CN116983238A - Ceramide co-delivery nanoemulsion and barrier repair cream - Google Patents
Ceramide co-delivery nanoemulsion and barrier repair cream Download PDFInfo
- Publication number
- CN116983238A CN116983238A CN202311011480.7A CN202311011480A CN116983238A CN 116983238 A CN116983238 A CN 116983238A CN 202311011480 A CN202311011480 A CN 202311011480A CN 116983238 A CN116983238 A CN 116983238A
- Authority
- CN
- China
- Prior art keywords
- nanoemulsion
- ceramide
- delivery
- water
- skin
- Prior art date
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- Pending
Links
- 239000007908 nanoemulsion Substances 0.000 title claims abstract description 47
- 239000006071 cream Substances 0.000 title claims abstract description 16
- YDNKGFDKKRUKPY-JHOUSYSJSA-N C16 ceramide Natural products CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)C=CCCCCCCCCCCCCC YDNKGFDKKRUKPY-JHOUSYSJSA-N 0.000 title claims abstract description 14
- CRJGESKKUOMBCT-VQTJNVASSA-N N-acetylsphinganine Chemical compound CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC(C)=O CRJGESKKUOMBCT-VQTJNVASSA-N 0.000 title claims abstract description 14
- 229940106189 ceramide Drugs 0.000 title claims abstract description 14
- ZVEQCJWYRWKARO-UHFFFAOYSA-N ceramide Natural products CCCCCCCCCCCCCCC(O)C(=O)NC(CO)C(O)C=CCCC=C(C)CCCCCCCCC ZVEQCJWYRWKARO-UHFFFAOYSA-N 0.000 title claims abstract description 14
- VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 title claims abstract description 14
- 230000008439 repair process Effects 0.000 title claims abstract description 14
- 230000004888 barrier function Effects 0.000 title abstract description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 45
- 241001135917 Vitellaria paradoxa Species 0.000 claims abstract description 27
- 235000018936 Vitellaria paradoxa Nutrition 0.000 claims abstract description 27
- 229920002385 Sodium hyaluronate Polymers 0.000 claims abstract description 20
- 229940010747 sodium hyaluronate Drugs 0.000 claims abstract description 20
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims abstract description 20
- 239000002537 cosmetic Substances 0.000 claims abstract description 18
- 241001071795 Gentiana Species 0.000 claims abstract description 14
- 150000003077 polyols Chemical class 0.000 claims abstract description 7
- 229920005862 polyol Polymers 0.000 claims abstract description 6
- 229940057910 shea butter Drugs 0.000 claims abstract description 5
- 239000004519 grease Substances 0.000 claims abstract 2
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims description 25
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 20
- UWJJYHHHVWZFEP-UHFFFAOYSA-N pentane-1,1-diol Chemical compound CCCCC(O)O UWJJYHHHVWZFEP-UHFFFAOYSA-N 0.000 claims description 17
- BBAFBDLICMHBNU-MFZOPHKMSA-N N-(2-hydroxyoctadecanoyl)-4-hydroxysphinganine Chemical compound CCCCCCCCCCCCCCCCC(O)C(=O)N[C@@H](CO)[C@H](O)[C@H](O)CCCCCCCCCCCCCC BBAFBDLICMHBNU-MFZOPHKMSA-N 0.000 claims description 16
- GCDXVKZXCQGDHC-BLCQCPAESA-N [30-oxo-30-[[(2s,3s,4r)-1,3,4-trihydroxyoctadecan-2-yl]amino]triacontyl] (9z,12z)-octadeca-9,12-dienoate Chemical compound CCCCCCCCCCCCCC[C@@H](O)[C@@H](O)[C@H](CO)NC(=O)CCCCCCCCCCCCCCCCCCCCCCCCCCCCCOC(=O)CCCCCCC\C=C/C\C=C/CCCCC GCDXVKZXCQGDHC-BLCQCPAESA-N 0.000 claims description 16
- 229940086668 ceramide eop Drugs 0.000 claims description 16
- AFWTZXXDGQBIKW-UHFFFAOYSA-N C14 surfactin Natural products CCCCCCCCCCCC1CC(=O)NC(CCC(O)=O)C(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(=O)NC(C(C)C)C(=O)NC(CC(O)=O)C(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(=O)O1 AFWTZXXDGQBIKW-UHFFFAOYSA-N 0.000 claims description 14
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 14
- 150000002148 esters Chemical class 0.000 claims description 14
- 229910052708 sodium Inorganic materials 0.000 claims description 14
- 239000011734 sodium Substances 0.000 claims description 14
- NJGWOFRZMQRKHT-UHFFFAOYSA-N surfactin Natural products CC(C)CCCCCCCCCC1CC(=O)NC(CCC(O)=O)C(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(=O)NC(C(C)C)C(=O)NC(CC(O)=O)C(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(=O)O1 NJGWOFRZMQRKHT-UHFFFAOYSA-N 0.000 claims description 14
- NJGWOFRZMQRKHT-WGVNQGGSSA-N surfactin C Chemical compound CC(C)CCCCCCCCC[C@@H]1CC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O1 NJGWOFRZMQRKHT-WGVNQGGSSA-N 0.000 claims description 14
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims description 10
- TXFPEBPIARQUIG-UHFFFAOYSA-N 4'-hydroxyacetophenone Chemical compound CC(=O)C1=CC=C(O)C=C1 TXFPEBPIARQUIG-UHFFFAOYSA-N 0.000 claims description 10
- 238000002360 preparation method Methods 0.000 claims description 10
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 claims description 8
- 235000019197 fats Nutrition 0.000 claims description 8
- 125000005456 glyceride group Chemical group 0.000 claims description 8
- 239000000203 mixture Substances 0.000 claims description 6
- DNIAPMSPPWPWGF-VKHMYHEASA-N (+)-propylene glycol Chemical compound C[C@H](O)CO DNIAPMSPPWPWGF-VKHMYHEASA-N 0.000 claims description 5
- YPFDHNVEDLHUCE-UHFFFAOYSA-N 1,3-propanediol Substances OCCCO YPFDHNVEDLHUCE-UHFFFAOYSA-N 0.000 claims description 5
- 229940035437 1,3-propanediol Drugs 0.000 claims description 5
- OMIGHNLMNHATMP-UHFFFAOYSA-N 2-hydroxyethyl prop-2-enoate Chemical compound OCCOC(=O)C=C OMIGHNLMNHATMP-UHFFFAOYSA-N 0.000 claims description 5
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 5
- 239000004475 Arginine Substances 0.000 claims description 5
- 229920002125 Sokalan® Polymers 0.000 claims description 5
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims description 5
- 229960001631 carbomer Drugs 0.000 claims description 5
- 229940082500 cetostearyl alcohol Drugs 0.000 claims description 5
- 229920001577 copolymer Polymers 0.000 claims description 5
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 5
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 claims description 5
- 229940100460 peg-100 stearate Drugs 0.000 claims description 5
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 5
- -1 polydimethylsiloxane Polymers 0.000 claims description 5
- 229920000166 polytrimethylene carbonate Polymers 0.000 claims description 5
- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 claims description 5
- LADGBHLMCUINGV-UHFFFAOYSA-N tricaprin Chemical compound CCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCC)COC(=O)CCCCCCCCC LADGBHLMCUINGV-UHFFFAOYSA-N 0.000 claims description 5
- 239000000230 xanthan gum Substances 0.000 claims description 5
- 229920001285 xanthan gum Polymers 0.000 claims description 5
- 229940082509 xanthan gum Drugs 0.000 claims description 5
- 235000010493 xanthan gum Nutrition 0.000 claims description 5
- LXAHHHIGZXPRKQ-UHFFFAOYSA-N 5-fluoro-2-methylpyridine Chemical compound CC1=CC=C(F)C=N1 LXAHHHIGZXPRKQ-UHFFFAOYSA-N 0.000 claims description 4
- 239000003995 emulsifying agent Substances 0.000 claims description 4
- 239000013543 active substance Substances 0.000 claims description 2
- OWBTYPJTUOEWEK-UHFFFAOYSA-N butane-2,3-diol Chemical compound CC(O)C(C)O OWBTYPJTUOEWEK-UHFFFAOYSA-N 0.000 claims description 2
- ACCCMOQWYVYDOT-UHFFFAOYSA-N hexane-1,1-diol Chemical compound CCCCCC(O)O ACCCMOQWYVYDOT-UHFFFAOYSA-N 0.000 claims description 2
- 229940094541 polyglycerin-10 Drugs 0.000 claims description 2
- 239000010493 quinoa oil Substances 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 abstract description 21
- 230000003020 moisturizing effect Effects 0.000 abstract description 5
- 230000007246 mechanism Effects 0.000 abstract description 4
- 230000002195 synergetic effect Effects 0.000 abstract description 4
- 230000008685 targeting Effects 0.000 abstract description 3
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 238000004945 emulsification Methods 0.000 abstract 1
- 210000003491 skin Anatomy 0.000 description 35
- 240000006162 Chenopodium quinoa Species 0.000 description 30
- 238000012360 testing method Methods 0.000 description 16
- 235000015493 Chenopodium quinoa Nutrition 0.000 description 15
- 235000015112 vegetable and seed oil Nutrition 0.000 description 15
- 238000010438 heat treatment Methods 0.000 description 14
- 238000002156 mixing Methods 0.000 description 14
- 235000019198 oils Nutrition 0.000 description 14
- 238000003756 stirring Methods 0.000 description 14
- 230000000052 comparative effect Effects 0.000 description 13
- 235000014121 butter Nutrition 0.000 description 12
- 235000013399 edible fruits Nutrition 0.000 description 7
- 230000000694 effects Effects 0.000 description 7
- 238000000034 method Methods 0.000 description 7
- 239000002539 nanocarrier Substances 0.000 description 7
- 239000002245 particle Substances 0.000 description 7
- 239000005632 Capric acid (CAS 334-48-5) Substances 0.000 description 6
- 239000005635 Caprylic acid (CAS 124-07-2) Substances 0.000 description 6
- GHVNFZFCNZKVNT-UHFFFAOYSA-N Decanoic acid Natural products CCCCCCCCCC(O)=O GHVNFZFCNZKVNT-UHFFFAOYSA-N 0.000 description 6
- 238000009792 diffusion process Methods 0.000 description 6
- 229960002446 octanoic acid Drugs 0.000 description 6
- 238000010521 absorption reaction Methods 0.000 description 5
- 235000011187 glycerol Nutrition 0.000 description 5
- 230000008569 process Effects 0.000 description 5
- 239000007788 liquid Substances 0.000 description 4
- 229940015975 1,2-hexanediol Drugs 0.000 description 3
- 230000001186 cumulative effect Effects 0.000 description 3
- 238000011156 evaluation Methods 0.000 description 3
- FHKSXSQHXQEMOK-UHFFFAOYSA-N hexane-1,2-diol Chemical compound CCCCC(O)CO FHKSXSQHXQEMOK-UHFFFAOYSA-N 0.000 description 3
- 150000002632 lipids Chemical class 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 238000005070 sampling Methods 0.000 description 3
- 230000008591 skin barrier function Effects 0.000 description 3
- 210000000434 stratum corneum Anatomy 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 238000002834 transmittance Methods 0.000 description 3
- 206010067484 Adverse reaction Diseases 0.000 description 2
- 235000000857 Pentadesma butyracea Nutrition 0.000 description 2
- 240000002134 Pentadesma butyracea Species 0.000 description 2
- 206010040844 Skin exfoliation Diseases 0.000 description 2
- 230000006838 adverse reaction Effects 0.000 description 2
- 238000013270 controlled release Methods 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 238000011076 safety test Methods 0.000 description 2
- 238000013271 transdermal drug delivery Methods 0.000 description 2
- 230000036572 transepidermal water loss Effects 0.000 description 2
- 239000003109 Disodium ethylene diamine tetraacetate Substances 0.000 description 1
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 description 1
- 102100039215 Guanine nucleotide-binding protein G(t) subunit alpha-3 Human genes 0.000 description 1
- 101000888145 Homo sapiens Guanine nucleotide-binding protein G(t) subunit alpha-3 Proteins 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 210000000577 adipose tissue Anatomy 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- 238000000889 atomisation Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 239000008406 cosmetic ingredient Substances 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 239000007933 dermal patch Substances 0.000 description 1
- 210000004207 dermis Anatomy 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 230000035618 desquamation Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 235000019301 disodium ethylene diamine tetraacetate Nutrition 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 210000000883 ear external Anatomy 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 239000011888 foil Substances 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- WVULKSPCQVQLCU-BUXLTGKBSA-N glycodeoxycholic acid Chemical compound C([C@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(=O)NCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 WVULKSPCQVQLCU-BUXLTGKBSA-N 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 231100000435 percutaneous penetration Toxicity 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000010298 pulverizing process Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 238000007790 scraping Methods 0.000 description 1
- 239000002453 shampoo Substances 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 238000010025 steaming Methods 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000001839 systemic circulation Effects 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000037317 transdermal delivery Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/06—Emulsions
- A61K8/068—Microemulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Emergency Medicine (AREA)
- Dispersion Chemistry (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a ceramide co-delivering nanoemulsion and barrier repair cream. The co-delivery nanoemulsion comprises the following components in percentage by mass: (1) emulsification 3-6% of an agent; (2) ceramide 0.2-1%; (3) 5-10% of grease; (4) 10-30% of a polyol; (5) 0.1-1% of water-soluble active; (6) 50-80% of water. According to the invention, active ingredients of different skin care mechanisms such as ceramide, shea butter, sodium hyaluronate, gentian extract and the like are simultaneously coated in the same nanoemulsion, and the skin targeting co-delivery of different active ingredients is realized by a nano co-delivery system, so that the efficacy is enhanced, the problems that the active ingredients are difficult to absorb transdermally, the water dispersibility is poor and the like are solved, and the synergistic effect of multiple-effect multi-target moisturizing active ingredients is utilized, so that the repairing efficacy of cosmetics is improved.
Description
Technical Field
The invention relates to the field of cosmetics, in particular to ceramide co-delivery nanoemulsion and barrier repair cream.
Background
Transdermal absorption of the cosmetic active ingredients refers to the process by which the active ingredients in the cosmetic pass through the skin and reach the different layers of the skin to exert various effects. The main difference between cosmetics and medicines is that the functional components of cosmetics are accumulated on the acting skin layer after percutaneous penetration for the final purpose. Most cosmetic functional ingredients need to enter the skin, either to act on the surface of the skin or to enter the epidermis or dermis, and accumulate and act at that site, depending on the effectiveness of the product, without going through the skin into the systemic circulation.
Passive transdermal drug delivery based on nano-carrier does not change the skin stratum corneum structure, can avoid damaging the skin barrier function, and is an ideal transdermal drug delivery mode. The skin functional components are prepared into nano carriers, so that the transdermal absorption of the functional components can be effectively promoted, the retention of the functional components at the skin focus position is obviously increased, and the skin targeted delivery of the functional components is realized. The nano carrier has good slow release and controlled release performance, can play a role of a reservoir in skin tissues, continuously release functional components and better play a curative effect. Meanwhile, the nano carrier can effectively improve the solubility and water dispersibility of indissolvable functional components, avoid crystallization and precipitation in the standing process and improve the content of the functional components in the preparation. The nano carrier can effectively improve the stability of photosensitive and thermosensitive functional components, and reduce and eliminate the side effect of the stimulatory functional components on the skin [1] 。
The co-delivery nano carrier can simultaneously pack active ingredients of different skin care mechanisms in the same nano emulsion, can effectively promote transdermal absorption of the active ingredients, ensure that the active ingredients are retained in skin for a long time, realize slow release and controlled release, realize skin targeting co-delivery of different active ingredients, solve the problems that the active ingredients are difficult to be absorbed transdermally, have poor water dispersibility and the like, realize synergistic effect through co-loading and co-delivery of multiple-effect multi-target skin care active ingredients, and improve the moisturizing and skin barrier repairing effects of cosmetics [2] 。
Reference is made to:
[1] chen Dan, et al, skin efficacy component nanocarrier research progress [ J ]. Medical guide, 2018,37 (6): 6.
[2] Shen Huihui development of multiple-effect moisturizing co-delivery nanoemulsion and efficacy evaluation thereof [ J ]. Daily chemical science 2019,42 (4): 5.
Disclosure of Invention
In view of the above, the invention provides a co-delivery nanoemulsion, which is prepared by simultaneously encapsulating active ingredients of different skin care mechanisms such as ceramide, shea butter, gentian extract and the like in the same nanoemulsion, realizing skin-targeting co-delivery of different active ingredients by a nano co-delivery system, enhancing the efficacy, solving the problems that the active ingredients are difficult to be absorbed transdermally, the water dispersibility is poor and the like, and improving the repairing efficacy of cosmetics by the synergistic effect of multi-effect multi-target moisturizing active ingredients.
In order to achieve the above object, the present invention provides the following technical solutions:
the co-delivery nanoemulsion comprises the following components in percentage by mass:
(1) 3-6% of emulsifying agent
(2) Ceramide 0.2-1%
(3) Fat 5-10%
(4) 10-30% of polyol
(5) 0.1-1% of water-soluble active substance
(6) 50-80% of water.
In some embodiments, the emulsifier is a mixture of sodium surfactin, caprylic/capric glyceride polyglycerin-10 esters.
In some of these embodiments, the ceramide is a mixture of ceramide EOP, ceramide AP.
In some of these embodiments, the lipid is a blend of shea butter (BUTYROSPERMUM PARKII) lipid, quinoa (CHENOPODIUM QUINOA) seed oil.
The polyol can be one or more than one of methyl propylene glycol, glycerin, pentanediol, hexanediol and butanediol. In some of these embodiments, the polyol is pentanediol.
In some embodiments, the water-soluble active is sodium hyaluronate, gentian extract having an average molecular weight of less than 5000D (daltons).
The invention also provides application of the co-delivery nanoemulsion in preparation of cosmetics. The co-delivery nanoemulsion can be used as an active ingredient in cosmetics.
Specifically, the cosmetic can be shampoo, bath lotion, cosmetic water, essence, facial mask, skin care cream, and skin care emulsion.
The embodiment of the invention also provides a repair cream which comprises the following components in percentage by mass: 1-3% of cetostearyl alcohol, 3-6% of caprylic/capric triglyceride, 1-3% of polydimethylsiloxane, 0.1-1% of glycerol stearate, 0.5-1.5% of PEG-100 stearate, 0.3-0.6% of 1, 3-propanediol, 1-5% of glycerol, 0.4-0.6% of p-hydroxyacetophenone, 0.5-1% of hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, 0.1-0.4% of carbomer, 1-5% of butanediol, 0.01-0.1% of xanthan gum, 0.01-0.05% of EDTA disodium, 0.1-0.4% of arginine, 1-10% of the common delivery nanoemulsion and the balance of water.
Compared with the prior art, the technical scheme provided by the embodiment of the invention has the beneficial effects that: the invention provides co-delivery nanoemulsion, active ingredients of different skin care mechanisms such as ceramide, shea butter, sodium hyaluronate, gentian extract and the like are simultaneously coated in the same nanoemulsion, and the skin targeting co-delivery of different active ingredients is realized by a nano co-delivery system, so that the efficacy is enhanced, the problems that the active ingredients are difficult to absorb transdermally, the water dispersibility is poor and the like are solved, and the synergistic effect of multiple-effect multi-target moisturizing active ingredients is utilized, so that the repairing efficacy of cosmetics is improved.
Detailed Description
The invention discloses ceramide co-delivery nanoemulsion and barrier repair cream. Those skilled in the art can, with the benefit of this disclosure, suitably modify the process parameters to achieve this. It is specifically noted that all similar substitutions and modifications will be apparent to those skilled in the art, and are intended to be included in the present invention. While the methods and applications of this invention have been described in terms of preferred embodiments, it will be apparent to those skilled in the relevant art that the methods and applications described herein can be practiced and practiced with modification and combination of parts and without departing from the spirit and scope of the invention.
The raw materials and the reagents used in the ceramide co-delivery nanoemulsion and the barrier repair cream provided by the invention can be purchased from the market.
The cosmetic standard Chinese name of the gentian root extract is gentian (GENTIANA scana) root extract. The gentian extract can be obtained commercially or by extraction according to the following process: pulverizing radix Gentianae, soaking and extracting with 10 times of 75% V/V ethanol water solution for 4 hr, steaming to obtain extract, re-dissolving with 50% V/V butanediol water solution, and centrifuging to obtain supernatant.
The invention is further illustrated by the following examples:
example 1
The co-delivery nanoemulsion comprises the following components in percentage by mass: 0.5% of sodium surfactin, 5.5% of caprylic/capric glyceride polyglycerol-10 esters, 0.1% of ceramide EOP, 0.1% of ceramide AP, 1% of butter (BUTYROSPERMUM PARKII) fruit fat, 9% of quinoa (CHENOPODIUM QUINOA) seed oil, 10% of pentanediol, 0.1% of 5000D sodium hyaluronate, 0.9% of gentian extract and the balance of water.
The preparation process comprises the following steps: mixing caprylic acid/capric acid glyceride polyglycerol-10 esters, ceramide EOP, ceramide AP, butter of Butyrospermum parkii (BUTYROSPERMUM PARKII), quinoa (CHENOPODIUM QUINOA) seed oil, heating for dissolving and transparency to obtain oil phase, and keeping the temperature for later use; mixing sodium surfactin, pentanediol, 5000D sodium hyaluronate, radix Gentianae extract, and water, heating to 85deg.C, stirring, and dispersing to obtain water phase; under stirring, slowly dripping the water phase into the oil phase, homogenizing at 3000rpm for 3 min, and treating with 15000PSI micro-jet homogenizer for 2 times to obtain co-delivery nanoemulsion.
Example 2
The co-delivery nanoemulsion comprises the following components in percentage by mass: 1% of sodium surfactin, 2% of caprylic/capric glyceride polyglycerol-10 esters, 0.5% of ceramide EOP, 0.5% of ceramide AP, 1.5% of butter tree (BUTYROSPERMUM PARKII) fruit fat, 3.5% of quinoa (CHENOPODIUM QUINOA) seed oil, 30% of pentanediol, 0.01% of 5000D sodium hyaluronate, 0.09% of gentian root extract and the balance of water.
The preparation process comprises the following steps: mixing caprylic acid/capric acid glyceride polyglycerol-10 esters, ceramide EOP, ceramide AP, butter of Butyrospermum parkii (BUTYROSPERMUM PARKII), quinoa (CHENOPODIUM QUINOA) seed oil, heating for dissolving and transparency to obtain oil phase, and keeping the temperature for later use; mixing sodium surfactin, pentanediol, 5000D sodium hyaluronate, radix Gentianae extract, and water, heating to 85deg.C, stirring, and dispersing to obtain water phase; under stirring, slowly dripping the water phase into the oil phase, homogenizing at 3000rpm for 3 min, and treating with 15000PSI micro-jet homogenizer for 2 times to obtain co-delivery nanoemulsion.
Example 3
The co-delivery nanoemulsion comprises the following components in percentage by mass: 0.75% of sodium surfactin, 3% of caprylic/capric glyceride polyglycerol-10 esters, 0.3% of ceramide EOP, 0.3% of ceramide AP, 1.2% of butter (BUTYROSPERMUM PARKII) fruit fat, 5% of quinoa (CHENOPODIUM QUINOA) seed oil, 20% of pentanediol, 0.05% of 5000D sodium hyaluronate, 0.1% of gentian extract and the balance of water.
The preparation process comprises the following steps: mixing caprylic acid/capric acid glyceride polyglycerol-10 esters, ceramide EOP, ceramide AP, butter of Butyrospermum parkii (BUTYROSPERMUM PARKII), quinoa (CHENOPODIUM QUINOA) seed oil, heating for dissolving and transparency to obtain oil phase, and keeping the temperature for later use; mixing sodium surfactin, pentanediol, 5000D sodium hyaluronate, radix Gentianae extract, and water, heating to 85deg.C, stirring, and dispersing to obtain water phase; under stirring, slowly dripping the water phase into the oil phase, homogenizing at 3000rpm for 3 min, and treating with 15000PSI micro-jet homogenizer for 2 times to obtain co-delivery nanoemulsion.
Comparative example 1
The co-delivery nanoemulsion comprises the following components in percentage by mass: 3.75% of sodium surfactin, 0.3% of ceramide EOP, 0.3% of ceramide AP, 1.2% of butter (BUTYROSPERMUM PARKII) fruit fat, 5% of quinoa (CHENOPODIUM QUINOA) seed oil, 20% of pentanediol, 0.05% of 5000D sodium hyaluronate, 0.1% of gentian extract and the balance of water.
The preparation process comprises the following steps: mixing ceramide EOP, ceramide AP, butter of Butyrospermum parkii (BUTYROSPERMUM PARKII) and quinoa (CHENOPODIUM QUINOA) seed oil, heating to dissolve and obtain transparent oil phase, and keeping the temperature for later use; mixing sodium surfactin, pentanediol, 5000D sodium hyaluronate, radix Gentianae extract, and water, heating to 85deg.C, stirring, and dispersing to obtain water phase; under stirring, slowly dripping the water phase into the oil phase, homogenizing at 3000rpm for 3 min, and treating with 15000PSI micro-jet homogenizer for 2 times to obtain co-delivery nanoemulsion.
Comparative example 2
The co-delivery nanoemulsion comprises the following components in percentage by mass: caprylic/capric glyceride polyglycerol-10 ester 3.75%, ceramide EOP 0.3%, ceramide AP 0.3%, butter tree (BUTYROSPERMUM PARKII) fruit lipid 1.2%, quinoa (CHENOPODIUM QUINOA) seed oil 5%, pentanediol 20%, 5000D sodium hyaluronate 0.05%, radix Gentianae extract 0.1%, and water in balance.
The preparation process comprises the following steps: mixing caprylic acid/capric acid glyceride polyglycerol-10 esters, ceramide EOP, ceramide AP, butter of Butyrospermum parkii (BUTYROSPERMUM PARKII), quinoa (CHENOPODIUM QUINOA) seed oil, heating for dissolving and transparency to obtain oil phase, and keeping the temperature for later use; mixing pentanediol, 5000D sodium hyaluronate, radix Gentianae extract, and water, heating to 85deg.C, stirring, and dispersing to obtain water phase; under stirring, slowly dripping the water phase into the oil phase, homogenizing at 3000rpm for 3 min, and treating with 15000PSI micro-jet homogenizer for 2 times to obtain co-delivery nanoemulsion.
Test one particle size test
The co-delivery nanoemulsions prepared in examples 1-3 and comparative examples 1-2 were measured for particle size and PI dispersion index using a Winner802 photon correlation nanolaser particle sizer and the results are recorded in table 1 below.
Table 1 particle size test record table
| Test set | Particle size/nm | PI dispersion index | Appearance of |
| Example 1 | 94.32 | 0.1453 | Transparent and transparent |
| Example 2 | 56.47 | 0.1788 | Transparent and transparent |
| Example 3 | 97.15 | 0.1643 | Transparent and transparent |
| Comparative example 1 | 859.66 | 0.5484 | Opaque |
| Comparative example 2 | 678.32 | 0.8017 | Opaque |
As can be seen from Table 1, the samples prepared in examples 1-3 of the present invention all had particle diameters of less than 100nm and were transparent in appearance, while the samples prepared in comparative examples 1-2 all had particle diameters of much greater than 100nm and were opaque in appearance.
Test two safety test
The skin closed patch test was performed according to the human skin patch test method described in 2015 edition, "cosmetic safety Specification".
The test organizes 30 volunteers and tests the co-delivered nanoemulsions prepared in examples 1-3 to assess whether they have potential adverse reactions and can be safely used. The results are shown in Table 2, which are obtained by observing the samples at 0.5h, 24h and 48h according to the evaluation criteria described in the specifications.
Table 2 safety test record table
As can be seen from table 2 above, the co-delivery nanoemulsion prepared in this example was safe, and the subjects were all negative reactions, and no potential adverse reactions were found.
Test three transdermal test
The co-delivered nanoemulsions prepared in examples 1-3 and comparative examples 1-2 were tested as follows:
reference (Li Haile) study of the effect of atomization spray technology on the transdermal absorption of cosmetic ingredients [ J]Chemical design communication 2023,49 (03): 92-94), purchasing fresh pig ear skin, peeling pig ear outer ear skin, scraping skin back adipose tissue and adhesion (note that skin thickness is uniform), washing pig ear skin with PBS, wrapping with aluminum foil, freezing at-20deg.C, and storing for 3 months. The transdermal absorption permeation diffusion device adopts FAnd (3) a ranz diffusion cell. The diffusion pool consists of 2 parts, the left chamber is a supply pool, the right chamber is a receiving chamber, and the upper part of the receiving chamber is connected with a sampling tube. The volume of the receiving tank is 7mL, the receiving liquid is PBS, and the diffusion area is 0.95cm 2 The temperature of the thermostatic water bath was maintained at (37.0.+ -. 0.5) ℃and the sampling amount was 200. Mu.L. The area of skin was trimmed slightly greater than the surface area of the diffusion cell and the area was recorded. The quantitative repairing atomized liquid is applied to the horny layer of the pig ear in a smearing and spraying mode by a sprayer, and is fully contacted. Pig ear skin was placed on the junction of the supply cell and the receiving cell of the Franz diffusion cell, the stratum corneum was made to face the supply cell, and the skin was fixed with a spring clip, the rotation speed and temperature were kept in parallel for 3 parts, 20. Mu.L of the receiving liquid (the same amount of the blank receiving liquid was added after each sampling) was taken out at 6 hours, the taken out sample was passed through a 0.45 μm filter membrane, and the sodium hyaluronate content was measured by HPLC, and the cumulative transmittance (Tn) was calculated. The specific records are shown in Table 3.
TABLE 3 cumulative transmittance of sodium hyaluronate
| Test set | Cumulative transmittance of sodium hyaluronate (Tn,%) |
| Example 1 | 0.37±±0.11 |
| Example 2 | 0.44±0.05 |
| Example 3 | 0.34±0.02 |
| Comparative example 1 | 0.04±0.03 |
| Comparative example 2 | 0.06±0.02 |
As can be seen from Table 3 above, the samples prepared in examples 1-3 of the present invention have good transdermal delivery of the active.
Comparative example 3
The co-delivery nanoemulsion comprises the following components in percentage by mass: 0.75% of sodium surfactin, 3% of caprylic/capric glyceride polyglycerol-10 esters, 0.3% of ceramide EOP, 0.3% of ceramide AP, 1.2% of butter (BUTYROSPERMUM PARKII) fruit fat, 5% of quinoa (CHENOPODIUM QUINOA) seed oil, 20% of pentanediol, 0.15% of 5000D sodium hyaluronate and the balance of water.
The preparation process comprises the following steps: mixing caprylic acid/capric acid glyceride polyglycerol-10 esters, ceramide EOP, ceramide AP, butter of Butyrospermum parkii (BUTYROSPERMUM PARKII), quinoa (CHENOPODIUM QUINOA) seed oil, heating for dissolving and transparency to obtain oil phase, and keeping the temperature for later use; mixing sodium surfactin, pentanediol, 5000D sodium hyaluronate and water, heating to 85 ℃, stirring and dispersing uniformly to obtain a water phase; under stirring, slowly dripping the water phase into the oil phase, homogenizing at 3000rpm for 3 min, and treating with 15000PSI micro-jet homogenizer for 2 times to obtain co-delivery nanoemulsion.
Comparative example 4
The co-delivery nanoemulsion comprises the following components in percentage by mass: 0.75% of sodium surfactin, 3% of caprylic/capric glyceride polyglycerol-10 esters, 0.3% of ceramide EOP, 0.3% of ceramide AP, 1.2% of butter (BUTYROSPERMUM PARKII) fruit fat, 5% of quinoa (CHENOPODIUM QUINOA) seed oil, 20% of pentanediol, 0.15% of gentian extract and the balance of water.
The preparation process comprises the following steps: mixing caprylic acid/capric acid glyceride polyglycerol-10 esters, ceramide EOP, ceramide AP, butter of Butyrospermum parkii (BUTYROSPERMUM PARKII), quinoa (CHENOPODIUM QUINOA) seed oil, heating for dissolving and transparency to obtain oil phase, and keeping the temperature for later use; mixing sodium surfactin, pentanediol, 5000D sodium hyaluronate, radix Gentianae extract, and water, heating to 85deg.C, stirring, and dispersing to obtain water phase; under stirring, slowly dripping the water phase into the oil phase, homogenizing at 3000rpm for 3 min, and treating with 15000PSI micro-jet homogenizer for 2 times to obtain co-delivery nanoemulsion.
Example 4
A repair cream consists of the following components in percentage by mass: 2% of cetostearyl alcohol, 5% of caprylic/capric triglyceride, 2% of polydimethylsiloxane, 0.5% of glycerol stearate, 1% of PEG-100 stearate, 0.5% of 1, 2-hexanediol, 3% of 1, 3-propanediol, 3% of glycerol, 0.5% of p-hydroxyacetophenone, 0.7% of hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, 0.3% of carbomer, 3% of butanediol, 0.05% of xanthan gum, 0.03% of disodium EDTA, 0.3% of arginine, 1-10% of co-delivery nanoemulsion prepared in example 3 and the balance of water.
Example 5
A repair cream consists of the following components in percentage by mass: 2% of cetostearyl alcohol, 5% of caprylic/capric triglyceride, 2% of polydimethylsiloxane, 0.5% of glycerol stearate, 1% of PEG-100 stearate, 0.5% of 1, 2-hexanediol, 3% of 1, 3-propanediol, 3% of glycerol, 0.5% of p-hydroxyacetophenone, 0.7% of hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, 0.3% of carbomer, 3% of butanediol, 0.05% of xanthan gum, 0.03% of EDTA disodium, 0.3% of arginine, 1-10% of co-delivery nanoemulsion prepared in comparative example 3 and the balance of water.
Example 6
A repair cream consists of the following components in percentage by mass: 2% of cetostearyl alcohol, 5% of caprylic/capric triglyceride, 2% of polydimethylsiloxane, 0.5% of glycerol stearate, 1% of PEG-100 stearate, 0.5% of 1, 2-hexanediol, 3% of 1, 3-propanediol, 3% of glycerol, 0.5% of p-hydroxyacetophenone, 0.7% of hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, 0.3% of carbomer, 3% of butanediol, 0.05% of xanthan gum, 0.03% of EDTA disodium, 0.3% of arginine, 1-10% of co-delivery nanoemulsion prepared in comparative example 4 and the balance of water.
Trial four, volunteer trial test
The repair cream prepared in examples 4 to 6 was evaluated for repair efficacy by reference to the group standard "cosmetic repair efficacy human evaluation method T/GDCA 009-2022" organized volunteers formulated by the chemical society of guangdong province, and specifically tested as follows:
93 volunteers were summoned, and the volunteers were randomly divided into 3 groups of 31 persons each, and the cream prepared in examples 4 to 6 was tried out, and the cream was applied to the face of each person once a day, each time in the morning and evening, with the dose of each time being 0.1g/10cm 2 。
The inclusion criteria for volunteers were: age between 18 and 60 years, healthy men or women; lactic acid stinging positive; subjective skin has one of symptoms of impaired skin barrier function, such as dryness, desquamation, redness, etc.; the test process can be understood, and the test is voluntarily participated in and the informed consent person is signed; the product can be used in a proper amount according to the requirement.
The skin TEWL values and moisture content of the volunteers on day 0, day 14, and day 28 were tested using a trans-epidermal water loss tester, a stratum corneum moisture content tester, and the arithmetic mean of the test group was calculated. The specific test results are shown in Table 4.
TABLE 4 Table of skin TEWL values and moisture content of volunteers
From the above table 4, the skin transepidermal water loss and the skin cuticle water content of the volunteers are obviously improved after the 14 th day of the application of the repairing cream prepared by the embodiment of the invention, and the effect is enhanced after the 28 th day, thus showing good repairing effect.
The foregoing is merely a preferred embodiment of the present invention and it should be noted that modifications and adaptations to those skilled in the art may be made without departing from the principles of the present invention, which are intended to be comprehended within the scope of the present invention.
Claims (8)
1. The co-delivery nanoemulsion is characterized by comprising the following components in percentage by mass:
(1) 3-6% of emulsifying agent
(2) Ceramide 0.2-1%
(3) Fat 5-10%
(4) 10-30% of polyol
(5) 0.1-1% of water-soluble active substance
(6) 50-80% of water.
2. The co-delivery nanoemulsion of claim 1, wherein the emulsifier is a mixture of sodium surfactin, caprylic/capric glyceride polyglycerin-10 esters.
3. The co-delivered nanoemulsion according to claim 1, wherein the ceramide is a mixture of ceramide EOP, ceramide AP.
4. The co-delivered nanoemulsion of claim 1, wherein the grease is a blend of shea butter, quinoa oil.
5. The co-delivered nanoemulsion of claim 1, wherein the polyol is one or more of methyl propylene glycol, glycerol, pentanediol, hexanediol, and butanediol.
6. The co-delivered nanoemulsion of claim 1, wherein the water-soluble active is sodium hyaluronate having an average molecular weight of less than 5000D, gentian extract.
7. Use of the co-delivered nanoemulsion according to any one of claims 1-6 for the preparation of cosmetics.
8. The repair cream is characterized by comprising the following components in percentage by mass: 1-3% of cetostearyl alcohol, 3-6% of caprylic/capric triglyceride, 1-3% of polydimethylsiloxane, 0.1-1% of glycerol stearate, 0.5-1.5% of PEG-100 stearate, 0.3-0.6% of 1, 3-propanediol, 1-5% of glycerol, 0.4-0.6% of p-hydroxyacetophenone, 0.5-1% of hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, 0.1-0.4% of carbomer, 1-5% of butanediol, 0.01-0.1% of xanthan gum, 0.01-0.05% of EDTA disodium, 0.1-0.4% of arginine, 1-10% of the co-delivery nanoemulsion of any one of claims 1-6, and the balance of water.
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| KR102104214B1 (en) * | 2019-12-24 | 2020-04-23 | 오한상 | Cosmetic composition comprising potassium alum |
| CN111148505A (en) * | 2017-09-01 | 2020-05-12 | 株式会社爱茉莉太平洋 | Oil-in-water cosmetic composition with stable high content of oil inner phase |
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| CN111148505A (en) * | 2017-09-01 | 2020-05-12 | 株式会社爱茉莉太平洋 | Oil-in-water cosmetic composition with stable high content of oil inner phase |
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