CN117030419B - Detection method and equipment for measuring radioactive impurities in pertechnetate sodium injection - Google Patents
Detection method and equipment for measuring radioactive impurities in pertechnetate sodium injection Download PDFInfo
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- CN117030419B CN117030419B CN202311007670.1A CN202311007670A CN117030419B CN 117030419 B CN117030419 B CN 117030419B CN 202311007670 A CN202311007670 A CN 202311007670A CN 117030419 B CN117030419 B CN 117030419B
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- fixedly connected
- pertechnetate
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- scintillation
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- 239000012535 impurity Substances 0.000 title claims abstract description 61
- 238000002347 injection Methods 0.000 title claims abstract description 45
- 239000007924 injection Substances 0.000 title claims abstract description 45
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 title claims abstract description 44
- 229910052708 sodium Inorganic materials 0.000 title claims abstract description 44
- 239000011734 sodium Substances 0.000 title claims abstract description 44
- 238000001514 detection method Methods 0.000 title claims abstract description 36
- 230000002285 radioactive effect Effects 0.000 title claims abstract description 36
- 229910052700 potassium Inorganic materials 0.000 claims abstract description 38
- 239000011591 potassium Substances 0.000 claims abstract description 38
- 239000003480 eluent Substances 0.000 claims description 31
- 239000007788 liquid Substances 0.000 claims description 20
- 239000000463 material Substances 0.000 claims description 14
- 239000000243 solution Substances 0.000 claims description 13
- 229930182555 Penicillin Natural products 0.000 claims description 6
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 claims description 6
- 238000004458 analytical method Methods 0.000 claims description 6
- 239000003957 anion exchange resin Substances 0.000 claims description 6
- 150000001450 anions Chemical group 0.000 claims description 6
- 230000000694 effects Effects 0.000 claims description 6
- 238000011010 flushing procedure Methods 0.000 claims description 6
- 229940049954 penicillin Drugs 0.000 claims description 6
- 238000000034 method Methods 0.000 description 6
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 5
- 238000003384 imaging method Methods 0.000 description 3
- 210000001503 joint Anatomy 0.000 description 2
- 238000005096 rolling process Methods 0.000 description 2
- 208000033469 Gastrooesophageal heterotopia Diseases 0.000 description 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000002610 neuroimaging Methods 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 210000003079 salivary gland Anatomy 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- 229910052713 technetium Inorganic materials 0.000 description 1
- GKLVYJBZJHMRIY-UHFFFAOYSA-N technetium atom Chemical compound [Tc] GKLVYJBZJHMRIY-UHFFFAOYSA-N 0.000 description 1
- 210000001685 thyroid gland Anatomy 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/38—Diluting, dispersing or mixing samples
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
- B01F31/20—Mixing the contents of independent containers, e.g. test tubes
- B01F31/26—Mixing the contents of independent containers, e.g. test tubes the containers being submitted to a wobbling movement
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/15—Medicinal preparations ; Physical properties thereof, e.g. dissolubility
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01T—MEASUREMENT OF NUCLEAR OR X-RADIATION
- G01T1/00—Measuring X-radiation, gamma radiation, corpuscular radiation, or cosmic radiation
- G01T1/16—Measuring radiation intensity
- G01T1/20—Measuring radiation intensity with scintillation detectors
- G01T1/204—Measuring radiation intensity with scintillation detectors the detector being a liquid
- G01T1/2042—Composition for liquid scintillation systems
- G01T1/2047—Sample preparation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01T—MEASUREMENT OF NUCLEAR OR X-RADIATION
- G01T1/00—Measuring X-radiation, gamma radiation, corpuscular radiation, or cosmic radiation
- G01T1/36—Measuring spectral distribution of X-rays or of nuclear radiation spectrometry
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
- B01F2101/23—Mixing of laboratory samples e.g. in preparation of analysing or testing properties of materials
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E30/00—Energy generation of nuclear origin
- Y02E30/30—Nuclear fission reactors
Abstract
The invention relates to the technical field of pertechnetate sodium injection detection, in particular to a detection method and equipment for measuring radioactive impurities in pertechnetate sodium injection, comprising a frame body, a plurality of low-potassium scintillation bottles and a shaking mechanism, wherein the shaking mechanism comprises two vertical plates, two shaft bodies, a supporting rod, a vertical rod, a connecting block, a sliding block, a stress piece, a cam and a driving piece, the two vertical plates are fixedly connected with the frame body and are positioned above the frame body, the vertical rod is fixedly connected with the supporting rod, the supporting rod is provided with a plurality of storage tanks, the low-potassium scintillation bottles are respectively arranged in the corresponding storage tanks, the frame body is provided with a sliding chute, the sliding block is in sliding connection with the sliding chute, the driving piece is fixedly connected with the frame body, the output end of the driving piece is fixedly connected with the cam, and the cam is matched with the supporting tank.
Description
Technical Field
The invention relates to the technical field of pertechnetate sodium injection detection, in particular to a detection method and equipment for measuring radioactive impurities in pertechnetate sodium injection.
Background
Pertechnetum [99mTc ]]Sodium sulfate injection for thyroid imaging, brain imaging, salivary gland imaging, ectopic gastric mucosa imaging and technetium-containing preparation 99m Tc]The radioactive drug, pertechnetate sodium injection is colorless clear liquid, and due to the specificity of pertechnetate sodium injection, radioactive impurities in pertechnetate sodium injection need to be detected, and one measurement disclosed in the prior patent publication No. CN113970564AThe detection method of radioactive impurities in pertechnetate sodium injection solves the problems that the traditional decay method has long detection period, the impurities with short half-life also decay in the decay process, the detection method is not suitable for detecting the impurities with short half-life, the detection result is inaccurate, and the [ Tc after decay]There is also a problem that radioactivity affects the detection result of impurities.
However, in the above mode, the eluent needs to be added into the low-potassium scintillation bottle, and the scintillation liquid is added for shaking, so that the existing mode is that shaking is performed manually, and the labor intensity of detection personnel is high.
Disclosure of Invention
The invention aims to provide a detection method and equipment for measuring radioactive impurities in pertechnetate sodium injection, and aims to solve the technical problem that eluent is required to be added into a low-potassium scintillation bottle in the prior art, scintillation liquid is added for shaking, and the existing mode is that shaking is performed manually, so that the labor intensity of detection personnel is high.
In order to achieve the above purpose, the detection device for measuring the radioactive impurities in the pertechnetate sodium injection comprises a frame body, a plurality of low-potassium scintillation bottles and a shaking mechanism, wherein the shaking mechanism comprises two vertical plates, two shaft bodies, a supporting rod, a vertical rod, a connecting block, a sliding block, a stress piece, a cam and a driving piece, the two vertical plates are fixedly connected with the frame body and are positioned above the frame body, one ends of the two shaft bodies are fixedly connected with the supporting rod, the other ends of the two shaft bodies are respectively and rotatably connected with the corresponding vertical plates, the vertical rod is fixedly connected with the supporting rod, a plurality of storage grooves are formed in the supporting rod, the low-potassium scintillation bottles are respectively arranged in the corresponding storage grooves, the frame body is provided with a sliding groove, one end of the connecting block is hinged with the vertical rod, the other end of the connecting block is hinged with the sliding block, the stress piece is fixedly connected with the sliding block, the other end of the connecting block is positioned below the sliding block, the cam is in butt joint with the driving piece, and the driving piece is in butt joint with the fixed groove.
The shaking mechanism further comprises two limiting rings, and the two limiting rings are fixedly connected with the corresponding shaft bodies respectively.
The bearing piece comprises a bearing frame and a connecting plate, wherein the connecting plate is fixedly connected with the sliding block and is positioned below the sliding block, the bearing frame is fixedly connected with the connecting plate, and the supporting groove is formed in the bearing frame.
The driving piece comprises a mounting plate and a first motor, wherein the mounting plate is fixedly connected with the frame body, and the first motor is mounted on the mounting plate.
The detection equipment for measuring the radioactive impurities in the pertechnetate sodium injection further comprises a material taking mechanism, and the material taking mechanism is arranged on the frame body.
The feeding mechanism comprises a support plate, a second motor, a disc, a rod body, a block body, a sliding rod and a feeding plate, wherein one end of the sliding rod is fixedly connected with the feeding plate, the other end of the sliding rod penetrates through the frame body and is fixedly connected with the block body, the block body is provided with a through hole, the second motor is fixed on the frame body through the support plate, the output end of the second motor is fixedly connected with the disc, one end of the rod body is fixedly connected with the disc, and the other end of the rod body is inserted into the through hole.
The invention also provides a detection method for measuring the radioactive impurities in the pertechnetate sodium injection, which is applied to the detection equipment for measuring the radioactive impurities in the pertechnetate sodium injection, and comprises the following steps:
step one: firstly, filling the pretreated anion exchange resin into a 3ml filter column with the height of about 3.5cm, flushing the column with 5ml of 0.9% NaCl-0.1MHCl solution after finishing column filling, standing for later use, and standing for three days by using pertechnetate sodium injection;
step two: transferring 3ml of pertechnetate sodium injection after three days into a filter column, eluting with 2ml of 0.1M HCl solution at room temperature at a flow rate of 2 drops/second, and stopping eluting when 5ml of eluent is collected;
step three: taking 2ml of eluent into a 10ml penicillin bottle, and detecting whether the eluent comprises radioactive impurities of Mo, tc, I and Ru in an anion form by using an energy spectrometer;
step four: adding 2ml of eluent into 20ml of low-potassium scintillation bottle, adding 18ml of scintillation liquid, placing the scintillation liquid into a corresponding storage tank, and driving the low-potassium scintillation bottle to swing through the swing mechanism to swing uniformly;
step five: and (3) standing the shaken low-potassium scintillation bottle in a dark place for 30 minutes, detecting the counting rate of alpha impurities and beta impurities in the eluent by using an alpha/beta analysis method of a liquid scintillation counter, and calculating the activity of the alpha impurities and the beta impurities to finish detection.
The invention relates to a detection method and equipment for measuring radioactive impurities in pertechnetate sodium injection, wherein the shaking mechanism is arranged, when the detection method and equipment are specifically used, firstly, pretreated anion exchange resin is filled into 3ml of filter columns with the height of about 3.5cm, after the column filling is finished, 5ml of 0.9% NaCl-0.1MHCl solution is used for flushing columns for standby, the pertechnetate sodium injection is placed for three days, 3ml of the pertechnetate sodium injection after three days is taken and transferred into the filter columns, 2ml of 0.1M HCl solution is used for eluting at room temperature, the eluting flow rate is 2 drops/second, the eluting is stopped when 5ml of eluent is collected, 2ml of eluent is taken into 10ml of penicillin bottles, whether the radioactive impurities which exist in the form of anions of Mo, tc, I and Ru are included or not is detected by an energy spectrometer, 2ml of eluent is taken into 20ml of low-potassium scintillation bottles, 18ml scintillation liquid is added, and the pertechnetate is placed into corresponding storage tanks, opening the driving piece, driving the cam to rotate, driving the stress piece to move by the cam, driving the sliding block to slide in the sliding groove by the stress piece, driving the two ends of the connecting block to rotate on the sliding block and the vertical rod respectively, driving the vertical rod to rotate while rotating at the two ends of the connecting block, driving the supporting rod to rotate by the vertical rod, driving the two shaft bodies to rotate on the corresponding vertical plates respectively, after the shaft bodies rotate to the designated positions, indirectly driving the supporting rod to rotate towards the other direction when the cam continuously rotates, so that the liquid in the low-potassium scintillation bottle can be uniformly shaken by reciprocation, keeping the low-potassium scintillation bottle after shaking out of light for 30 minutes, detecting the counting rate of alpha impurities and beta impurities in eluent by using a liquid scintillation counter alpha/beta analysis method, and calculate alpha impurity and beta impurity's activity, accomplish the detection to this mode has replaced the manual work to shake evenly, has reduced inspector's intensity of labour, has improved efficiency, and can shake evenly many simultaneously low potassium scintillation bottle.
Drawings
In order to more clearly illustrate the embodiments of the invention or the technical solutions in the prior art, the drawings that are required in the embodiments or the description of the prior art will be briefly described, it being obvious that the drawings in the following description are only some embodiments of the invention, and that other drawings may be obtained according to these drawings without inventive effort for a person skilled in the art.
Fig. 1 is a schematic structural view of a first embodiment of the present invention.
Fig. 2 is a front view of a first embodiment of the present invention.
Fig. 3 is a cross-sectional view of the A-A line structure of fig. 2 in accordance with the present invention.
Fig. 4 is a schematic structural view of a second embodiment of the present invention.
Fig. 5 is a cross-sectional view of a second embodiment of the present invention.
Fig. 6 is a schematic structural view of a third embodiment of the present invention.
FIG. 7 is a flow chart of the steps of the method for detecting radioactive impurities in sodium pertechnetate injection of the present invention.
101-frame body, 102-low potassium scintillation bottle, 103-riser, 104-shaft body, 105-supporting rod, 106-montant, 107-connecting block, 108-slider, 109-cam, 110-spacing ring, 111-stress frame, 112-connecting plate, 113-mounting plate, 114-first motor, 115-chute, 116-storage tank, 117-holding tank, 201-supporting plate, 202-second motor, 203-disc, 204-supporting rod, 205-block, 206-sliding rod, 207-taking plate, 208-through hole, 301-transverse plate, 302-cylinder, 303-bottom plate, 304-caster, 305-guide rod.
Detailed Description
First embodiment:
referring to fig. 1 to 3, fig. 1 is a schematic structural view of a first embodiment of the present invention, fig. 2 is a front view of the first embodiment of the present invention, and fig. 3 is a sectional view of the A-A line structure of fig. 2 of the present invention.
The invention provides a detection device for measuring radioactive impurities in pertechnetate sodium injection, which comprises: including support body 101, many low potassium scintillation bottle 102 and shake even mechanism, shake even mechanism and include two risers 103, two axis body 104, branch 105, montant 106, connecting block 107, slider 108, atress spare, cam 109, driving piece and two spacing rings 110, the atress spare includes atress frame 111 and connecting plate 112, the driving piece includes mounting panel 113 and first motor 114, and the aforesaid scheme has solved among the prior art and has got the eluent and add low potassium scintillation bottle 102 in, adds the scintillation and shakes even, and the current mode is shaking even through the manual work, leads to the higher technical problem of intensity of labour of inspector.
For this embodiment, the frame 101 is used to be placed on the ground for supporting, and the plurality of low-potassium scintillation vials 102 are used to store liquid.
Wherein, two vertical plates 103 are fixedly connected with the frame 101 and are positioned above the frame 101, one ends of two shaft bodies 104 are fixedly connected with the supporting rods 105, the other ends of two shaft bodies 104 are respectively and rotatably connected with the corresponding vertical plates 103, the vertical rods 106 are fixedly connected with the supporting rods 105, a plurality of storage grooves 116 are arranged on the supporting rods 105, a plurality of low-potassium scintillation bottles 102 are respectively arranged in the corresponding storage grooves 116, the frame 101 is provided with a chute 115, the sliding blocks 108 are in sliding connection with the chute 115, one end of a connecting block 107 is hinged with the vertical rods 106, the other end of the connecting block 107 is hinged with the sliding blocks 108, a stress piece is fixedly connected with the sliding blocks 108 and is positioned below the sliding blocks 108, a supporting groove 117 is arranged on the stress piece, a driving piece is fixedly connected with the frame 101, the output end of the driving piece is fixedly connected with the cam 109, the cam 109 is matched with the propping groove 117, by arranging the shaking mechanism, when the device is specifically used, firstly, the pretreated anion exchange resin is filled into 3ml of filter columns with the height of about 3.5cm, after the column is filled, 5ml of 0.9% NaCl-0.1MHCl solution is used for flushing the columns for standby, the sodium pertechnetate injection is placed for three days, 3ml of the sodium pertechnetate injection after three days is taken and transferred into the filter columns, 2ml of 0.1M HCl solution is used for eluting at room temperature, the eluting flow rate is 2 drops/second, 5ml of eluent is collected, 2ml of eluent is taken into 10ml of penicillin bottles, whether the radioactive impurities of Mo, tc, I and Ru exist in the form of anions are included or not is detected by an energy spectrometer, 2ml of eluent is taken into 20ml of low-potassium scintillation bottle 102, 18ml of scintillation liquid is added, and will place in the corresponding storage tank 116, open the driving piece, the driving piece drives the cam 109 rotates, the cam 109 drives the atress piece removes, the atress piece drives the slider 108 slides in spout 115, the slider 108 drives the both ends of connecting block 107 respectively in slider 108 and montant 106 rotate, the both ends of connecting block 107 drive the montant 106 rotates when rotating, montant 106 drives branch 105 rotates, branch 105 drives two the axis body 104 respectively rotate on corresponding riser 103, after the rotation arrives the assigned position, cam 109 continues to rotate the time can indirectly drive branch 105 rotates towards another direction to this reciprocal can shake evenly to low potassium scintillation bottle 102's liquid, keep away from the light and stand 30 minutes with liquid scintillation counter alpha/beta analysis method detects the count rate of alpha impurity and beta impurity in the eluent, and calculate alpha impurity and beta and detect the activity of beta, has accomplished the detection and has reduced the manual work efficiency that has replaced the manual work that shakes the mode, has reduced the scintillation bottle 102 more evenly, has reduced the cost of shaking the personnel simultaneously.
Secondly, the two limiting rings 110 are respectively and fixedly connected with the corresponding shaft bodies 104, and the positions of the two shaft bodies 104 can be limited and fixed by arranging the two limiting rings 110.
Meanwhile, the connecting plate 112 is fixedly connected with the sliding block 108 and is located below the sliding block 108, the stress frame 111 is fixedly connected with the connecting plate 112, the supporting groove 117 is formed in the stress frame 111, and the stress frame 111 can be connected with the sliding block 108 through the connecting plate 112 by arranging the connecting plate 112 and the stress frame 111.
The mounting plate 113 is fixedly connected to the frame 101, the first motor 114 is mounted on the mounting plate 113, and the first motor 114 can be fixed to the frame 101 through the mounting plate 113 by providing the mounting plate 113 and the first motor 114.
By setting the shaking mechanism, in specific use, firstly filling pretreated anion exchange resin into a 3ml filter column with the height of about 3.5cm, flushing the column with 5ml of 0.9% NaCl-0.1MHCl solution after loading, standing for three days, transferring 3ml of sodium pertechnetate injection after standing for three days into the filter column, eluting with 2ml of 0.1M HCl solution at room temperature, eluting at the flow rate of 2 drops/sec, stopping eluting when 5ml of eluent is collected, taking 2ml of eluent into a 10ml penicillin bottle, detecting by an energy spectrometer whether the anion form of the radioactive impurities including Mo, tc, I and Ru exists, taking 2ml of eluent into a 20ml low-potassium scintillation bottle 102, adding 18ml of scintillation liquid, and the driving piece is opened in the corresponding storage groove 116, the driving piece drives the cam 109 to rotate, the cam 109 drives the stressed piece to move, the stressed piece drives the sliding block 108 to slide in the sliding groove 115, the sliding block 108 drives the two ends of the connecting block 107 to rotate on the sliding block 108 and the vertical rod 106 respectively, the two ends of the connecting block 107 drive the vertical rod 106 to rotate while rotating, the vertical rod 106 drives the supporting rod 105 to rotate, the supporting rod 105 drives the two shaft bodies 104 to rotate on the corresponding vertical plates 103 respectively, after the cams 109 rotate to the designated positions, the cams 109 indirectly drive the supporting rod 105 to rotate towards the other direction, so that the liquid of the low-potassium scintillation bottle 102 can be uniformly shaken in a reciprocating manner, the low-potassium scintillation bottle 102 after uniform shaking can be kept away from light for 30 minutes, the alpha/beta analysis method of the liquid scintillation counter is used for detecting the counting rate of alpha impurities and beta impurities in the eluent, calculating the activities of the alpha impurities and the beta impurities and finishing the detection, the mode replaces manual shaking, reduces the labor intensity of detection personnel, improves the efficiency, and can shake a plurality of low-potassium scintillation vials 102 at the same time.
Second embodiment:
referring to fig. 4 and 5 on the basis of the first embodiment, fig. 4 is a schematic structural view of a second embodiment of the present invention, and fig. 5 is a sectional view of the second embodiment of the present invention.
The invention provides detection equipment for measuring radioactive impurities in pertechnetate sodium injection, which also comprises a material taking mechanism, wherein the material taking mechanism comprises a support plate 201, a second motor 202, a disc 203, a rod body 204, a block 205, a slide rod 206 and a material taking plate 207.
For this embodiment, the material taking mechanism is disposed on the frame 101, and by setting the material taking mechanism, the low-potassium scintillation bottle 102 can be more conveniently pushed out after shaking, so as to be convenient for a detector to pick up.
One end of the sliding rod 206 is fixedly connected with the material taking plate 207, the other end of the sliding rod 206 penetrates through the frame 101 and is fixedly connected with the block 205, the block 205 is provided with a through hole 208, the second motor 202 is fixed on the frame 101 through the supporting plate 201, the output end of the second motor 202 is fixedly connected with the disc 203, one end of the rod body 204 is fixedly connected with the disc 203, the other end of the rod body 204 is inserted into the through hole 208, after shaking, the second motor 202 is opened, the output end of the second motor 202 drives the disc 203 to rotate, the disc 203 drives the rod body 204 to slide in the through hole 208, the rod body 204 abuts against the block 205 to move upwards while rotating, the block 205 drives the sliding rod 206 to move upwards, the rod body 206 drives the plate 207 to move upwards, and the low-potassium scintillation material taking plate 207 pushes the low-potassium scintillation bottle 102 out of the corresponding storage groove 116, so that a detector can pick up the material.
With the detection device for measuring radioactive impurities in pertechnetate sodium injection in this embodiment, after shaking is completed, the second motor 202 is turned on, the output end of the second motor 202 drives the disc 203 to rotate, the disc 203 drives the rod 204 to slide in the through hole 208, the rod 204 supports against the block 205 to move upwards while rotating, the block 205 drives the slide bar 206 to move upwards, the slide bar 206 drives the material taking plate 207 to move upwards, and the material taking plate 207 pushes the low-potassium scintillation bottle 102 out of the corresponding storage groove 116, so that detection personnel can pick up the low-potassium scintillation bottle conveniently.
Third embodiment:
referring to fig. 6 on the basis of the second embodiment, fig. 6 is a schematic structural diagram of a third embodiment of the present invention.
The invention provides detection equipment for measuring radioactive impurities in pertechnetate sodium injection, which also comprises a moving assembly, wherein the moving assembly comprises a transverse plate 301, two air cylinders 302, a bottom plate 303, a plurality of casters 304 and a guide rod 305.
For this embodiment, the moving component is disposed on the frame 101, and by setting the moving mechanism, the frame 101 can be moved more conveniently.
The transverse plate 301 is fixedly connected with the frame 101, two air cylinders 302 are mounted on the transverse plate 301, output ends of the two air cylinders 302 are fixedly connected with the bottom plate 303, a plurality of casters 304 are arranged on the bottom plate 303, the frame 101 is pushed to drive the casters 304 to roll on the ground to move the frame 101, after the frame 101 is moved to a designated position, the two air cylinders 302 are opened, the output ends of the two air cylinders 302 drive the bottom plate 303 to move upwards, the bottom plate 303 drives the casters 304 to move upwards, the casters 304 are stored, and the frame 101 is placed on the ground to support, so that the frame 101 can be moved more conveniently, and the casters 304 can be prevented from rolling randomly.
Secondly, one end of the guide rod 305 is fixedly connected with the bottom plate 303, the other end of the guide rod 305 penetrates through the transverse plate 301, and by arranging the guide rod 305, when the bottom plate 303 moves, the bottom plate 303 drives the guide rod 305 to slide on the transverse plate 301, so that the stability of the bottom plate 303 can be improved.
By pushing the frame 101, the frame 101 drives the casters 304 to roll on the ground to move the frame 101, after moving to a designated position, the two cylinders 302 are opened, the output ends of the two cylinders 302 drive the bottom plate 303 to move upwards, the bottom plate 303 drives the casters 304 to move upwards, so that the casters 304 are stored, the frame 101 is placed on the ground to support, in this way, the frame 101 can be moved more conveniently, the casters 304 can be prevented from rolling at will, and by arranging the guide rods 305, when the bottom plate 303 moves, the bottom plate 303 drives the guide rods 305 to slide on the transverse plate 301, so that the stability of the bottom plate 303 can be improved.
Fig. 7 is a flow chart showing steps of the method for detecting radioactive impurities in pertechnetate sodium injection according to the present invention, and the present invention further provides a method for detecting radioactive impurities in pertechnetate sodium injection, which is applied to the above-mentioned detecting device for detecting radioactive impurities in pertechnetate sodium injection, and includes the following steps:
s1: firstly, filling the pretreated anion exchange resin into a 3ml filter column with the height of about 3.5cm, flushing the column with 5ml of 0.9% NaCl-0.1MHCl solution after finishing column filling, standing for later use, and standing for three days by using pertechnetate sodium injection;
s2: transferring 3ml of pertechnetate sodium injection after three days into a filter column, eluting with 2ml of 0.1M HCl solution at room temperature at a flow rate of 2 drops/second, and stopping eluting when 5ml of eluent is collected;
s3: taking 2ml of eluent into a 10ml penicillin bottle, and detecting whether the eluent comprises radioactive impurities of Mo, tc, I and Ru in an anion form by using an energy spectrometer;
s4: 2ml of eluent is taken to 20ml of low-potassium scintillation vial 102, 18ml of scintillation liquid is added, and the eluent is placed in the corresponding storage groove 116, and the low-potassium scintillation vial 102 is driven to swing and shake uniformly through the shaking mechanism;
s5: and (3) standing the shaken low-potassium scintillation vial 102 for 30 minutes in a dark place, detecting the counting rate of alpha impurities and beta impurities in the eluent by using a liquid scintillation counter alpha/beta analysis method, and calculating the activities of the alpha impurities and the beta impurities to finish detection.
The above disclosure is only a preferred embodiment of the present invention, and it should be understood that the scope of the invention is not limited thereto, and those skilled in the art will appreciate that all or part of the procedures described above can be performed according to the equivalent changes of the claims, and still fall within the scope of the present invention.
Claims (7)
1. A detection device for measuring radioactive impurities in pertechnetate sodium injection comprises a frame body and a plurality of low-potassium scintillation bottles, and is characterized in that,
the shaking-up mechanism is also included;
the shaking mechanism comprises two vertical plates, two shaft bodies, a supporting rod, a vertical rod, a connecting block, a sliding block, a stress piece, a cam and a driving piece, wherein the two vertical plates are fixedly connected with the frame body and are respectively located above the frame body, one ends of the two shaft bodies are fixedly connected with the supporting rod, the other ends of the two shaft bodies are respectively and correspondingly connected with the vertical plate in a rotating mode, the vertical rod is fixedly connected with the supporting rod, a plurality of storage tanks are arranged on the supporting rod, a plurality of low-potassium scintillation bottles are respectively arranged in the corresponding storage tanks, the frame body is provided with a sliding groove, the sliding block is in sliding connection with the sliding groove, one end of the connecting block is hinged with the vertical rod, the other end of the connecting block is hinged with the sliding block, the stress piece is fixedly connected with the sliding block and located below the sliding block, the stress piece is provided with a supporting groove, the driving piece is fixedly connected with the frame body, and the output end of the driving piece is fixedly connected with the cam, and the cam is matched with the supporting groove.
2. The detecting device for detecting radioactive impurities in a sodium pertechnetate injection according to claim 1,
the shaking mechanism further comprises two limiting rings, and the two limiting rings are fixedly connected with the corresponding shaft bodies respectively.
3. The detecting device for measuring radioactive impurities in a sodium pertechnetate injection as set forth in claim 2, wherein,
the stress piece comprises a stress frame and a connecting plate, wherein the connecting plate is fixedly connected with the sliding block and is positioned below the sliding block, the stress frame is fixedly connected with the connecting plate, and the supporting groove is formed in the stress frame.
4. The detecting device for measuring radioactive impurities in a sodium pertechnetate injection as defined in claim 3, wherein,
the driving piece comprises a mounting plate and a first motor, wherein the mounting plate is fixedly connected with the frame body, and the first motor is mounted on the mounting plate.
5. The detecting device for detecting radioactive impurities in a sodium pertechnetate injection as claimed in claim 4, wherein,
the detection equipment for measuring the radioactive impurities in the pertechnetate sodium injection further comprises a material taking mechanism, and the material taking mechanism is arranged on the frame body.
6. The detecting device for detecting radioactive impurities in a sodium pertechnetate injection according to claim 5,
the feeding mechanism comprises a support plate, a second motor, a disc, a rod body, a block body, a sliding rod and a feeding plate, wherein one end of the sliding rod is fixedly connected with the feeding plate, the other end of the sliding rod penetrates through the frame body and is fixedly connected with the block body, the block body is provided with a through hole, the second motor is fixed on the frame body through the support plate, the output end of the second motor is fixedly connected with the disc, one end of the rod body is fixedly connected with the disc, and the other end of the rod body is inserted into the through hole.
7. A detection method for measuring radioactive impurities in pertechnetate sodium injection, which is applied to the detection equipment for measuring radioactive impurities in pertechnetate sodium injection according to claim 6, and is characterized by comprising the following steps:
step one: firstly, filling the pretreated anion exchange resin into a 3ml filter column with the height of about 3.5cm, flushing the column with 5ml of 0.9% NaCl-0.1MHCl solution after finishing column filling, standing for later use, and standing for three days by using pertechnetate sodium injection;
step two: transferring 3ml of pertechnetate sodium injection after three days into a filter column, eluting with 2ml of 0.1M HCl solution at room temperature at a flow rate of 2 drops/second, and stopping eluting when 5ml of eluent is collected;
step three: taking 2ml of eluent into a 10ml penicillin bottle, and detecting whether the eluent comprises radioactive impurities of Mo, tc, I and Ru in an anion form by using an energy spectrometer;
step four: adding 2ml of eluent into 20ml of low-potassium scintillation bottle, adding 18ml of scintillation liquid, placing the low-potassium scintillation bottle into a corresponding storage tank, and driving the low-potassium scintillation bottle to swing through the swing mechanism to swing uniformly;
step five: and (3) standing the shaken low-potassium scintillation bottle in a dark place for 30 minutes, detecting the counting rate of alpha impurities and beta impurities in the eluent by using an alpha/beta analysis method of a liquid scintillation counter, and calculating the activity of the alpha impurities and the beta impurities to finish detection.
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