CN1170814C - 用于强化胆碱能活性的酰胺化合物 - Google Patents

用于强化胆碱能活性的酰胺化合物 Download PDF

Info

Publication number
CN1170814C
CN1170814C CNB008043035A CN00804303A CN1170814C CN 1170814 C CN1170814 C CN 1170814C CN B008043035 A CNB008043035 A CN B008043035A CN 00804303 A CN00804303 A CN 00804303A CN 1170814 C CN1170814 C CN 1170814C
Authority
CN
China
Prior art keywords
compound
salt
mixture
reaction
aryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB008043035A
Other languages
English (en)
Chinese (zh)
Other versions
CN1341095A (zh
Inventor
������ɽ����
山田明
青木敏
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yamanouchi Pharmaceutical Co Ltd
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Publication of CN1341095A publication Critical patent/CN1341095A/zh
Application granted granted Critical
Publication of CN1170814C publication Critical patent/CN1170814C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/65—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/30—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by halogen atoms, or by nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CNB008043035A 1999-02-26 2000-02-03 用于强化胆碱能活性的酰胺化合物 Expired - Fee Related CN1170814C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AUPP8912A AUPP891299A0 (en) 1999-02-26 1999-02-26 New 6-membered cyclic compounds
AUPP8912 1999-02-26

Publications (2)

Publication Number Publication Date
CN1341095A CN1341095A (zh) 2002-03-20
CN1170814C true CN1170814C (zh) 2004-10-13

Family

ID=3813111

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB008043035A Expired - Fee Related CN1170814C (zh) 1999-02-26 2000-02-03 用于强化胆碱能活性的酰胺化合物

Country Status (19)

Country Link
EP (1) EP1159258B1 (enExample)
JP (1) JP4089159B2 (enExample)
KR (1) KR100620406B1 (enExample)
CN (1) CN1170814C (enExample)
AR (1) AR029618A1 (enExample)
AT (1) ATE282022T1 (enExample)
AU (2) AUPP891299A0 (enExample)
BR (1) BR0010225A (enExample)
CA (1) CA2371827C (enExample)
DE (1) DE60015732T2 (enExample)
DK (1) DK1159258T3 (enExample)
ES (1) ES2226775T3 (enExample)
HK (1) HK1044934B (enExample)
HU (1) HUP0200116A3 (enExample)
PT (1) PT1159258E (enExample)
RU (1) RU2211215C2 (enExample)
TR (1) TR200102494T2 (enExample)
TW (1) TWI225856B (enExample)
WO (1) WO2000051970A1 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2351347A1 (en) 1998-11-23 2000-06-02 Bonnie Davis Dosage formulations for acetylcholinesterase inhibitors
CN100370990C (zh) 1998-12-24 2008-02-27 詹森药业有限公司 控释加兰他敏组合物
MY136316A (en) 2001-02-13 2008-09-30 Sanofi Aventis Deutschland Acylated 6,7,8,9-tetrahydro-5h-benzocycloheptenyl amines and their use as pharmaceutical.
TWI243164B (en) 2001-02-13 2005-11-11 Aventis Pharma Gmbh Acylated indanyl amines and their use as pharmaceuticals
PE20020856A1 (es) 2001-02-13 2002-11-11 Aventis Pharma Gmbh 1,2,3,4-tetrahidronaftil aminas aciladas
TWI241190B (en) 2001-02-13 2005-10-11 Aventis Pharma Gmbh 4-Fluoro-N-indan-2-yl benzamide and its use as pharmaceutical
US6984647B2 (en) * 2002-05-17 2006-01-10 Janssen Pharmaceutica N.V. Aminotetralin-derived urea modulators of vanilloid VR1 receptor
JP5036310B2 (ja) 2003-08-06 2012-09-26 セノミックス インコーポレイテッド 新規な風味、風味改質剤、味覚剤、味覚向上剤、旨味および甘味味覚剤、および／またはそれらの向上剤および使用
EP3398452B1 (en) 2006-04-21 2024-10-02 Firmenich Incorporated Comestible compositions comprising high potency savory flavorants
EP2025674A1 (de) 2007-08-15 2009-02-18 sanofi-aventis Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
UY32442A (es) 2009-02-13 2010-09-30 Sanofi Aventis Nuevos indanos sustituidos, procesos para su preparacion y uso de los mismos como un medicamento
JP2025066196A (ja) * 2022-03-14 2025-04-23 国立大学法人東北大学 認知機能改善剤

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR8287M (enExample) * 1968-12-31 1970-11-09
US4797419A (en) * 1986-11-03 1989-01-10 Warner-Lambert Company Method of treating the symptoms of senile cognitive decline employing di- or trisubstituted urea cholinergic agents
EP0306375A1 (fr) * 1987-08-07 1989-03-08 Synthelabo Dérivés de[(pipéridinyl-4)méthyl]-2 tétrahydro-1,2,3,4 isoquinoléine, leur préparation et leur application en thérapeutique
IL90279A (en) * 1988-05-24 1995-03-30 American Home Prod Piperazinyl carboxamide derivatives, their preparation and pharmaceutical com¦ositions containing them
GB8917687D0 (en) * 1989-08-02 1989-09-20 Fujisawa Pharmaceutical Co Aminopiperazine derivatives,processes for preparation thereof and pharmaceutical composition comprising the same
RU2024507C1 (ru) * 1991-11-18 1994-12-15 Евгений Яковлевич Левитин 5-хлор-2-пиридиламид-4-нитро-n-(карбоксиметил)антраниловой кислоты, проявляющий противовоспалительную активность
JPH06107544A (ja) * 1992-09-29 1994-04-19 Taisho Pharmaceut Co Ltd コリン作動性神経不全の改善・治療薬
JPH06298732A (ja) * 1993-02-16 1994-10-25 Taisho Pharmaceut Co Ltd インドール誘導体

Also Published As

Publication number Publication date
CA2371827C (en) 2008-06-10
HK1044934B (zh) 2005-06-03
TWI225856B (en) 2005-01-01
AU766655B2 (en) 2003-10-23
DE60015732T2 (de) 2005-03-31
JP2002538132A (ja) 2002-11-12
RU2211215C2 (ru) 2003-08-27
WO2000051970A1 (en) 2000-09-08
AU2325700A (en) 2000-09-21
ES2226775T3 (es) 2005-04-01
PT1159258E (pt) 2005-02-28
TR200102494T2 (tr) 2002-01-21
EP1159258A1 (en) 2001-12-05
JP4089159B2 (ja) 2008-05-28
HK1044934A1 (en) 2002-11-08
HUP0200116A3 (en) 2002-11-28
DK1159258T3 (da) 2005-02-14
EP1159258B1 (en) 2004-11-10
DE60015732D1 (de) 2004-12-16
AUPP891299A0 (en) 1999-03-25
ATE282022T1 (de) 2004-11-15
KR20010102140A (ko) 2001-11-15
BR0010225A (pt) 2002-01-22
AR029618A1 (es) 2003-07-10
CN1341095A (zh) 2002-03-20
CA2371827A1 (en) 2000-09-08
KR100620406B1 (ko) 2006-09-13
HUP0200116A2 (hu) 2002-05-29

Similar Documents

Publication Publication Date Title
CN1067067C (zh) 杂环速激肽受体拮抗物
CN1123564C (zh) 抗炎化合物
CN1041203C (zh) 吡唑并吡啶化合物的制备方法
CN1213046C (zh) 四氢吡啶衍生物,它们的制备和它们作为细胞增殖抑制剂的应用
CN1170814C (zh) 用于强化胆碱能活性的酰胺化合物
CN1289481C (zh) 作为降低脂质剂的联苯甲酰胺化合物
CN1141043A (zh) 非肽类速激肽受体拮抗剂
CN1113059C (zh) 用作神经激肽拮抗剂的哌嗪并衍生物
CN1340044A (zh) 莫维诺林衍生物
CN1729173A (zh) N－(吲哚乙基)环胺化合物
CN1414956A (zh) 作为mip抑制剂的经取代的哌嗪衍生物
CN1212835C (zh) 含异羟肟酸酯的半胱氨酸和丝氨酸蛋白酶抑制剂
CN1097006A (zh) O-芳基吗啡喃的醚类化合物
CN1278789A (zh) 作为磷脂酶抑制剂的9,10－二氢－9,10－桥亚乙基蒽衍生物
CN1404467A (zh) 氨基磺酰基联苯基衍生物
CN1164580C (zh) 用作5-羟色胺激活剂的二唑衍生物
US7241811B2 (en) Amide compounds for the potentiation of cholinergic activity
CN1167694C (zh) 1-苯基-4-(1-[2-芳基]环丙基)甲基哌嗪:多巴胺受体配体
CN1227230C (zh) Nmda受体配体的前药
CN1100033C (zh) 苯乙醇氨基－1,2,3,4－四氢化萘氧烃基酰胺衍生物
RU2181119C2 (ru) Новые производные феноксиэтиламина, способ их получения, их применение в качестве лекарственных средств и содержащие их фармацевтические композиции
CN1183765A (zh) 对5-ht1a受体具高度亲和力的苯氧乙胺衍生物,其制备方法、作为药物的用途及含有它们的药物组合物
CN1863769A (zh) 氨基吡咯烷衍生物的制备方法和中间体化合物
CN1753870A (zh) 新的苯甲酰胺衍生物及其制备方法
HK1025948B (en) Anti-inflammatory compounds

Legal Events

Date Code Title Description
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C06 Publication
PB01 Publication
C14 Grant of patent or utility model
GR01 Patent grant
C56 Change in the name or address of the patentee

Owner name: ASTELLAS PHARMA INC.

Free format text: FORMER NAME OR ADDRESS: FUJISAWA PHARMACEUTICAL CO., LTD.

CP03 Change of name, title or address

Address after: Tokyo, Japan

Patentee after: Yamanouchi Pharma Co., Ltd.

Address before: Osaka City, Osaka of Japan

Patentee before: Fujisawa Pharmaceutical Co., Ltd.

C17 Cessation of patent right
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20041013

Termination date: 20100203