CN215005149U - High-efficient sampling device of liquid chromatogram-tandem mass spectrometer - Google Patents

High-efficient sampling device of liquid chromatogram-tandem mass spectrometer Download PDF

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CN215005149U
CN215005149U CN202120800275.9U CN202120800275U CN215005149U CN 215005149 U CN215005149 U CN 215005149U CN 202120800275 U CN202120800275 U CN 202120800275U CN 215005149 U CN215005149 U CN 215005149U
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sample
pipe
mass spectrometer
tandem mass
sampling
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宗珊盈
赵晓丽
董安辉
周盼
张慧
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Ccic Zhongyuan Nongshi Product Testing Henan Co ltd
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Ccic Zhongyuan Nongshi Product Testing Henan Co ltd
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Abstract

The utility model relates to a liquid chromatogram-tandem mass spectrometer high efficiency sampling device, it includes base and sample injector, base upper surface right side is provided with the laying out dish, evenly be provided with a plurality of laying out groove on the laying out dish, the laying out dish below is provided with the constant head tank, the constant head tank is inside to be provided with the separation post, the separation post right side is provided with the purger, base top left side is provided with the telescopic link, the telescopic link top is provided with the swinging boom, the swinging boom top is provided with the rotating electrical machines, the swinging boom front is provided with two high-pressure pumps, all be provided with the mobile phase pipe below the high-pressure pump, mobile phase pipe left side all is provided with the expansion valve, the high-pressure pump top all is provided with the connecting pipe, the swinging boom right side is provided with telescopic cylinder, telescopic cylinder right side sets up the mount, the mount right side is provided with the sample injector; the utility model has the advantages of simple structure, convenient use, uniform mixing of the sample and the solution and high degree of automation.

Description

High-efficient sampling device of liquid chromatogram-tandem mass spectrometer
Technical Field
The utility model belongs to the technical field of liquid chromatogram-tandem mass spectrometer, concretely relates to liquid chromatogram-tandem mass spectrometer high efficiency sampling device.
Background
The Liquid Chromatography (LC) can effectively separate organic matter components in a sample to be detected of organic matters, the Mass Spectrometer (MS) can analyze the separated organic matters one by one to obtain information of molecular weight, structure (under certain conditions) and concentration (quantitative analysis) of the organic matters, and the liquid chromatography-tandem mass spectrometer has an ESI source and an API source which are rapidly switched, and is mainly used for high-efficiency rapid detection of various medicine and pesticide residues; the working principle of the liquid chromatogram-tandem mass spectrometer is that a mobile phase in a liquid storage device is pumped into a detection system by a high-pressure pump, a sample solution enters the mobile phase through a sample injector and is loaded into a chromatographic column (stationary phase) by the mobile phase, when the sample solution passes through the detector, the concentration of the sample is converted into an electric signal and is transmitted to a recorder, and data outputs a detection result in a map form; therefore, it is very necessary to provide a high-efficiency sample introduction device for a liquid chromatography-tandem mass spectrometer, which has the advantages of simple structure, convenient use, uniform mixing of a sample and a solution, and high automation degree.
Disclosure of Invention
The utility model aims at overcoming the defects of the prior art and providing a high-efficiency sample feeding device of a liquid chromatogram-tandem mass spectrometer, which has simple structure, convenient use, uniform mixing of samples and solution and high automation degree.
The purpose of the utility model is realized like this: a high-efficiency sample introduction device of a liquid chromatography-tandem mass spectrometer comprises a base and a sample introduction device, wherein a sample placing disc is arranged on the right side of the upper surface of the base, a plurality of sample placing grooves are uniformly formed in the sample placing disc, positioning grooves are formed below the sample placing disc, a separation column is arranged in each positioning groove, a cleaning device is arranged on the right side of the separation column, an inlet and an outlet are respectively arranged on the upper side and the lower side of the right side of the cleaning device, an inlet valve and an outlet valve are respectively arranged on the upper side and the lower side of the left side of the cleaning device, an inlet pipe and an outlet pipe are respectively arranged on the left sides of the inlet valve and the outlet valve, a telescopic rod is arranged on the left side above the base, a rotary arm is arranged above the telescopic rod, a rotary motor is arranged above the rotary arm, two high-pressure pumps are arranged in front of the rotary arm, and a mobile phase pipe is arranged below the high-pressure pumps, the left side of the mobile phase pipe is provided with an expansion valve, the upper part of the high-pressure pump is provided with a connecting pipe, the right side of the rotating arm is provided with a telescopic cylinder, the right side of the telescopic cylinder is provided with a fixing frame, the right side of the fixing frame is provided with a sample injector, the lower part of the sample injector is provided with a side groove plate corresponding to the fixing frame, the lower part of the side groove plate is provided with a positioning plate, the right side of the upper part of the side groove plate is provided with a connecting rod, the right side of the connecting rod is provided with an electric control slider, the left side and the right side of the electric control slider are both provided with slide rods, the outer part of the slide rod below the electric control slider is provided with a spring, the middle part of the lower part of the electric control slider is provided with a sampling valve, the lower part of the sampling valve is provided with a sampling pipe, the lower part of the sampling pipe is provided with a sampling needle, and the upper part of the electric control slider is provided with a sample mixing pipe, mix appearance pipe top be provided with the apron, apron top be provided with the motor cabinet, motor cabinet top be provided with and mix the appearance motor, the inside shaft coupling that is provided with of motor cabinet, shaft coupling below be provided with and mix the appearance axle, the appearance axle outside of mixing be provided with and mix the model.
The high-pressure pump pass through the connecting pipe and mix a kind pipe intercommunication, telescopic cylinder pass through the mount and be connected with the side frid, purger left side upper end through advance pipe and detached column intercommunication, left side lower extreme pass through exit tube and detached column intercommunication, slide bar one end be connected with the side frid, the other end and cover connection, the sampling pipe pass through the sampling valve and mix a kind pipe intercommunication, the kind motor that mixes pass through the shaft coupling and mix a kind hub connection.
The sample placing disc is of a fan-shaped structure.
Five rows of the lofting grooves are uniformly arranged on the lofting disc from inside to outside, and two, four, seven, ten and twelve rows of the lofting grooves are uniformly arranged respectively.
The side groove plate is of an L-shaped structure.
The positioning plate is of an O-shaped structure.
The mixing plate is of a spiral structure.
The utility model has the advantages that: the utility model relates to a high-efficiency sample introduction device used by a liquid chromatogram-tandem mass spectrometer, in use, a high-pressure pump is communicated with a liquid storage tank through a mobile phase tube, a sample bottle is placed in a sample introduction groove of a sample introduction plate, a telescopic cylinder adjusts the lateral displacement of a sample introduction device, then a rotary motor drives the sample introduction device to rotate through a rotary arm, a telescopic rod drives the longitudinal displacement of the sample introduction device, a sample introduction device on the sample introduction device sends a sample in the sample bottle into a sample mixing tube through a sampling needle, then the high-pressure pump sends the liquid in the liquid storage tank into a sample mixing tube through the mobile phase tube, the sample mixing motor drives the sample mixing plate to rotate through a sample mixing shaft, the samples in the sample mixing tube are fully and uniformly mixed, the separation effect of the sample mixing solvent in a separation column is improved, the detection quality is improved, the detection efficiency is improved, after the mixing is finished, the sample introduction device of the sample introduction device sends the sample mixing solvent into the separation column through the sampling needle, subsequent detection work is carried out, the whole device is very convenient to use, only a sample bottle needs to be manually placed in the lofting groove, the device can automatically complete sample feeding work, manual excessive intervention is not needed, and the work efficiency is greatly improved; the utility model has the advantages of simple structure, convenient use, uniform mixing of the sample and the solution and high degree of automation.
Drawings
Fig. 1 is a front view of the high-efficiency sample introduction device of the liquid chromatography-tandem mass spectrometer of the present invention.
Fig. 2 is an internal structure schematic diagram of the high-efficiency sample introduction device of the liquid chromatography-tandem mass spectrometer of the utility model.
Fig. 3 is a top view of the base of the high-efficiency sample introduction device for the liquid chromatography-tandem mass spectrometer of the present invention.
Fig. 4 is a partial structural diagram of fig. 2.
Fig. 5 is a partial schematic structural diagram of fig. 2.
In the figure: 1. the device comprises a base 2, a separation column 3, a cleaner 4, an expansion rod 5, a rotating arm 6, a rotating motor 7, a high-pressure pump 8, a mobile phase pipe 9, an expansion valve 10, a connecting pipe 11, a telescopic cylinder 12, a fixing frame 13, a sample injector 14, a lofting disc 15, a lofting groove 16, a positioning groove 17, an inlet 18, an outlet 19, a valve inlet 20, a pipe inlet 21, a pipe outlet 22, a valve outlet 23, a side groove plate 24, a positioning plate 25, a connecting rod 26, an electric control slide block 27, a slide rod 28, a spring 29, a sampling valve 30, a sampling pipe 31, a sampler 32, a sampling needle 33, a sample mixing pipe 34, a cover plate 35, a motor seat 36, a sample mixing motor 37, a coupler 38, a sample mixing shaft 39 and a sample mixing plate.
Detailed Description
The present invention will be further described with reference to the accompanying drawings.
Example 1
As shown in fig. 1-5, a high-efficiency sample introduction device for liquid chromatography-tandem mass spectrometer comprises a base 1 and a sample injector 13, wherein a sample placing disc 14 is arranged on the right side of the upper surface of the base 1, a plurality of sample placing grooves 15 are uniformly arranged on the sample placing disc 14, a positioning groove 16 is arranged below the sample placing disc 14, a separation column 2 is arranged inside the positioning groove 16, a cleaning device 3 is arranged on the right side of the separation column 2, an inlet 17 and an outlet 18 are respectively arranged on the upper side and the lower side of the right side of the cleaning device 3, an inlet valve 19 and an outlet valve 22 are respectively arranged on the upper side and the lower side of the left side of the cleaning device 3, an inlet pipe 20 and an outlet pipe 21 are respectively arranged on the left side of the inlet valve 19 and the outlet valve 22, a telescopic rod 4 is arranged on the left side of the top of the base 1, a rotary arm 5 is arranged above the telescopic rod 5, a rotary motor 6 is arranged above the rotary arm 5, the rotary arm 5 is provided with two high-pressure pumps 7 in front, the lower parts of the high-pressure pumps 7 are provided with mobile phase pipes 8, the left sides of the mobile phase pipes 8 are provided with expansion valves 9, the upper parts of the high-pressure pumps 7 are provided with connecting pipes 10, the right side of the rotary arm 5 is provided with a telescopic cylinder 11, the right side of the telescopic cylinder 11 is provided with a fixing frame 12, the right side of the fixing frame 12 is provided with a sample injector 13, the lower part of the sample injector 13 is provided with a side groove plate 23 corresponding to the fixing frame 12, the lower part of the side groove plate 23 is provided with a positioning plate 24, the right side above the side groove plate 23 is provided with a connecting rod 25, the right side of the connecting rod 25 is provided with an electric control slide block 26, the left side and the right side of the electric control slide block 26 are provided with slide rods 27, the outer parts of the slide rods 27 below the electric control slide block 26 are provided with springs 28, the middle part below the electric control slide block 26 is provided with a sampling valve 29, sampling valve 29 below be provided with sampling pipe 30, sampling pipe 30 below be provided with sampler 31, sampler 31 below be provided with sampling needle 32, automatically controlled slider 26 top be provided with mix appearance pipe 33, mix appearance pipe 33 top be provided with apron 34, apron 34 top be provided with motor cabinet 35, motor cabinet 35 top be provided with mix appearance motor 36, motor cabinet 35 inside be provided with shaft coupling 37, shaft coupling 37 below be provided with mix appearance axle 38, mix appearance axle 38 outside be provided with mix appearance 39.
The utility model relates to a high-efficient sampling device that liquid chromatogram-tandem mass spectrometer used, in use, high-pressure pump 7 communicates with the liquid storage pot through mobile phase pipe 8, place the sample bottle in lofting groove 15 of lofting dish 14, telescopic cylinder 11 adjusts the horizontal displacement of sample injector 13, then rotating electrical machines 6 drives sample injector 13 through swinging boom 5 and rotates, telescopic link 4 drives sample injector 13 vertical displacement, sample sampler 31 on sample injector 13 sends the sample in the sample bottle into mixing tube 33 through sampling tube 30 through sampling needle 32, then high-pressure pump 7 sends the liquid in the liquid storage pot into mixing tube 33 through mobile phase pipe 8, mixing motor 36 drives mixing plate 39 through mixing shaft 38 and rotates, the sample in mixing tube 33 is abundant, the homogeneous mixing, the separation effect of sample mixing solvent in separation column 2 is improved, the detection quality is improved, the detection efficiency is improved, after the mixing is finished, the sampler 31 of the sample injector 13 sends the sample mixed solvent into the separation column 2 through the sampling needle 32 to carry out subsequent detection work, the whole device is very convenient to use, only a sample bottle needs to be manually placed in the lofting groove 15, the device can automatically finish the sample injection work, manual excessive intervention is not needed, and the work efficiency is greatly improved; the utility model has the advantages of simple structure, convenient use, uniform mixing of the sample and the solution and high degree of automation.
Example 2
As shown in fig. 1-5, a high-efficiency sample introduction device for liquid chromatography-tandem mass spectrometer comprises a base 1 and a sample injector 13, wherein a sample placing disc 14 is arranged on the right side of the upper surface of the base 1, a plurality of sample placing grooves 15 are uniformly arranged on the sample placing disc 14, a positioning groove 16 is arranged below the sample placing disc 14, a separation column 2 is arranged inside the positioning groove 16, a cleaning device 3 is arranged on the right side of the separation column 2, an inlet 17 and an outlet 18 are respectively arranged on the upper side and the lower side of the right side of the cleaning device 3, an inlet valve 19 and an outlet valve 22 are respectively arranged on the upper side and the lower side of the left side of the cleaning device 3, an inlet pipe 20 and an outlet pipe 21 are respectively arranged on the left side of the inlet valve 19 and the outlet valve 22, a telescopic rod 4 is arranged on the left side of the top of the base 1, a rotary arm 5 is arranged above the telescopic rod 5, a rotary motor 6 is arranged above the rotary arm 5, the rotary arm 5 is provided with two high-pressure pumps 7 in front, the lower parts of the high-pressure pumps 7 are provided with mobile phase pipes 8, the left sides of the mobile phase pipes 8 are provided with expansion valves 9, the upper parts of the high-pressure pumps 7 are provided with connecting pipes 10, the right side of the rotary arm 5 is provided with a telescopic cylinder 11, the right side of the telescopic cylinder 11 is provided with a fixing frame 12, the right side of the fixing frame 12 is provided with a sample injector 13, the lower part of the sample injector 13 is provided with a side groove plate 23 corresponding to the fixing frame 12, the lower part of the side groove plate 23 is provided with a positioning plate 24, the right side above the side groove plate 23 is provided with a connecting rod 25, the right side of the connecting rod 25 is provided with an electric control slide block 26, the left side and the right side of the electric control slide block 26 are provided with slide rods 27, the outer parts of the slide rods 27 below the electric control slide block 26 are provided with springs 28, the middle part below the electric control slide block 26 is provided with a sampling valve 29, sampling valve 29 below be provided with sampling pipe 30, sampling pipe 30 below be provided with sampler 31, sampler 31 below be provided with sampling needle 32, automatically controlled slider 26 top be provided with mix appearance pipe 33, mix appearance pipe 33 top be provided with apron 34, apron 34 top be provided with motor cabinet 35, motor cabinet 35 top be provided with mix appearance motor 36, motor cabinet 35 inside be provided with shaft coupling 37, shaft coupling 37 below be provided with mix appearance axle 38, mix appearance axle 38 outside be provided with mix appearance 39.
For better effect, high-pressure pump 7 communicate with mixing appearance pipe 33 through connecting pipe 10, telescopic cylinder 11 be connected with side frid 23 through mount 12, purger 3 left side upper end through advancing pipe 20 and separation column 2 intercommunication, the left side lower extreme through exit tube 21 and separation column 2 intercommunication, slide bar 27 one end be connected with side frid 23, the other end is connected with apron 34, sampling pipe 30 pass through sampling valve 31 and mix appearance pipe 33 intercommunication, mix appearance motor 36 pass through shaft coupling 37 and be connected with mixing appearance axle 38.
For better effect, the sample tray 14 has a fan-shaped structure.
For better effect, five rows of the lofting grooves 15 are uniformly arranged on the lofting disc 14 from inside to outside, and two, four, seven, ten and twelve rows are uniformly arranged on the lofting disc.
For better effect, the side slot plate 23 is in an L-shaped structure.
For better effect, the positioning plate 24 has an "O" shape.
For better effect, the sample mixing plate 39 has a spiral structure.
The utility model relates to a high-efficient sampling device that liquid chromatogram-tandem mass spectrometer used, in use, high-pressure pump 7 communicates with the liquid storage pot through mobile phase pipe 8, place the sample bottle in lofting groove 15 of lofting dish 14, telescopic cylinder 11 adjusts the horizontal displacement of sample injector 13, then rotating electrical machines 6 drives sample injector 13 through swinging boom 5 and rotates, telescopic link 4 drives sample injector 13 vertical displacement, sample sampler 31 on sample injector 13 sends the sample in the sample bottle into mixing tube 33 through sampling tube 30 through sampling needle 32, then high-pressure pump 7 sends the liquid in the liquid storage pot into mixing tube 33 through mobile phase pipe 8, mixing motor 36 drives mixing plate 39 through mixing shaft 38 and rotates, the sample in mixing tube 33 is abundant, the homogeneous mixing, the separation effect of sample mixing solvent in separation column 2 is improved, the detection quality is improved, the detection efficiency is improved, after the mixing is finished, the sampler 31 of the sample injector 13 sends the sample mixed solvent into the separation column 2 through the sampling needle 32 to carry out subsequent detection work, the whole device is very convenient to use, only a sample bottle needs to be manually placed in the lofting groove 15, the device can automatically finish the sample injection work, manual excessive intervention is not needed, and the work efficiency is greatly improved; the utility model has the advantages of simple structure, convenient use, uniform mixing of the sample and the solution and high degree of automation.

Claims (7)

1. The utility model provides a high-efficient sampling device of liquid chromatogram-tandem mass spectrometer, it includes base and injector, its characterized in that: the right side of the upper surface of the base is provided with a sample placing disc, the sample placing disc is uniformly provided with a plurality of sample placing grooves, a positioning groove is arranged below the sample placing disc, a separation column is arranged inside the positioning groove, the right side of the separation column is provided with a cleaner, the upper side and the lower side of the right side of the cleaner are respectively provided with an inlet and an outlet, the upper side and the lower side of the left side of the cleaner are respectively provided with an inlet valve and an outlet valve, the left sides of the inlet valve and the outlet valve are respectively provided with an inlet pipe and an outlet pipe, the left side of the upper part of the base is provided with a telescopic rod, a rotary arm is arranged above the telescopic rod, a rotary motor is arranged above the rotary arm, two high-pressure pumps are arranged in front of the rotary arm, a mobile phase pipe is arranged below the high-pressure pumps, an expansion valve is arranged on the left side of the mobile phase pipe, and a connecting pipe is arranged above the high-pressure pumps, the right side of the rotary arm is provided with a telescopic cylinder, the right side of the telescopic cylinder is provided with a fixing frame, the right side of the fixing frame is provided with a sample injector, a side groove plate is arranged below the sample injector corresponding to the fixing frame, a positioning plate is arranged below the side groove plate, a connecting rod is arranged on the right side above the side groove plate, an electric control slider is arranged on the right side of the connecting rod, slide rods are arranged on the left side and the right side of the electric control slider, springs are arranged outside the slide rods below the electric control slider, a sampling valve is arranged in the middle of the lower part of the electric control slider, a sampling pipe is arranged below the sampling valve, a sample injector is arranged below the sampling pipe, a sampling needle is arranged below the sample injector, a sample mixing pipe is arranged above the electric control slider, a cover plate is arranged above the sample mixing pipe, and a motor base is arranged above the cover plate, the motor cabinet top be provided with and mix a kind motor, the inside shaft coupling that is provided with of motor cabinet, shaft coupling below be provided with and mix a kind axle, the outside sample that mixes of axle be provided with and mix the model.
2. The high-efficiency sample introduction device for the liquid chromatography-tandem mass spectrometer as claimed in claim 1, wherein: the high-pressure pump pass through the connecting pipe and mix a kind pipe intercommunication, telescopic cylinder pass through the mount and be connected with the side frid, purger left side upper end through advance pipe and detached column intercommunication, left side lower extreme pass through exit tube and detached column intercommunication, slide bar one end be connected with the side frid, the other end and cover connection, the sampling pipe pass through the sampling valve and mix a kind pipe intercommunication, the kind motor that mixes pass through the shaft coupling and mix a kind hub connection.
3. The high-efficiency sample introduction device for the liquid chromatography-tandem mass spectrometer as claimed in claim 1, wherein: the sample placing disc is of a fan-shaped structure.
4. The high-efficiency sample introduction device for the liquid chromatography-tandem mass spectrometer as claimed in claim 1, wherein: five rows of the lofting grooves are uniformly arranged on the lofting disc from inside to outside, and two, four, seven, ten and twelve rows of the lofting grooves are uniformly arranged respectively.
5. The high-efficiency sample introduction device for the liquid chromatography-tandem mass spectrometer as claimed in claim 1, wherein: the side groove plate is of an L-shaped structure.
6. The high-efficiency sample introduction device for the liquid chromatography-tandem mass spectrometer as claimed in claim 1, wherein: the positioning plate is of an O-shaped structure.
7. The high-efficiency sample introduction device for the liquid chromatography-tandem mass spectrometer as claimed in claim 1, wherein: the mixing plate is of a spiral structure.
CN202120800275.9U 2021-04-19 2021-04-19 High-efficient sampling device of liquid chromatogram-tandem mass spectrometer Active CN215005149U (en)

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CN202120800275.9U CN215005149U (en) 2021-04-19 2021-04-19 High-efficient sampling device of liquid chromatogram-tandem mass spectrometer

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CN202120800275.9U CN215005149U (en) 2021-04-19 2021-04-19 High-efficient sampling device of liquid chromatogram-tandem mass spectrometer

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115524432A (en) * 2022-09-22 2022-12-27 内蒙古仓颉科技有限公司 Intelligent sample separation system of chromatographic analyzer

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115524432A (en) * 2022-09-22 2022-12-27 内蒙古仓颉科技有限公司 Intelligent sample separation system of chromatographic analyzer
CN115524432B (en) * 2022-09-22 2023-10-20 内蒙古仓颉科技有限公司 Chromatographic analyzer intelligent sample separation system

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