WO2019015190A1 - Radiation-proof automatic radiopharmaceutical preparation and injection device - Google Patents

Radiation-proof automatic radiopharmaceutical preparation and injection device Download PDF

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Publication number
WO2019015190A1
WO2019015190A1 PCT/CN2017/112370 CN2017112370W WO2019015190A1 WO 2019015190 A1 WO2019015190 A1 WO 2019015190A1 CN 2017112370 W CN2017112370 W CN 2017112370W WO 2019015190 A1 WO2019015190 A1 WO 2019015190A1
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WO
WIPO (PCT)
Prior art keywords
drug
injection
syringe
preparation
coupled
Prior art date
Application number
PCT/CN2017/112370
Other languages
French (fr)
Chinese (zh)
Inventor
李思进
刘海燕
胡光
Original Assignee
山西医科大学
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CN201710585686.9A external-priority patent/CN107184397B/en
Priority claimed from CN201720870640.7U external-priority patent/CN208339789U/en
Application filed by 山西医科大学 filed Critical 山西医科大学
Publication of WO2019015190A1 publication Critical patent/WO2019015190A1/en

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    • GPHYSICS
    • G21NUCLEAR PHYSICS; NUCLEAR ENGINEERING
    • G21FPROTECTION AGAINST X-RADIATION, GAMMA RADIATION, CORPUSCULAR RADIATION OR PARTICLE BOMBARDMENT; TREATING RADIOACTIVELY CONTAMINATED MATERIAL; DECONTAMINATION ARRANGEMENTS THEREFOR
    • G21F5/00Transportable or portable shielded containers
    • G21F5/015Transportable or portable shielded containers for storing radioactive sources, e.g. source carriers for irradiation units; Radioisotope containers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/1407Infusion of two or more substances
    • A61M5/1409Infusion of two or more substances in series, e.g. first substance passing through container holding second substance, e.g. reconstitution systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/1785Syringes comprising radioactive shield means
    • GPHYSICS
    • G21NUCLEAR PHYSICS; NUCLEAR ENGINEERING
    • G21GCONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
    • G21G1/00Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
    • G21G1/0005Isotope delivery systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M2005/1401Functional features
    • A61M2005/1403Flushing or purging
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M2005/3114Filling or refilling
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/20Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/2066Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically comprising means for injection of two or more media, e.g. by mixing

Definitions

  • the invention belongs to the technical field of radiopharmaceutical preparation devices, and particularly relates to an anti-radiation radiopharmaceutical automatic preparation injection device.
  • the production of radiopharmaceuticals needs to be carried out in a lead-protected cabinet with ventilation.
  • the protective cabinet has two circular holes with doors to allow the staff to put their hands in for operation.
  • radiopharmaceuticals are carried out in a special injection window, and some are injected at the bedside.
  • it is generally necessary to operate behind the protective screen with lead glass, and the staff hands up and operate.
  • Radiopharmaceutical production SPECT/CT imaging drugs were labeled with fresh 99m TcO 4 - eluted daily using a 99 Mo- 99m Tc generator rinse device.
  • the general rinsing process requires the staff to reach into the radiation-proof ventilator, insert physiological saline into the 99 Mo- 99m Tc generator rinsing device, and use an empty vial to collect and collect the fresh 99m TcO 4 - rinsed.
  • the 99 Mo- 99m Tc generator was rinsed with fresh 99m TcO 4 - for labeling.
  • Nuclear medicine SPECT single photon emission computed tomography
  • 99mTc-MIBI methoxy isobutyl acetonitrile
  • the drug in a vial can be divided into 2-4 patients depending on the drug.
  • the prepared drug is extracted with a disposable syringe, and after being pumped, it is placed in an r-type detector for measurement, and then the activity data is recorded.
  • Preparation of nuclear medicine imaging injections requires the drug to be drawn into the syringe in a ventilated kitchen, measuring activity, recording the drug name and dosage with a marker, and then placing it in a professional Inside the lead box, pry the lead box containing the radioactive syringe to the injection window or bedside.
  • nuclear medicine imaging injection whether it is in special window injection or bedside injection
  • the current commonly used measures are lead gloves, affecting the sensitivity of the operation, increasing the operation Difficulty; or radiation-proof injection of lead sets, can reduce radiation, but the operation is not easy.
  • Radioactive waste such as syringes after injection of radiopharmaceuticals during nuclear medicine imaging, storage time, and storage of radioactive waste treatment standards are essential.
  • the production, preparation, injection, and treatment of the syringe after drug injection are all subject to varying degrees of radiation and inconvenient operation during operation.
  • the present invention provides an anti-radiation radiopharmaceutical automatic preparation injection device, which saves manpower, reduces radiation exposure, automation, avoids artificial random errors, reduces residual radioactive drugs in the syringe, and protects the environment.
  • the technical solution adopted by the present invention is:
  • An anti-radiation radiopharmaceutical automatic preparation injection device comprises a protective cover, a drug eluting device, a drug preparing device, a preparation extracting device and an injecting device, wherein the drug eluting device, the drug preparing device, the preparing extracting device and the injecting device are both It is disposed in the protective cover, and the protective cover is further provided with a mechanical claw, and the mechanical claw can be moved between the drug eluting device, the medicine preparing device, the preparation extracting device and the injection device.
  • the medicament comprises a rinsing device 99 Mo- 99m Tc generators and detectors, rinse the drug by 99 Mo- 99m Tc generator and producing fresh 99m TcO 4 - solution, fresh detector 99m TcO 4 - The solution is measured.
  • the drug preparation device comprises a drug heating device and a drug vibration device.
  • the drug heating device is an electric wire heating device;
  • the drug vibration device includes a holder for placing a drug and a vibration block, and the vibration block is disposed on the holder.
  • said preparation extraction device comprises a slide rail and a syringe pumping device, said syringe pumping device being slidably coupled to a slide rail, said syringe pumping device comprising a fixed cylinder, a pumping block and a pumping screw, said pumping
  • the injection block is slidably coupled to the fixed cylinder for fixing the syringe
  • the fixed cylinder is provided with a groove for coupling with the syringe barrel block
  • the pumping block is provided with a syringe push end
  • the pumping screw is coupled to the fixed cylinder by a thread, and one end of the pumping screw is rotatably coupled to the pumping block.
  • the injection device comprises two oppositely disposed slides and a syringe injection device, the slide being provided with a chute 421 coupled to the syringe barrel stop, the syringe injection device comprising a connecting barrel, an injection block and an injection screw
  • the connecting barrel is provided with an opening
  • the injection block is provided with a through slot
  • the injection block is slidably coupled with the connecting barrel
  • the injection screw is coupled with the connecting barrel by a thread
  • the injection screw is rotated at one end and the injection block Join.
  • a track for coupling with the medical communication tube is provided above the slide, and the track is coupled to the slide by a telescopic device.
  • the mechanical claw comprises a transverse rail and a longitudinal rail
  • the longitudinal rail is slidably coupled with the cross rail
  • the longitudinal rail is provided with a mechanical arm
  • the mechanical arm is coupled with the longitudinal rail by a telescopic mechanism, the mechanical arm
  • the rotating device and the fixed disc are coupled to the fixed disc.
  • the fixed disc is provided with a rotatable active arm and a driven arm, and the medicine bottle can be clamped by the active arm and the driven arm.
  • the protective cover is further provided with a needle taking track and a needle taking device, wherein the needle picking device comprises a longitudinal telescopic mechanism and a lateral telescopic mechanism, and the longitudinal telescopic mechanism is coupled with a lateral telescopic mechanism, and the transverse telescopic mechanism is There are needles for picking up.
  • the needle picking device comprises a longitudinal telescopic mechanism and a lateral telescopic mechanism
  • the longitudinal telescopic mechanism is coupled with a lateral telescopic mechanism
  • the transverse telescopic mechanism is There are needles for picking up.
  • the bottom of the protective cover is provided with a waste storage device, and the injected syringe can fall into the waste storage device.
  • a tightening device is also included, the tightening device including a tightening mechanism and a link coupled to the tightening mechanism.
  • the invention has the following beneficial effects:
  • the drug rinsing device, the drug preparation device, the preparation extraction device, and the injection device are all disposed in a protective cover, and the mechanical claw can be moved between the drug rinsing device, the drug preparation device, the preparation extraction device, and the injection device.
  • the mechanical claw can replace the operation of the staff to realize the automatic operation of drug production, preparation and injection; the worker protects through the protective cover to avoid unnecessary damage.
  • Figure 1 is a schematic view of the structure of the present invention
  • Figure 2 is a schematic view of the internal structure of the present invention.
  • Figure 3 is a schematic view showing the structure of the preparation extracting device of the present invention.
  • Figure 4 is a schematic view showing the structure of the mechanical claw of the present invention.
  • Figure 5 is a schematic structural view of the needle removing device of the present invention.
  • Figure 6 is a schematic structural view of a drug preparation device of the present invention.
  • Figure 7 is a schematic structural view of an injection device of the present invention.
  • Figure 8 is a schematic structural view of a syringe injection device of the present invention.
  • Figure 9 is a schematic view showing the use of the syringe injection device of the present invention.
  • Figure 10 is a schematic structural view of a connecting pipe of the present invention.
  • Figure 11 is a schematic view showing the structure of the slide of the present invention.
  • 1 is a drug rinsing device
  • 10 is a 99 Mo- 99m Tc generator
  • 11 is a detector
  • 2 is a drug preparation device
  • 20 is a TC solution holder
  • 21 is a medicine box
  • 22 is a drug heating device
  • 23 is Drug vibration device
  • 24 is a drug dilution storage box
  • 25 is a bracket
  • 26 is a vibration block
  • 3 is a preparation extraction device
  • 300 is a slide rail
  • 310 is a syringe pumping device
  • 311 is a fixed cylinder
  • 312 is a pumping block
  • 313 For the suction screw, 314 groove, 315 is the card slot
  • 316 is the socket
  • 4 is the injection device
  • 400 is the slide
  • 410 is the syringe injection device
  • 411 is connected to the barrel
  • 412 is the injection block
  • 413 is the injection screw
  • 414 is Opening
  • 415 is a through slot
  • 416 is
  • 511 is a telescopic mechanism
  • 512 is a rotating device
  • 513 is a fixed disc
  • 514 is an active arm
  • 515 is a follower arm
  • 516 is a traverse device
  • 600 is a needle taking track
  • 610 is a needle taking device
  • 611 is a longitudinal telescopic mechanism
  • 612 is a lateral telescopic mechanism
  • 613 is a needle removing claw
  • 700 is a waste storage device
  • 800 is a tightening mechanism.
  • Connecting rod 810, the quality detection means 90, the protective cover 100, a through hole 101, 102 is a connection hole.
  • an anti-radiation radiopharmaceutical automatic preparation injection device comprises a protective cover 100, a drug eluting device 1, a drug preparing device 2, a preparation extracting device 3 and an injecting device 4, and a drug eluting device 1
  • the medicine preparation device 2, the preparation extraction device 3, the injection device 4 and the quality detecting device 90 are all disposed in the protective cover 100.
  • the protective cover 100 is further provided with a mechanical claw 5, and the mechanical claw 5 can be used in the drug eluting device 1.
  • the preparation device 2, the preparation extraction device 3, the injection device 4, and the mass detection device 90 are moved.
  • the protective cover 100 is provided with a through hole 101 and a connecting hole 102.
  • the worker can perform the setting or taking of the syringe and the vial through the through hole 101; the connecting hole 102 is disposed at a position corresponding to the injection device 4,
  • An external syringe and communication tube 418 (three-way tube) can enter the protective cover 100 through the slide 400 and the track 416.
  • a baffle (not shown) that can be opened and closed may be disposed at the through hole 101 and the connecting hole 102, and the through hole 101 and the connecting hole 102 may be blocked by the baffle or the through hole 101 and the connecting hole 102 may be leaked as needed.
  • the medicine preparation device 2 includes a medicine heating device 22, a medicine vibration device 23, a TC solution holder 20, a medicine cartridge 21, and a drug dilution storage box 24.
  • the TC solution holder 20 is used to place a vial containing the rinsed Tc solution.
  • the kit 21 is used to place a vial ready for labeling.
  • the drug dilution storage box 24 is used to place the diluted labeled drug.
  • the drug heating device 22 is an electric wire heating device with a timing heating function; the drug vibration device 23 includes a holder 25 for placing a drug and a vibration block 26, and the vibration block 26 is disposed on the holder 25.
  • the preparation extraction device 3 includes a slide rail 300 and a syringe pumping device 310.
  • the syringe pumping device 310 is slidably coupled to the slide rail 300.
  • the number of the syringe pumping devices 310 can be set according to actual conditions.
  • the syringe pumping device 310 includes a fixed cylinder 311, a pumping block 312 and a pumping screw 313.
  • the pumping block 312 is located in the fixed cylinder 311 and is slidably coupled with the fixed cylinder 311.
  • the fixing cylinder 311 is used for fixing the syringe, and the fixing cylinder 311 is provided. There is a groove 314 for coupling with the syringe barrel block.
  • the pumping block 312 is provided with a card slot 315 coupled to the syringe push end.
  • the pumping screw 313 is coupled to the fixed barrel 311 by a thread, and the pumping screw 313 is provided with one end.
  • the pumping block 312 is rotationally coupled, and when the pumping screw 313 is rotated, the pumping block 312 does not rotate with it.
  • One side of the fixing cylinder 311 is provided with a socket 316.
  • the syringe is inserted into the fixing cylinder 311 through the socket 316, and the blocking piece provided on the syringe barrel of the syringe enters the recess 314 of the fixing cylinder 311 to realize the syringe.
  • the syringe is fixed; the push end of the syringe is engaged by a card slot 315 provided on the drawer block 312.
  • the movement of the suction block 312 is realized by the rotation of the suction screw 313, thereby driving the piston rod of the syringe to move, and the medicine is extracted; and the injection of the medicine is realized by the reverse rotation of the suction screw 313.
  • the mass detecting device 90 employs the same structure as the syringe pumping device 310; a syringe that is well-labeled and diluted with a drug is taken out, and then taken out from the protective cover 100 for quality inspection.
  • the injection device 4 includes two oppositely disposed slides 400 and syringe injections.
  • the device 410 has a sliding slot 421 coupled to the syringe barrel block.
  • the syringe injection device 410 includes a connecting barrel 411, an injection block 412 and an injection screw 413.
  • the connecting barrel 411 is provided with an opening 414, and the injection block 412 is provided.
  • a through slot 415 is defined.
  • the injection block 412 is located in the connecting cylinder 411 and is slidably coupled to the connecting cylinder 411.
  • the injection screw 413 is coupled to the connecting cylinder 411 by threads, and one end of the injection screw 413 is rotatably coupled to the injection block 412.
  • the number of syringe injection devices 410 can be set according to actual conditions.
  • the syringe at the injection device 4 is located between the two oppositely disposed slides 400 and is slidably coupled to the slide 400.
  • the flap provided on the syringe of the syringe is slidably coupled to the sliding groove 421 provided on the slide 400.
  • the syringe injection device 410 is located below the slideway 400 and coupled to the slideway 400.
  • the push end of the syringe is coupled to the injection block 412 through a through slot 415 provided in the injection block 412; the ends of the connection barrel 411 are provided with an opening 414 that does not block the piston rod of the syringe Without affecting the movement of the syringe, the syringe can pass through the connecting barrel 411 and the injection block 412.
  • the movement of the injection block 412 is realized by the rotation of the injection screw 413, thereby driving the piston rod of the syringe to move the medicine, and the medicine is injected by the reverse rotation of the injection screw 413.
  • the used syringe can be clamped by the mechanical claw 5 and driven to move along the slide 400. After the used syringe is separated from the slide 400, the used syringe is used by the robot.
  • the bottom of the protective cover 100 is disposed in the waste storage device 700 to realize the treatment of the syringe after the radiopharmaceutical injection.
  • the waste storage device 700 employs a drawer-like structure to facilitate removal of the syringe within the waste storage device 700.
  • the upper end of the slideway 400 is provided with a rail 416 for coupling with the medical communication tube 418.
  • the rail 416 is provided with a connecting slot 420 coupled to the connecting tube 418.
  • the connecting tube 418 is provided with a connecting plate 419, and through the connecting plate 419 The connecting groove 420 cooperates to realize the sliding connection of the communication pipe 418 and the rail 416.
  • the rail 416 is coupled to the slide rail 400 by the telescopic device 417. The distance between the rail 416 and the slide rail 400 can be changed by the telescopic device 417.
  • the position of the syringe and the communication tube 418 is adjusted by the mechanical claw 5 so that the injection head (without the needle) of the syringe is opposed to the communication tube 418, and the telescopic device 417 telescopically drives the rail 416 and the communication tube 418 to move downward, so that the communication tube 418 is moved.
  • the injection head of the syringe is inserted to realize communication between the communication tube 418 and the syringe.
  • the mechanical claw 5 includes a cross rail 500 and a longitudinal rail 510.
  • the longitudinal rail 510 is slidably coupled to the cross rail 500.
  • the vertical rail 510 is provided with a moving device.
  • the vertical rail 510 can be realized along the cross rail 500 by the moving device.
  • the mobile device can adopt a gear transmission mechanism, a belt transmission mechanism, a ball screw mechanism or the like.
  • the longitudinal rail 510 is provided with a mechanical arm.
  • the mechanical arm is coupled to the longitudinal rail 510 through the telescopic mechanism 511.
  • the telescopic mechanism 511 can drive the upper and lower movement of the mechanical arm.
  • the telescopic mechanism 511 is slidably coupled with the longitudinal rail 510.
  • the telescopic mechanism 511 is provided with a horizontal cross.
  • the device 516 is moved and moved back and forth along the longitudinal rail 510 by the traverse device 516.
  • the telescopic mechanism 511 can employ a mechanism such as a cylinder, a hydraulic cylinder, or an electric telescopic rod.
  • the traverse device 516 can employ a gearing mechanism, a belt drive mechanism, a ball screw mechanism, or other similar linear movement mechanism.
  • the mechanical arm includes a rotating device 512 and a fixed plate 513.
  • the rotating device 512 is coupled to the fixed plate 513.
  • the fixed plate 513 is provided with a rotatable active arm 514 and a driven arm 515.
  • the active arm 514 and the driven arm 515 are coupled by gears.
  • the follower arm 515 When the active arm 514 rotates, the follower arm 515 also rotates, and the distance between the active arm 514 and the driven arm 515 changes, by controlling the rotational direction of the active arm 514 (clockwise or counterclockwise).
  • the opening and closing of the active arm 514 and the follower arm 515 realizes clamping of the vial.
  • the protective cover 100 is further provided with a needle take-up rail 600 and a needle taking device 610 for picking up the needle on the syringe.
  • the needle taking device 610 includes a longitudinal telescopic mechanism 611 and a lateral telescopic mechanism 612.
  • the longitudinal telescopic mechanism 611 is coupled to the lateral telescopic mechanism 612, and the lateral telescopic mechanism 612 is provided with a picking claw 613.
  • the up and down movement of the needle removing claw 613 can be realized by the longitudinal stretching mechanism 611 and the lateral expansion mechanism.
  • the needle taking mechanism is slidably connected to the needle taking rail 600, and the moving device can be disposed on the longitudinal stretching mechanism 611 to realize the left and right movement of the longitudinal stretching mechanism 611 along the needle taking track 600.
  • the moving device can adopt a gear transmission mechanism, a belt transmission mechanism, and a ball wire. Bar mechanism or other similar linear moving mechanism.
  • the longitudinal telescopic mechanism 611 and the lateral telescopic mechanism 612 may employ a mechanism such as a cylinder, a hydraulic cylinder, or an electric telescopic rod.
  • the syringe pumping device 310 and the syringe injection device 410 are respectively provided with a tightening device including a tightening mechanism 800 and a link 810, and the link 810 is coupled to the tightening mechanism 800.
  • the spinning screw 313 and the injection screw 413 can be rotated by the tightening mechanism 800.
  • the tightening mechanism 800 is coupled to the other end of the pumping screw 313, and the tightening mechanism 800 is slidably coupled to the fixed barrel 311 through the link 810; the tightening mechanism 800 is coupled to the other end of the injection screw 413, and the tightening mechanism 800 passes through the link 810. It is slidably coupled to the connecting barrel 411.
  • the tightening mechanism 800 can employ a rotating mechanism such as a motor.
  • the operation process is as follows:
  • a 1 ml empty syringe is fixed at the quality detecting device 90.
  • the 99 Mo- 99m Tc generator 10 is rinsed as usual. After the rinsing is completed, the vial containing the 99m TcO 4 - solution is grasped by the mechanical claw 5 and moved to the detector 11 for measurement, and the radioactivity data is recorded. The activity per ml is calculated based on the data and the number of ml.
  • the vial containing the 99m TcO 4 - solution is inverted by the rotating device 512 of the mechanical claw 5 and inserted into the syringe fixed by the syringe pumping device 310.
  • the spinning screw 313 is rotated by the tightening mechanism 800 to extract an appropriate amount of 99m TcO 4 - solution.
  • the mechanical claw 5 removes the vial.
  • the drug to be heated is grasped by the mechanical claw 5 to the drug heating device 22 for heating. After the heating is completed, it is moved to the drug shaking device 23 to vibrate. The vibration is directly mixed to the drug shaking device 23 without heating.
  • the labeled drug vial is grasped by the mechanical claw 5 to the quality detecting device 90, a certain amount of the drug is taken, and then taken out for quality inspection. After the test is passed, the drug is injected.
  • a syringe with physiological saline and an empty syringe are first pushed into the protective cover 100 through the connecting hole 102 and the slide 400.
  • the injector injection device 410 is coupled to the alignment, and the telescopic device 417 is coupled to the two syringes.
  • the radiopharmaceutical syringe is pushed by the tightening mechanism 800. After the injection is completed, the saline syringe is pushed again to flush the tubing and the injection point.
  • the intravenous indwelling needle is pulled out.
  • the post-injection tee and the two syringes are removed from the slide 400 and track 416 by the mechanical jaws 5 and fall into the waste storage device 700.
  • the next set of empty syringes and syringes and tees with saline are pushed through the slide 400 and track 416, respectively.

Abstract

A radiation-proof automatic radiopharmaceutical preparation and injection device, comprising: a protective cover (100), a drug rinsing device (1), a drug preparation device (2), a preparation extraction device (3), and an injection device (4); the drug rinsing device (1), the drug preparation device (2), the preparation extraction device (3) and the injection device (4) are all disposed within the protective cover (100), and the protective cover (100) is further internally provided with a mechanical claw (5); the mechanical claw (5) may move between the drug rinsing device (1), the drug preparation device (2), the preparation extraction device (3) and the injection device (4). The mechanical claw (5) may replace operation by a worker, thereby achieving automatic operation in drug production, preparation and injection, while the worker is protected by means of the protective cover (100) so as to prevent unnecessary injuries.

Description

一种防辐射的放射性药物自动制备注射装置Radiation-proof radiopharmaceutical automatic preparation injection device 技术领域Technical field
本发明属于放射性药物制备装置技术领域,具体涉及一种防辐射的放射性药物自动制备注射装置。The invention belongs to the technical field of radiopharmaceutical preparation devices, and particularly relates to an anti-radiation radiopharmaceutical automatic preparation injection device.
背景技术Background technique
放射性药物的生产需要在具有通风设施的铅防护柜内进行,防护柜上面有两个圆形的具有门的孔,方便工作人员把双手伸进去进行操作。The production of radiopharmaceuticals needs to be carried out in a lead-protected cabinet with ventilation. The protective cabinet has two circular holes with doors to allow the staff to put their hands in for operation.
放射性药物的注射,有的在专门的注射窗口进行,有的在床旁注射,注射时,为了保护工作人员,一般需要在有铅玻璃的防护屏后面进行操作,工作人员把手伸过去操作。The injection of radiopharmaceuticals is carried out in a special injection window, and some are injected at the bedside. In order to protect the staff during the injection, it is generally necessary to operate behind the protective screen with lead glass, and the staff hands up and operate.
放射性药物产生:SPECT/CT显像药物是利用99Mo-99mTc发生器淋洗装置,每日淋洗出来的新鲜99mTcO4 -进行标记的。一般淋洗的过程需要工作人员把手伸入防辐射通风厨,在99Mo-99mTc发生器淋洗装置上插入生理盐水,用空西林瓶准备收集淋洗下来的新鲜99mTcO4 -99Mo-99mTc发生器淋洗下来的新鲜的99mTcO4 -进行标记。Radiopharmaceutical production: SPECT/CT imaging drugs were labeled with fresh 99m TcO 4 - eluted daily using a 99 Mo- 99m Tc generator rinse device. The general rinsing process requires the staff to reach into the radiation-proof ventilator, insert physiological saline into the 99 Mo- 99m Tc generator rinsing device, and use an empty vial to collect and collect the fresh 99m TcO 4 - rinsed. The 99 Mo- 99m Tc generator was rinsed with fresh 99m TcO 4 - for labeling.
核医学SPECT(单光子发射型计算机断层显像)心肌灌注显像,目前常用的显像药物为99mTc-MIBI(甲氧基异丁基乙腈),其制备过程需要在沸水中煮15分钟,才可以标记成功。Nuclear medicine SPECT (single photon emission computed tomography) myocardial perfusion imaging, the commonly used imaging drug is 99mTc-MIBI (methoxy isobutyl acetonitrile), the preparation process needs to be boiled in boiling water for 15 minutes. Can be marked successfully.
放射性药物制备好后,根据药物的不同,一个西林瓶内的药物可以分给2-4个患者使用。用一次性注射器进行抽取制备好的药物,抽好后,放入r井型探测器测量,然后记录放射性活度数据。After the radiopharmaceutical is prepared, the drug in a vial can be divided into 2-4 patients depending on the drug. The prepared drug is extracted with a disposable syringe, and after being pumped, it is placed in an r-type detector for measurement, and then the activity data is recorded.
核医学显像注射药物的准备,不管是在专门的窗口注射还是床旁注射,都需要把药物在通风厨内抽入注射器,测量活性,用标记笔记录药物名称和剂量,然后放置入专业的铅盒内,把装有放射性注射器的铅盒拎到注射窗口或者床旁。Preparation of nuclear medicine imaging injections, whether in a special window injection or bedside injection, requires the drug to be drawn into the syringe in a ventilated kitchen, measuring activity, recording the drug name and dosage with a marker, and then placing it in a professional Inside the lead box, pry the lead box containing the radioactive syringe to the injection window or bedside.
放射性药物的注射:核医学显像注射,不管是在专门的窗口注射还是床旁注射,目前一般采用的措施是带铅手套,影响操作的灵敏度,增加了操作 难度;或者用防辐射注射铅套,可以减少辐射,但是操作不易。Injection of radiopharmaceuticals: nuclear medicine imaging injection, whether it is in special window injection or bedside injection, the current commonly used measures are lead gloves, affecting the sensitivity of the operation, increasing the operation Difficulty; or radiation-proof injection of lead sets, can reduce radiation, but the operation is not easy.
放射性药物注射后注射器的处理:为了环境的保护,核医学显像时注射放射性药品后的注射器等放射性废物的存放器具、存放时间、存放是否达到放射性废物处理标准是至关重要的环节。Treatment of syringes after radiopharmaceutical injection: For environmental protection, storage of radioactive waste such as syringes after injection of radiopharmaceuticals during nuclear medicine imaging, storage time, and storage of radioactive waste treatment standards are essential.
放射性药物的生产、制备、注射和药物注射后注射器的处理在操作过程中工作人员都会受到不同程度的辐射且操作不便。The production, preparation, injection, and treatment of the syringe after drug injection are all subject to varying degrees of radiation and inconvenient operation during operation.
发明内容Summary of the invention
针对上述技术问题,本发明提供了一种防辐射的放射性药物自动制备注射装置,该装置节省人力、减少工作人员受辐射、自动化、避免人为随机误差、减少注射器内放射性药物的残留,保护环境。In view of the above technical problems, the present invention provides an anti-radiation radiopharmaceutical automatic preparation injection device, which saves manpower, reduces radiation exposure, automation, avoids artificial random errors, reduces residual radioactive drugs in the syringe, and protects the environment.
为了解决上述技术问题,本发明采用的技术方案是:In order to solve the above technical problems, the technical solution adopted by the present invention is:
一种防辐射的放射性药物自动制备注射装置,包括保护罩、药物淋洗装置、药物制备装置、制备抽取装置和注射装置,所述药物淋洗装置、药物制备装置、制备抽取装置和注射装置均设置在保护罩内,所述保护罩内还设有机械爪,所述机械爪可以在药物淋洗装置、药物制备装置、制备抽取装置和注射装置之间移动。An anti-radiation radiopharmaceutical automatic preparation injection device comprises a protective cover, a drug eluting device, a drug preparing device, a preparation extracting device and an injecting device, wherein the drug eluting device, the drug preparing device, the preparing extracting device and the injecting device are both It is disposed in the protective cover, and the protective cover is further provided with a mechanical claw, and the mechanical claw can be moved between the drug eluting device, the medicine preparing device, the preparation extracting device and the injection device.
作为优选,所述药物淋洗装置包括99Mo-99mTc发生器和探测器,通过99Mo-99mTc发生器进行药物的淋洗并产生新鲜99mTcO4 -溶液,探测器对新鲜99mTcO4 -溶液进行测量。Advantageously, the medicament comprises a rinsing device 99 Mo- 99m Tc generators and detectors, rinse the drug by 99 Mo- 99m Tc generator and producing fresh 99m TcO 4 - solution, fresh detector 99m TcO 4 - The solution is measured.
作为优选,所述药物制备装置包括药物加热装置和药物震动装置。Preferably, the drug preparation device comprises a drug heating device and a drug vibration device.
作为优选,所述药物加热装置为电炉丝加热装置;所述药物震动装置包括用于放置药物的支架和震动块,所述震动块设置在支架上。Preferably, the drug heating device is an electric wire heating device; the drug vibration device includes a holder for placing a drug and a vibration block, and the vibration block is disposed on the holder.
作为优选,所述制备抽取装置包括滑轨和注射器抽注装置,所述注射器抽注装置与滑轨滑动联接,所述注射器抽注装置包括固定筒、抽注块和抽注螺杆,所述抽注块与固定筒滑动联接,所述固定筒用于固定注射器,所述固定筒上设有用于与注射器注射筒挡片联接的凹槽,所述抽注块上设有与注射器推注端联接的卡槽,所述抽注螺杆通过螺纹与固定筒联接,所述抽注螺杆一端与抽注块转动联接。 Advantageously, said preparation extraction device comprises a slide rail and a syringe pumping device, said syringe pumping device being slidably coupled to a slide rail, said syringe pumping device comprising a fixed cylinder, a pumping block and a pumping screw, said pumping The injection block is slidably coupled to the fixed cylinder for fixing the syringe, and the fixed cylinder is provided with a groove for coupling with the syringe barrel block, and the pumping block is provided with a syringe push end The pumping screw is coupled to the fixed cylinder by a thread, and one end of the pumping screw is rotatably coupled to the pumping block.
作为优选,所述注射装置包括两个相对设置的滑道和注射器注射装置,滑道上设有与注射器注射筒挡片联接的滑槽421,所述注射器注射装置包括连接筒、注射块和注射螺杆,所述连接筒上设有开口,所述注射块上设有通槽,所述注射块与连接筒滑动联接,所述注射螺杆通过螺纹与连接筒联接,所述注射螺杆一端与注射块转动联接。Preferably, the injection device comprises two oppositely disposed slides and a syringe injection device, the slide being provided with a chute 421 coupled to the syringe barrel stop, the syringe injection device comprising a connecting barrel, an injection block and an injection screw The connecting barrel is provided with an opening, the injection block is provided with a through slot, the injection block is slidably coupled with the connecting barrel, the injection screw is coupled with the connecting barrel by a thread, and the injection screw is rotated at one end and the injection block Join.
作为优选,所述滑道上方设有用于与医用连通管联接的轨道,所述轨道通过伸缩装置与滑道联接。Preferably, a track for coupling with the medical communication tube is provided above the slide, and the track is coupled to the slide by a telescopic device.
作为优选,所述机械爪包括横轨和纵轨,所述纵轨与横轨滑动联接,所述纵轨上设有机械臂,所述机械臂通过伸缩机构与纵轨联接,所述机械臂包括转动装置和固定盘,所述转动装置与固定盘联接,所述固定盘上设有可以转动的主动臂和从动臂,通过主动臂和从动臂可以对药瓶进行夹持。Preferably, the mechanical claw comprises a transverse rail and a longitudinal rail, the longitudinal rail is slidably coupled with the cross rail, and the longitudinal rail is provided with a mechanical arm, and the mechanical arm is coupled with the longitudinal rail by a telescopic mechanism, the mechanical arm The rotating device and the fixed disc are coupled to the fixed disc. The fixed disc is provided with a rotatable active arm and a driven arm, and the medicine bottle can be clamped by the active arm and the driven arm.
作为优选,所述保护罩内还设有取针轨道和取针装置,所述取针装置包括纵向伸缩机构和横向伸缩机构,所述纵向伸缩机构与横向伸缩机构联接,所述横向伸缩机构上设有取针爪。Preferably, the protective cover is further provided with a needle taking track and a needle taking device, wherein the needle picking device comprises a longitudinal telescopic mechanism and a lateral telescopic mechanism, and the longitudinal telescopic mechanism is coupled with a lateral telescopic mechanism, and the transverse telescopic mechanism is There are needles for picking up.
作为优选,所述保护罩底部设有废物储存装置,注射后的注射器可以落入废物储存装置内。Preferably, the bottom of the protective cover is provided with a waste storage device, and the injected syringe can fall into the waste storage device.
作为优选,还包括旋紧装置,所述旋紧装置包括旋紧机构和连杆,所述连杆与旋紧机构联接。Preferably, a tightening device is also included, the tightening device including a tightening mechanism and a link coupled to the tightening mechanism.
本发明与现有技术相比,具有的有益效果是:Compared with the prior art, the invention has the following beneficial effects:
药物淋洗装置、药物制备装置、制备抽取装置和注射装置均设置在保护罩内,机械爪可以在药物淋洗装置、药物制备装置、制备抽取装置和注射装置之间移动。通过机械爪可以代替工作人员操作,实现药物生产、制备、注射的自动化操作;工作人员通过保护罩进行防护,避免不必要的损伤。The drug rinsing device, the drug preparation device, the preparation extraction device, and the injection device are all disposed in a protective cover, and the mechanical claw can be moved between the drug rinsing device, the drug preparation device, the preparation extraction device, and the injection device. The mechanical claw can replace the operation of the staff to realize the automatic operation of drug production, preparation and injection; the worker protects through the protective cover to avoid unnecessary damage.
附图说明DRAWINGS
图1是本发明的结构示意图;Figure 1 is a schematic view of the structure of the present invention;
图2是本发明的内部结构示意图;Figure 2 is a schematic view of the internal structure of the present invention;
图3是本发明的制备抽取装置结构示意图;Figure 3 is a schematic view showing the structure of the preparation extracting device of the present invention;
图4是本发明的机械爪结构示意图; Figure 4 is a schematic view showing the structure of the mechanical claw of the present invention;
图5是本发明的取针装置结构示意图;Figure 5 is a schematic structural view of the needle removing device of the present invention;
图6是本发明的药物制备装置结构示意图;Figure 6 is a schematic structural view of a drug preparation device of the present invention;
图7是本发明的注射装置结构示意图;Figure 7 is a schematic structural view of an injection device of the present invention;
图8是本发明的注射器注射装置结构示意图;Figure 8 is a schematic structural view of a syringe injection device of the present invention;
图9是本发明的注射器注射装置使用示意图;Figure 9 is a schematic view showing the use of the syringe injection device of the present invention;
图10是本发明的连通管结构示意图;Figure 10 is a schematic structural view of a connecting pipe of the present invention;
图11是本发明的滑道结构示意图;Figure 11 is a schematic view showing the structure of the slide of the present invention;
其中:1为药物淋洗装置,10为99Mo-99mTc发生器,11为探测器,2为药物制备装置,20为TC溶液固定架,21为药盒,22为药物加热装置,23为药物震动装置,24为药物稀释存放盒,25为支架,26为震动块,3为制备抽取装置,300为滑轨,310为注射器抽注装置,311为固定筒,312为抽注块,313为抽注螺杆,314凹槽,315为卡槽,316为插口,4为注射装置,400为滑道,410为注射器注射装置,411连接筒,412为注射块,413为注射螺杆,414为开口,415为通槽,416为轨道,417为伸缩装置,418为连通管,419为连接板,420连接槽,421为滑槽,5为机械爪,500为横轨,510为纵轨,511为伸缩机构,512为转动装置,513为固定盘,514为主动臂,515为从动臂,516为横移装置,600为取针轨道,610为取针装置,611为纵向伸缩机构,612为横向伸缩机构,613为取针爪,700为废物储存装置,800为旋紧机构,810为连杆,90为质量检测装置,100为保护罩,101为通孔,102为连接孔。Among them: 1 is a drug rinsing device, 10 is a 99 Mo- 99m Tc generator, 11 is a detector, 2 is a drug preparation device, 20 is a TC solution holder, 21 is a medicine box, 22 is a drug heating device, 23 is Drug vibration device, 24 is a drug dilution storage box, 25 is a bracket, 26 is a vibration block, 3 is a preparation extraction device, 300 is a slide rail, 310 is a syringe pumping device, 311 is a fixed cylinder, 312 is a pumping block, 313 For the suction screw, 314 groove, 315 is the card slot, 316 is the socket, 4 is the injection device, 400 is the slide, 410 is the syringe injection device, 411 is connected to the barrel, 412 is the injection block, 413 is the injection screw, 414 is Opening, 415 is a through slot, 416 is a track, 417 is a telescopic device, 418 is a connecting tube, 419 is a connecting plate, 420 is a connecting slot, 421 is a sliding slot, 5 is a mechanical claw, 500 is a horizontal rail, and 510 is a vertical rail. 511 is a telescopic mechanism, 512 is a rotating device, 513 is a fixed disc, 514 is an active arm, 515 is a follower arm, 516 is a traverse device, 600 is a needle taking track, 610 is a needle taking device, and 611 is a longitudinal telescopic mechanism. 612 is a lateral telescopic mechanism, 613 is a needle removing claw, 700 is a waste storage device, and 800 is a tightening mechanism. Connecting rod 810, the quality detection means 90, the protective cover 100, a through hole 101, 102 is a connection hole.
具体实施方式Detailed ways
如图1~2所示,一种防辐射的放射性药物自动制备注射装置,包括保护罩100、药物淋洗装置1、药物制备装置2、制备抽取装置3和注射装置4,药物淋洗装置1、药物制备装置2、制备抽取装置3、注射装置4和质量检测装置90均设置在保护罩100内,保护罩100内还设有机械爪5,机械爪5可以在药物淋洗装置1、药物制备装置2、制备抽取装置3、注射装置4和质量检测装置90之间移动。As shown in FIG. 1 to 2, an anti-radiation radiopharmaceutical automatic preparation injection device comprises a protective cover 100, a drug eluting device 1, a drug preparing device 2, a preparation extracting device 3 and an injecting device 4, and a drug eluting device 1 The medicine preparation device 2, the preparation extraction device 3, the injection device 4 and the quality detecting device 90 are all disposed in the protective cover 100. The protective cover 100 is further provided with a mechanical claw 5, and the mechanical claw 5 can be used in the drug eluting device 1. The preparation device 2, the preparation extraction device 3, the injection device 4, and the mass detection device 90 are moved.
保护罩100上设有通孔101和连接孔102,工作人员通过通孔101可以进行注射器和西林瓶的安置或拿取;连接孔102设置在注射装置4所对应的位置处, 外部注射器和连通管418(三通管)可以通过滑道400和轨道416进入保护罩100内。通孔101和连接孔102处均可设置可以开闭的挡板(图中未示出),根据需要可以通过挡板挡住通孔101和连接孔102或者漏出通孔101和连接孔102。The protective cover 100 is provided with a through hole 101 and a connecting hole 102. The worker can perform the setting or taking of the syringe and the vial through the through hole 101; the connecting hole 102 is disposed at a position corresponding to the injection device 4, An external syringe and communication tube 418 (three-way tube) can enter the protective cover 100 through the slide 400 and the track 416. A baffle (not shown) that can be opened and closed may be disposed at the through hole 101 and the connecting hole 102, and the through hole 101 and the connecting hole 102 may be blocked by the baffle or the through hole 101 and the connecting hole 102 may be leaked as needed.
药物淋洗装置1包括99Mo-99mTc发生器10和探测器11,通过99Mo-99mTc发生器10进行药物的淋洗并产生新鲜99mTcO4 -溶液,探测器11对99mTcO4 -溶液进行测量。1 comprises a pharmaceutical rinsing apparatus 99 Mo- 99m Tc generator 10 and detector 11, rinse the drug by 99 Mo- 99m Tc generator 10 generates a fresh and 99m TcO 4 - solution, the detector 11 pairs of 99m TcO 4 - The solution was measured.
如图6所示,药物制备装置2包括药物加热装置22、药物震动装置23、TC溶液固定架20、药盒21和药物稀释存放盒24。TC溶液固定架20用于放置装有淋洗出来Tc溶液的西林瓶。药盒21用于放置准备标记的西林瓶。药物稀释存放盒24用于放置稀释标记好的药物。As shown in FIG. 6, the medicine preparation device 2 includes a medicine heating device 22, a medicine vibration device 23, a TC solution holder 20, a medicine cartridge 21, and a drug dilution storage box 24. The TC solution holder 20 is used to place a vial containing the rinsed Tc solution. The kit 21 is used to place a vial ready for labeling. The drug dilution storage box 24 is used to place the diluted labeled drug.
药物加热装置22为带有定时加热功能的电炉丝加热装置;药物震动装置23包括用于放置药物的支架25和震动块26,震动块26设置在支架25上。The drug heating device 22 is an electric wire heating device with a timing heating function; the drug vibration device 23 includes a holder 25 for placing a drug and a vibration block 26, and the vibration block 26 is disposed on the holder 25.
如图3所示,制备抽取装置3包括滑轨300和注射器抽注装置310,注射器抽注装置310与滑轨300滑动联接,注射器抽注装置310的数量可以根据实际情况设定。注射器抽注装置310包括固定筒311、抽注块312和抽注螺杆313,抽注块312位于固定筒311内并与固定筒311滑动联接,固定筒311用于固定注射器,固定筒311上设有用于与注射器注射筒挡片联接的凹槽314,抽注块312上设有与注射器推注端联接的卡槽315,抽注螺杆313通过螺纹与固定筒311联接,抽注螺杆313一端与抽注块312转动联接,抽注螺杆313转动时,抽注块312不会随之转动。As shown in FIG. 3, the preparation extraction device 3 includes a slide rail 300 and a syringe pumping device 310. The syringe pumping device 310 is slidably coupled to the slide rail 300. The number of the syringe pumping devices 310 can be set according to actual conditions. The syringe pumping device 310 includes a fixed cylinder 311, a pumping block 312 and a pumping screw 313. The pumping block 312 is located in the fixed cylinder 311 and is slidably coupled with the fixed cylinder 311. The fixing cylinder 311 is used for fixing the syringe, and the fixing cylinder 311 is provided. There is a groove 314 for coupling with the syringe barrel block. The pumping block 312 is provided with a card slot 315 coupled to the syringe push end. The pumping screw 313 is coupled to the fixed barrel 311 by a thread, and the pumping screw 313 is provided with one end. The pumping block 312 is rotationally coupled, and when the pumping screw 313 is rotated, the pumping block 312 does not rotate with it.
固定筒311的一侧设有插口316,使用时,将注射器通过插口316与固定筒311插接,注射器的注射筒上设有的挡片进入固定筒311的凹槽314中,实现对注射器的注射筒进行固定;注射器的推注端通过抽注块312上设有的卡槽315进行卡接。通过抽注螺杆313的转动实现抽注块312的移动,从而带动注射器的活塞杆移动,实现药物的抽取;通过抽注螺杆313的反向转动,实现药物的注射。One side of the fixing cylinder 311 is provided with a socket 316. In use, the syringe is inserted into the fixing cylinder 311 through the socket 316, and the blocking piece provided on the syringe barrel of the syringe enters the recess 314 of the fixing cylinder 311 to realize the syringe. The syringe is fixed; the push end of the syringe is engaged by a card slot 315 provided on the drawer block 312. The movement of the suction block 312 is realized by the rotation of the suction screw 313, thereby driving the piston rod of the syringe to move, and the medicine is extracted; and the injection of the medicine is realized by the reverse rotation of the suction screw 313.
如图7所示,质量检测装置90采用与注射器抽注装置310相同的结构;抽取微量标记好、稀释好药物的注射器,然后从保护罩100中取出进行质量检测。As shown in Fig. 7, the mass detecting device 90 employs the same structure as the syringe pumping device 310; a syringe that is well-labeled and diluted with a drug is taken out, and then taken out from the protective cover 100 for quality inspection.
如图7~11所示,注射装置4包括两个相对设置的滑道400和注射器注射 装置410,滑道400上设有与注射器注射筒挡片联接的滑槽421,注射器注射装置410包括连接筒411、注射块412和注射螺杆413,连接筒411上设有开口414,注射块412上设有通槽415,注射块412位于连接筒411内并与连接筒411滑动联接,注射螺杆413通过螺纹与连接筒411联接,注射螺杆413一端与注射块412转动联接。注射器注射装置410的数量可以根据实际情况设定。As shown in Figures 7-11, the injection device 4 includes two oppositely disposed slides 400 and syringe injections. The device 410 has a sliding slot 421 coupled to the syringe barrel block. The syringe injection device 410 includes a connecting barrel 411, an injection block 412 and an injection screw 413. The connecting barrel 411 is provided with an opening 414, and the injection block 412 is provided. A through slot 415 is defined. The injection block 412 is located in the connecting cylinder 411 and is slidably coupled to the connecting cylinder 411. The injection screw 413 is coupled to the connecting cylinder 411 by threads, and one end of the injection screw 413 is rotatably coupled to the injection block 412. The number of syringe injection devices 410 can be set according to actual conditions.
注射装置4处的注射器位于两个相对设置的滑道400之间,并与滑道400滑动联接,注射器的注射筒上设有的挡片与滑道400上设有的滑槽421滑动联接。注射器注射装置410位于滑道400下方并与滑道400联接。当注射器沿滑道400移动时,注射器的推注端会通过注射块412上设有的通槽415与注射块412联接;连接筒411的两端设有开口414,不会挡住注射器的活塞杆,不会影响注射器的移动,注射器可以穿过连接筒411和注射块412。通过注射螺杆413的转动实现注射块412的移动,从而带动注射器的活塞杆移动,实现药物的抽取;通过注射螺杆413的反向转动,实现药物的注射。当注射装置4处的注射器使用完后,可以通过机械爪5对使用后的注射器进行夹持并带动其沿滑道400移动,使用后的注射器脱离滑道400后,通过机械手将使用后的注射器落入保护罩100底部设有废物储存装置700内,实现放射性药物注射后注射器的处理。废物储存装置700采用类似抽屉的结构,便于将废物储存装置700内注射器取出。The syringe at the injection device 4 is located between the two oppositely disposed slides 400 and is slidably coupled to the slide 400. The flap provided on the syringe of the syringe is slidably coupled to the sliding groove 421 provided on the slide 400. The syringe injection device 410 is located below the slideway 400 and coupled to the slideway 400. When the syringe moves along the slide 400, the push end of the syringe is coupled to the injection block 412 through a through slot 415 provided in the injection block 412; the ends of the connection barrel 411 are provided with an opening 414 that does not block the piston rod of the syringe Without affecting the movement of the syringe, the syringe can pass through the connecting barrel 411 and the injection block 412. The movement of the injection block 412 is realized by the rotation of the injection screw 413, thereby driving the piston rod of the syringe to move the medicine, and the medicine is injected by the reverse rotation of the injection screw 413. After the syringe at the injection device 4 is used, the used syringe can be clamped by the mechanical claw 5 and driven to move along the slide 400. After the used syringe is separated from the slide 400, the used syringe is used by the robot. The bottom of the protective cover 100 is disposed in the waste storage device 700 to realize the treatment of the syringe after the radiopharmaceutical injection. The waste storage device 700 employs a drawer-like structure to facilitate removal of the syringe within the waste storage device 700.
滑道400的上端设有用于与医用连通管418联接的轨道416,轨道416上设有与连通管418联接的连接槽420,连通管418上设有连接板419,并通过该连接板419与连接槽420配合实现连通管418与轨道416的滑动联接。轨道416通过伸缩装置417与滑道400联接,轨道416与滑道400间的距离可以通过伸缩装置417进行改变;当滑道400内联接有注射器、且轨道416内联接有连通管418后,通过机械爪5对注射器和连通管418的位置进行调整,使注射器的注射头(不带针头)与连通管418相对,通过伸缩装置417伸缩带动轨道416和连通管418移动下移,使连通管418与注射器的注射头插接,实现连通管418与注射器的连通。The upper end of the slideway 400 is provided with a rail 416 for coupling with the medical communication tube 418. The rail 416 is provided with a connecting slot 420 coupled to the connecting tube 418. The connecting tube 418 is provided with a connecting plate 419, and through the connecting plate 419 The connecting groove 420 cooperates to realize the sliding connection of the communication pipe 418 and the rail 416. The rail 416 is coupled to the slide rail 400 by the telescopic device 417. The distance between the rail 416 and the slide rail 400 can be changed by the telescopic device 417. When the syringe 400 is coupled to the slide rail 400 and the communication tube 418 is coupled to the rail 416, the passage is passed. The position of the syringe and the communication tube 418 is adjusted by the mechanical claw 5 so that the injection head (without the needle) of the syringe is opposed to the communication tube 418, and the telescopic device 417 telescopically drives the rail 416 and the communication tube 418 to move downward, so that the communication tube 418 is moved. The injection head of the syringe is inserted to realize communication between the communication tube 418 and the syringe.
如图4所示,机械爪5包括横轨500和纵轨510,纵轨510与横轨500滑动联接,纵轨510上设有移动装置,通过移动装置可以实现纵轨510沿横轨500 的左右移动,移动装置可以采用齿轮传动机构、皮带传动机构、滚珠丝杠机构或者其它类似直线移动机构。As shown in FIG. 4, the mechanical claw 5 includes a cross rail 500 and a longitudinal rail 510. The longitudinal rail 510 is slidably coupled to the cross rail 500. The vertical rail 510 is provided with a moving device. The vertical rail 510 can be realized along the cross rail 500 by the moving device. For the left and right movement, the mobile device can adopt a gear transmission mechanism, a belt transmission mechanism, a ball screw mechanism or the like.
纵轨510上设有机械臂,机械臂通过伸缩机构511与纵轨510联接,通过伸缩机构511可以带动机械臂的上下移动,伸缩机构511与纵轨510滑动联接,伸缩机构511上设有横移装置516,并通过横移装置516实现沿纵轨510的前后移动。伸缩机构511可以采用气缸、液压缸、电动伸缩杆等机构。横移装置516可以采用齿轮传动机构、皮带传动机构、滚珠丝杠机构或者其它类似直线移动机构。The longitudinal rail 510 is provided with a mechanical arm. The mechanical arm is coupled to the longitudinal rail 510 through the telescopic mechanism 511. The telescopic mechanism 511 can drive the upper and lower movement of the mechanical arm. The telescopic mechanism 511 is slidably coupled with the longitudinal rail 510. The telescopic mechanism 511 is provided with a horizontal cross. The device 516 is moved and moved back and forth along the longitudinal rail 510 by the traverse device 516. The telescopic mechanism 511 can employ a mechanism such as a cylinder, a hydraulic cylinder, or an electric telescopic rod. The traverse device 516 can employ a gearing mechanism, a belt drive mechanism, a ball screw mechanism, or other similar linear movement mechanism.
机械臂包括转动装置512和固定盘513,转动装置512与固定盘513联接,固定盘513上设有可以转动的主动臂514和从动臂515,主动臂514和从动臂515通过齿轮联接,当主动臂514转动时,从动臂515也会随之转动,并且主动臂514和从动臂515间的距离会发生改变,通过控制主动臂514的旋转方向(顺时针或逆时针),实现主动臂514与从动臂515的开合,实现对药瓶进行夹持。The mechanical arm includes a rotating device 512 and a fixed plate 513. The rotating device 512 is coupled to the fixed plate 513. The fixed plate 513 is provided with a rotatable active arm 514 and a driven arm 515. The active arm 514 and the driven arm 515 are coupled by gears. When the active arm 514 rotates, the follower arm 515 also rotates, and the distance between the active arm 514 and the driven arm 515 changes, by controlling the rotational direction of the active arm 514 (clockwise or counterclockwise). The opening and closing of the active arm 514 and the follower arm 515 realizes clamping of the vial.
如图5所示,保护罩100内还设有取针轨道600和取针装置610,取针装置610用于拔取注射器上的针头。取针装置610包括纵向伸缩机构611和横向伸缩机构612,纵向伸缩机构611与横向伸缩机构612联接,横向伸缩机构612上设有取针爪613。通过纵向伸缩机构611和横向伸缩机构可以实现取针爪613的上下、前后移动。取针机构与取针轨道600滑动连接,可以在纵向伸缩机构611上设置移动装置,实现纵向伸缩机构611沿取针轨道600的左右移动,移动装置可以采用齿轮传动机构、皮带传动机构、滚珠丝杠机构或者其它类似直线移动机构。纵向伸缩机构611和横向伸缩机构612可以采用气缸、液压缸、电动伸缩杆等机构。As shown in FIG. 5, the protective cover 100 is further provided with a needle take-up rail 600 and a needle taking device 610 for picking up the needle on the syringe. The needle taking device 610 includes a longitudinal telescopic mechanism 611 and a lateral telescopic mechanism 612. The longitudinal telescopic mechanism 611 is coupled to the lateral telescopic mechanism 612, and the lateral telescopic mechanism 612 is provided with a picking claw 613. The up and down movement of the needle removing claw 613 can be realized by the longitudinal stretching mechanism 611 and the lateral expansion mechanism. The needle taking mechanism is slidably connected to the needle taking rail 600, and the moving device can be disposed on the longitudinal stretching mechanism 611 to realize the left and right movement of the longitudinal stretching mechanism 611 along the needle taking track 600. The moving device can adopt a gear transmission mechanism, a belt transmission mechanism, and a ball wire. Bar mechanism or other similar linear moving mechanism. The longitudinal telescopic mechanism 611 and the lateral telescopic mechanism 612 may employ a mechanism such as a cylinder, a hydraulic cylinder, or an electric telescopic rod.
如图3和8所示,注射器抽注装置310和注射器注射装置410上分别设有旋紧装置,旋紧装置包括旋紧机构800和连杆810,连杆810与旋紧机构800联接。通过旋紧机构800可以带动抽注螺杆313、注射螺杆413转动。旋紧机构800与抽注螺杆313的另一端联接,旋紧机构800通过连杆810与固定筒311滑动联接;旋紧机构800与注射螺杆413的另一端联接,旋紧机构800通过连杆810与连接筒411滑动联接。旋紧机构800可以采用电机等旋转机构。As shown in FIGS. 3 and 8, the syringe pumping device 310 and the syringe injection device 410 are respectively provided with a tightening device including a tightening mechanism 800 and a link 810, and the link 810 is coupled to the tightening mechanism 800. The spinning screw 313 and the injection screw 413 can be rotated by the tightening mechanism 800. The tightening mechanism 800 is coupled to the other end of the pumping screw 313, and the tightening mechanism 800 is slidably coupled to the fixed barrel 311 through the link 810; the tightening mechanism 800 is coupled to the other end of the injection screw 413, and the tightening mechanism 800 passes through the link 810. It is slidably coupled to the connecting barrel 411. The tightening mechanism 800 can employ a rotating mechanism such as a motor.
操作过程如下: The operation process is as follows:
1)通过通孔101,在两个注射器抽注装置310上分别固定一个空的10ml注射器和一个抽满生理盐水的10ml注射器。1) An empty 10 ml syringe and a 10 ml syringe pumped with saline were respectively attached to the two syringe pumping devices 310 through the through holes 101.
2)质量检测装置90处固定一个1ml的空注射器。2) A 1 ml empty syringe is fixed at the quality detecting device 90.
3)在药盒21处安置需要标记的药盒西林瓶。3) Place the vial of the kit to be labeled at the kit 21.
药物淋洗和测量:Drug leaching and measurement:
1)按照常规工作进行99Mo-99mTc发生器10淋洗工作。待淋洗完成后,采用机械爪5抓取装有99mTcO4 -溶液的西林瓶并移动至探测器11处进行测量,记录放射性活度数据。根据数据和ml数,计算每ml内的放射性活度。1) The 99 Mo- 99m Tc generator 10 is rinsed as usual. After the rinsing is completed, the vial containing the 99m TcO 4 - solution is grasped by the mechanical claw 5 and moved to the detector 11 for measurement, and the radioactivity data is recorded. The activity per ml is calculated based on the data and the number of ml.
2)测量完成后,把装有99mTcO4 -溶液的西林瓶通过机械爪5的转动装置512倒置插入注射器抽注装置310固定的注射器上。通过旋紧机构800带动抽注螺杆313转动,进行抽取适量99mTcO4 -溶液。抽取后机械爪5将西林瓶移走。2) After the measurement is completed, the vial containing the 99m TcO 4 - solution is inverted by the rotating device 512 of the mechanical claw 5 and inserted into the syringe fixed by the syringe pumping device 310. The spinning screw 313 is rotated by the tightening mechanism 800 to extract an appropriate amount of 99m TcO 4 - solution. After the extraction, the mechanical claw 5 removes the vial.
3)待注射器抽取适量99mTcO4 -溶液后,把注射器内的99mTcO4 -溶液推入(通过旋紧机构800反向旋转带动抽注螺杆313转动)药盒21处放有的西林瓶(通过机械爪5移动并插入注射器上)内进行药物标记。3) until syringe to draw an appropriate amount of 99m TcO 4 - solution was put in the syringe 99m TcO 4 - solution pushed (rotated by the reverse rotation of the clamping mechanism 800 driven injection screw pump 313) placed at some vials 21 kit ( Drug labeling is performed by moving the mechanical jaw 5 and inserting it into the syringe.
4)需要加热的药物,利用机械爪5抓到药物加热装置22处进行加热。加热完成后,移动至药物震动装置23处进行震动。不需要加热的直接到药物震动装置23处进行震动混匀。4) The drug to be heated is grasped by the mechanical claw 5 to the drug heating device 22 for heating. After the heating is completed, it is moved to the drug shaking device 23 to vibrate. The vibration is directly mixed to the drug shaking device 23 without heating.
5)需要稀释的药物,把西林瓶抓到抽满生理盐水的10ml注射器处,推入一定量的生理盐水。不需要稀释的药物,即完成标记。5) The drug to be diluted is taken, and the vial is caught in a 10 ml syringe filled with physiological saline, and a certain amount of physiological saline is pushed. Do not need to dilute the drug, that is, complete the mark.
标记好的放射性药物的质量控制采样:Quality control sampling of labeled radiopharmaceuticals:
把标记好的药物西林瓶,利用机械爪5抓到质量检测装置90处,抽取一定量的药物,然后取出进行质量检测。检测合格后,进行药物注射。The labeled drug vial is grasped by the mechanical claw 5 to the quality detecting device 90, a certain amount of the drug is taken, and then taken out for quality inspection. After the test is passed, the drug is injected.
放射性药物注射:Radiopharmaceutical injection:
1)先把抽有生理盐水的一个注射器和一个空的注射器,通过连接孔102和滑道400推入保护罩100内。1) A syringe with physiological saline and an empty syringe are first pushed into the protective cover 100 through the connecting hole 102 and the slide 400.
2)把装有制备好的放射性药物的西林瓶,通过机械爪5抓到空注射器上方,抽取需要注射的量,然后移开西林瓶。2) The vial containing the prepared radiopharmaceutical is grasped by the mechanical claw 5 over the empty syringe, the amount to be injected is taken, and then the vial is removed.
3)把连通管418(三通管)及静脉留置针通过连接孔102和轨道416推入保护罩100内,利用机械爪5将三通管与两个注射器(两个注射器分别与注射 器注射装置410联接)对准,通过伸缩装置417使三通管与两个注射器联接。3) Push the communication tube 418 (three-way tube) and the venous indwelling needle into the protective cover 100 through the connecting hole 102 and the rail 416, and use the mechanical claw 5 to connect the tee tube and the two syringes (two syringes respectively and the injection) The injector injection device 410 is coupled to the alignment, and the telescopic device 417 is coupled to the two syringes.
4)通过旋紧机构800带动注射螺杆413转动,推动生理盐水,待充满三通及静脉留置针后,工作人员给患者建立静脉通路。4) The rotation of the injection screw 413 is driven by the tightening mechanism 800 to push the physiological saline. After the three-way and the intravenous indwelling needle are filled, the worker establishes a venous access to the patient.
5)静脉通路建立成功后,通过旋紧机构800推动放射性药物注射器。注射完成后,再推动生理盐水注射器,冲洗管道及注射点。5) After the venous access is successfully established, the radiopharmaceutical syringe is pushed by the tightening mechanism 800. After the injection is completed, the saline syringe is pushed again to flush the tubing and the injection point.
6)注射完成后,拔出静脉留置针。通过机械爪5将注射后三通管和两个注射器移出滑道400和轨道416,并落入废物储存装置700内。再次注射时,分别通过滑道400和轨道416推入下一套空注射器和装有生理盐水的注射器及三通管。6) After the injection is completed, the intravenous indwelling needle is pulled out. The post-injection tee and the two syringes are removed from the slide 400 and track 416 by the mechanical jaws 5 and fall into the waste storage device 700. Upon re-injection, the next set of empty syringes and syringes and tees with saline are pushed through the slide 400 and track 416, respectively.
7)待所有注射工作结束后,下方的使用过的注射器通过机械爪5推入放射性废物储存装置700内,上方的西林瓶通过机械爪5抓入放射性废物储存装置700内。完成药物制备和注射。 7) After all injection work is completed, the lower used syringe is pushed into the radioactive waste storage device 700 by the mechanical claw 5, and the upper vial is grasped into the radioactive waste storage device 700 by the mechanical claw 5. Drug preparation and injection are completed.

Claims (10)

  1. 一种防辐射的放射性药物自动制备注射装置,其特征在于:包括保护罩(100)、药物淋洗装置(1)、药物制备装置(2)、制备抽取装置(3)和注射装置(4),所述药物淋洗装置(1)、药物制备装置(2)、制备抽取装置(3)和注射装置(4)均设置在保护罩(100)内,所述保护罩(100)内还设有机械爪(5),所述机械爪(5)可以在药物淋洗装置(1)、药物制备装置(2)、制备抽取装置(3)和注射装置(4)之间移动。An anti-radiation radiopharmaceutical automatic preparation injection device, comprising: a protective cover (100), a drug eluting device (1), a drug preparing device (2), a preparation extracting device (3) and an injecting device (4) The drug rinsing device (1), the drug preparation device (2), the preparation extraction device (3), and the injection device (4) are all disposed in the protective cover (100), and the protective cover (100) is further provided There is a mechanical jaw (5) that can be moved between the drug eluting device (1), the drug preparation device (2), the preparation extraction device (3) and the injection device (4).
  2. 根据权利要求1所述的一种防辐射的放射性药物自动制备注射装置,其特征在于:所述药物淋洗装置(1)包括99Mo-99mTc发生器(10)和探测器(11),通过99Mo-99mTc发生器(10)进行药物的淋洗并产生新鲜99mTcO4 -溶液,探测器(11)对99mTcO4 -溶液进行测量。An anti-radiation radiopharmaceutical automatic preparation injection device according to claim 1, wherein said drug eluting device (1) comprises a 99 Mo- 99m Tc generator (10) and a detector (11), The 99 Mo- 99m Tc generator (10) was used for the leaching of the drug and a fresh 99m TcO 4 - solution was produced, and the detector (11) was measured for the 99m TcO 4 - solution.
  3. 根据权利要求1所述的一种防辐射的放射性药物自动制备注射装置,其特征在于:所述药物制备装置(2)包括药物加热装置(22)和药物震动装置(23)。A radiation-proof radiopharmaceutical automatic preparation injection device according to claim 1, characterized in that the drug preparation device (2) comprises a drug heating device (22) and a drug vibration device (23).
  4. 根据权利要求3所述的一种防辐射的放射性药物自动制备注射装置,其特征在于:所述药物加热装置(22)为电炉丝加热装置;所述药物震动装置(23)包括用于放置药物的支架(25)和震动块(26),所述震动块(26)设置在支架(25)上。A radiation-proof radiopharmaceutical automatic preparation injection device according to claim 3, wherein said drug heating device (22) is an electric wire heating device; said drug vibration device (23) comprises a drug for placing a drug The bracket (25) and the vibration block (26) are disposed on the bracket (25).
  5. 根据权利要求1所述的一种防辐射的放射性药物自动制备注射装置,其特征在于:所述制备抽取装置(3)包括滑轨(300)和注射器抽注装置(310),所述注射器抽注装置(310)与滑轨(300)滑动联接,所述注射器抽注装置(310)包括固定筒(311)、抽注块(312)和抽注螺杆(313),所述抽注块(312)与固定筒(311)滑动联接,所述固定筒(311)用于固定注射器,所述固定筒(311)上设有用于与注射器注射筒挡片联接的凹槽(314),所述抽注块(312)上设有与注射器推注端联接的卡槽(315),所述抽注螺杆(313)通过螺纹与固定筒(311)联接,所述抽注螺杆(313)一端与抽注块(312)转动联接。A radiation-proof radiopharmaceutical automatic preparation injection device according to claim 1, wherein said preparation extraction device (3) comprises a slide rail (300) and a syringe pumping device (310), said syringe pumping The injection device (310) is slidably coupled to the slide rail (300), the syringe pumping device (310) including a fixed cylinder (311), a pumping block (312), and a pumping screw (313), the pumping block ( 312) slidably coupled with a fixed barrel (311) for fixing a syringe, the fixed barrel (311) being provided with a groove (314) for coupling with a syringe barrel block, The drawer block (312) is provided with a card slot (315) coupled to the syringe push end, the pumping screw (313) being coupled to the fixed cylinder (311) by a thread, and the pumping screw (313) is provided at one end. The pumping block (312) is rotationally coupled.
  6. 根据权利要求1所述的一种防辐射的放射性药物自动制备注射装置,其特征在于:所述注射装置(4)包括两个相对设置的滑道(400)和注射器注射装置(410),滑道(400)上设有与注射器注射筒挡片联接的滑槽(421),所述注射器注射装置(410)包括连接筒(411)、注射块(412)和注射螺杆(413),所述连接筒(411)上设有开口(414),所述注射块(412)上设有通槽(415), 所述注射块(412)与连接筒(411)滑动联接,所述注射螺杆(413)通过螺纹与连接筒(411)联接,所述注射螺杆(413)一端与注射块(412)转动联接。A radiation-proof radiopharmaceutical automatic preparation injection device according to claim 1, wherein said injection device (4) comprises two oppositely disposed slides (400) and a syringe injection device (410), which are slidable a channel (400) is provided with a chute (421) coupled to the syringe barrel block, the syringe injection device (410) comprising a connection barrel (411), an injection block (412) and an injection screw (413), An opening (414) is disposed on the connecting barrel (411), and the injection block (412) is provided with a through groove (415). The injection block (412) is slidably coupled to a coupling barrel (411) that is coupled to the coupling barrel (411) by a thread, and one end of the injection screw (413) is rotationally coupled to the injection block (412).
  7. 根据权利要求6所述的一种防辐射的放射性药物自动制备注射装置,其特征在于:所述滑道(400)上方设有用于与医用连通管(418)联接的轨道(416),所述轨道(416)通过伸缩装置(417)与滑道(400)联接。An anti-radiation radiopharmaceutical automatic preparation injection device according to claim 6, wherein a track (416) for coupling with a medical communication tube (418) is provided above the slide (400), The track (416) is coupled to the runner (400) by a telescoping device (417).
  8. 根据权利要求1所述的一种防辐射的放射性药物自动制备注射装置,其特征在于:所述机械爪(5)包括横轨(500)和纵轨(510),所述纵轨(510)与横轨(500)滑动联接,所述纵轨(510)上设有机械臂,所述机械臂通过伸缩机构(511)与纵轨(510)联接,所述机械臂包括转动装置(512)和固定盘(513),所述转动装置(512)与固定盘(513)联接,所述固定盘(513)上设有可以转动的主动臂(514)和从动臂(515),通过主动臂(514)和从动臂(515)可以对药瓶进行夹持。A radiation-proof radiopharmaceutical automatic preparation injection device according to claim 1, wherein said mechanical claw (5) comprises a transverse rail (500) and a longitudinal rail (510), said longitudinal rail (510) Slidably coupled to the cross rail (500), the longitudinal rail (510) is provided with a mechanical arm coupled to the longitudinal rail (510) by a telescopic mechanism (511), the mechanical arm including a rotating device (512) And a fixed plate (513) coupled to the fixed plate (513), the fixed plate (513) is provided with a rotatable active arm (514) and a follower arm (515), The arm (514) and the follower arm (515) can hold the vial.
  9. 根据权利要求1所述的一种防辐射的放射性药物自动制备注射装置,其特征在于:所述保护罩(100)内还设有取针轨道(600)和取针装置(610),所述取针装置(610)包括纵向伸缩机构(611)和横向伸缩机构(612),所述纵向伸缩机构(611)与横向伸缩机构(612)联接,所述横向伸缩机构(612)上设有取针爪(613)。The radiation-proof radiopharmaceutical automatic preparation injection device according to claim 1, characterized in that: the protective cover (100) further comprises a needle taking track (600) and a needle taking device (610), The needle taking device (610) includes a longitudinal telescopic mechanism (611) and a lateral telescopic mechanism (612) coupled to the lateral telescopic mechanism (612), and the lateral telescopic mechanism (612) is provided with Needle (613).
  10. 根据权利要求1所述的一种防辐射的放射性药物自动制备注射装置,其特征在于:所述保护罩(100)底部设有废物储存装置(700),注射后的注射器可以落入废物储存装置(700)内。 The radiation-proof radiopharmaceutical automatic preparation injection device according to claim 1, characterized in that: the bottom of the protective cover (100) is provided with a waste storage device (700), and the injected syringe can fall into the waste storage device. Within (700).
PCT/CN2017/112370 2017-07-18 2017-11-22 Radiation-proof automatic radiopharmaceutical preparation and injection device WO2019015190A1 (en)

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CN201710585686.9A CN107184397B (en) 2017-07-18 2017-07-18 Radiation-proof automatic radiopharmaceutical preparation injection device
CN201710585686.9 2017-07-18
CN201720870640.7U CN208339789U (en) 2017-07-18 2017-07-18 A kind of radiopharmaceutical of radiation protection prepares injection device automatically
CN201720870640.7 2017-07-18

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