CN117085047A - 优化的溶瘤病毒及其用途 - Google Patents

优化的溶瘤病毒及其用途 Download PDF

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Publication number
CN117085047A
CN117085047A CN202310850191.XA CN202310850191A CN117085047A CN 117085047 A CN117085047 A CN 117085047A CN 202310850191 A CN202310850191 A CN 202310850191A CN 117085047 A CN117085047 A CN 117085047A
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Prior art keywords
virus
cells
oncolytic
viruses
cell
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Pending
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CN202310850191.XA
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Chinese (zh)
Inventor
彼得·M·丘马科夫
阿纳斯塔西娅·V·利帕脱娃
斯泰潘·P·丘马科夫
娜塔莉亚·D·塔拉罗娃
斯蒂芬·A·查尔斯
安东·A·科马尔
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Sator Therapeutics LLC
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Sator Therapeutics LLC
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Publication of CN117085047A publication Critical patent/CN117085047A/zh
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66Microorganisms or materials therefrom
    • A61K35/76Viruses; Subviral particles; Bacteriophages
    • A61K35/768Oncolytic viruses not provided for in groups A61K35/761 - A61K35/766
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66Microorganisms or materials therefrom
    • A61K35/76Viruses; Subviral particles; Bacteriophages
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/01Preparation of mutants without inserting foreign genetic material therein; Screening processes therefor
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    • C12N7/00Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5011Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
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    • C12N2770/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011Details
    • C12N2770/32011Picornaviridae
    • C12N2770/32311Enterovirus
    • C12N2770/32321Viruses as such, e.g. new isolates, mutants or their genomic sequences
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2770/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011Details
    • C12N2770/32011Picornaviridae
    • C12N2770/32311Enterovirus
    • C12N2770/32332Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011Details
    • C12N2770/32011Picornaviridae
    • C12N2770/32311Enterovirus
    • C12N2770/32351Methods of production or purification of viral material
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/08RNA viruses
    • G01N2333/085Picornaviridae, e.g. coxsackie virus, echovirus, enterovirus
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
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  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
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  • General Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
CN202310850191.XA 2016-09-27 2017-09-27 优化的溶瘤病毒及其用途 Pending CN117085047A (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201662400310P 2016-09-27 2016-09-27
US62/400,310 2016-09-27
US201662426724P 2016-11-28 2016-11-28
US62/426,724 2016-11-28
PCT/US2017/053659 WO2018064134A1 (en) 2016-09-27 2017-09-27 Optimized oncolytic viruses and uses thereof
CN201780072002.3A CN109982708B (zh) 2016-09-27 2017-09-27 优化的溶瘤病毒及其用途

Related Parent Applications (1)

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CN201780072002.3A Division CN109982708B (zh) 2016-09-27 2017-09-27 优化的溶瘤病毒及其用途

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CN117085047A true CN117085047A (zh) 2023-11-21

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CN202310850191.XA Pending CN117085047A (zh) 2016-09-27 2017-09-27 优化的溶瘤病毒及其用途
CN201780072002.3A Active CN109982708B (zh) 2016-09-27 2017-09-27 优化的溶瘤病毒及其用途

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US (3) US11253558B2 (https=)
EP (3) EP3518947B1 (https=)
JP (3) JP7138946B2 (https=)
CN (2) CN117085047A (https=)
AU (1) AU2017335673B2 (https=)
BR (1) BR112019005700A2 (https=)
CA (1) CA3037573A1 (https=)
MX (3) MX2019003546A (https=)
WO (1) WO2018064134A1 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7138946B2 (ja) * 2016-09-27 2022-09-20 セイター セラピューティクス エルエルシー 最適化された腫瘍溶解性ウイルスおよびその使用
CN108635380A (zh) * 2018-04-13 2018-10-12 北京唯源立康生物科技有限公司 重组溶瘤病毒组合物及其在制备用于治疗肿瘤的药物中的应用
CN110387353B (zh) * 2018-04-16 2023-07-18 厦门大学 一种用于治疗肿瘤的柯萨奇b组病毒
CA3138657A1 (en) * 2019-05-09 2020-11-12 Sator Therapeutics LLC Delivery of oncolytic viruses using dendritic cells
CN111494433A (zh) * 2020-04-26 2020-08-07 吴建国 一种新型溶瘤病毒在制备治疗结直肠癌药物的用途
CN116507721A (zh) * 2020-08-14 2023-07-28 上海行深生物科技有限公司 构建溶瘤病毒的方法
WO2023051607A1 (zh) * 2021-09-29 2023-04-06 上海行深生物科技有限公司 病毒培养方法
WO2024088585A1 (en) * 2022-10-27 2024-05-02 Technische Universität Berlin Method for generation of tumor-adapted oncolytic viruses

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7306902B2 (en) 2002-06-28 2007-12-11 Oncolyties Biotech Inc. Oncolytic viruses as phenotyping agents for neoplasms
AU2002953436A0 (en) 2002-12-18 2003-01-09 The University Of Newcastle Research Associates Limited A method of treating a malignancy in a subject via direct picornaviral-mediated oncolysis
JP5748656B2 (ja) * 2008-05-22 2015-07-15 ジェ イル ファーマシューティカル カンパニー リミテッド 過剰増殖細胞の腫瘍抑制因子に基づいた腫瘍崩壊ウイルスに対する感受性を判定する方法
US20100297072A1 (en) 2009-05-19 2010-11-25 Depinho Ronald A Combinations of Immunostimulatory Agents, Oncolytic Virus, and Additional Anticancer Therapy
AU2012204467B2 (en) 2011-01-04 2016-08-18 Sillajen, Inc. Generation of antibodies to tumor antigens and generation of tumor specific complement dependent cytotoxicity by administration of oncolytic vaccinia virus
US20140350087A9 (en) * 2012-03-22 2014-11-27 Halozyme, Inc. Oncovector Nucleic Acid Molecules and Methods of Use
RU2519763C9 (ru) * 2012-11-26 2015-04-27 Ольга Вячеславовна Матвеева Метод иммунотерапии онкологических заболеваний и фармацевтические композиции на основе онколитического вируса сендай
WO2014138314A1 (en) 2013-03-05 2014-09-12 Baylor College Of Medicine Oncolytic virus
HRP20200439T1 (hr) * 2015-04-30 2020-06-12 Psioxus Therapeutics Limited Onkolitički adenovirus koji kodira protein b7
JP7138946B2 (ja) 2016-09-27 2022-09-20 セイター セラピューティクス エルエルシー 最適化された腫瘍溶解性ウイルスおよびその使用

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Publication number Publication date
JP7462345B2 (ja) 2024-04-05
CN109982708A (zh) 2019-07-05
EP4023233B1 (en) 2026-01-07
JP2022164823A (ja) 2022-10-27
JP7138946B2 (ja) 2022-09-20
EP4019029A1 (en) 2022-06-29
EP3518947C0 (en) 2023-07-05
US11253558B2 (en) 2022-02-22
AU2017335673A1 (en) 2019-04-11
US20220088097A1 (en) 2022-03-24
US12521424B2 (en) 2026-01-13
EP4023233C0 (en) 2026-01-07
MX2019003546A (es) 2019-09-19
JP2024069529A (ja) 2024-05-21
JP2019533015A (ja) 2019-11-14
EP3518947B1 (en) 2023-07-05
US20220088098A1 (en) 2022-03-24
WO2018064134A1 (en) 2018-04-05
US20180085411A1 (en) 2018-03-29
EP3518947A1 (en) 2019-08-07
AU2017335673B2 (en) 2024-11-14
CA3037573A1 (en) 2018-04-05
MX2023011105A (es) 2023-10-02
US12357664B2 (en) 2025-07-15
EP4023233A3 (en) 2022-09-21
EP4023233A2 (en) 2022-07-06
MX2024004156A (es) 2024-04-23
BR112019005700A2 (pt) 2021-07-27
CN109982708B (zh) 2023-05-23

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