CN117030798A - Sample analysis system and analyzer - Google Patents

Abstract

The embodiment of the application discloses a sample analysis system and an analyzer. The detection structure includes a WBC cell and a RBC cell. The first fluid pathway can be in communication with the solution supply structure, the dilution fluid reservoir, and the WBC reservoir. The second liquid path is provided with a sample sucking needle, and part of the structure of the second liquid path can be used for communicating the dilution liquid pool with the rear pool of the RBC pool. The positive pressure structure is capable of providing positive pressure to the diluent reservoir. The duplex injector comprises a first injector and a second injector, the first injector is connected to the first liquid path, and the first injector can be respectively communicated with the solution supply structure, the dilution liquid tank and the WBC tank. The second injector is connected to the second liquid path, and the second injector can be respectively communicated with the dilution liquid pool and the sample sucking needle. Through the arrangement, the WBC pool and the RBC pool can be cleaned simultaneously, the cleaning time is shortened, and the analysis efficiency of sample analysis is improved.

Description

Sample analysis system and analyzer

Technical Field

The present application relates to the field of analyzers, and in particular, to a sample analysis system and an analyzer.

Background

At present, the main technical principle of the three-class blood cells is an impedance method, and the technology has the advantages of simple and reliable control mode, low cost and the like, and is widely applied to medium-low end blood cell analysis products;

current three-class sample analysis systems are limited by cost and volume due to their positioning in the low-end market, resulting in serious limitations in resources, including sample preparation, testing, and especially cleaning of parts, throughout the sample analysis process.

In the related art, the cleaning of the sample needle and the cleaning of the front and rear cells of the counting cell are performed sequentially one by a single syringe, and the parallel action of the cleaning operation cannot be achieved, so that the whole sample analysis speed is reduced, and the sample analysis efficiency is low.

Disclosure of Invention

In view of the above, it is necessary to provide a sample analysis system and an analyzer that increase the sample analysis speed.

An embodiment of the present application provides a sample analysis system, including:

the detection structure comprises a WBC pool and an RBC pool, wherein the rear pool of the RBC pool is communicated with the rear pool of the WBC pool;

a solution supply structure for supplying a hemolytic agent and a diluent;

a dilution liquid tank capable of storing a dilution liquid;

a first fluid path capable of communicating with the solution supply structure, the dilution liquid tank, and the WBC tank;

the second liquid path is provided with a sample suction needle, and part of the structure of the second liquid path can be used for communicating the dilution liquid pool with the rear pool of the RBC pool;

a positive pressure structure connected to the dilution tank capable of providing positive pressure to the dilution tank to transport liquid within the dilution tank to a rear tank of the RBC tank;

and a duplex syringe comprising a first syringe and a second syringe, the first syringe being connected to the first fluid line such that the first syringe is capable of communicating with the solution supply structure, the dilution liquid pool, and the WBC pool, respectively;

the second injector is connected to the second liquid path so that the second injector can be communicated with the dilution liquid pool and the sample sucking needle respectively.

In some embodiments, the first fluid path includes a first control valve, a second control valve, a third control valve, a fourth control valve, and a plurality of first pipes, two ports of the first control valve are respectively communicated with the port of the second control valve and the solution supply structure through the first pipes, another port of the first control valve is connected with the first injector, the third control valve and the fourth control valve are respectively connected to two ports of the second control valve, two ports of the third control valve are respectively communicated with the solution supply structure and the WBC tank through the first pipes, and one port of the fourth control valve is communicated with the dilution liquid tank.

In some embodiments, the second fluid path includes a fifth control valve, a sixth control valve, a seventh control valve, and a plurality of second lines, where the fifth control valve, the sixth control valve, and the seventh control valve can be sequentially communicated through the second lines, the sample suction needle is connected to one valve port of the fifth control valve, the other valve port of the fifth control valve is communicated with the second syringe, one valve port of the sixth control valve is communicated with the dilution liquid tank, and the valve port of the seventh control valve is communicated to the back tank of the RBC tank.

In some embodiments, the positive pressure structure comprises a positive pressure chamber, an air pump, an eighth control valve and a positive pressure sensor, wherein the air pump is connected to the positive pressure chamber to provide positive pressure for the positive pressure chamber, one end of the eighth control valve is connected with the positive pressure chamber, and the other end of the eighth control valve is respectively connected with the WBC pool and the RBC pool.

In some embodiments, the system further comprises a negative pressure structure comprising a negative pressure chamber, a liquid pump, a negative pressure sensor, a ninth control valve, a tenth control valve, and an eleventh control valve, wherein the ninth control valve, the tenth control valve, and the eleventh control valve are respectively connected between the WBC pool and the negative pressure chamber, between the RBC pool and the negative pressure chamber, the eleventh control valve is connected between the negative pressure chamber and a back pool of the WBC, and the liquid pump and the negative pressure sensor are both connected on the negative pressure chamber.

In some embodiments, the WBC cell has a first outlet and two first fluid ports, the RBC cell has a second outlet and two second fluid ports, the seventh control valve is connected to the second outlet, the two second fluid ports are connected to the first outlet, and the two first fluid ports are connected to the eleventh control valve.

In some embodiments, the device further comprises a swab for cleaning the sample sucking needle, wherein two openings of the swab are respectively connected with the dilution liquid pool and the negative pressure chamber, and a twelfth control valve is arranged between the swab and the negative pressure chamber.

In some embodiments, the negative pressure structure further comprises a waste reservoir connected to the negative pressure chamber by a liquid pump.

In some embodiments, the solution supply structure includes a hemolysis agent cartridge and a diluent cartridge.

The embodiment of the application also provides an analyzer comprising the sample analysis system.

The embodiment of the application has the following beneficial effects:

according to the sample analysis system and the analyzer in the above embodiments, by providing the first liquid path and the second liquid path, the first syringe can suck the diluent in the solution supply structure and then inject the diluent into the WBC pool, so as to clean the front pool of the WBC pool. Because the first injector and the second injector are of a linkage structure, the second injector can absorb the diluent in the solution supply structure through the sample absorbing needle at the same time, and then the diluent is injected into the RBC pool through the sample absorbing needle to clean the front pool of the RBC pool. Through setting up dilution liquid pond and positive pressure structure, apply positive pressure to the dilution liquid pond through positive pressure structure, can transport the back pond in RBC pond with the interior dilution liquid in the dilution liquid pond, the back pond in RBC pond again communicates with the back pond in WBC pond, consequently, can clear up the back pond in WBC pond and the back pond in RBC pond. Therefore, through the arrangement, the WBC pool and the RBC pool can be cleaned simultaneously, and compared with the prior art that the WBC pool and the RBC pool are cleaned one by one, the cleaning time can be reduced, and the analysis efficiency of sample analysis can be improved.

Drawings

In order to more clearly illustrate the embodiments of the application or the technical solutions in the prior art, the drawings that are required in the embodiments or the description of the prior art will be briefly described, it being obvious that the drawings in the following description are only some embodiments of the application, and that other drawings may be obtained according to these drawings without inventive effort for a person skilled in the art.

Wherein:

FIG. 1 shows a schematic diagram of a sample analysis system provided in accordance with the present application;

fig. 2 shows a schematic structural diagram of WBC and RBC cell connection structures provided in accordance with the present application.

Description of main reference numerals:

1. a duplex syringe; 11. a first syringe; 12. a second syringe; 2. a first liquid path; 21. a first control valve; 22. a second control valve; 23. a third control valve; 24. a fourth control valve; 25. a first pipeline; 3. a second liquid path; 31. a fifth control valve; 32. a sixth control valve; 33. a seventh control valve; 34. a sample sucking needle; 35. a second pipeline; 4. a positive pressure structure; 41. an air pump; 42. a positive pressure chamber; 43. an eighth control valve; 44. a positive pressure sensor; 5. a negative pressure structure; 51. a ninth control valve; 52. a tenth control valve; 53. an eleventh control valve; 54. a negative pressure sensor; 55. a negative pressure chamber; 56. a liquid pump; 57. a waste liquid pool; 6. a solution supply structure; 61. a diluent bin; 62. a hemolysis agent bin; 70. a swab; 8. a detection structure; 81. a WBC pool; 810. WBC pre-pool; 811. WBC back pool; 812. a first outlet; 813. a first liquid port; 82. a RBC pool; 820. a RBC pre-pool; 821. a RBC back cell; 822. a second outlet; 823. a second liquid port; 90. a twelfth control valve; 100. a dilution liquid pool.

Detailed Description

In order that the application may be readily understood, a more complete description of the application will be rendered by reference to the appended drawings. Preferred embodiments of the present application are shown in the drawings. This application may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete.

It will be understood that when an element is referred to as being "fixed to" another element, it can be directly on the other element or intervening elements may also be present. When an element is referred to as being "connected" to another element, it can be directly connected to the other element or intervening elements may also be present. The terms "vertical," "horizontal," "left," "right," and the like are used herein for illustrative purposes only.

Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs. The terminology used herein in the description of the application is for the purpose of describing particular embodiments only and is not intended to be limiting of the application. The term "and/or" as used herein includes any and all combinations of one or more of the associated listed items.

In one aspect, the present application provides a sample analysis system that can be applied to an analyzer to perform detection and analysis on white blood cells, red blood cells, etc., and in one embodiment, referring to fig. 1, the sample analysis system includes a detection structure 8, a solution supply structure 6, a dilution liquid tank 100, a first liquid path 2, a second liquid path 3, a positive pressure structure 4, and a duplex injector 1.

The detection structure 8 is capable of detecting not only white blood cells and red blood cells, but also platelets, hemoglobin, and the like, and in this embodiment, the detection structure 8 mainly includes a WBC cell 81 and a RBC cell 82, which detect white blood cells and red blood cells, respectively. And in this embodiment, the back pool of RBC pool 82 and the back pool of WBC pool 81 are in communication.

The solution supply structure 6 is used for supplying a solution for reaction or washing, such as the solution supply structure 6 in the embodiment of the present application is mainly used for supplying a hemolyzing agent and a diluting liquid.

The dilution liquid tank 100 is capable of storing dilution liquid, and the dilution liquid tank 100 is different from the solution supply structure 6, but the dilution liquid in the solution supply structure 6 can be driven into the dilution liquid tank 100 by a double syringe 1 hereinafter.

The first fluid circuit 2 has a plurality of ports, some of which can communicate with the solution supply structure 6, the dilution liquid tank 100, and the WBC tank 81.

The second liquid path 3 also has a plurality of ports, one of which is connected with the sample suction needle 34, and part of the structure of the second liquid path 3 can communicate the dilution liquid pool 100 with the rear pool of the RBC pool 82.

The positive pressure structure 4 is connected to the dilution liquid tank 100, and the positive pressure structure 4 is capable of generating a predetermined pressure, and providing a positive pressure to the dilution liquid tank 100 to press the liquid in the dilution liquid tank 100 out of the dilution liquid tank 100 and transport the dilution liquid to the rear tank of the RBC tank 82 through the second liquid path 3.

The duplex injector 1 comprises a first injector 11 and a second injector 12, the piston of the first injector 11 and the piston of the second injector 12 are connected through the same fixing piece, one piston is pushed, the other piston can move simultaneously, and the piston linkage of the two injectors is realized, so that the structure of the first injector 11 and the structure of the second injector 12 are the duplex injector 1.

It should be noted that, the injection port of the first syringe 11 is connected to one of the ports of the first liquid path 2, and the ports of the first liquid path 2 can be connected to each other, so that the first syringe 11 can be respectively connected to the solution supply structure 6, the dilution liquid tank 100 and the WBC tank 81, and when the piston of the first syringe 11 is pulled, the liquid can be sucked from another structure through the first liquid path 2, and the liquid inside the first syringe 11 can be injected into the external structure by pushing the piston.

The injection port of the second syringe 12 communicates with one port of the second liquid path 3, and the respective ports of the second liquid path 3 can communicate with each other, so that the second syringe 12 can communicate with the dilution liquid pool 100 and the pipette tip 34, respectively. When the second syringe 12 is in communication with the aspiration needle 34, the aspiration needle 34 is capable of aspirating the liquid into the second syringe 12, and the aspiration needle 34 is also capable of injecting the liquid in the second syringe 12 into the corresponding structure.

By providing the first liquid path 2 and the second liquid path 3, the first syringe 11 can suck the diluent in the solution supply structure 6 and then inject the diluent into the WBC tank 81 to wash the front tank of the WBC tank 81. Since the first syringe 11 and the second syringe 12 are of a linkage structure, the second syringe 12 can simultaneously suck the diluent in the solution supply structure 6 through the sample sucking needle 34, and then inject the diluent into the RBC tank 82 through the sample sucking needle 34 to clean the front tank of the RBC tank 82. By providing the dilution liquid pool 100 and the positive pressure structure 4, the positive pressure structure 4 can apply positive pressure to the dilution liquid pool 100, so that the dilution liquid in the dilution liquid pool 100 can be transported to the back pool of the RBC pool 82, and the back pool of the RBC pool 82 is communicated with the back pool of the WBC pool 81, so that the back pool of the WBC pool 81 and the back pool of the RBC pool 82 can be cleaned. Therefore, through the arrangement, the cleaning operation can be simultaneously carried out on the WBC pool 81 and the RBC pool 82, and compared with the prior art that the WBC pool 81 and the RBC pool 82 are cleaned one by one, the cleaning time can be reduced, and the analysis efficiency of sample analysis can be improved.

In one embodiment, referring to fig. 1, the first liquid path 2 includes a first control valve 21, a second control valve 22, a third control valve 23, a fourth control valve 24, and a plurality of first pipelines 25, wherein each structure of the first liquid path 2 is connected through the first pipeline 25, and the first liquid path 2 is also connected with other structures through the first pipeline 25.

Specifically, the first control valve 21, the second control valve 22, the third control valve 23 and the fourth control valve 24 are preferably two-position three-way control valves, each control valve has an inlet and two outlets, which are three main valve ports, the inlet can be respectively communicated with the two outlets, and when the inlet is communicated with one outlet, the inlet is not communicated with the other outlet, and the specific structure is also referred to the two-position three-way control valve structure in the prior art, which is not described herein.

The two outlets of the first control valve 21 are respectively communicated with the inlet of the second control valve 22 and the solution supply structure 6 through the first pipeline 25, and the inlet of the first control valve 21 is communicated with the outlet end of the first syringe 11, so that by controlling the first control valve 21, the inlet of the first control valve 21 and any one of the two outlets can be controlled to be communicated, and further, the first syringe 11 is communicated with the second control valve 22 or the solution supply structure 6 is realized.

The inlets of the third control valve 23 and the fourth control valve 24 are connected to the two outlets of the second control valve 22 via a first line 25, respectively, i.e. by controlling the second control valve 22, communication of the first syringe 11 with the third control valve 23 or the fourth control valve 24 can be achieved. Two outlets of the third control valve 23 are connected to the solution supply structure 6 and the WBC reservoir 81, respectively, via a first line 25, and one outlet of the fourth control valve 24 is connected to the dilution liquid reservoir 100 via a first line 25.

Through the first liquid path 2 described above, the operations that can be implemented are: if the first control valve 21 is controlled to communicate the first syringe 11 with the solution supply structure 6, the hemolytic agent or the diluent in the solution supply structure 6 can be sucked up when the plunger of the first syringe 11 is pulled. When the liquid in the first syringe 11 needs to be output, the first control valve 21 can be controlled to communicate the first syringe 11 with the second control valve 22, the second control valve 22 has two outlets, one can be communicated with the WBC pool 81 through the third control valve 23, the other can be communicated with the dilution liquid pool 100 through the fourth control valve 24, and the inlet of the second control valve 22 is controlled to communicate with the outlet of the corresponding structure when the liquid in the first syringe 11 needs to be input into the structure. For example, if the first syringe 11 is filled with the diluent from the solution supply structure 6, and the diluent is desired to be discharged into the diluent reservoir 100 for storage, it is necessary to control the first control valve 21 and the second control valve 22 to communicate with each other, then control the second control valve 22 to communicate with the fourth control valve 24, control the inlet of the fourth control valve 24 to communicate with the outlet of the diluent reservoir 100, and then push the piston of the first syringe 11 to deliver the diluent into the diluent reservoir 100.

It should be noted that one outlet of the first control valve 21 and one outlet of the third control valve 23 are each connected to the solution supply structure 6, in order to be able to suck different solutions into the first syringe 11. Because different solutions (hemolytic agent and diluent) can be supplied to the solution supply structure 6, the different solutions are stored separately by different structures, so that two different ports are required to be communicated with the structures containing the different solutions, thereby realizing separate suction of the different solutions.

In one embodiment, referring to fig. 1, the second liquid path 3 includes a fifth control valve 31, a sixth control valve 32, a seventh control valve 33, and a plurality of second pipelines 35, each structure of the second liquid path 3 is connected through the second pipeline 35, and the second liquid path 3 is also connected with other structures through the second pipeline 35. The fifth control valve 31, the sixth control valve 32, and the seventh control valve 33 can communicate in sequence through the second pipe 35. In the present embodiment, the fifth control valve 31 is preferably a two-position three-way valve, and the sixth control valve 32 and the seventh control valve 33 are preferably two-position two-way control valves. As described above, the fifth control valve 31 of the two-position three-way valve has one inlet and two outlets, and the two-position two-way control valve has one inlet and one outlet, by controlling the operation capable of communicating and closing the inlet and the outlet.

The outlet end of the second syringe 12 is connected to the inlet of the fifth control valve 31 via a second line 35, and the sample-sucking needle 34 is connected to an outlet of the fifth control valve 31 via the second line 35. The outlet of the sixth control valve 32 communicates with the dilution liquid reservoir 100 and the inlet communicates with the other outlet of the fifth control valve 31 via a second line 35. The outlet of the seventh control valve 33 communicates through a second line 35 to the back sump of the RBC sump 82.

It should be noted that, the inlet of the seventh control valve 33 can also be connected to the outlet of the sixth control valve 32, and a joint structure is needed at this time, and a three-way joint is selected in this embodiment to connect the outlet of the sixth control valve 32, the dilution liquid tank 100 and the inlet of the seventh control valve 33 through the second pipeline 35. In this way, the second syringe 12 is able to draw diluent from the reservoir 100, and when the inlet and outlet of the sixth control valve 32 are disconnected and the inlet and outlet of the seventh control valve 33 are in communication, the diluent in the reservoir 100 can be forced into the back reservoir of the RBC reservoir 82 by the positive pressure arrangement 4.

Through the above-mentioned second liquid path 3, the operations that can be realized are: when the fifth control valve 31 is controlled so that the second syringe 12 and the sample sucking needle 34 are communicated, the piston of the second syringe 12 is pulled, the solution can be sucked through the sample sucking needle 34, the solution is sucked into the second syringe 12, the second syringe 12 can be pushed during sample adding, and the solution is added into the corresponding structure through the sample sucking needle 34. When it is desired to draw the diluent from the diluent reservoir 100, the fifth control valve 31 may be controlled to connect the second syringe 12 to the sixth control valve 32, and at the same time, the sixth control valve 32 is opened, and the diluent in the diluent reservoir 100 may be drawn by pulling the second syringe 12. If it is desired to introduce the diluent in the diluent reservoir 100 into the RBC tank 82, as also mentioned above, the sixth control valve 32 is closed and then the seventh control valve 33 is opened, whereby the diluent in the diluent reservoir 100 is forced into the RBC tank 82 by the positive pressure of the positive pressure structure 4.

In one embodiment, referring to fig. 1, the positive pressure structure 4 includes a positive pressure chamber 42, an air pump 41, an eighth control valve 43, and a positive pressure sensor 44, wherein the air pump 41 is connected to an opening of the positive pressure chamber 42 to provide a power source for establishing positive pressure in the positive pressure chamber 42, and the positive pressure sensor 44 is connected to the inside of the positive pressure chamber 42 to measure the pressure in the positive pressure chamber 42, and if the pressure exceeds a predetermined pressure, pressure relief is required, and if the pressure is less than the predetermined pressure, pressure supplement is required. An outlet of the plenum 42 communicates with the diluent reservoir 100 via an air line such that positive pressure generated by the plenum 42 can be delivered into the diluent reservoir 100.

The eighth control valve 43 is preferably a two-position two-way valve, with its inlet connected to the plenum 42 by a conduit and its outlet connected to the front sump of the WBC sump 81 and the front sump of the RBC sump 82, respectively, by a three-way connection. The solution supplied to the WBC tank 81 and the RBC tank 82 is generally injected into the front tank of the WBC tank 81 and the RBC tank 82, and the solution in the WBC tank 81 and the RBC tank 82 can be uniformly mixed by opening the eighth control valve 43 and then supplying positive pressure to the inside of the WBC tank 81 and the RBC tank 82 by the positive pressure chamber 42.

In one embodiment, the analysis system further comprises a negative pressure structure 5, the negative pressure structure 5 comprising a negative pressure chamber 55, a liquid pump 56, a negative pressure sensor 54, a ninth control valve 51, a tenth control valve 52 and an eleventh control valve 53. The liquid pump 56 is connected to the negative pressure chamber 55 to establish a negative pressure for the negative pressure chamber 55, and the negative pressure sensor 54 is connected to the negative pressure chamber 55 to detect a pressure inside the negative pressure chamber 55 so as to determine whether the pressure inside the negative pressure chamber 55 satisfies a preset negative pressure.

The ninth control valve 51 and the tenth control valve 52 are preferably two-position two-way valves, or the ninth control valve 51 and the tenth control valve 52 can be two-position three-way valves. Wherein, the ninth control valve 51 is connected between the front tank of the WBC tank 81 and the negative pressure chamber 55 through a pipeline, the tenth control valve 52 is communicated between the front tank of the RBC tank 82 and the negative pressure chamber 55 through a pipeline, and when the ninth control valve 51 and the tenth control valve 52 are opened, the WBC tank 81 and the RBC tank 82 can be emptied through the negative pressure action of the negative pressure chamber 55.

The eleventh control valve 53 is connected between the negative pressure chamber 55 and the back cell of the WBC, and can control measurement of the sample liquid.

Specifically, referring to fig. 1 and 2, WBC cell 81 has a WBC front cell 810 and a WBC back cell 811, RBC cell 82 has a RBC front cell 820 and a RBC back cell 821, wherein WBC back cell 811 and WBC front cell 810 can communicate, and WBC back cell 811 has a first outlet 812 and two first liquid outlets 813. The RBC rear tank 821 has a second outlet 822 and two second fluid ports 823, and the seventh control valve 33 is connected to the second outlet 822 through a second pipe 35.

The two second liquid ports 823 and the first outlet 812 are communicated with a three-way joint through three pipelines, the two first liquid ports 813 are also connected with the inlet of the eleventh control valve 53 through three pipelines and a three-way joint, and the outlet of the eleventh control valve 53 is connected with the negative pressure chamber 55. When measurement is required, the eleventh control valve 53 is opened, suction force can be established for the WBC rear cell 811 by the negative pressure in the negative pressure chamber 55, and the sample liquid in the WBC front cell 810 is sucked into the WBC rear cell 811, thereby realizing counting measurement. Because the WBC back cell 811 is communicated with the two second liquid ports 823 of the RBC back cell 821 through the first outlet 812, when the negative pressure chamber 55 provides negative pressure for the WBC back cell 811, negative pressure is also provided for the RBC back cell 821, so that the sample liquid of the RBC front cell 820 can be sucked into the RBC back cell 821, and counting measurement is realized.

When the RBC back pool 821 and the WBC back pool 811 need to be cleaned, the positive pressure of the positive pressure chamber 42 drives the diluent in the diluent pool 100 to enter the RBC back pool 821 to clean the RBC back pool 821, and the diluent can also enter the WBC back pool 811 through the second liquid port 823 of the RBC back pool 821 to clean the WBC back pool 811.

It should be noted that the negative pressure structure 5 further includes a waste liquid tank 57, and the waste liquid tank 57 is connected to the negative pressure chamber 55 through a liquid pump 56. The waste liquid sucked up by the liquid pump 56 can flow into the waste liquid pool 57, and the collection of the waste liquid is realized.

In one embodiment, the analysis system further comprises a swab 70, the swab 70 being capable of cleaning the outer wall of the sample needle. Specifically, one port of the swab 70 can communicate with the inlet of the sixth control valve 32, because the inlet of the sixth control valve 32 communicates with the fifth control valve 31, a three-way connection is also required here to communicate the outlet of the fifth control valve 31, the port of the swab 70, and the inlet of the sixth control valve 32. The sample sucking needle 34 can be inserted into the swab 70, the port of the swab 70 is communicated with the interior of the swab 70, the sixth control valve 32 is opened, and then the diluent in the diluent pool 100 can be driven into the swab 70 under the drive of the positive pressure chamber 42 so as to flush the outer wall of the sample sucking needle 34.

The swab 70 is also provided with another port which is also communicated with the interior of the swab 70, and the port is connected with a twelfth control valve 90 through a pipeline, the twelfth control valve 90 is a two-position two-way valve, another opening of the twelfth control valve 90 is connected with the negative pressure chamber 55 through a pipeline, and waste liquid after the outer wall of the sample suction needle 34 is cleaned in the interior of the swab 70 can be sucked out of the swab 70 through the negative pressure effect of the negative pressure chamber 55.

In addition, the other outlet of the fourth control valve 24 may be connected to the second syringe 12 through the first pipe 25, so that when the first syringe 11 has the diluent therein, the first control valve 21 and the second control valve 22 may be connected, and the second control valve 22 and the fourth control valve 24 may be connected, at the same time, the first syringe 11 and the second syringe 12 may be connected. The fifth control valve 31 is controlled to communicate the second syringe 12 with the sample sucking needle 34, and then the second syringe 12 is pushed, so that the diluent in the first syringe 11 can be conveyed into the second syringe 12, then the diluent can be injected into the sample sucking needle 34 to clean the inner wall of the sample sucking needle 34, the outer wall of the sample sucking needle 34 is cleaned by matching with the swab 70, the inner and outer walls of the sample sucking needle 34 can be cleaned simultaneously, the time for detecting and cleaning the whole system can be reduced, the detection efficiency is increased,

in one embodiment, the solution supply structure 6 mainly includes a hemolysis agent tank 62 and a diluent tank, where the hemolysis agent tank 62 is used for containing hemolysis agent, and the diluent tank is used for containing diluent.

On the other hand, the application also provides an analyzer, which comprises the sample analysis system.

The technical features of the above-described embodiments may be arbitrarily combined, and all possible combinations of the technical features in the above-described embodiments are not described for brevity of description, however, as long as there is no contradiction between the combinations of the technical features, they should be considered as the scope of the description.

The above examples illustrate only a few embodiments of the application, which are described in detail and are not to be construed as limiting the scope of the claims. It should be noted that it will be apparent to those skilled in the art that several variations and modifications can be made without departing from the spirit of the application, which are all within the scope of the application. Accordingly, the scope of protection of the present application is to be determined by the appended claims.

Claims (10)

1. A sample analysis system, comprising:

the detection structure comprises a WBC pool and an RBC pool, wherein the rear pool of the RBC pool is communicated with the rear pool of the WBC pool;

a solution supply structure for supplying a hemolytic agent and a diluent;

a dilution liquid tank capable of storing a dilution liquid;

a first fluid path capable of communicating with the solution supply structure, the dilution liquid tank, and the WBC tank;

the second liquid path is provided with a sample suction needle, and part of the structure of the second liquid path can be used for communicating the dilution liquid pool with the rear pool of the RBC pool;

a positive pressure structure connected to the dilution tank capable of providing positive pressure to the dilution tank to transport liquid within the dilution tank to a rear tank of the RBC tank;

and a duplex syringe comprising a first syringe and a second syringe, the first syringe being connected to the first fluid line such that the first syringe is capable of communicating with the solution supply structure, the dilution liquid pool, and the WBC pool, respectively;

the second injector is connected to the second liquid path so that the second injector can be communicated with the dilution liquid pool and the sample sucking needle respectively.

2. The sample analysis system of claim 1, wherein the first fluid circuit comprises a first control valve, a second control valve, a third control valve, a fourth control valve, and a plurality of first conduits, two of the first control valves being in communication with the port of the second control valve and the solution supply structure, respectively, through the first conduits, the other port of the first control valve being connected to the first syringe, the third control valve and the fourth control valve being connected to the two ports of the second control valve, respectively, two of the third control valves being in communication with the solution supply structure and the WBC reservoir, respectively, through the first conduits, one port of the fourth control valve being in communication with the dilution reservoir.

3. The sample analysis system of claim 1, wherein the second fluid circuit comprises a fifth control valve, a sixth control valve, a seventh control valve, and a plurality of second lines, wherein the fifth control valve, the sixth control valve, and the seventh control valve are capable of communicating sequentially through the second lines, the sample-absorbing needle is connected to one port of the fifth control valve, the other port of the fifth control valve is in communication with the second syringe, one port of the sixth control valve is in communication with the dilution liquid tank, and the port of the seventh control valve is in communication with the back tank of the RBC tank.

4. A sample analysis system according to any one of claims 1 to 3, wherein the positive pressure structure comprises a positive pressure chamber, an air pump, an eighth control valve and a positive pressure sensor, the air pump being connected to the positive pressure chamber to provide positive pressure to the positive pressure chamber, one end of the eighth control valve being connected to the positive pressure chamber, and the other end being connected to the WBC and RBC reservoirs, respectively.

5. The sample analysis system of claim 3, further comprising a negative pressure structure comprising a negative pressure chamber, a liquid pump, a negative pressure sensor, a ninth control valve, a tenth control valve, and an eleventh control valve, the ninth control valve, the tenth control valve being connected between the WBC reservoir and the negative pressure chamber, the RBC reservoir and the negative pressure chamber, respectively, the eleventh control valve being connected between the negative pressure chamber and a back-tank of the WBC, the liquid pump and the negative pressure sensor both being connected to the negative pressure chamber.

6. The sample analysis system of claim 5, wherein the WBC cell has a first outlet and two first fluid ports, the RBC cell has a second outlet and two second fluid ports, the seventh control valve is connected to the second outlet, two second fluid ports are connected to the first outlet, and two first fluid ports are connected to the eleventh control valve.

7. The sample analysis system of claim 5, further comprising a swab for cleaning the sample suction needle, two of the swab openings being connected to the dilution liquid bath and the negative pressure chamber, respectively, a twelfth control valve being provided between the swab and the negative pressure chamber.

8. The sample analysis system of claim 5, wherein the negative pressure structure further comprises a waste reservoir connected to the negative pressure chamber by a liquid pump.

9. The sample analysis system of claim 1, wherein the solution supply structure comprises a hemolysis agent cartridge and a diluent cartridge.

10. An analyser comprising a sample analysis system as claimed in any one of claims 1 to 9.