CN117137983A - Traditional Chinese medicine composition and traditional Chinese medicine preparation for promoting wound healing and preparation method thereof - Google Patents
Traditional Chinese medicine composition and traditional Chinese medicine preparation for promoting wound healing and preparation method thereof Download PDFInfo
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- 239000003814 drug Substances 0.000 title claims abstract description 36
- 238000002360 preparation method Methods 0.000 title claims abstract description 23
- 230000029663 wound healing Effects 0.000 title claims abstract description 23
- 230000001737 promoting effect Effects 0.000 title claims abstract description 20
- 239000000203 mixture Substances 0.000 title claims abstract description 17
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims abstract description 9
- 235000009388 Parthenocissus quinquefolia Nutrition 0.000 claims abstract description 8
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 claims abstract description 7
- 241000205585 Aquilegia canadensis Species 0.000 claims abstract description 7
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 claims abstract description 7
- 229940037003 alum Drugs 0.000 claims abstract description 7
- 229940116229 borneol Drugs 0.000 claims abstract description 7
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 claims abstract description 7
- 229940075397 calomel Drugs 0.000 claims abstract description 7
- ZOMNIUBKTOKEHS-UHFFFAOYSA-L dimercury dichloride Chemical compound Cl[Hg][Hg]Cl ZOMNIUBKTOKEHS-UHFFFAOYSA-L 0.000 claims abstract description 7
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 claims abstract description 7
- 239000010446 mirabilite Substances 0.000 claims abstract description 7
- 240000003146 Lobelia chinensis Species 0.000 claims abstract description 6
- QMGVPVSNSZLJIA-UHFFFAOYSA-N Nux Vomica Natural products C1C2C3C4N(C=5C6=CC=CC=5)C(=O)CC3OCC=C2CN2C1C46CC2 QMGVPVSNSZLJIA-UHFFFAOYSA-N 0.000 claims abstract description 6
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- 241000576429 Forsythia suspensa Species 0.000 claims abstract description 5
- 240000000774 Cunila origanoides Species 0.000 claims abstract description 3
- 235000018274 Cunila origanoides Nutrition 0.000 claims abstract description 3
- 235000014866 Dictamnus albus Nutrition 0.000 claims abstract description 3
- 241000219099 Parthenocissus quinquefolia Species 0.000 claims abstract 3
- 229940098465 tincture Drugs 0.000 claims description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 6
- 238000010438 heat treatment Methods 0.000 claims description 6
- 238000010992 reflux Methods 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- 241000563984 Ampelopsis Species 0.000 claims description 5
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- 239000002994 raw material Substances 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 3
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- 210000000582 semen Anatomy 0.000 claims description 2
- RSIJVJUOQBWMIM-UHFFFAOYSA-L sodium sulfate decahydrate Chemical compound O.O.O.O.O.O.O.O.O.O.[Na+].[Na+].[O-]S([O-])(=O)=O RSIJVJUOQBWMIM-UHFFFAOYSA-L 0.000 claims description 2
- 239000002131 composite material Substances 0.000 claims 2
- 208000027418 Wounds and injury Diseases 0.000 abstract description 18
- 206010052428 Wound Diseases 0.000 abstract description 17
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A61K2236/50—Methods involving additional extraction steps
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Abstract
The application discloses a traditional Chinese medicine composition for promoting wound healing, a traditional Chinese medicine preparation and a preparation method thereof. The traditional Chinese medicine composition comprises the following components in parts by weight: 10-15 parts of nux vomica, 20-25 parts of honeysuckle, 15-20 parts of weeping forsythia, 10-15 parts of herba patriniae, 10-15 parts of Chinese lobelia herb, 15-20 parts of Japanese ampelopsis root, 10-15 parts of mirabilite, 10-15 parts of borneol, 15-20 parts of kuh-seng, 10-15 parts of alum, 15-20 parts of dittany bark, 15-20 parts of rhizoma atractylodis and 5-10 parts of calomel. The traditional Chinese medicine composition has the effects of clearing heat and detoxicating, resolving hard mass and detumescence, can effectively inhibit bacterial reproduction of wound surfaces, astringe wound surfaces and effectively promote wound healing.
Description
Technical Field
The application relates to the field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for promoting wound healing, a traditional Chinese medicine preparation and a preparation method thereof.
Background
Wound surfaces are damage to normal skin (tissue) caused by external injury factors such as surgery, external force, heat, current, chemicals, low temperature, and internal factors of the body such as local blood supply disorder. At present, after surgery, the wound surface is often changed by adopting an iodophor solution and a treatment method of dressing by using a sterile dressing, and the wound surface infection probability is higher after the conventional dressing change of the iodophor solution, the wound surface has good healing rate, the healing days are longer, and the wound surface is easy to develop into a chronic wound surface difficult to heal, so that more serious consequences are caused.
Disclosure of Invention
The application aims to solve the technical problems and provides a traditional Chinese medicine composition for promoting wound healing, a traditional Chinese medicine preparation and a preparation method thereof.
In a first aspect, the present application provides a traditional Chinese medicine composition for promoting wound healing, which is realized by adopting the following technical scheme.
A traditional Chinese medicine composition for promoting wound healing comprises the following components in parts by weight:
10-15 parts of nux vomica, 20-25 parts of honeysuckle, 15-20 parts of weeping forsythia, 10-15 parts of herba patriniae, 10-15 parts of Chinese lobelia herb, 15-20 parts of Japanese ampelopsis root, 10-15 parts of mirabilite, 10-15 parts of borneol, 15-20 parts of kuh-seng, 10-15 parts of alum, 15-20 parts of dittany bark, 15-20 parts of rhizoma atractylodis and 5-10 parts of calomel.
In the formula of the application, the honeysuckle has aromatic smell, light weight, good property, and can disperse and dispel the cold and sweet smell, enter the lung and stomach, and has the effects of clearing heat and detoxicating; fructus forsythiae is fragrant in smell, light in weight, and has the effects of clearing heat, purging pathogenic fire, removing sore toxin, resolving carbuncles and resolving masses, and the two are combined to serve as monarch drugs to play roles of clearing heat, removing toxicity, resolving masses and relieving swelling. Herba Patriniae has effects of clearing heat and detoxicating, expelling pus and removing blood stasis; half Bian Lianqing is a good product for sterilization and anti-inflammation, and has the effects of heat and detoxification, and inducing diuresis to alleviate edema; the ampelopsis japonica has the effects of clearing heat and detoxicating, promoting tissue regeneration and relieving pain, and can promote wound healing; kuh-seng clears heat and eliminates dampness, kills insects; cortex Dictamni Radicis has effects of clearing heat, eliminating dampness, dispelling pathogenic wind and removing toxic substances; the rhizoma atractylodis has the effects of strengthening spleen, drying dampness, resolving depression and avoiding dirt, and the medicines are used as ministerial medicines to assist in increasing the effects of clearing heat and detoxicating, killing parasites and sterilizing, removing stasis and expelling pus, inhibit bacterial reproduction of wound surfaces and facilitate wound surface drying. The mirabilite has the effects of moistening dryness, softening hard masses, clearing heat, relieving swelling, clearing heat and removing toxicity, enabling borneol to clear away heat, enabling alum to detoxify, killing parasites, eliminating dampness, relieving itching, and has good antibacterial and astringent effects, and the calomel has the effects of killing parasites, counteracting toxins and healing sores when being used for external use, and the effects of killing parasites, disinfecting, astringing wound surfaces and promoting wound healing of the whole prescription are further improved by using the medicine as an adjuvant.
Preferably, the traditional Chinese medicine composition for promoting wound healing comprises the following components in parts by weight:
12 parts of nux vomica, 24 parts of honeysuckle, 16 parts of weeping forsythia, 14 parts of herba patriniae, 12 parts of Chinese lobelia herb, 18 parts of Japanese ampelopsis root, 12 parts of mirabilite, 14 parts of borneol, 16 parts of kuh-seng, 14 parts of alum, 16 parts of cortex dictamni, 18 parts of rhizoma atractylodis and 6 parts of calomel.
In a second aspect, the application provides a traditional Chinese medicine preparation for promoting wound healing, which is realized by adopting the following technical scheme.
A Chinese medicinal preparation for promoting wound healing comprises the Chinese medicinal composition.
Further, the traditional Chinese medicine preparation is tincture.
In a third aspect, the application provides a preparation method of a traditional Chinese medicine preparation for promoting wound healing, which is realized by adopting the following technical scheme.
The preparation method of the traditional Chinese medicine preparation for promoting wound healing comprises the following steps:
a. weighing specified amount of semen Strychni, flos Lonicerae, fructus forsythiae, herba Patriniae, herba Lobeliae chinensis, radix Ampelopsis, natrii sulfas, borneolum Syntheticum, radix Sophorae Flavescentis, alumen, cortex Dictamni Radicis, rhizoma Atractylodis and Calomelas, adding 5.5-6 times of water, heating to boil, condensing and refluxing for 35-40min, and collecting condensate; then adding water 5.5-6 times of the total weight of the raw materials, heating to boiling, condensing and refluxing for 35-40min, and collecting condensate;
b. combining the condensate collected in the two steps, and concentrating under reduced pressure for 36-48h under the pressure of-1.2 MPa to obtain extract;
c. adding the extract into 75% ethanol solution to prepare 10% solution by mass.
The application has the following beneficial effects.
The traditional Chinese medicine composition has the effects of clearing heat and detoxicating, resolving hard mass and detumescence, can effectively inhibit bacterial reproduction of wound surfaces, astringe wound surfaces and effectively promote wound healing. The traditional Chinese medicine composition disclosed by the application is scientific and reasonable in compatibility, good in treatment effect and wide in application prospect.
Drawings
FIG. 1 is a state diagram of the application prior to treatment of a clinically typical case;
FIG. 2 is a state diagram of the application after a treatment of a clinical typical case;
FIG. 3 is a state diagram of the application prior to treatment in clinical exemplary case two;
fig. 4 is a state diagram after treatment of a clinical typical case two according to the present application.
Detailed Description
The present application is further illustrated below with reference to examples.
Examples
A preparation method of a topical Chinese medicinal tincture for promoting wound healing comprises the following steps:
a. weighing 12g of nux vomica, 24g of honeysuckle, 16g of fructus forsythiae, 14g of herba patriniae, 12g of Chinese lobelia, 18g of Japanese ampelopsis root, 12g of mirabilite, 14g of borneol, 16g of kuh-seng, 14g of alum, 16g of cortex dictamni, 18g of rhizoma atractylodis and 6g of calomel;
b. placing the weighed raw materials into a container, adding water which is 5.5 times of the total weight of the raw materials into the container, heating to boiling, condensing and refluxing for 35min, and collecting condensate; then adding water which is 5.5 times of the total weight of the raw materials into a container, heating to boiling, condensing and refluxing for 35min, and collecting condensate;
c. combining the condensate collected in the two steps, placing the condensate in a rotary evaporator, and concentrating under reduced pressure for 48 hours under the pressure of-1.2 MPa to obtain extract;
d. adding the extract into 75% ethanol solution to prepare 10% solution by mass fraction, and obtaining the external traditional Chinese medicine tincture.
Clinical trials
120 patients receiving surgical treatment were all from the urban hospitals in Qingdao city.
The subject of the clinical study is from
(1) Inclusion criteria
(1) About 1 week after orthopaedics operation, the examination can see that more exudates appear at the incision or yellow exudates appear on the dressing; (2) pressing the patient incision, with free necrotic tissue or floating fat droplets; (3) the exudates are microscopic in that a large number of fat drops are visible, and bacteria are not grown after continuous multiple culture.
(2) Exclusion criteria
(1) Sinus formation, or severe infection with incisions; (2) there are other systemic underlying primary diseases; (3) mental abnormalities, failing to match the study.
120 patients receiving surgery were randomly divided into a Chinese medicinal tincture group and an iodophor group, each group of 60 patients. Spraying Chinese medicinal tincture (prepared in example 1) on wound surface and sterile gauze covering the wound surface, and maintaining sterile gauze wet dressing for 1 time every 3 days; patients in the iodophor group were conventionally dressed with iodophor solution, wrapped with sterile dressing, and dressed 1 time every 3 days.
The results show that 12 cases of patients in the traditional Chinese medicine tincture group have wound redness, 3 cases of patients have wound infection, the wound infection rate is 5%, the good healing rate is 75%, and the healing days are 12.78+/-1.21 days; the iodophor group has wound redness of 15 patients, wound infection of 7 patients, wound infection rate of 11.66%, good healing rate of 63.33%, and healing days of 14.78+ -1.77 days.
The statistical comparison shows that the wound infection rate of the traditional Chinese medicine tincture group is obviously lower than that of the iodophor group (P < 0.001), the good wound healing rate is obviously higher than that of the iodophor group (P < 0.001), and the healing days are obviously shorter than that of the iodophor group (P < 0.001).
The state diagrams of the application before and after the treatment of the clinical typical case I and the case II are shown in figures 1-4, and the clinical result shows that the improvement is obvious after the use.
The embodiments of the present application are all preferred embodiments of the present application, and are not intended to limit the scope of the present application in this way, therefore: all equivalent changes in structure, shape and principle of the application should be covered in the scope of protection of the application.
Claims (5)
1. A traditional Chinese medicine composition for promoting wound healing is characterized in that: the composite material consists of the following components in parts by weight:
10-15 parts of nux vomica, 20-25 parts of honeysuckle, 15-20 parts of weeping forsythia, 10-15 parts of herba patriniae, 10-15 parts of Chinese lobelia herb, 15-20 parts of Japanese ampelopsis root, 10-15 parts of mirabilite, 10-15 parts of borneol, 15-20 parts of kuh-seng, 10-15 parts of alum, 15-20 parts of dittany bark, 15-20 parts of rhizoma atractylodis and 5-10 parts of calomel.
2. The traditional Chinese medicine composition for promoting wound healing according to claim 1, wherein the traditional Chinese medicine composition is characterized in that: the composite material consists of the following components in parts by weight:
12 parts of nux vomica, 24 parts of honeysuckle, 16 parts of weeping forsythia, 14 parts of herba patriniae, 12 parts of Chinese lobelia herb, 18 parts of Japanese ampelopsis root, 12 parts of mirabilite, 14 parts of borneol, 16 parts of kuh-seng, 14 parts of alum, 16 parts of cortex dictamni, 18 parts of rhizoma atractylodis and 6 parts of calomel.
3. A traditional Chinese medicine preparation for promoting wound healing is characterized in that: the traditional Chinese medicine preparation comprises the traditional Chinese medicine composition of claim 1 or 2.
4. A traditional Chinese medicine preparation for promoting wound healing according to claim 3, wherein: the Chinese medicinal preparation is tincture.
5. A method for preparing the traditional Chinese medicine preparation for promoting wound healing according to claim 4, which is characterized in that: the method comprises the following steps:
a. weighing specified amount of semen Strychni, flos Lonicerae, fructus forsythiae, herba Patriniae, herba Lobeliae chinensis, radix Ampelopsis, natrii sulfas, borneolum Syntheticum, radix Sophorae Flavescentis, alumen, cortex Dictamni Radicis, rhizoma Atractylodis and Calomelas, adding 5.5-6 times of water, heating to boil, condensing and refluxing for 35-40min, and collecting condensate; then adding water 5.5-6 times of the total weight of the raw materials, heating to boiling, condensing and refluxing for 35-40min, and collecting condensate;
b. combining the condensate collected in the two steps, and concentrating under reduced pressure for 36-48h under the pressure of-1.2 MPa to obtain extract;
c. adding the extract into 75% ethanol solution to prepare 10% solution by mass.
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Application publication date: 20231201 |