KR100620406B1 - 콜린작용 활성을 강화시키기 위한 아미드 화합물 - Google Patents

콜린작용 활성을 강화시키기 위한 아미드 화합물 Download PDF

Info

Publication number
KR100620406B1
KR100620406B1 KR1020017010325A KR20017010325A KR100620406B1 KR 100620406 B1 KR100620406 B1 KR 100620406B1 KR 1020017010325 A KR1020017010325 A KR 1020017010325A KR 20017010325 A KR20017010325 A KR 20017010325A KR 100620406 B1 KR100620406 B1 KR 100620406B1
Authority
KR
South Korea
Prior art keywords
compound
salts
mixture
salt
dementia
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR1020017010325A
Other languages
English (en)
Korean (ko)
Other versions
KR20010102140A (ko
Inventor
야마다아키라
아오키사토시
Original Assignee
아스텔라스세이야쿠 가부시키가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 아스텔라스세이야쿠 가부시키가이샤 filed Critical 아스텔라스세이야쿠 가부시키가이샤
Publication of KR20010102140A publication Critical patent/KR20010102140A/ko
Application granted granted Critical
Publication of KR100620406B1 publication Critical patent/KR100620406B1/ko
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/65—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/30—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by halogen atoms, or by nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1020017010325A 1999-02-26 2000-02-03 콜린작용 활성을 강화시키기 위한 아미드 화합물 Expired - Fee Related KR100620406B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AUPP8912A AUPP891299A0 (en) 1999-02-26 1999-02-26 New 6-membered cyclic compounds
AUPP8912 1999-02-26

Publications (2)

Publication Number Publication Date
KR20010102140A KR20010102140A (ko) 2001-11-15
KR100620406B1 true KR100620406B1 (ko) 2006-09-13

Family

ID=3813111

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020017010325A Expired - Fee Related KR100620406B1 (ko) 1999-02-26 2000-02-03 콜린작용 활성을 강화시키기 위한 아미드 화합물

Country Status (19)

Country Link
EP (1) EP1159258B1 (enExample)
JP (1) JP4089159B2 (enExample)
KR (1) KR100620406B1 (enExample)
CN (1) CN1170814C (enExample)
AR (1) AR029618A1 (enExample)
AT (1) ATE282022T1 (enExample)
AU (2) AUPP891299A0 (enExample)
BR (1) BR0010225A (enExample)
CA (1) CA2371827C (enExample)
DE (1) DE60015732T2 (enExample)
DK (1) DK1159258T3 (enExample)
ES (1) ES2226775T3 (enExample)
HK (1) HK1044934B (enExample)
HU (1) HUP0200116A3 (enExample)
PT (1) PT1159258E (enExample)
RU (1) RU2211215C2 (enExample)
TR (1) TR200102494T2 (enExample)
TW (1) TWI225856B (enExample)
WO (1) WO2000051970A1 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2351347A1 (en) 1998-11-23 2000-06-02 Bonnie Davis Dosage formulations for acetylcholinesterase inhibitors
CN100370990C (zh) 1998-12-24 2008-02-27 詹森药业有限公司 控释加兰他敏组合物
MY136316A (en) 2001-02-13 2008-09-30 Sanofi Aventis Deutschland Acylated 6,7,8,9-tetrahydro-5h-benzocycloheptenyl amines and their use as pharmaceutical.
TWI243164B (en) 2001-02-13 2005-11-11 Aventis Pharma Gmbh Acylated indanyl amines and their use as pharmaceuticals
PE20020856A1 (es) 2001-02-13 2002-11-11 Aventis Pharma Gmbh 1,2,3,4-tetrahidronaftil aminas aciladas
TWI241190B (en) 2001-02-13 2005-10-11 Aventis Pharma Gmbh 4-Fluoro-N-indan-2-yl benzamide and its use as pharmaceutical
US6984647B2 (en) * 2002-05-17 2006-01-10 Janssen Pharmaceutica N.V. Aminotetralin-derived urea modulators of vanilloid VR1 receptor
JP5036310B2 (ja) 2003-08-06 2012-09-26 セノミックス インコーポレイテッド 新規な風味、風味改質剤、味覚剤、味覚向上剤、旨味および甘味味覚剤、および／またはそれらの向上剤および使用
EP3398452B1 (en) 2006-04-21 2024-10-02 Firmenich Incorporated Comestible compositions comprising high potency savory flavorants
EP2025674A1 (de) 2007-08-15 2009-02-18 sanofi-aventis Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
UY32442A (es) 2009-02-13 2010-09-30 Sanofi Aventis Nuevos indanos sustituidos, procesos para su preparacion y uso de los mismos como un medicamento
JP2025066196A (ja) * 2022-03-14 2025-04-23 国立大学法人東北大学 認知機能改善剤

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR8287M (enExample) * 1968-12-31 1970-11-09
US4797419A (en) * 1986-11-03 1989-01-10 Warner-Lambert Company Method of treating the symptoms of senile cognitive decline employing di- or trisubstituted urea cholinergic agents
EP0306375A1 (fr) * 1987-08-07 1989-03-08 Synthelabo Dérivés de[(pipéridinyl-4)méthyl]-2 tétrahydro-1,2,3,4 isoquinoléine, leur préparation et leur application en thérapeutique
IL90279A (en) * 1988-05-24 1995-03-30 American Home Prod Piperazinyl carboxamide derivatives, their preparation and pharmaceutical com¦ositions containing them
GB8917687D0 (en) * 1989-08-02 1989-09-20 Fujisawa Pharmaceutical Co Aminopiperazine derivatives,processes for preparation thereof and pharmaceutical composition comprising the same
RU2024507C1 (ru) * 1991-11-18 1994-12-15 Евгений Яковлевич Левитин 5-хлор-2-пиридиламид-4-нитро-n-(карбоксиметил)антраниловой кислоты, проявляющий противовоспалительную активность
JPH06107544A (ja) * 1992-09-29 1994-04-19 Taisho Pharmaceut Co Ltd コリン作動性神経不全の改善・治療薬
JPH06298732A (ja) * 1993-02-16 1994-10-25 Taisho Pharmaceut Co Ltd インドール誘導体

Also Published As

Publication number Publication date
CA2371827C (en) 2008-06-10
HK1044934B (zh) 2005-06-03
TWI225856B (en) 2005-01-01
AU766655B2 (en) 2003-10-23
DE60015732T2 (de) 2005-03-31
JP2002538132A (ja) 2002-11-12
RU2211215C2 (ru) 2003-08-27
WO2000051970A1 (en) 2000-09-08
AU2325700A (en) 2000-09-21
ES2226775T3 (es) 2005-04-01
PT1159258E (pt) 2005-02-28
TR200102494T2 (tr) 2002-01-21
CN1170814C (zh) 2004-10-13
EP1159258A1 (en) 2001-12-05
JP4089159B2 (ja) 2008-05-28
HK1044934A1 (en) 2002-11-08
HUP0200116A3 (en) 2002-11-28
DK1159258T3 (da) 2005-02-14
EP1159258B1 (en) 2004-11-10
DE60015732D1 (de) 2004-12-16
AUPP891299A0 (en) 1999-03-25
ATE282022T1 (de) 2004-11-15
KR20010102140A (ko) 2001-11-15
BR0010225A (pt) 2002-01-22
AR029618A1 (es) 2003-07-10
CN1341095A (zh) 2002-03-20
CA2371827A1 (en) 2000-09-08
HUP0200116A2 (hu) 2002-05-29

Similar Documents

Publication Publication Date Title
EP1140836B1 (en) Amide compounds
EP0512570B1 (en) Urea derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same
JP3897594B2 (ja) ミクロソームトリグリセリド輸送タンパク質およびアポリポタンパク質分泌の阻害剤として有用なカルボキサミド
JPH06239822A (ja) 新規なｎ−ベンゾイルアミノ酸誘導体、これらの化合物を含有する医薬組成物およびこれらの化合物を製造する方法
CN100508975C (zh) 吡唑并吡啶化合物的用途
KR100620406B1 (ko) 콜린작용 활성을 강화시키기 위한 아미드 화합물
JPH08176145A (ja) アロイル−ピペリジン誘導体
JP2001500864A (ja) トロンビン阻害物質
EP0330026A1 (en) Piperidinoalkyl derivatives of carboxylic acid amides
AU714523B2 (en) Chromone derivatives
US6664293B2 (en) Amide compounds for the potentiation of cholinergic activity
US5025033A (en) Alkylene diamines
JPH11130750A (ja) 新規誘導体
HU218274B (en) N,n'-bis hydroxyalkyl and alkoxyalkyl-pyridine-2,4-dicarboxylic acid diamide derivatives and pharmaceutical compositions comprising such compounds and process for producing them
HUT56340A (en) Process for producing tetrahydronaphthalene derivatives and pharmaceutical compositions comprising such compounds
WO2001005767A1 (en) Organic compounds
MXPA01008252A (en) Amide compounds for the potentiation of cholinergic activity
WO2002098871A1 (en) Phenylcarboxamides and process for preparation thereof
HU210312B (en) Process for prepg tetrahydro-naphtalene deriv.s and pharmaceutical compn.s contg. them
IE921494A1 (en) New urea derivatives, processes for the preparation thereof¹and pharmaceutical composition comprising the same

Legal Events

Date Code Title Description
PA0105 International application

St.27 status event code: A-0-1-A10-A15-nap-PA0105

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

A201 Request for examination
P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

N231 Notification of change of applicant
PN2301 Change of applicant

St.27 status event code: A-3-3-R10-R13-asn-PN2301

St.27 status event code: A-3-3-R10-R11-asn-PN2301

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

E13-X000 Pre-grant limitation requested

St.27 status event code: A-2-3-E10-E13-lim-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

GRNT Written decision to grant
PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U12-oth-PR1002

Fee payment year number: 1

PG1601 Publication of registration

St.27 status event code: A-4-4-Q10-Q13-nap-PG1601

FPAY Annual fee payment

Payment date: 20090824

Year of fee payment: 4

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 4

LAPS Lapse due to unpaid annual fee
PC1903 Unpaid annual fee

St.27 status event code: A-4-4-U10-U13-oth-PC1903

Not in force date: 20100830

Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

PC1903 Unpaid annual fee

St.27 status event code: N-4-6-H10-H13-oth-PC1903

Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

Not in force date: 20100830

P22-X000 Classification modified

St.27 status event code: A-4-4-P10-P22-nap-X000

P22-X000 Classification modified

St.27 status event code: A-4-4-P10-P22-nap-X000