CN212180706U

CN212180706U - Sample feeding device for liquid chromatograph-mass spectrometer

Info

Publication number: CN212180706U
Application number: CN202020580976.1U
Authority: CN
Inventors: 李镁娟; 孔娜; 李斌; 景志渊; 吴小燕
Original assignee: Henan Guodebiao Detection Technology Co ltd
Current assignee: Henan Guodebiao Detection Technology Co ltd
Priority date: 2020-04-18
Filing date: 2020-04-18
Publication date: 2020-12-18
Anticipated expiration: 2030-04-18

Abstract

The utility model belongs to the technical field of the chemical analysis instrument and specifically relates to indicate a sampling device for liquid chromatography-mass spectrometer, including base and automatic sampling mechanism, automatic sampling mechanism pass through the mounting bracket with base (1) are connected, be equipped with sample platform and sample platform on the base side by side, sample platform and sample platform are located automatic sampling mechanism's below, sample platform and automatic sampling mechanism pass through the controller electricity and connect. When the instrument needs to carry out sample test, the sample injection platform enters a waiting state, the controller controls the automatic sampling mechanism to move to the position above the sample platform for automatic sampling, and after sampling is completed, the automatic sampling mechanism returns to the position above the sample injection platform for sample injection. The utility model discloses manual sampling device changes the autoinjection into when checking up the instrument, can effectual raising the efficiency to avoid a lot of artificial operation errors.

Description

Sample feeding device for liquid chromatograph-mass spectrometer

Technical Field

The utility model belongs to the technical field of chemical analysis instrument and specifically relates to a sampling device for LC-MS.

Background

Liquid chromatography-mass spectrometry (HPLC-MS) is also called as a liquid chromatography-mass spectrometry technology, and takes liquid chromatography as a separation system and mass spectrometry as a detection system. Separating the sample in the mass spectrum part and the flowing phase, ionizing, separating the ion fragments by mass through a mass analyzer of the mass spectrum, and obtaining a mass spectrogram through a detector. The liquid chromatography-mass spectrometry reflects the complementation of the advantages of the chromatogram and the mass spectrum, combines the advantages of high separation capability of the chromatogram on a complex sample, high selectivity and high sensitivity of MS and capability of providing relative molecular mass and structural information, and is widely applied to a plurality of fields such as pharmaceutical analysis, food analysis, environmental analysis and the like. Development and innovation through modern technology generally all adopt six-way valve autoinjection at the in-process instrument of test sample, but at the start test, or some special samples or still need to use the manual sampling system who is different from big sample test autoinjection system when carrying out the instrument check, manual sampling directly advances the appearance at the mass spectrograph, and it will have many problems in the aspect of the operation to relate to manual sampling, operation error appears, influence final test result, if can also change manual sampling device into autoinjection, just can effectual raising the efficiency, and avoid many people to be operation error.

Disclosure of Invention

The to-be-solved technical problem of the utility model is to provide a sampling device for liquid chromatograph-mass spectrometer, the manual process of advancing that uses when checking the instrument is changed into autoinjection device, can effectual raising the efficiency to avoid a lot of human operating errors, improve the accuracy of test result.

In order to solve the technical problem, the utility model discloses a following technical scheme:

the utility model is used for sampling device of LC-MS, can be used to LC-MS to carry out automatic sampling. The six-way valve of the automatic sample introduction device is communicated with a sample introduction system of the liquid chromatograph-mass spectrometer, and a sample to be analyzed is conveyed to the sample introduction system of the liquid chromatograph-mass spectrometer for analysis after being sampled by the micro injector.

The sample introduction device for the liquid chromatograph-mass spectrometer comprises a base and an automatic sampling mechanism, wherein the automatic sampling mechanism is connected with the base through a mounting frame, a sample introduction table and a sample table are arranged on the base in parallel, the sample introduction table and the sample table are positioned below the automatic sampling mechanism, and the sample introduction table and the automatic sampling mechanism are electrically connected through a controller;

further, automatic sampling mechanism includes fixed mounting and is in the lead screw motor and the fixed mounting of the upper end of mounting bracket are in the horizontal guide holder at mounting bracket middle part, lead screw motor's ball screw level stretches out and threaded connection has the slider, be connected with upper and lower cylinder on the slider, the piston rod of upper and lower cylinder stretches out downwards and is connected with miniature syringe, miniature syringe with horizontal guide holder sliding connection, lead screw motor and upper and lower cylinder all are connected with the controller electricity.

Furthermore, the horizontal guide seat is a bar-shaped seat, a bar-shaped guide hole is vertically formed in the bar-shaped seat, and the micro injector is movably clamped in the bar-shaped guide hole.

Furthermore, the miniature injector comprises a needle cylinder, a push rod and a sampling needle, wherein a small air cylinder is arranged on the push rod and electrically connected with a controller, the needle cylinder is fixedly connected with piston rods of the upper air cylinder and the lower air cylinder, the cylinder wall of the needle cylinder is clamped with the strip-shaped guide hole, and a circle of limiting ring is arranged on the upper portion of the needle cylinder.

Furthermore, the sample platform is including being fixed in the rotation motor on the base, the output shaft that rotates the motor upwards stretches out and is connected with the sample dish, be equipped with a plurality of sample fixing bases on the sample dish, it is a plurality of sample fixing base evenly distributed be in on the circumference of sample dish, it is connected with the controller electricity to rotate the motor.

Furthermore, the sample injection platform comprises a rotating platform, a six-way valve is arranged on the rotating platform, six sample injection ports are arranged on the six-way valve, one of the sample injection ports is right opposite to a needle head of the miniature injector above, and the rotating platform is electrically connected with the controller.

The utility model has the advantages that:

in an actual use situation, when the instrument is tested, when the rotating platform rotates to a required position, the controller controls the automatic sampling system to work, the screw rod motor is started to push the micro injector to move to the position above the sample fixing seat along the guide hole of the horizontal guide seat, the upper air cylinder and the lower air cylinder push the micro injector to move downwards, the needle head is pricked into the sample bottle, the small air cylinder drives the injector piston to suck samples, after the samples are sucked, the upper air cylinder and the lower air cylinder drive the micro injector to lift up, the screw rod motor moves to drive the micro injector to return to the position above the six-way valve, when the injector needle head is aligned with the sample inlet of the six-way valve, the upper air cylinder and the lower air cylinder push the injector downwards, the needle head is pricked into the sample inlet, the small air cylinder pushes the injector piston to inject the samples in. The utility model is used for sampling device of LC-MS, can be used to LC-MS to carry out automatic sampling. The six-way valve of the automatic sample introduction device is communicated with a sample introduction system of the liquid chromatograph-mass spectrometer, and a sample to be analyzed is conveyed to the sample introduction system of the liquid chromatograph-mass spectrometer for analysis after being sampled by the micro injector. The utility model discloses change the direct manual sampling mode of start test into autoinjection device, just can effectual raising the efficiency to avoid a lot of artificial operation errors.

Drawings

Fig. 1 is a schematic view of the overall structure of the present invention.

Description of reference numerals:

1-a base; 11-a mounting frame; 2-a sample introduction channel; 21-a six-way valve; 22-a rotating table; 23-a sample inlet; 3-an automatic sampling mechanism; 31-a controller; 32-a screw motor; 33-upper and lower cylinders; 34-a small cylinder; 35-a micro-injector; 36-horizontal guide seat; 37-a stop collar; 4-sample stage; 41-sample plate; 42-sample holder; 43-rotating the motor.

Detailed Description

In order to facilitate understanding of those skilled in the art, the present invention will be further described with reference to the following examples and drawings, which are not intended to limit the present invention.

As shown in fig. 1, a sample introduction device for a liquid chromatograph-mass spectrometer comprises a base 1 and an automatic sampling mechanism 3, wherein the automatic sampling mechanism 3 is connected with the base 1 through a mounting frame 11, a sample introduction table 2 and a sample table 4 are arranged on the base 1 in parallel, the sample introduction table 2 and the sample table 4 are positioned below the automatic sampling mechanism 3, and the sample introduction table 2 and the automatic sampling mechanism 3 are electrically connected through a controller 31;

automatic sampling mechanism 3 includes fixed mounting and is in the lead screw motor 32 fixed mounting of the upper end of mounting bracket 11 the horizontal guide seat 36 at mounting bracket 11 middle part, the ball screw level of lead screw motor 32 stretches out and threaded connection has the slider, be connected with upper and lower cylinder 33 on the slider, the piston rod of upper and lower cylinder 33 stretches out downwards and is connected with miniature syringe 35, miniature syringe 35 with 36 sliding connection of horizontal guide seat, lead screw motor 32 and upper and lower cylinder 33 all are connected with controller 31 electricity.

In this embodiment, when the instrument needs to be calibrated by a start-up test instrument, the sample injection platform 2 enters a waiting state, the controller 31 controls the automatic sampling mechanism 3 to move to the position above the sample platform 4 for automatic sampling, in actual work, the controller 31 controls the lead screw motor 32 to drive the micro injector 35 to move to the position above a sample to be detected of the sample platform 4 for sample injection, after sample injection is completed, the lead screw motor 32 drives the micro injector 35 to return to a fixed position above the sample injection platform 2, the upper and lower cylinders 33 push the micro injector 35 to complete sample injection, and after completion, the sample injection returns to the original position. The automatic sampling device has the advantages that manual sampling is replaced by automatic sampling, efficiency can be effectively improved, a plurality of manual operation errors are avoided, automatic operation is repeated when the sampling of the same sample is carried out, and the manual errors can be prevented.

As shown in fig. 1, the horizontal guide seat 36 is a bar-shaped seat, a bar-shaped guide hole is vertically formed on the bar-shaped seat, and the micro-syringe 35 is movably clamped in the bar-shaped guide hole. In this embodiment, in order to prevent the micro-injector 35 from rotating along with the movement of the motor, a horizontal guide seat 36 is provided to limit the movement track.

As shown in fig. 1, the micro injector 35 includes a needle cylinder, a push rod and a sampling needle, the push rod is provided with a small cylinder 34 electrically connected to the controller 31, the needle cylinder is fixedly connected to the piston rods of the upper and lower cylinders 33, the wall of the needle cylinder is clamped to the strip-shaped guide hole, and the upper portion of the needle cylinder is provided with a circle of limit ring 37. In this embodiment, small-size cylinder 34 is controlled by controller 31, inhales a kind and annotates a kind work, and the effect dynamics of every turn is the same, can guarantee the accuracy of sample.

As shown in fig. 1, the sample stage 4 includes a rotating motor 43 fixed on the base 1, an output shaft of the rotating motor 43 extends upward to be connected with a sample tray 41, a plurality of sample fixing seats 42 are arranged on the sample tray 41, the plurality of sample fixing seats 42 are uniformly distributed on the circumference of the sample tray 41, and the rotating motor 43 is electrically connected with the controller 31. In this embodiment, after the sample is through the preliminary treatment, pack into the sample bottle and place at sample fixing base 42 internal fixation, during the sampling of sampling mechanism, sample dish 41 rotates along with rotating the motor, and controller 31 control rotates motor 43 and rotates the sample that conveniently awaits measuring and transfer to the sampler below according to setting for the order, and the fixed trench of sample fixing base 42 is placed to wash needle liquid and waste liquid bottle simultaneously, makes things convenient for the sampler to wash after having got the sample at every turn, places the mutual contamination between the sample.

As shown in fig. 1, the sample injection platform 2 includes a rotation platform 22, the rotation platform is provided with a six-way valve 21, the six-way valve 21 is provided with six sample inlets 23, one of the sample inlets 23 is right opposite to the needle of the micro-injector 35, and the rotation platform 22 is electrically connected with the controller 31. In this embodiment, when one of the sample inlets 23 of the six-way valve 21 of the sample injection mechanism 2 rotates to a specific position, the controller controls the micro-injector 35 to perform sample injection.

All technical features in the embodiment can be subjected to appearance modification according to actual needs.

The above-mentioned embodiment is the utility model discloses the implementation scheme of preferred, in addition, the utility model discloses can also realize by other modes, any obvious replacement is all within the protection scope of the utility model under the prerequisite that does not deviate from this technical scheme design.

Claims

1. The utility model provides a sampling device for LC-MS, its characterized in that: the automatic sampling device comprises a base (1) and an automatic sampling mechanism (3), wherein the automatic sampling mechanism (3) is connected with the base (1) through a mounting frame (11), a sample feeding table (2) and a sample table (4) are arranged on the base (1) in parallel, the sample feeding table (2) and the sample table (4) are positioned below the automatic sampling mechanism (3), and the sample feeding table (2) is electrically connected with the automatic sampling mechanism (3) through a controller (31);

automatic sampling mechanism (3) are including fixed mounting screw motor (32) and the fixed mounting of the upper end of mounting bracket (11) are in horizontal guide holder (36) at mounting bracket (11) middle part, the ball screw level of screw motor (32) stretches out and threaded connection has the slider, be connected with upper and lower cylinder (33) on the slider, the piston rod of upper and lower cylinder (33) stretches out downwards and is connected with miniature syringe (35), miniature syringe (35) with horizontal guide holder (36) sliding connection, screw motor (32) and upper and lower cylinder (33) all are connected with controller (31) electricity.

2. The sample introduction device for the LC-MS according to claim 1, wherein: the horizontal guide seat (36) is a strip-shaped seat, a strip-shaped guide hole is vertically formed in the strip-shaped seat, and the micro injector (35) is movably clamped in the strip-shaped guide hole.

3. The sample introduction device for the LC-MS according to claim 2, wherein: the miniature injector (35) comprises a needle cylinder, a push rod and a sampling needle, wherein a small air cylinder (34) is arranged on the push rod and is electrically connected with a controller (31), the needle cylinder is fixedly connected with piston rods of the upper air cylinder and the lower air cylinder (33), the cylinder wall of the needle cylinder is clamped with the strip-shaped guide hole, and the upper part of the needle cylinder is provided with a circle of limiting ring (37).

4. The sample introduction device for the LC-MS according to claim 1, wherein: sample platform (4) is including being fixed in rotation motor (43) on base (1), the output shaft that rotates motor (43) upwards stretches out to be connected with sample dish (41), be equipped with a plurality of sample fixing base (42) on sample dish (41), it is a plurality of sample fixing base (42) evenly distributed is in on the circumference of sample dish (41), it is connected with controller (31) electricity to rotate motor (43).

5. The sample introduction device for the LC-MS according to claim 1, wherein: sample introduction platform (2) is including rotating platform (22), be equipped with six way valve (21) on the rotating platform, be equipped with six introduction port (23) on six way valve (21), one of them introduction port (23) is just to the syringe needle of top micro-injector (35), rotating platform (22) is connected with controller (31) electricity.