CN107184397B - Radiation-proof automatic radiopharmaceutical preparation injection device - Google Patents

Radiation-proof automatic radiopharmaceutical preparation injection device Download PDF

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Publication number
CN107184397B
CN107184397B CN201710585686.9A CN201710585686A CN107184397B CN 107184397 B CN107184397 B CN 107184397B CN 201710585686 A CN201710585686 A CN 201710585686A CN 107184397 B CN107184397 B CN 107184397B
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injection
preparation
injector
extraction
medicine
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CN107184397A (en
Inventor
李思进
刘海燕
崔永萍
张岩波
张会生
刘淳
王宝国
吕锐
李雁杰
武志芳
胡光
秦品乐
王红亮
李莉
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Shanxi Medical University
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Shanxi Medical University
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Priority to PCT/CN2017/112370 priority patent/WO2019015190A1/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/22—Arrangements for transferring or mixing fluids, e.g. from vial to syringe with means for metering the amount of fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2048—Connecting means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2048—Connecting means
    • A61J1/2051—Connecting means having tap means, e.g. tap means activated by sliding
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2048—Connecting means
    • A61J1/2055—Connecting means having gripping means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
    • A61N2005/1019—Sources therefor
    • A61N2005/1021—Radioactive fluid

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Fluid Mechanics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Dermatology (AREA)
  • Medical Informatics (AREA)
  • Anesthesiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

The invention belongs to the technical field of radiopharmaceutical preparation devices, and particularly relates to a radiation-proof radiopharmaceutical automatic preparation injection device which comprises a protective cover, a radiopharmaceutical leaching device, a radiopharmaceutical preparation device, a preparation extraction device and an injection device, wherein the radiopharmaceutical leaching device, the drug preparation device, the preparation extraction device and the injection device are all arranged in the protective cover, and a mechanical claw is further arranged in the protective cover and can move among the radiopharmaceutical leaching device, the radiopharmaceutical preparation device, the preparation extraction device and the injection device. The mechanical claw can replace the operation of workers, so that the automatic operation of medicine production, preparation and injection is realized; the staff protects through the safety cover, avoids unnecessary damage.

Description

Radiation-proof automatic radiopharmaceutical preparation injection device
Technical Field
The invention belongs to the technical field of radiopharmaceutical preparation devices, and particularly relates to a radiation-proof automatic radiopharmaceutical preparation injection device.
Background
Production of radiopharmaceuticals needs to be carried out in a lead protection cabinet with ventilation facilities, and two round holes with doors are arranged on the protection cabinet, so that workers can conveniently stretch hands into the protection cabinet to operate the protection cabinet.
The injection of the radioactive drugs is performed at a special injection window in some cases, and is performed at the bedside, so that during the injection, in order to protect workers, the operation is generally required to be performed behind a protective screen with lead glass, and the workers stretch handles to perform the operation.
Radiopharmaceutical production: the SPECT/CT imaging medicine is used 99 Mo- 99m Tc generator leaching device, fresh leaching out every day 99m TcO 4 - And (4) marking. The general leaching process requires the staff to put the handle into the radiation-proof ventilation kitchen 99 Mo- 99m Normal saline is inserted into a Tc generator leaching device, and an empty penicillin bottle is used for preparing to collect and leach fresh 99m TcO 4 - 。 99 Mo- 99m Fresh rinsed from Tc generator 99m TcO 4 - And (6) marking.
The myocardial perfusion imaging of nuclear medicine SPECT (single photon emission computed tomography) has the commonly used imaging medicine of 99mTc-MIBI (methoxyisobutylacetonitrile) at present, and the preparation process needs to be boiled in boiling water for 15 minutes to mark successfully.
After the radioactive medicines are prepared, the medicines in one penicillin bottle can be distributed to 2-4 patients according to different medicines. And extracting the prepared medicine by using a disposable syringe, placing the medicine into an r-well type detector for measurement after extraction, and then recording the radioactivity data.
Preparation of nuclear medicine imaging injection, whether injection is carried out at a special window or bedside, the medicine is sucked into an injector in a ventilation kitchen, the activity is measured, the name and the dosage of the medicine are recorded by using a marking note, and then the medicine is placed into a professional lead box, and the lead box with the radioactive injector is lifted to the injection window or bedside.
Injection of the radiopharmaceutical: the nuclear medicine imaging injection, whether the injection is carried out at a special window or at the bedside, the lead gloves are generally adopted at present, the operation sensitivity is influenced, and the operation difficulty is increased; or a radiation-proof lead sheath can be used to reduce radiation, but the operation is not easy.
Handling of syringes after radiopharmaceutical injection: for environmental protection, storage tools, storage time and storage of radioactive wastes such as injectors after injection of radioactive drugs during nuclear medicine imaging are critical links whether the storage meets the radioactive waste treatment standard or not.
Production, preparation, injection of radiopharmaceuticals and handling of syringes after injection of the radiopharmaceuticals all suffer from varying degrees of radiation and inconvenience in operation during the procedure.
Disclosure of Invention
Aiming at the technical problems, the invention provides the automatic preparation injection device for the radioprotective radiopharmaceutical, which saves manpower, reduces the radiation of workers, is automatic, avoids artificial random errors, reduces the residue of the radiopharmaceuticals in an injector and protects the environment.
In order to solve the technical problems, the invention adopts the technical scheme that:
the utility model provides a radioprotective radiopharmaceutical automatic preparation injection apparatus, includes safety cover, medicine drip washing device, medicine preparation device, preparation draw-out device and injection device all set up in the safety cover, still be equipped with the gripper in the safety cover, the gripper can remove between medicine drip washing device, medicine preparation device, preparation draw-out device and injection device.
Preferably, the drug eluting device comprises 99 Mo- 99m A Tc generator and a detector, wherein the Tc generator and the detector,by passing 99 Mo- 99m Tc generator for elution of drug and generation of fresh 99m TcO 4 - Solution, detector pair fresh 99m TcO 4 - The solution was measured.
Preferably, the drug preparation device comprises a drug heating device and a drug shaking device.
Preferably, the medicine heating device is an electric furnace wire heating device; the medicine vibrating device comprises a support for placing medicine and a vibrating block, wherein the vibrating block is arranged on the support.
Preferably, the preparation and extraction device comprises a slide rail and an injector pumping device, the injector pumping device is connected with the slide rail in a sliding manner, the injector pumping device comprises a fixed cylinder, a pumping block and a pumping screw rod, the pumping block is connected with the fixed cylinder in a sliding manner, the fixed cylinder is used for fixing the injector, the fixed cylinder is provided with a groove for connecting with a separation blade of an injection cylinder of the injector, the pumping block is provided with a clamping groove connected with an injection end of the injector, the pumping screw rod is connected with the fixed cylinder through threads, and one end of the pumping screw rod is rotationally connected with the pumping block.
Preferably, the injection device comprises two opposite slideways and an injector injection device, the slideways are provided with sliding grooves 421 connected with a blocking plate of an injector injection cylinder, the injector injection device comprises a connecting cylinder, an injection block and an injection screw, the connecting cylinder is provided with an opening, the injection block is provided with a through groove, the injection block is connected with the connecting cylinder in a sliding manner, the injection screw is connected with the connecting cylinder through threads, and one end of the injection screw is rotationally connected with the injection block.
Preferably, a track used for being connected with the medical communicating pipe is arranged above the slideway, and the track is connected with the slideway through a telescopic device.
Preferably, the gripper includes horizontal rail and vertical rail, vertical rail and horizontal rail sliding connection, be equipped with the arm on the vertical rail, the arm passes through telescopic machanism and vertical rail hookup, the arm includes rotating device and fixed disk, rotating device and fixed disk hookup, be equipped with on the fixed disk and can rotate initiative arm and driven arm, can carry out the centre gripping to the medicine bottle through initiative arm and driven arm.
Preferably, a needle taking track and a needle taking device are further arranged in the protective cover, the needle taking device comprises a longitudinal telescopic mechanism and a transverse telescopic mechanism, the longitudinal telescopic mechanism is connected with the transverse telescopic mechanism, and a needle taking claw is arranged on the transverse telescopic mechanism.
Preferably, the bottom of the protective cover is provided with a waste storage device, and the syringe after injection can fall into the waste storage device.
Preferably, the device further comprises a screwing device, wherein the screwing device comprises a screwing mechanism and a connecting rod, and the connecting rod is connected with the screwing mechanism.
Compared with the prior art, the invention has the following beneficial effects:
the medicine leaching device, the medicine preparation device, the preparation extraction device and the injection device are all arranged in the protective cover, and the mechanical claw can move among the medicine leaching device, the medicine preparation device, the preparation extraction device and the injection device. The mechanical claw can replace the operation of workers, so that the automatic operation of medicine production, preparation and injection is realized; the staff protects through the safety cover, avoids the unnecessary damage.
Drawings
FIG. 1 is a schematic structural view of the present invention;
FIG. 2 is a schematic view of the internal structure of the present invention;
FIG. 3 is a schematic diagram of the configuration of a preparative extraction apparatus according to the present invention;
FIG. 4 is a schematic view of the gripper of the present invention;
FIG. 5 is a schematic view of the needle withdrawing device of the present invention;
FIG. 6 is a schematic view of the construction of a drug preparation device of the present invention;
FIG. 7 is a schematic view of the injection device of the present invention;
FIG. 8 is a schematic view of the syringe injection device of the present invention;
FIG. 9 is a schematic view of the use of the syringe injection device of the present invention;
FIG. 10 is a schematic view of the communication tube configuration of the present invention;
FIG. 11 is a schematic view of the chute configuration of the present invention;
wherein: 1 is a medicine leaching device, 10 is 99 Mo- 99m Tc generator, 11 is detector, 2 is drug preparation device, 20 is Tc solution fixing frame, 21 is drug box, 22 is drug heating device, 23 is drug vibration device, 24 is drug dilution storage box, 25 is bracket, 26 is vibration block, 3 is preparation extraction device, 300 is slide rail, 310 is injector extraction device, 311 is fixed barrel, 312 is extraction block, 313 is extraction screw, 314 groove, 315 is slot, 316 is socket, 4 is injection device, 400 is slide rail, 410 is injector injection device, 411 connecting barrel, 412 is injection block, 413 is injection screw, 414 is opening, 415 is through groove, 416 is rail, 417 is telescopic device, 418 is communicating pipe, 419 is connecting plate, 420, 421 is sliding groove, 5 is mechanical claw, 500 is transverse rail, 510 is longitudinal rail, 511 is telescopic mechanism, 512 is rotating device, 513 is fixed disk, 514 is driving arm, 515 is transverse moving arm, 516 is transverse moving device, 600 is needle extraction rail, 610 is needle extraction device, 610 is longitudinal telescopic mechanism, 611 is screw, 611 is transverse telescopic mechanism, 512 is connecting groove, 512 is connecting plate, 800 is connecting rod, and test device is test device, and test device is 100.
Detailed Description
As shown in fig. 1 to 2, an automatic radiation-proof radiopharmaceutical preparation and injection device includes a protective cover 100, a drug leaching device 1, a drug preparation device 2, a preparation extraction device 3, and an injection device 4, wherein the drug leaching device 1, the drug preparation device 2, the preparation extraction device 3, the injection device 4, and a quality detection device 90 are all disposed in the protective cover 100, a gripper 5 is further disposed in the protective cover 100, and the gripper 5 can move among the drug leaching device 1, the drug preparation device 2, the preparation extraction device 3, the injection device 4, and the quality detection device 90.
The protective cover 100 is provided with a through hole 101 and a connecting hole 102, and workers can place or take the injector and the penicillin bottle through the through hole 101; the connection hole 102 is provided at a position corresponding to the injection device 4, and the external injector and the communication pipe 418 (tee) can enter into the protection cap 100 through the slide 400 and the rail 416. A baffle (not shown in the figure) capable of opening and closing can be arranged at each of the through holes 101 and the connecting holes 102, and the through holes 101 and the connecting holes 102 or the through holes 101 and the connecting holes 102 can be blocked by the baffle according to needs.
The medicine leaching device 1 comprises 99 Mo- 99m Tc generator 10 and detector 11, by 99 Mo- 99m The Tc generator 10 effects a leaching of the drug and produces fresh 99m TcO 4 - Solution, probe 11 pair 99m TcO 4 - The solution was measured.
As shown in fig. 6, the medicine preparing apparatus 2 includes a medicine heating apparatus 22, a medicine vibrating apparatus 23, a TC solution holder 20, a medicine cartridge 21, and a medicine dilution storage box 24. The TC solution holder 20 is used for placing a vial containing the TC solution to be eluted. The kit 21 is used for placing vials ready for marking. The drug dilution storage box 24 is used for storing dilution-marked drugs.
The medicine heating device 22 is an electric furnace wire heating device with a timing heating function; the medicine vibration device 23 includes a support 25 for placing the medicine and a vibration block 26, and the vibration block 26 is disposed on the support 25.
As shown in fig. 3, the preparation and extraction device 3 includes a slide rail 300 and syringe pumping devices 310, the syringe pumping devices 310 are slidably coupled with the slide rail 300, and the number of the syringe pumping devices 310 can be set according to actual situations. The injector pumping device 310 comprises a fixed cylinder 311, a pumping block 312 and a pumping screw 313, the pumping block 312 is positioned in the fixed cylinder 311 and is connected with the fixed cylinder 311 in a sliding manner, the fixed cylinder 311 is used for fixing the injector, the fixed cylinder 311 is provided with a groove 314 for connecting with a separation blade of an injector syringe, the pumping block 312 is provided with a clamping groove 315 connected with an injection end of the injector, the pumping screw 313 is connected with the fixed cylinder 311 through threads, one end of the pumping screw 313 is rotationally connected with the pumping block 312, and when the pumping screw 313 rotates, the pumping block 312 cannot rotate along with the pumping screw.
A socket 316 is arranged on one side of the fixed cylinder 311, when in use, the injector is inserted into the fixed cylinder 311 through the socket 316, and a baffle plate arranged on the injection cylinder of the injector enters the groove 314 of the fixed cylinder 311, so that the injection cylinder of the injector is fixed; the injection end of the injector is clamped by a clamping groove 315 arranged on the injection block 312. The pumping and injecting block 312 moves through the rotation of the pumping and injecting screw 313, so that a piston rod of the injector is driven to move, and the medicine is pumped; injection of the drug is achieved by reverse rotation of the pump screw 313.
As shown in fig. 7, the quality detection device 90 is of the same construction as the syringe pump 310; the syringe with the micro-amount of the labeled and diluted drug is withdrawn and then taken out of the protective cap 100 for quality inspection.
As shown in fig. 7 to 11, the injection device 4 includes two opposite slideways 400 and an injector injection device 410, the slideways 400 are provided with sliding grooves 421 connected with the stopper of the injector syringe, the injector injection device 410 includes a connecting cylinder 411, an injection block 412 and an injection screw 413, the connecting cylinder 411 is provided with an opening 414, the injection block 412 is provided with a through groove 415, the injection block 412 is located in the connecting cylinder 411 and is connected with the connecting cylinder 411 in a sliding manner, the injection screw 413 is connected with the connecting cylinder 411 through a screw thread, and one end of the injection screw 413 is rotatably connected with the injection block 412. The number of the syringe injection devices 410 may be set according to actual circumstances.
The injector of the injection device 4 is positioned between the two oppositely arranged slideways 400 and is in sliding connection with the slideways 400, and the baffle plate arranged on the injection cylinder of the injector is in sliding connection with the sliding groove 421 arranged on the slideways 400. The injector injection device 410 is located below the slide 400 and is coupled to the slide 400. When the injector moves along the slide 400, the injection end of the injector is coupled with the injection block 412 through the through groove 415 formed on the injection block 412; the connecting cylinder 411 has openings 414 at both ends thereof so as not to block the piston rod of the syringe and not to affect the movement of the syringe, which can pass through the connecting cylinder 411 and the injection block 412. The injection block 412 is moved by the rotation of the injection screw 413, so that a piston rod of the injector is driven to move, and the medicine is extracted; injection of the drug is achieved by reverse rotation of the injection screw 413. After the injector at the injection device 4 is used up, the used injector can be clamped by the mechanical claw 5 and driven to move along the slide way 400, and after the used injector is separated from the slide way 400, the used injector falls into the waste storage device 700 arranged at the bottom of the protective cover 100 through the mechanical arm, so that the treatment of the injector after the injection of the radioactive drug is realized. The waste storage device 700 is constructed like a drawer to facilitate the removal of the syringe from the waste storage device 700.
The upper end of the chute 400 is provided with a rail 416 for being coupled with a medical communication pipe 418, the rail 416 is provided with a connection groove 420 coupled with the communication pipe 418, the communication pipe 418 is provided with a connection plate 419, and the connection pipe 418 and the rail 416 are slidably coupled by matching the connection plate 419 and the connection groove 420. The rail 416 is coupled to the slide 400 by a pantograph 417, and the distance between the rail 416 and the slide 400 can be varied by the pantograph 417; when an injector is connected in the slide way 400 and the communicating pipe 418 is connected in the track 416, the positions of the injector and the communicating pipe 418 are adjusted through the mechanical claw 5, so that an injection head (without a needle) of the injector is opposite to the communicating pipe 418, the track 416 and the communicating pipe 418 are driven to move downwards through the extension and contraction of the telescopic device 417, the communicating pipe 418 is inserted into the injection head of the injector, and the communicating pipe 418 is communicated with the injector.
As shown in fig. 4, the gripper 5 includes a transverse rail 500 and a longitudinal rail 510, the longitudinal rail 510 is slidably coupled to the transverse rail 500, a moving device is disposed on the longitudinal rail 510, the moving device can realize left and right movement of the longitudinal rail 510 along the transverse rail 500, and the moving device can adopt a gear transmission mechanism, a belt transmission mechanism, a ball screw mechanism or other similar linear moving mechanisms.
The longitudinal rail 510 is provided with a mechanical arm, the mechanical arm is connected with the longitudinal rail 510 through a telescopic mechanism 511, the mechanical arm can be driven to move up and down through the telescopic mechanism 511, the telescopic mechanism 511 is connected with the longitudinal rail 510 in a sliding mode, the telescopic mechanism 511 is provided with a transverse moving device 516, and the transverse moving device 516 can move back and forth along the longitudinal rail 510. The telescopic mechanism 511 may be a cylinder, a hydraulic cylinder, an electric telescopic rod, or the like. The traverse device 516 may employ a gear drive, a belt drive, a ball screw mechanism, or other similar linear movement mechanism.
The mechanical arm comprises a rotating device 512 and a fixed disc 513, the rotating device 512 is connected with the fixed disc 513, a driving arm 514 and a driven arm 515 which can rotate are arranged on the fixed disc 513, the driving arm 514 is connected with the driven arm 515 through a gear, when the driving arm 514 rotates, the driven arm 515 rotates along with the driving arm, the distance between the driving arm 514 and the driven arm 515 changes, the opening and closing of the driving arm 514 and the driven arm 515 are realized by controlling the rotating direction (clockwise or anticlockwise) of the driving arm 514, and the medicine bottle is clamped.
As shown in fig. 5, a needle taking track 600 and a needle taking device 610 are further arranged in the protective cover 100, and the needle taking device 610 is used for taking out a needle head on the syringe. The needle taking device 610 comprises a longitudinal telescopic mechanism 611 and a transverse telescopic mechanism 612, the longitudinal telescopic mechanism 611 is connected with the transverse telescopic mechanism 612, and a needle taking claw 613 is arranged on the transverse telescopic mechanism 612. The needle-taking claw 613 can move up and down and back and forth by the longitudinal telescopic mechanism 611 and the transverse telescopic mechanism. The needle taking mechanism is connected with the needle taking track 600 in a sliding mode, a moving device can be arranged on the longitudinal stretching mechanism 611 to achieve the left and right movement of the longitudinal stretching mechanism 611 along the needle taking track 600, and the moving device can be a gear transmission mechanism, a belt transmission mechanism, a ball screw mechanism or other similar linear moving mechanisms. The longitudinal stretching mechanism 611 and the transverse stretching mechanism 612 can adopt a cylinder, a hydraulic cylinder, an electric stretching rod and other mechanisms.
As shown in fig. 3 and 8, the syringe pumping device 310 and the syringe injection device 410 are respectively provided with a screwing device, the screwing device comprises a screwing mechanism 800 and a connecting rod 810, and the connecting rod 810 is connected with the screwing mechanism 800. The screwing mechanism 800 can drive the pumping screw 313 and the injection screw 413 to rotate. The screwing mechanism 800 is connected with the other end of the pumping screw 313, and the screwing mechanism 800 is connected with the fixed cylinder 311 in a sliding way through a connecting rod 810; the screwing mechanism 800 is coupled to the other end of the injection screw 413, and the screwing mechanism 800 is slidably coupled to the connection cylinder 411 through a connection rod 810. The screwing mechanism 800 may employ a rotating mechanism such as a motor.
The operation process is as follows:
1) An empty 10ml syringe and a 10ml syringe filled with saline are respectively fixed to the two syringe pumps 310 through the through hole 101.
2) A1 ml empty syringe is fixed at the position of the quality detection device 90.
3) And arranging a vial of the medicine box needing to be marked at the position 21 of the medicine box.
And (3) leaching and measuring the drug:
1) According to the conventional work 99 Mo- 99m The Tc generator 10 operates as a rinse. After the leaching is finished, the mechanical claw 5 is adopted to grab 99m TcO 4 - The vial of solution is moved to detector 11 for measurement and the radioactivity data is recorded. From the data and the number of ml, the activity per ml was calculated.
2) After the measurement is finished, the handle is provided with 99m TcO 4 - The vial of penicillin is inserted upside down into the syringe fixed to the syringe pump 310 by the rotating means 512 of the gripper 5. The pumping screw 313 is driven to rotate by the screwing mechanism 800 to pump a proper amount 99m TcO 4 - And (3) solution. After extraction, the mechanical claw 5 removes the penicillin bottle.
3) When the injector draws a proper amount 99m TcO 4 - After the solution is injected into the syringe 99m TcO 4 - The solution is pushed into a vial (moved by the gripper 5 and inserted into the syringe) placed at the drug cassette 21 (by rotating the screwing mechanism 800 in the reverse direction to rotate the pumping screw 313) for drug labeling.
4) The medicine to be heated is held by the gripper 5 to the medicine heating device 22 for heating. After the heating is completed, the device is moved to the medicine vibration device 23 for vibration. The medicine is directly conveyed to the medicine vibrating device 23 without heating for vibrating and mixing.
5) The medicine to be diluted is grasped by a vial of penicillin to a 10ml syringe filled with physiological saline, and a certain amount of physiological saline is pushed in. Marking is accomplished without the need for diluted drug.
Quality control sampling of labeled radiopharmaceuticals:
and grabbing the marked medicine penicillin bottle to the position of the quality detection device 90 by using the mechanical claw 5, extracting a certain amount of medicine, and then taking out the medicine for quality detection. And after the detection is qualified, injecting the medicine.
And (3) radioactive drug injection:
1) A syringe with saline drawn therein and an empty syringe are first pushed into the protective cap 100 through the connection hole 102 and the slide 400.
2) The vial containing the prepared radiopharmaceutical is grasped above the empty syringe by the gripper 5, the amount to be injected is extracted, and then the vial is removed.
3) The communicating tube 418 (t-piece) and the venous indwelling needle are pushed into the boot 100 through the connecting hole 102 and the rail 416, the t-piece is aligned with the two syringes (which are respectively coupled with the syringe injection device 410) by the gripper 5, and the t-piece is coupled with the two syringes by the telescopic device 417.
4) The injection screw 413 is driven to rotate by the screwing mechanism 800, the normal saline is pushed, and after the tee joint and the venous indwelling needle are filled, a worker establishes a venous access for a patient.
5) After the venous access is successfully established, the radiopharmaceutical syringe is advanced by screwing mechanism 800. After the injection is finished, the normal saline injector is pushed again to wash the pipeline and the injection point.
6) After the injection is finished, the venous indwelling needle is pulled out. The post-injection tee and two syringes are moved out of the slide 400 and track 416 by the gripper 5 and fall into the waste storage device 700. When the injection is performed again, the next set of empty syringe, the syringe filled with the normal saline and the three-way pipe are pushed in through the slide way 400 and the track 416 respectively.
7) After all injection operations are completed, the used syringe at the lower part is pushed into the radioactive waste storage device 700 by the gripper 5, and the vial at the upper part is grabbed into the radioactive waste storage device 700 by the gripper 5. Completing the preparation and injection of the medicine.

Claims (7)

1. The utility model provides a radioprotective radiopharmaceutical automatic preparation injection device which characterized in that: the medicine washing device comprises a protective cover (100), a medicine washing device (1), a medicine preparation device (2), a preparation extraction device (3) and an injection device (4), wherein the medicine washing device (1), the medicine preparation device (2), the preparation extraction device (3) and the injection device (4) are all arranged in the protective cover (100), a mechanical claw (5) is further arranged in the protective cover (100), and the mechanical claw (5) can move among the medicine washing device (1), the medicine preparation device (2), the preparation extraction device (3) and the injection device (4);
the injection device (4) comprises two opposite slideways (400) and an injector injection device (410), wherein the slideways (400) are provided with sliding grooves (421) connected with a blocking plate of an injector syringe, the injector injection device (410) comprises a connecting cylinder (411), an injection block (412) and an injection screw (413), the connecting cylinder (411) is provided with an opening (414), the injection block (412) is provided with a through groove (415), the injection block (412) is in sliding connection with the connecting cylinder (411), the injection screw (413) is connected with the connecting cylinder (411) through threads, and one end of the injection screw (413) is in rotating connection with the injection block (412);
a track (416) used for being connected with a medical communicating pipe (418) is arranged above the slideway (400), and the track (416) is connected with the slideway (400) through a telescopic device (417);
the medicine leaching device (1) comprises 99 Mo- 99m Tc generator (10) and detector (11) by 99 Mo- 99m The Tc generator (10) performs elution of the drug and produces fresh 99m TcO 4 - Solution, probe (11) pair 99m TcO 4 - The solution was measured.
2. The radioprotective radiopharmaceutical automatic preparation injection device of claim 1, wherein: the drug preparation device (2) comprises a drug heating device (22) and a drug shaking device (23).
3. The radioprotective radiopharmaceutical automatic preparation injection device of claim 2, wherein: the medicine heating device (22) is an electric furnace wire heating device; the drug vibrating device (23) comprises a bracket (25) for placing the drug and a vibrating block (26), wherein the vibrating block (26) is arranged on the bracket (25).
4. The radioprotective radiopharmaceutical automatic preparation injection device of claim 1, which comprises: the preparation extraction device (3) comprises a sliding rail (300) and an injector extraction device (310), the injector extraction device (310) is connected with the sliding rail (300) in a sliding mode, the injector extraction device (310) comprises a fixed cylinder (311), an extraction block (312) and an extraction screw (313), the extraction block (312) is connected with the fixed cylinder (311) in a sliding mode, the fixed cylinder (311) is used for fixing the injector, a groove (314) used for being connected with a separation blade of an injector injection cylinder is formed in the fixed cylinder (311), a clamping groove (315) connected with an injection end of the injector is formed in the extraction block (312), the extraction screw (313) is connected with the fixed cylinder (311) through threads, and one end of the extraction screw (313) is connected with the extraction block (312) in a rotating mode.
5. The radioprotective radiopharmaceutical automatic preparation injection device of claim 1, which comprises: gripper (5) are including horizontal rail (500) and vertical rail (510), vertical rail (510) and horizontal rail (500) sliding connection, be equipped with the arm on vertical rail (510), the arm passes through telescopic machanism (511) and links with vertical rail (510), the arm includes rotating device (512) and fixed disk (513), rotating device (512) and fixed disk (513) hookup, be equipped with on fixed disk (513) and can rotate initiative arm (514) and driven arm (515), can carry out the centre gripping to the medicine bottle through initiative arm (514) and driven arm (515).
6. The radioprotective radiopharmaceutical automatic preparation injection device of claim 1, which comprises: still be equipped with in safety cover (100) and get needle track (600) and get needle device (610), it includes vertical telescopic machanism (611) and horizontal telescopic machanism (612) to get needle device (610), vertical telescopic machanism (611) and horizontal telescopic machanism (612) hookup, be equipped with on horizontal telescopic machanism (612) and get needle claw (613).
7. The radioprotective radiopharmaceutical automatic preparation injection device of claim 1, which comprises: the bottom of the protective cover (100) is provided with a waste storage device (700), and the injected syringe can fall into the waste storage device (700).
CN201710585686.9A 2017-07-18 2017-07-18 Radiation-proof automatic radiopharmaceutical preparation injection device Active CN107184397B (en)

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Families Citing this family (3)

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Publication number Priority date Publication date Assignee Title
WO2019015190A1 (en) * 2017-07-18 2019-01-24 山西医科大学 Radiation-proof automatic radiopharmaceutical preparation and injection device
CN115400693B (en) * 2022-05-06 2024-05-28 深圳瑞吉生物科技有限公司 Drug synthesis apparatus and method
CN117357731B (en) * 2023-12-08 2024-03-12 四川汉辉盛世医疗科技有限公司 Automatic nuclide feeding device

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105833422A (en) * 2016-03-18 2016-08-10 程大彦 Semi-automatic preparing and injecting system of radioactive medicine

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2673401B2 (en) * 1992-01-30 1997-11-05 株式会社ライティング Injection needle removal device
WO2003037240A1 (en) * 2001-11-02 2003-05-08 Showa Yakuhin Kako Co.,Ltd. Injection needle remover in dental cartridge syringe
TWI238715B (en) * 2004-02-06 2005-09-01 Shr Ji Tau Medicament dispensing and injecting system with radiation protection
CN1810310A (en) * 2005-12-15 2006-08-02 魏川人 Automatic control method for self-destructor of syringe, infusion set and hemostix
CN100522269C (en) * 2006-08-08 2009-08-05 林作钱 Needle retraction type safety injector
JP2009006120A (en) * 2007-06-01 2009-01-15 Terumo Corp Applicator
JP5161622B2 (en) * 2008-03-19 2013-03-13 テルモ株式会社 Needle removal device
CN201171671Y (en) * 2008-04-03 2008-12-31 徐州雷奥医疗设备有限公司 Injection device for diagnosis and treatment of uterus oviduct
KR101559219B1 (en) * 2011-03-25 2015-10-12 가부시키가이샤 유야마 세이사쿠쇼 Co-infusion device
CN102260349A (en) * 2011-07-12 2011-11-30 山西医科大学 Anti-amyloid beta protein (A beta) 31-35 antibody for treating and preventing Alzheimer's disease (AD), and preparation method thereof
CN202179751U (en) * 2011-07-25 2012-04-04 徐州雷奥医疗设备有限公司 Automatic liquid inlet device for medical instrument
CN102793967A (en) * 2012-08-09 2012-11-28 张帆 Intravenous injection method of radiopharmaceutical
CN103768673A (en) * 2014-01-23 2014-05-07 高杨 Automatic medicine dispenser
CN204468703U (en) * 2015-02-09 2015-07-15 吉林大学 Automatization's venous transfusion ampoule class dispensation apparatus
JP6041275B2 (en) * 2015-02-12 2016-12-07 公立大学法人札幌市立大学 Needle removal container
CN205111858U (en) * 2015-10-13 2016-03-30 深圳市桑谷医疗机器人有限公司 Medicine extraction and injection manipulator
CN106668981A (en) * 2015-11-10 2017-05-17 曹宇 Indwelling needle
US10080875B2 (en) * 2015-12-01 2018-09-25 Medtronic Vascular, Inc. Handle component for providing a pressurized material
CN106730306A (en) * 2017-01-04 2017-05-31 山西医科大学 A kind of radiation proof injection device
CN208339789U (en) * 2017-07-18 2019-01-08 山西医科大学 A kind of radiopharmaceutical of radiation protection prepares injection device automatically

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105833422A (en) * 2016-03-18 2016-08-10 程大彦 Semi-automatic preparing and injecting system of radioactive medicine

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