CN107184397A - A kind of radiopharmaceutical of radiation proof prepares injection device automatically - Google Patents
A kind of radiopharmaceutical of radiation proof prepares injection device automatically Download PDFInfo
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- CN107184397A CN107184397A CN201710585686.9A CN201710585686A CN107184397A CN 107184397 A CN107184397 A CN 107184397A CN 201710585686 A CN201710585686 A CN 201710585686A CN 107184397 A CN107184397 A CN 107184397A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/22—Arrangements for transferring or mixing fluids, e.g. from vial to syringe with means for metering the amount of fluid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
- A61J1/2006—Piercing means
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
- A61J1/2048—Connecting means
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
- A61J1/2048—Connecting means
- A61J1/2051—Connecting means having tap means, e.g. tap means activated by sliding
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
- A61J1/2048—Connecting means
- A61J1/2055—Connecting means having gripping means
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
- A61N2005/1019—Sources therefor
- A61N2005/1021—Radioactive fluid
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Fluid Mechanics (AREA)
- Engineering & Computer Science (AREA)
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- Dermatology (AREA)
- Anesthesiology (AREA)
- Medical Informatics (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Pathology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
The invention belongs to radiopharmaceutical preparation facilities technical field; specifically related to a kind of radiopharmaceutical of radiation proof prepares injection device automatically; including protective cover, medicine elution device, pharmaceutical preparation facilities, prepare draw-out device and injection device; the medicine elution device, pharmaceutical preparation facilities, prepare draw-out device and injection device is arranged in protective cover; be additionally provided with gripper in the protective cover, the gripper can in medicine elution device, pharmaceutical preparation facilities, prepare and moved between draw-out device and injection device.Staff can be replaced to operate by gripper, the automation mechanized operation for realize medicine production, preparing, injecting；Staff is protected by protective cover, it is to avoid unnecessary damage.
Description
Technical field
The invention belongs to radiopharmaceutical preparation facilities technical field, and in particular to a kind of radiopharmaceutical of radiation proof is certainly
It is dynamic to prepare injection device.
Background technology
The production of radiopharmaceutical needs to carry out in the lead protection cabinet with ventilation equipment, has two circles above protection cabinet
The hole with door of shape, facilitates staff that both hands are put in and is operated.
The injection of radiopharmaceutical, what is had is carried out in special injection window, and what is had penetrates in bed sidenote, during injection, in order to
Staff is protected, is generally required in the protecting screen for having lead glass followed by operation, hand is extended through operation by staff.
Radiopharmaceutical is produced：SPECT/CT imaging medicaments are to utilize99Mo-99mTc generator elution devices, daily elution
Out fresh99mTcO4 -It is marked.The process typically eluted needs staff that hand is stretched into radiation proof ventilating kitchen,
99Mo-99mInsert physiological saline on Tc generator elution devices, with empty cillin bottle prepare collect elute it is fresh99mTcO4 -。99Mo-99mIt is fresh that Tc generators are eluted99mTcO4 -It is marked.
Nuclear medicine SPECT（Single photon emission computer tomography is imaged）Myocardial perfusion imaging, the imaging medicine commonly used at present
Thing is 99mTc-MIBI（Methoxy isobutyl base acetonitrile）, its preparation process need boiled in boiling water 15 minutes, can just be marked as
Work(.
After radiopharmaceutical is prepared, according to the difference of medicine, the medicine in a cillin bottle can give 2-4 patient
Use.Carried out extracting the medicine prepared with disposable syringe, after taking out, be put into the measurement of r well detectors, then record is put
Penetrating property activity data.
Nuclear medicine image injects the preparation of medicine, is either penetrated in special window injection or bed sidenote, is required for handle
Medicine is pumped into syringe in ventilating kitchen, and measurement activity records medicine name and dosage with marker pen, is then placed into specialty
In lead box, the lead box equipped with radioactive injection device is carried by injection window or bed.
The injection of radiopharmaceutical：Nuclear medicine image is injected, and is either penetrated in special window injection or bed sidenote, mesh
The measure used as previous is band lead gloves, influences the sensitivity of operation, adds operation difficulty；Or inject lead with radiation proof
Set, it is possible to reduce radiation, but operation is difficult.
The processing of syringe after radiopharmaceutical injection：For the protection of environment, radioactivity medicine is injected during nuclear medicine image
Whether the storing utensil of the radwastes such as the syringe after product, resting period, storage reach that Radwastes treatment standard is
Vital link.
The processing of syringe works people in operation after the production of radiopharmaceutical, preparation, injection and drug injection
Member can be by different degrees of radiation and operation inconvenience.
The content of the invention
For above-mentioned technical problem, injection device is prepared automatically the invention provides a kind of radiopharmaceutical of radiation proof,
The device saves manpower, reduces staff's raying, automate, avoid artificial random error, reduce radioactivity in syringe
The residual of medicine, environmental protection.
In order to solve the above-mentioned technical problem, the technical solution adopted by the present invention is：
A kind of radiopharmaceutical of radiation proof prepares injection device, including protective cover, medicine elution device, medicine preparation dress automatically
Put, prepare draw-out device and injection device, the medicine elution device, pharmaceutical preparation facilities, prepare draw-out device and injection dress
Put and be arranged in protective cover, gripper is additionally provided with the protective cover, the gripper can be in medicine elution device, medicine
Preparation facilities, prepare and moved between draw-out device and injection device.
Preferably, the medicine elution device includes99Mo-99mTc generators and detector, pass through99Mo-99mTc occurs
Device carries out the elution of medicine and produced fresh99mTcO4 -Solution, detector is to fresh99mTcO4 -Solution is measured.
Preferably, the pharmaceutical preparation facilities include drug-heating apparatus and medicine shaking device.
Preferably, the drug-heating apparatus is electric furnace heating wire heater；The medicine shaking device includes being used to put
The support and seismic mass of medicine are put, the seismic mass is arranged on support.
Preferably, the draw-out device for preparing includes slide rail and Syringing device, the Syringing device
It is slidably connected with slide rail, the Syringing device includes fixed cylinder, pumping block and pumping screw rod, the pumping block and fixation
Cylinder is slidably connected, and the fixed cylinder is used to fix syringe, and the fixed cylinder, which is provided with, to be used to join with syringe injection tube catch
The groove connect, the pumping block is provided with injects the neck that end couples with syringe, and the pumping screw rod passes through screw thread and fixation
Cylinder connection, described pumping screw rod one end is rotated with pumping block to be coupled.
Preferably, the injection device includes setting on two slideways and syringe injection device being oppositely arranged, slideway
There is the chute 421 coupled with syringe injection tube catch, the syringe injection device includes connecting cylinder, injection block and injection spiral shell
Bar, the connecting cylinder is provided with opening, and the injection block is provided with groove, and the injection block is slidably connected with connecting cylinder, described
Injection screw is coupled by screw thread with connecting cylinder, and described injection screw one end is rotated with injection block to be coupled.
Preferably, being provided with the track for being used for coupling with Medical communicating pipe above the slideway, the track passes through flexible
Device couples with slideway.
Preferably, the gripper includes traverse rod and vertical rail, the vertical rail is slidably connected with traverse rod, set on the vertical rail
There is mechanical arm, the mechanical arm is by telescoping mechanism and vertical rail coupling, and the mechanical arm includes tumbler and fixed disk, described
Tumbler couples with fixed disk, the fixed disk be provided with rotary master arm and slave arm, by master arm and from
Swing arm can be clamped to medicine bottle.
Take pin track preferably, being additionally provided with the protective cover and take needle device, it is described to take needle device to include longitudinal stretch
Contracting mechanism and transversal stretching mechanism, the longitudinal extension mechanism couple with transversal stretching mechanism, are set in the transversal stretching mechanism
Take pin pawl.
Preferably, the protective cover bottom is provided with waste storage device, the syringe after injection can fall into waste storage
In cryopreservation device.
Preferably, also including winding device, the winding device includes screwing mechanism and connecting rod, and the connecting rod is with screwing
Mechanism couples.
The present invention compared with prior art, has an advantageous effect in that：
Medicine elution device, pharmaceutical preparation facilities, prepare draw-out device and injection device is arranged in protective cover, gripper can
With in medicine elution device, pharmaceutical preparation facilities, prepare and moved between draw-out device and injection device.Can generation by gripper
Human users are made in temporary substitute, the automation mechanized operation for realize medicine production, preparing, injecting；Staff is protected by protective cover,
Avoid unnecessary damage.
Brief description of the drawings
Fig. 1 is the structural representation of the present invention；
Fig. 2 is the internal structure schematic diagram of the present invention；
Fig. 3 be the present invention prepare draw-out device structural representation；
Fig. 4 is the gripper structural representation of the present invention；
Fig. 5 be the present invention take needle device structural representation；
Fig. 6 is the pharmaceutical preparation facilities structural representation of the present invention；
Fig. 7 is the injection device structural representation of the present invention；
Fig. 8 is the syringe injection device structural representation of the present invention；
The syringe injection device that Fig. 9 is the present invention uses schematic diagram；
Figure 10 is the communicating tube structure schematic diagram of the present invention；
Figure 11 is the slideway structure schematic diagram of the present invention；
Wherein：1 is medicine elution device, and 10 are99Mo-99mTc generators, 11 be detector, and 2 be pharmaceutical preparation facilities, and 20 are
TC solution fixed mounts, 21 be medicine box, and 22 be drug-heating apparatus, and 23 be medicine shaking device, and 24 be drug dilution case, 25
It is seismic mass for support, 26,3 is prepare draw-out device, and 300 be slide rail, and 310 be Syringing device, and 311 be fixed cylinder,
312 be pumping block, 313 be pumping screw rod, 314 grooves, 315 be neck, and 316 be socket, and 4 be injection device, and 400 be slideway,
410 be syringe injection device, 411 connecting cylinders, 412 be injection block, and 413 be injection screw, and 414 be opening, and 415 be groove,
416 be track, and 417 be retractor device, and 418 be communicating pipe, and 419 be connecting plate, 420 link slots, and 421 be chute, and 5 be machinery
Pawl, 500 be traverse rod, and 510 be vertical rail, and 511 be telescoping mechanism, and 512 be tumbler, and 513 be fixed disk, and 514 be master arm,
515 be slave arm, and 516 be traverse displacement unit, and 600 is take pin track, and 610 is take needle device, and 611 be longitudinal extension mechanism, and 612 are
Transversal stretching mechanism, 613 is take pin pawl, and 700 be waste storage device, and 800 be screwing mechanism, and 810 be connecting rod, and 90 be that quality is examined
Device is surveyed, 100 be protective cover, and 101 be through hole, and 102 be connecting hole.
Embodiment
As shown in Fig. 1~2, a kind of radiopharmaceutical of radiation proof prepares injection device, including protective cover 100, medicine automatically
Thing elution device 1, pharmaceutical preparation facilities 2, prepare draw-out device 3 and injection device 4, medicine elution device 1, pharmaceutical preparation facilities
2nd, draw-out device 3, injection device 4 and quality detection device 90 are prepared to be arranged in protective cover 100, is also set in protective cover 100
Have a gripper 5, gripper 5 can in medicine elution device 1, pharmaceutical preparation facilities 2, prepare draw-out device 3, the and of injection device 4
Moved between quality detection device 90.
Protective cover 100 be provided with through hole 101 and connecting hole 102, staff by through hole 101 can carry out syringe and
The placement of cillin bottle is taken；Connecting hole 102 is arranged at the position corresponding to injection device 4, outer injectors and communicating pipe
418（Three-way pipe）It can be entered by slideway 400 and track 416 in protective cover 100.It can be set at through hole 101 and connecting hole 102
Put the baffle plate that can be opened and closed（Not shown in figure）, through hole 101 and connecting hole 102 or leakage can be blocked by baffle plate as needed
Go out through hole 101 and connecting hole 102.
Medicine elution device 1 includes99Mo-99mTc generators 10 and detector 11, pass through99Mo-99mTc generators 10 are carried out
The elution of medicine is simultaneously produced fresh99mTcO4 -Solution, 11 pairs of detector99mTcO4 -Solution is measured.
As shown in fig. 6, pharmaceutical preparation facilities 2 include drug-heating apparatus 22, medicine shaking device 23, TC solution fixed mounts
20th, medicine box 21 and drug dilution case 24.TC solution fixed mount 20 is used to place the cillin bottle equipped with Tc solution is eluted.
Medicine box 21 is used to place the cillin bottle for preparing mark.Drug dilution case 24 is used to place the medicine that dilution has been marked.
Drug-heating apparatus 22 is the electric furnace heating wire heater with timing heated function；Medicine shaking device 23 includes using
In the support 25 and seismic mass 26 of holding medicine, seismic mass 26 is arranged on support 25.
As shown in figure 3, preparing draw-out device 3 includes slide rail 300 and Syringing device 310, Syringing device
310 are slidably connected with slide rail 300, and the quantity of Syringing device 310 can be set according to actual conditions.Syringing is filled
Putting 310 includes fixed cylinder 311, pumping block 312 and pumping screw rod 313, and pumping block 312 is located in fixed cylinder 311 and and fixed cylinder
311 are slidably connected, and fixed cylinder 311 is used to fix syringe, and fixed cylinder 311, which is provided with, to be used to couple with syringe injection tube catch
Groove 314, pumping block 312 is provided with injects the neck 315 that couple of end with syringe, and pumping screw rod 313 is by screw thread with consolidating
Safety barrel 311 couples, and the one end of pumping screw rod 313 is rotated with pumping block 312 to be coupled, and when pumping screw rod 313 is rotated, pumping block 312 is not
Can concomitant rotation.
The side of fixed cylinder 311 is provided with socket 316, in use, by syringe by socket 316 and the grafting of fixed cylinder 311,
The catch that the injection tube of syringe is provided with enters in the groove 314 of fixed cylinder 311, realizes and the injection tube of syringe is consolidated
It is fixed；The end of injecting of syringe passes through the progress clamping of neck 315 that pumping block 312 is provided with.It is real by the rotation of pumping screw rod 313
The movement of existing pumping block 312, so as to drive the piston rod of syringe to move, realizes the extraction of medicine；Pass through pumping screw rod 313
Rotate backward, realize the injection of medicine.
As shown in fig. 7, quality detection device 90 is used and the identical structure of Syringing device 310；Extract micro mark
Remember, diluted the syringe of medicine, then taken out from protective cover 100 and carry out quality testing.
As shown in Fig. 7~11, injection device 4 includes two slideways 400 and syringe injection device 410 being oppositely arranged,
Slideway 400 is provided with the chute 421 that couple with syringe injection tube catch, syringe injection device 410 including connecting cylinder 411,
Injection block 412 and injection screw 413, connecting cylinder 411 are provided with opening 414, and injection block 412 is provided with groove 415, injection block
412 are located in connecting cylinder 411 and are slidably connected with connecting cylinder 411, and injection screw 413 is coupled by screw thread with connecting cylinder 411, note
Penetrate the one end of screw rod 413 and rotated with injection block 412 and coupled.The quantity of syringe injection device 410 can be set according to actual conditions.
Syringe at injection device 4 is located between two slideways 400 being oppositely arranged, and is slidably connected with slideway 400,
The chute 421 that the catch that the injection tube of syringe is provided with is provided with slideway 400 is slidably connected.Syringe injection device 410
Couple positioned at the lower section of slideway 400 and with slideway 400.When syringe is moved along slideway 400, the end of injecting of syringe can be by note
The groove 415 that block 412 is provided with is penetrated with injection block 412 to couple；The two ends of connecting cylinder 411 are provided with opening 414, will not block injection
The piston rod of device, does not interfere with the movement of syringe, and syringe can pass through connecting cylinder 411 and injection block 412.By injecting spiral shell
The movement of injection block 412 is realized in the rotation of bar 413, so as to drive the piston rod of syringe to move, realizes the extraction of medicine；Pass through
Rotating backward for injection screw 413, realizes the injection of medicine.After syringe at injection device 4 has been used, machine can be passed through
Syringe after 5 pairs of uses of machinery claw is clamped and drives it to be moved along slideway 400, and the syringe after use departs from slideway 400
Afterwards, the syringe after is fallen into provided with waste storage device 700 by the bottom of protective cover 100 by manipulator, realizes radiation
The processing of syringe after property drug injection.Waste storage device 700 is easy to waste storage device using the structure of drawer-like
700 inner injectors take out.
The upper end of slideway 400 is provided with the track 416 for being used for coupling with Medical communicating pipe 418, and track 416 is provided with connecting
The link slot 420 that pipe 418 couples, communicating pipe 418 is provided with connecting plate 419, and is matched somebody with somebody by the connecting plate 419 and link slot 420
Close and realize being slidably connected for communicating pipe 418 and track 416.Track 416 is coupled by retractor device 417 with slideway 400, track
Distance between 416 and slideway 400 can be changed by retractor device 417；Syringe and rail are connected to when slideway 400 is inline
Road 416 is inline to be connected to after communicating pipe 418, and the position of syringe and communicating pipe 418 is adjusted by gripper 5, makes injection
The injection head of device（Without syringe needle）It is relative with communicating pipe 418, pass through the telescopic band dynamic rail road 416 of retractor device 417 and communicating pipe 418
Movement is moved down, and is made the injection head grafting of communicating pipe 418 and syringe, is realized the connection of communicating pipe 418 and syringe.
As shown in figure 4, gripper 5 includes traverse rod 500 and vertical rail 510, vertical rail 510 is slidably connected with traverse rod 500, indulges rail
510 are provided with mobile device, and vertical the moving left and right along traverse rod 500 of rail 510 can be realized by mobile device, and mobile device can be with
Using gear drive, belt gear, ball screw framework or other line-like travel mechanisms.
Vertical rail 510 is provided with mechanical arm, and mechanical arm is coupled by telescoping mechanism 511 with vertical rail 510, passes through telescoping mechanism
511 can moving up and down with driving mechanical arm, telescoping mechanism 511 is slidably connected with vertical rail 510, and telescoping mechanism 511 is provided with horizontal stroke
Moving device 516, and realized by traverse displacement unit 516 along the movable of vertical rail 510.Telescoping mechanism 511 can use cylinder, liquid
The mechanisms such as cylinder pressure, electric expansion bar.Traverse displacement unit 516 can use gear drive, belt gear, ball-screw machine
Structure or other line-like travel mechanisms.
Mechanical arm includes tumbler 512 and fixed disk 513, and tumbler 512 couples with fixed disk 513, fixed disk 513
Rotary master arm 514 and slave arm 515 are provided with, master arm 514 and slave arm 515 are coupled by gear, when actively
When arm 514 is rotated, the distance that slave arm 515 also can be between concomitant rotation, and master arm 514 and slave arm 515 can change,
By the direction of rotation for controlling master arm 514（Clockwise or counterclockwise）, the folding of master arm 514 and slave arm 515 is realized, it is real
Now medicine bottle is clamped.
Take pin track 600 as shown in figure 5, being additionally provided with protective cover 100 and take needle device 610, take needle device 610 to be used to pull out
Take the syringe needle on syringe.Needle device 610 is taken to include longitudinal extension mechanism 611 and transversal stretching mechanism 612, longitudinal extension mechanism
611 couple with transversal stretching mechanism 612, and transversal stretching mechanism 612 is provided with and takes pin pawl 613.Pass through the He of longitudinal extension mechanism 611
Transversal stretching mechanism, which can be realized, to be taken pin pawl about 613, moves forward and backward.Qu Zhen mechanisms, can with taking pin track 600 to be slidably connected
To set mobile device in longitudinal extension mechanism 611, longitudinal extension mechanism 611 is realized along taking moving left and right for pin track 600,
Mobile device can use gear drive, belt gear, ball screw framework or other line-like moving machines
Structure.Longitudinal extension mechanism 611 and transversal stretching mechanism 612 can be using mechanisms such as cylinder, hydraulic cylinder, electric expansion bars.
As shown in figs. 3 and 8, winding device is respectively equipped with Syringing device 310 and syringe injection device 410,
Winding device includes screwing mechanism 800 and connecting rod 810, and connecting rod 810 couples with screwing mechanism 800.Can be with by screwing mechanism 800
Pumping screw rod 313, injection screw 413 is driven to rotate.Screwing mechanism 800 couples with the other end of pumping screw rod 313, screwing mechanism
800 are slidably connected by connecting rod 810 with fixed cylinder 311；Screwing mechanism 800 couples with the other end of injection screw 413, tightening machine
Structure 800 is slidably connected by connecting rod 810 with connecting cylinder 411.Screwing mechanism 800 can be using rotating mechanisms such as motors.
Operating process is as follows：
1）By through hole 101, fix an empty 10ml syringe respectively on two Syringing devices 310 and one is taken out
The 10ml syringes of full physiological saline.
2）A 1ml empty syringe is fixed at quality detection device 90.
3）Placement needs the medicine box cillin bottle marked at medicine box 21.
Medicine is eluted and measured：
1）Carried out according to routine work99Mo-99mTc generators 10 elute work.Wait after the completion of eluting, captured using gripper 5
It is equipped with99mTcO4 -The cillin bottle of solution and being moved at detector 11 is measured, and records radioactive activity data.According to data
With ml numbers, the radioactive activity in per ml is calculated.
2）After being measured, being equipped with99mTcO4 -The cillin bottle of solution is inverted by the tumbler 512 of gripper 5 and inserted
On the syringe that Syringing device 310 is fixed.Drive pumping screw rod 313 to rotate by screwing mechanism 800, extract and fit
Amount99mTcO4 -Solution.Gripper 5 removes cillin bottle after extraction.
3）Device to be injected extracts appropriate99mTcO4 -After solution, in syringe99mTcO4 -Solution is pushed into（Pass through tightening machine
Structure 800, which is reversely rotated, drives pumping screw rod 313 to rotate）The cillin bottle being placed with medicine box 21（Moved by gripper 5 and insert note
In emitter）Interior carry out drug labelling.
4）The medicine of heating is needed, is caught and is heated at drug-heating apparatus 22 using gripper 5.After the completion of heating,
It is moved at medicine shaking device 23 and is shaken.What need not be heated is directly mixed to progress vibrations at medicine shaking device 23
It is even.
5）The medicine of dilution is needed, cillin bottle is caught at the 10ml syringes for pumping full physiological saline, is pushed into a certain amount of
Physiological saline.The medicine that need not be diluted, that is, complete mark.
The quality control sampling of the radiopharmaceutical marked：
The medicine cillin bottle marked, caught using gripper 5 at quality detection device 90, extract a certain amount of medicine, so
Take out afterwards and carry out quality testing.After detection is qualified, drug injection is carried out.
Radiopharmaceutical injection：
1）First the syringe and an empty syringe for pumping physiological saline, it is pushed into by connecting hole 102 and slideway 400
In protective cover 100.
2）The cillin bottle equipped with the radiopharmaceutical prepared, caught by gripper 5 above sky syringe, extracting needs
The amount to be injected, then removes cillin bottle.
3）Communicating pipe 418（Three-way pipe）And venous detaining needle is pushed into protective cover 100 by connecting hole 102 and track 416
It is interior, using gripper 5 by three-way pipe and two syringes（Two syringes couple with syringe injection device 410 respectively）It is right
Standard, makes three-way pipe couple with two syringes by retractor device 417.
4）Drive injection screw 413 to rotate by screwing mechanism 800, promote physiological saline, threeway to be full of and vein are stayed
Put after pin, staff sets up venous channel to patient.
5）After venous channel is successfully established, radiopharmaceutical syringe is promoted by screwing mechanism 800.After the completion of injection,
Physiological saline device, flushing pipe and injection point are promoted again.
6）After the completion of injection, venous detaining needle is extracted.Three-way pipe and two syringes are removed after being injected by gripper 5
Slideway 400 and track 416, and fall into waste storage device 700.When injecting again, pass through slideway 400 and track 416 respectively
A set of empty syringe and syringe and three-way pipe equipped with physiological saline under push-in.
7）After after all injection end-of-jobs, the used syringe of lower section is pushed into radwaste by gripper 5
In storage device 700, the cillin bottle of top is grabbed in radwaste storage device 700 by gripper 5.Complete medicine preparation
And injection.
Claims (10)
1. a kind of radiopharmaceutical of radiation proof prepares injection device automatically, it is characterised in that：Including protective cover（100）, medicine
Elution device（1）, pharmaceutical preparation facilities（2）, prepare draw-out device（3）And injection device（4）, the medicine elution device（1）、
Pharmaceutical preparation facilities（2）, prepare draw-out device（3）And injection device（4）It is arranged at protective cover（100）It is interior, the protective cover
（100）Inside it is additionally provided with gripper（5）, the gripper（5）Can be in medicine elution device（1）, pharmaceutical preparation facilities（2）, system
Standby draw-out device（3）And injection device（4）Between move.
2. a kind of radiopharmaceutical of radiation proof according to claim 1 prepares injection device automatically, it is characterised in that：Institute
State medicine elution device（1）Including99Mo-99mTc generators（10）And detector（11）, pass through99Mo-99mTc generators（10）Enter
The elution of row medicine is simultaneously produced fresh99mTcO4 -Solution, detector（11）It is right99mTcO4 -Solution is measured.
3. a kind of radiopharmaceutical of radiation proof according to claim 1 prepares injection device automatically, it is characterised in that：Institute
State pharmaceutical preparation facilities（2）Including drug-heating apparatus（22）With medicine shaking device（23）.
4. a kind of radiopharmaceutical of radiation proof according to claim 3 prepares injection device automatically, it is characterised in that：Institute
State drug-heating apparatus（22）For electric furnace heating wire heater；The medicine shaking device（23）Including the support for holding medicine
（25）And seismic mass（26）, the seismic mass（26）It is arranged on support（25）On.
5. a kind of radiopharmaceutical of radiation proof according to claim 1 prepares injection device automatically, it is characterised in that：Institute
State and prepare draw-out device（3）Including slide rail（300）With Syringing device（310）, the Syringing device（310）With
Slide rail（300）It is slidably connected, the Syringing device（310）Including fixed cylinder（311）, pumping block（312）With pumping spiral shell
Bar（313）, the pumping block（312）With fixed cylinder（311）It is slidably connected, the fixed cylinder（311）For fixing syringe, institute
State fixed cylinder（311）It is provided with the groove for being used for coupling with syringe injection tube catch（314）, the pumping block（312）On set
Have and inject the neck that end couples with syringe（315）, the pumping screw rod（313）Pass through screw thread and fixed cylinder（311）Connection, institute
State pumping screw rod（313）One end and pumping block（312）Rotate connection.
6. a kind of radiopharmaceutical of radiation proof according to claim 1 prepares injection device automatically, it is characterised in that：Institute
State injection device（4）Including two slideways being oppositely arranged（400）With syringe injection device（410）, slideway（400）It is provided with
The chute coupled with syringe injection tube catch（421）, the syringe injection device（410）Including connecting cylinder（411）, injection
Block（412）And injection screw（413）, the connecting cylinder（411）It is provided with opening（414）, the injection block（412）Provided with logical
Groove（415）, the injection block（412）With connecting cylinder（411）It is slidably connected, the injection screw（413）By screw thread with being connected
Cylinder（411）Connection, the injection screw（413）One end and injection block（412）Rotate connection.
7. a kind of radiopharmaceutical of radiation proof according to claim 6 prepares injection device automatically, it is characterised in that：Institute
State slideway（400）Top, which is provided with, to be used for and Medical communicating pipe（418）The track of connection（416）, the track（416）By flexible
Device（417）With slideway（400）Connection.
8. a kind of radiopharmaceutical of radiation proof according to claim 1 prepares injection device automatically, it is characterised in that：Institute
State gripper（5）Including traverse rod（500）With vertical rail（510）, the vertical rail（510）With traverse rod（500）It is slidably connected, the vertical rail
（510）Mechanical arm is provided with, the mechanical arm passes through telescoping mechanism（511）With vertical rail（510）Connection, the mechanical arm includes turning
Dynamic device（512）And fixed disk（513）, the tumbler（512）With fixed disk（513）Connection, the fixed disk（513）On
Provided with rotary master arm（514）And slave arm（515）, pass through master arm（514）And slave arm（515）Can be to medicine bottle
Clamped.
9. a kind of radiopharmaceutical of radiation proof according to claim 1 prepares injection device automatically, it is characterised in that：Institute
State protective cover（100）Inside it is additionally provided with and takes pin track（600）With take needle device（610）, it is described to take needle device（610）Stretched including longitudinal direction
Contracting mechanism（611）With transversal stretching mechanism（612）, the longitudinal extension mechanism（611）With transversal stretching mechanism（612）Connection,
The transversal stretching mechanism（612）It is provided with and takes pin pawl（613）.
10. a kind of radiopharmaceutical of radiation proof according to claim 1 prepares injection device automatically, it is characterised in that：
The protective cover（100）Bottom is provided with waste storage device（700）, the syringe after injection can fall into waste storage device
（700）It is interior.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710585686.9A CN107184397B (en) | 2017-07-18 | 2017-07-18 | Radiation-proof automatic radiopharmaceutical preparation injection device |
| PCT/CN2017/112370 WO2019015190A1 (en) | 2017-07-18 | 2017-11-22 | Radiation-proof automatic radiopharmaceutical preparation and injection device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710585686.9A CN107184397B (en) | 2017-07-18 | 2017-07-18 | Radiation-proof automatic radiopharmaceutical preparation injection device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN107184397A true CN107184397A (en) | 2017-09-22 |
| CN107184397B CN107184397B (en) | 2023-04-14 |
Family
ID=59882553
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710585686.9A Active CN107184397B (en) | 2017-07-18 | 2017-07-18 | Radiation-proof automatic radiopharmaceutical preparation injection device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107184397B (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019015190A1 (en) * | 2017-07-18 | 2019-01-24 | 山西医科大学 | Radiation-proof automatic radiopharmaceutical preparation and injection device |
| CN115400693A (en) * | 2022-05-06 | 2022-11-29 | 深圳市瑞吉生物科技有限公司 | Drug synthesis apparatus and method |
| CN117357731A (en) * | 2023-12-08 | 2024-01-09 | 四川汉辉盛世医疗科技有限公司 | Automatic nuclide feeding device |
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