salvia miltiorrhiza Bunge)25～30份、黄连(Coptis chinensis Franch.)40～50份、玄参(Scrophularia ningpoensis Hemsl.)40～50份、薄荷(Mentha haplocalyxBriq.)10～18份、人参(Panax ginseng C.A.Meyer)40～55份、竹茹(Caulis Bambusae inTaeniam)40～55份、火麻仁[为桑科植物大麻(Cannabis sativa L.)的干燥成熟种子]40～55份、麻黄(Ephedra sinica Stapf)40～55份、荆芥穗[为唇形科植物荆芥Schizonepetatenuifolia Briq.的干燥地上部分]45～65份、菊花[Dendranthema morifolium(Ramat.)Tzvel.]35～55份、赤芍(Paeoniae Radix Rubra)35～55份、牡丹皮(毛茛科植物牡丹Paeonia suffruticosa Andr.的根皮)35～55份、竹叶心[为慈竹属植物慈竹Sinocalamusaffinis(Rendle)Mcclure尚未能展开呈筒卷形的嫩叶]35～55份和淡豆豉[为豆科植物大豆Glycine max(L.)Merr.的成熟种子的发酵加工品]35～45份。
更进一步的，包括如下重量份原料：皂角20份、无患子20份、浮萍20份、灯芯草20份、首乌藤20份、茜草15份、透骨草20份、知母20份、侧柏叶20份、白芷22份、桑叶26份、花椒10份、当归20份、川芎20份、细辛25份、桂枝25份、丹参25份、黄连45份、玄参45份、薄荷10份、人参40份、竹茹40份、火麻仁40份、麻黄45份、荆芥穗45份、菊花35份、赤芍35份、牡丹皮35份、竹叶心35份和淡豆豉35份。
进一步的，所述中药组合物还包括如下重量份原料：地桃花(Urena lobataLinn.)15～20份和香薷[Elsholtzia ciliata(Thunb.)Hyland.]25～30份。
进一步的，包括如下重量份原料：皂角20～25份、无患子20～25份、浮萍20～25份、灯芯草20～25份、首乌藤20～25份、茜草15～20份、透骨草20～25份、知母20～25份、侧柏叶20～25份、白芷22～25份、桑叶20～30份、花椒10～15份、当归20～25份、川芎20～25份、细辛25～25份、桂枝25～28份、丹参25～28份、黄连40～45份、玄参40～45份、薄荷10～12份、人参40～45份、竹茹40～45份、火麻仁40～45份、麻黄40～45份、荆芥穗45～50份、菊花35～40份、赤芍35～45份、牡丹皮35～40份、竹叶心35～40份、淡豆豉35～40份、地桃花15～18份和香薷25～28份。
更进一步的，包括如下重量份原料：皂角20份、无患子20份、浮萍20份、灯芯草20份、首乌藤20份、茜草15份、透骨草20份、知母20份、侧柏叶20份、白芷22份、桑叶20份、花椒10份、当归20份、川芎20份、细辛25份、桂枝25份、丹参25份、黄连40份、玄参40份、薄荷10份、人参40份、竹茹40份、火麻仁40份、麻黄40份、荆芥穗45份、菊花35份、赤芍35、牡丹皮35份、竹叶心35份、淡豆豉35份、地桃花15份和香薷25份。
本发明的目的之二在于提供一种用于预防和治疗脂溢性脱发的中药发用洗剂，是由上述的中药组合物制得的中药发用洗剂。
进一步的，上述用于预防和治疗脂溢性脱发的中药发用洗剂的制备方法，包括以下步骤：按配方称取原料，煎煮过滤，得中药煎煮液，加入增稠剂搅拌，加入茶多酚、食盐、椰子油起泡剂和氨基酸起泡剂，搅拌，得中药发用洗剂。
进一步的，煎煮过程中，加入淘米水和茶枯液(料液质量比1：10)。
与现有技术相比，本发明的有益效果为：
本发明选用皂角，无患子，浮萍，灯芯草，首乌藤，茜草，透骨草，知母，侧伯叶，白芷，桑叶，花椒，当归，川芎，细辛，桂枝，丹参，黄连，玄参，薄荷，人参，竹茹，火麻仁，麻黄，荆芥穗，菊花，赤芍，牡丹皮，竹叶心，淡豆豉，以及地桃花，香薷，制成中药发用洗剂，对人永生化表皮细胞(HaCat细胞)具有增殖作用，可提高脂溢性脱发小鼠的平均毛发长度、重量，加速毛囊的发育，对脂溢性脱发的毛发生长具有促进作用。
本发明制得的中药发用洗剂，可取适量进行头部按摩5min，清水冲洗即可，可每天清洗一次，对预防脂溢性脱发效果更佳，起到滋养头皮、固护毛发的功效，使用方法简单，性质温和，不良反应少。
具体实施方式
为了更好理解本发明技术内容，下面提供具体实施例，对本发明做进一步的说明。
本发明实施例所用的实验方法如无特殊说明，均为常规方法。
本发明实施例所用的材料、试剂等，如无特殊说明，均可从商业途径得到。
人永生化表皮细胞(HaCat)，购买于上海酶联生物科技有限公司，进行细胞复苏和传代培养。
实施例1-中药组合物
皂角20g，无患子20g，浮萍20g，灯芯草20g，首乌藤20g，茜草15g，透骨草20g，知母20g，侧柏叶20g，白芷22g，桑叶26g，花椒10g，当归20g，川芎20g，细辛25g，桂枝25g，丹参25g，黄连45g，玄参45g，薄荷10g，人参40g，竹茹40g，火麻仁40g，麻黄45g，荆芥穗45g，菊花35g，赤芍35g，牡丹皮35g，竹叶心35g，淡豆豉35g。
实施例2-中药组合物
皂角30g，无患子30g，浮萍30g，灯芯草30g，首乌藤30g，茜草25g，透骨草30g，知母30g，侧柏叶30g，白芷28g，桑叶38g，花椒15g，当归30g，川芎30g，细辛30g，桂枝30g，丹参30g，黄连50g，玄参50g，薄荷15g，人参55g，竹茹55g，火麻仁55g，麻黄55g，荆芥穗65g，菊花55g，赤芍55g，牡丹皮55g，竹叶心55g，淡豆豉45g。
实施例3-中药组合物
皂角20g，无患子20g，浮萍20g，灯芯草20g，首乌藤20g，茜草15g，透骨草20g，知母20g，侧柏叶20g，白芷22g，桑叶20g，花椒10g，当归20g，川芎20g，细辛25g，桂枝25g，丹参25g，黄连40g，玄参40g，薄荷10g，人参40g，竹茹40g，火麻仁40g，麻黄40g，荆芥穗45g，菊花35g，赤芍35g，牡丹皮35g，竹叶心35g，淡豆豉35g，地桃花15g，香薷25g。
对比例1-中药组合物
本对比例与实施例1的区别在于，知母替换为熟地黄，透骨草替换为骨碎补，丹参替换为玄参，具体配方如下：
皂角20g，无患子20g，浮萍20g，灯芯草20g，首乌藤20g，茜草15g，骨碎补20g，熟地黄20g，侧柏叶20g，白芷22g，桑叶26g，花椒10g，当归20g，川芎20g，细辛25g，桂枝25g，黄连45g，玄参70g，薄荷10g，人参40g，竹茹40g，火麻仁40g，麻黄45g，荆芥穗45g，菊花35g，赤芍35g，牡丹皮35g，竹叶心35g，淡豆豉35g。
上述实施例1～3和对比例1的中药发用洗剂的制备方法为：按配方称取原料，加入10倍重量的水，煎煮，煎煮过程中加入淘米水100g和单独煮制半小时的茶枯液100g，过滤，得中药煎煮液；每1kg中药煎煮液中，加入增稠剂30g搅拌溶解后，加入茶多酚5g、食盐20g、椰子油起泡剂200g和氨基酸起泡剂200g，搅拌均匀，得中药发用洗剂。
一、HaCat的增殖实验
采用96孔酶标板培养人永生化表皮细胞，培养基为1640培养基，调整每孔细胞数量5×103个，接种100μL对数生长期的HaCat细胞，于恒温培养箱中以37℃、5％ CO2条件培养至细胞融合度为80％，吸去培养基，加入不同浓度的中药发用洗剂(1640培养基稀释)，空白组和对照组加入等量的培养基，其中，空白组为1640培养基，对照组为HaCat细胞，而后继续以37℃、5％ CO2条件分别培养24h和48h，随后加入10μL的CCK-8试剂，以37℃、5％CO2条件培养30min后，于450nm波长下检测吸光度值，计算细胞增殖率，细胞增殖率(％)＝(A1-A0)/(A2-A0)×100，式中，A0为空白组的OD值，A1为洗剂组的OD值，A2为对照组的OD值。
表1HaCat细胞增殖率的结果
由上表可知，与对照组相比，各组稀释20、40倍浓度的中药发用洗剂，HaCat细胞的存活率均在100％以上，并随着稀释倍数的增加，HaCat细胞的存活率均有不同程度的降低，其中，实施例1～3的HaCat细胞的存活率随着培养时间的延长，存活率也有所提高，表明选用皂角，无患子，浮萍，灯芯草，首乌藤，茜草，透骨草，知母，侧伯叶，白芷，桑叶，花椒，当归，川芎，细辛，桂枝，丹参，黄连，玄参，薄荷，人参，竹茹，火麻仁，麻黄，荆芥穗，菊花，赤芍，牡丹皮，竹叶心，淡豆豉，以及地桃花，香薷，制成中药发用洗剂，对人永生化表皮细胞(HaCat细胞)具有增殖作用。
二、脂溢性脱发的小鼠实验
选取C57BL/6J雄性小鼠，体重约18～22g，进行适应性喂养7d后，通过皮下注射5mg/kg/d的丙酸睾酮溶液，建立脂溢性脱发小鼠模型，给药时间35d，以皮下注射等量生理盐水的小鼠作为空白组(10只)，通过观察小鼠毛发脱落情况，并随机选取造模组小鼠2只处死，通过病理观察判定脂溢性脱发小鼠模型的构建成功。将造模组随机分成3组，每组10只，在小鼠背部约2cm×2cm区域进行脱毛处理，分别涂抹0.2mL和0.5mL的实施例3的中药发用洗剂(1g/mL)，一天一次，造模组继续注射丙酸睾酮溶液，以2％非那雄胺作为阳性组，涂抹0.2mL，连续涂抹22d，取背部脱毛区10根最长的毛进行测量，得新生毛长，取脱毛区所有体毛，电子称重，得新生毛重，结果如下。
表2小鼠新生毛长和新生毛重的结果
项目 新生毛长(mm) 新生毛重(g)
高剂量组 8.337 0.0154
低剂量组 7.684 0.0137
阳性组 8.267 0.0168
模型组 7.025 0.0108
空白组 8.409 0.0248
由上表可知，与模型组相比，中药发用洗剂的高剂量组和低剂量组对小鼠的新生毛发长度、重量有所增加，较接近于空白组，与阳性组相比，中药发用洗剂的高剂量组对小鼠的新生毛发长度较高于阳性组，表明选用皂角，无患子，浮萍，灯芯草，首乌藤，茜草，透骨草，知母，侧伯叶，白芷，桑叶，花椒，当归，川芎，细辛，桂枝，丹参，黄连，玄参，薄荷，人参，竹茹，火麻仁，麻黄，荆芥穗，菊花，赤芍，牡丹皮，竹叶心，淡豆豉，以及地桃花，香薷，制成中药发用洗剂，可提高脂溢性脱发小鼠的平均毛发长度、重量，对脂溢性脱发的毛发生长具有促进作用。
以上所述仅为本发明的较佳实施例而已，并不用以限制本发明，凡在本发明的精神和原则之内，所作的任何修改、等同替换、改进等，均应包含在本发明的保护范围之内。

Claims (8)

1.一种用于预防和治疗脂溢性脱发的中药组合物，其特征在于，包括如下重量份原料：皂角20～30份、无患子20～30份、浮萍20～30份、灯芯草20～30份、首乌藤20～30份、茜草15～25份、透骨草20～30份、知母20～30份、侧柏叶20～30份、白芷22～28份、桑叶20～38份、花椒10～18份、当归20～30份、川芎20～30份、细辛25～30份、桂枝25～30份、丹参25～30份、黄连40～50份、玄参40～50份、薄荷10～18份、人参40～55份、竹茹40～55份、火麻仁40～55份、麻黄40～55份、荆芥穗45～65份、菊花35～55份、赤芍35～55份、牡丹皮35～55份、竹叶心35～55份和淡豆豉35～45份。
2.根据权利要求1所述的一种用于预防和治疗脂溢性脱发的中药组合物，其特征在于，包括如下重量份原料：皂角20份、无患子20份、浮萍20份、灯芯草20份、首乌藤20份、茜草15份、透骨草20份、知母20份、侧柏叶20份、白芷22份、桑叶26份、花椒10份、当归20份、川芎20份、细辛25份、桂枝25份、丹参25份、黄连45份、玄参45份、薄荷10份、人参40份、竹茹40份、火麻仁40份、麻黄45份、荆芥穗45份、菊花35份、赤芍35份、牡丹皮35份、竹叶心35份和淡豆豉35份。
3.根据权利要求1所述的一种用于预防和治疗脂溢性脱发的中药组合物，其特征在于，所述中药组合物还包括如下重量份原料：地桃花15～20份和香薷25～30份。
4.根据权利要求3所述的一种用于预防和治疗脂溢性脱发的中药组合物，其特征在于，包括如下重量份原料：皂角20～25份、无患子20～25份、浮萍20～25份、灯芯草20～25份、首乌藤20～25份、茜草15～20份、透骨草20～25份、知母20～25份、侧柏叶20～25份、白芷22～25份、桑叶20～30份、花椒10～15份、当归20～25份、川芎20～25份、细辛25～25份、桂枝25～28份、丹参25～28份、黄连40～45份、玄参40～45份、薄荷10～12份、人参40～45份、竹茹40～45份、火麻仁40～45份、麻黄40～45份、荆芥穗45～50份、菊花35～40份、赤芍35～45份、牡丹皮35～40份、竹叶心35～40份、淡豆豉35～40份、地桃花15～18份和香薷25～28份。
5.根据权利要求4所述的一种用于预防和治疗脂溢性脱发的中药组合物，其特征在于，包括如下重量份原料：皂角20份、无患子20份、浮萍20份、灯芯草20份、首乌藤20份、茜草15份、透骨草20份、知母20份、侧柏叶20份、白芷22份、桑叶20份、花椒10份、当归20份、川芎20份、细辛25份、桂枝25份、丹参25份、黄连40份、玄参40份、薄荷10份、人参40份、竹茹40份、火麻仁40份、麻黄40份、荆芥穗45份、菊花35份、赤芍35、牡丹皮35份、竹叶心35份、淡豆豉35份、地桃花15份和香薷25份。
6.一种用于预防和治疗脂溢性脱发的中药发用洗剂，其特征在于，由权利要求1～5任意一项所述的中药组合物制得。
7.根据权利要求6所述的一种用于预防和治疗脂溢性脱发的中药发用洗剂的制备方法，其特征在于，包括以下步骤：按配方称取原料，煎煮，过滤，得中药煎煮液，加入增稠剂搅拌，加入茶多酚、食盐、椰子油起泡剂和氨基酸起泡剂，搅拌，得中药发用洗剂。
8.根据权利要求7所述的一种用于预防和治疗脂溢性脱发的中药发用洗剂的制备方法，其特征在于，煎煮过程中，加入淘米水和茶枯液。
CN202311100054.0A 2023-08-30 一种用于预防和治疗脂溢性脱发的中药组合物及其中药发用洗剂、制备方法 Active CN117138000B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202311100054.0A CN117138000B (zh) 2023-08-30 一种用于预防和治疗脂溢性脱发的中药组合物及其中药发用洗剂、制备方法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202311100054.0A CN117138000B (zh) 2023-08-30 一种用于预防和治疗脂溢性脱发的中药组合物及其中药发用洗剂、制备方法

Publications (2)

Publication Number Publication Date
CN117138000A true CN117138000A (zh) 2023-12-01
CN117138000B CN117138000B (zh) 2024-05-31

Family

ID=

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101829034A (zh) * 2009-12-23 2010-09-15 泰一和浦（北京）中医药研究院有限公司 一种具有乌发、美发作用的外用中药组合物及其制备方法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101829034A (zh) * 2009-12-23 2010-09-15 泰一和浦（北京）中医药研究院有限公司 一种具有乌发、美发作用的外用中药组合物及其制备方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
兰学良: "毛发再生汤等三联疗法治疗脱发126例", 《山东中医杂志》, vol. 22, no. 6, 20 June 2003 (2003-06-20), pages 341 - 342 *

Similar Documents

Publication Publication Date Title
CN106214592A (zh) 毛囊营养液组合物及其制备方法
CN111419769B (zh) 一种能有效促进头发生长的植物精华液配方及其制备方法
CN115381747B (zh) 一种防脱组合物、制备方法和用途
CN110755358A (zh) 一种五养归源中草药养发组合物及其制剂
CN102018771A (zh) 防脱药物生发制剂
CN113288853A (zh) 一种天然滋养毛囊、防脱生发、抗炎抗菌的组合物酊剂及其制备方法
CN111494496A (zh) 一种生发乌发的中药组合物、其制备方法及应用
CN111297770A (zh) 一种中草药防脱洗发水以及制备方法
CN110669598A (zh) 一种中药洗发皂及其制备方法
CN110876705A (zh) 一种洗手液及其制备方法
CN105726869A (zh) 一种抗氧化中药颗粒及其制备方法
CN105998652A (zh) 一种中药组合物、其应用与一种制剂
CN113069375A (zh) 含高含量腺苷及其衍生物的生发液及其制备方法和应用
CN117138000B (zh) 一种用于预防和治疗脂溢性脱发的中药组合物及其中药发用洗剂、制备方法
CN111068036A (zh) 草本生物酶头皮洗液
CN117138000A (zh) 一种用于预防和治疗脂溢性脱发的中药组合物及其中药发用洗剂、制备方法
CN111449998B (zh) 一种植萃防脱生发液及其制备方法
CN104306270A (zh) 一种含梣叶提取物的护养洁面乳及其制备方法
CN111481488B (zh) 一种防白发并能乌发健发的植物洗发水配方及其制备方法
CN112791034A (zh) 一种防脱育发草本洗发液及其制备方法
CN101991527A (zh) 一种营养保健洗发露
CN112675272A (zh) 一种防止脱发的中药组合物、洗发水及洗发水的制备方法
CN111631966A (zh) 一种滋润嫩肤精华液及其制备方法
CN103705728A (zh) 一种生发液及其制备方法
CN110934807A (zh) 一种养发黑发的首乌精华液

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant