CN116981657A - 含氟化合物及造影剂 - Google Patents

含氟化合物及造影剂 Download PDF

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Publication number
CN116981657A
CN116981657A CN202280020932.5A CN202280020932A CN116981657A CN 116981657 A CN116981657 A CN 116981657A CN 202280020932 A CN202280020932 A CN 202280020932A CN 116981657 A CN116981657 A CN 116981657A
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CN
China
Prior art keywords
fluorine
formula
general formula
substituent
carbon atoms
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
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CN202280020932.5A
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English (en)
Chinese (zh)
Inventor
矢内直子
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
TDK Corp
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TDK Corp
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Publication date
Application filed by TDK Corp filed Critical TDK Corp
Publication of CN116981657A publication Critical patent/CN116981657A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/20—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations containing free radicals, e.g. trityl radical for overhauser

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN202280020932.5A 2021-03-17 2022-03-16 含氟化合物及造影剂 Pending CN116981657A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2021043724 2021-03-17
JP2021-043724 2021-03-17
PCT/JP2022/011975 WO2022196734A1 (ja) 2021-03-17 2022-03-16 含フッ素化合物および造影剤

Publications (1)

Publication Number Publication Date
CN116981657A true CN116981657A (zh) 2023-10-31

Family

ID=83321051

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202280020932.5A Pending CN116981657A (zh) 2021-03-17 2022-03-16 含氟化合物及造影剂

Country Status (5)

Country Link
US (1) US20240156994A1 (https=)
JP (1) JPWO2022196734A1 (https=)
CN (1) CN116981657A (https=)
DE (1) DE112022001543T5 (https=)
WO (1) WO2022196734A1 (https=)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5318770A (en) * 1991-10-25 1994-06-07 Mallinckrodt Medical, Inc. Trifluoromethyl analogs of X-ray contrast media for magnetic resonance imaging
CN101035755A (zh) * 2004-10-05 2007-09-12 通用电气健康护理有限公司 脱保护的方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5362477A (en) * 1991-10-25 1994-11-08 Mallinckrodt Medical, Inc. 19F magnetic resonance imaging agents which include a nitroxide moiety

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5318770A (en) * 1991-10-25 1994-06-07 Mallinckrodt Medical, Inc. Trifluoromethyl analogs of X-ray contrast media for magnetic resonance imaging
CN101035755A (zh) * 2004-10-05 2007-09-12 通用电气健康护理有限公司 脱保护的方法

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
JEAN ROUILLON, 等: "Determination of Photoinduced Radical Generation Quantum Efficiencies by Combining Chemical Actinometry and 19F NMR Spectroscopy", 《ANAL. CHEM.》, vol. 93, 21 January 2021 (2021-01-21), pages 2926, XP055967399, DOI: 10.1021/acs.analchem.0c04540ï¿¿ *
NEIL R. CAMERON, 等: "Studies on controlled radical polymerisation using 5-membered cyclic PROXYL nitroxides and corresponding alkoxyamines", 《MACROMOL. CHEM. PHYS.》, vol. 201, no. 17, 31 December 2000 (2000-12-31), pages 2510 - 2518, XP055967402, DOI: 10.1002/1521-3935(20001101)201:17<2510::AID-MACP2510>3.0.CO;2-S *
NEIL R. CAMERON, 等: "The Use of PROXYL Nitroxides in Nitroxide-Mediated Polymerization", 《ACS SYMPOSIUM SERIES》, vol. 854, 31 December 2003 (2003-12-31), pages 452 - 465, XP055967400, DOI: 10.1021/bk-2003-0854.ch032 *

Also Published As

Publication number Publication date
WO2022196734A1 (ja) 2022-09-22
US20240156994A1 (en) 2024-05-16
JPWO2022196734A1 (https=) 2022-09-22
DE112022001543T5 (de) 2023-12-28

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