CN116942579B

CN116942579B - Gum protecting toothpaste and preparation method thereof

Info

Publication number: CN116942579B
Application number: CN202311124221.5A
Authority: CN
Inventors: 邓矿生; 黄文东; 王忠安
Original assignee: Lion King Oral Products Guangzhou Co ltd
Current assignee: Lion King Oral Products Guangzhou Co ltd
Priority date: 2023-09-01
Filing date: 2023-09-01
Publication date: 2024-01-30
Anticipated expiration: 2043-09-01
Also published as: CN116942579A

Abstract

The application relates to the field of toothpaste, in particular to gum-protecting toothpaste and a preparation method thereof. A gum protecting toothpaste comprises the following components: humectant, thickener, carrageenan extract, friction agent, sweetener, antiseptic, aromatic, herba Menthae extract, foaming agent, surfactant foaming agent, cetylpyridinium chloride, antiinflammatory agent, antibacterial agent, colorant, cinnamomum camphora root/stem extract, and water; the preparation method comprises the following steps: mixing sweetener, antiseptic, cetylpyridinium chloride, foaming agent, 45-55% of supplemental antiinflammatory agent, and camphor root/stem extract with water, adding humectant and supplemental antibacterial agent, and mixing to obtain primary mixture; mixing the thickener, the carrageenan extract, the friction agent, the surfactant foaming agent and the colorant, and then mixing with the primary mixed material to obtain a secondary mixed material; adding aromatic, the rest of supplementary antiinflammatory agent and herba Menthae extract into the mixture, and mixing to obtain the final product. The application has the advantages of ensuring the antibacterial effect and simultaneously reducing the irritation.

Description

Gum protecting toothpaste and preparation method thereof

Technical Field

The application relates to the field of toothpaste, in particular to gum-protecting toothpaste and a preparation method thereof.

Background

At present, with the continuous development of oral cleaning products, the variety of toothpastes is various, and the toothpastes with single cleaning function are developed into various toothpastes with different functions.

The oral cavity serves as a complex ecological system, and microorganisms in the oral cavity are various, so that the oral cavity becomes an initiating factor of various oral diseases. In order to effectively control the pathogenic effects of pathogenic microorganisms, various chemical bacteriostats such as chlorhexidine, cetylpyridinium chloride, etc. are used in oral care products. Although they have a certain effect, they have disadvantages of different degrees, such as bitter taste, irritation to mucous membrane, short action time, etc., and the oral cavity flora imbalance is easily caused by long-term use. Therefore, there is still a need for improvement.

Disclosure of Invention

In order to ensure the antibacterial effect and reduce the irritation, the application provides a gum-protecting toothpaste and a preparation method thereof.

In a first aspect, the present application provides a gum-protecting toothpaste, which adopts the following technical scheme:

the gum-protecting toothpaste comprises the following components in percentage by mass: 50-65% humectant, 0.1-6% thickener, 0.1-4.5% carrageenan extract, 10-20% friction material, 0.1-0.5% sweetener, 0-0.5% preservative, 0-1.5% fragrance, 0.1-0.5% peppermint extract, 0.1-0.5% foaming agent, 1-3% surfactant foaming agent, 0.1-0.15% cetylpyridinium chloride, 0-0.2% supplemental anti-inflammatory agent, 0-2% supplemental bacteriostatic agent, 0-0.2% colorant, 0.5-1.5% camphor root/stem, water supplemental balance to 100%.

In order to reduce the irritation of cetylpyridinium chloride to the oral cavity, the dosage of cetylpyridinium chloride in the gum-protecting toothpaste is reduced, and the irritation is relieved while the effective antibacterial and anti-inflammatory effects are ensured. In addition, in order to improve the antibacterial and anti-inflammatory effects, the camphor tree root/stem extract and the mint extract are also selected, and under the cooperation of the camphor tree root/stem extract and the mint extract, the effect on lipopolysaccharide is achieved, so that the inflammation can be effectively relieved, the uncomfortable feeling of sensitive teeth is reduced, and the effect of assisting cetylpyridinium chloride in anti-inflammation and antibacterial is achieved.

Although cetylpyridinium chloride can provide good antibacterial and anti-inflammatory effects, cetylpyridinium chloride can cause staining of teeth, which is unfavorable for whitening teeth. By adopting the technical scheme, under the joint coordination of the carrageenan extract, the mint extract and the camphor tree root/stem extract, the tea stain and the smoke stain can be quickly attached to teeth, become fluffy and can be more easily fallen off by the joint coordination of the tea stain and the smoke stain with the friction agent; part of the effective substances can also pass through enamel and dentin and move between enamel pillars, so that pigment molecules in teeth can be rapidly decomposed and removed. Meanwhile, the effect on the tooth surface and the tooth interior is achieved, double whitening is achieved, and the influence of cetylpyridinium chloride on tooth staining is relieved.

The toothpaste remains on the tooth surface for a short period of time, resulting in some of the actives not yet functioning and having been washed away by the water. In practice, the combination of the carrageenan extract, the mint extract and the camphor root/stem extract can generate a layer of film with ion selectivity on the surface of teeth, so that the retention time of effective substances on the enamel, dentin and tooth surface can be prolonged, external harmful substances can be isolated, and the whitening, antibacterial and anti-inflammatory effects of the gum-protecting toothpaste can be improved from multiple aspects.

Preferably, the mass ratio of the carrageenan extract, the mint extract and the camphor tree root/stem extract is (1.5-2.5): (0.2-0.4): (0.8-1.3).

By adopting the technical scheme, after the mass ratio of the carrageenan extract, the mint extract and the camphor tree root/stem extract is further limited, the stability of the specially formed film can be effectively enhanced, and the whitening, antibacterial and anti-inflammatory effects of the active substances on teeth are further promoted.

Preferably, the thickener comprises one or more of cellulose gum, xanthan gum, carrageenan, and hydroxyethyl cellulose.

Preferably, the thickener is cellulose gum and xanthan gum, and the mass ratio of the cellulose gum to the xanthan gum is 1: (1-3) based on the mass of the cellulose gum.

The thickener can make toothpaste have proper viscosity, consistency and good fluidity, so that the powder in the toothpaste system is more stably dispersed in the liquid phase.

By adopting the technical scheme, the thickening agent with specific types and proportions is matched with the carrageenan extract, the peppermint extract, the camphor root/stem extract and the friction agent, so that the effective substances can be uniformly dispersed in the system in a more stable state. After the friction agent is contacted with teeth to rub the surfaces of the teeth, the structures formed by the carrageenan extract, the mint extract and the camphor root/stem extract can be rapidly and stably formed into films at the positions of the friction agents and the teeth, so that good whitening, antibacterial and anti-inflammatory effects are achieved.

Preferably, the supplemental anti-inflammatory agent comprises one or more of honokiol, paeonol, eugenol.

Preferably, the supplementary anti-inflammatory agent is honokiol and paeonol, and the mass ratio of honokiol to paeonol is 1: (0.8-1.5) based on the mass of honokiol.

By adopting the technical scheme, the supplemental anti-inflammatory agent matched with specific types and proportions can provide a large amount of active hydrogen protons which are rapidly combined with peroxidation free radicals, so that better, faster and more stable anti-inflammatory effects are exerted.

Preferably, the humectant comprises one or more of sorbitol, glycerol, polyethylene glycol-8, propylene glycol.

Preferably, the humectant is sorbitol and glycerin, wherein the sorbitol accounts for 50-60% of the total gum-protecting toothpaste, and the glycerin accounts for 2-4% of the total gum-protecting toothpaste.

Preferably, the friction agent comprises one or more of hydrated silica, dibasic calcium phosphate dihydrate, aluminum hydroxide.

Preferably, the abrasive is hydrated silica.

Preferably, the sweetener comprises one or more of saccharin sodium, xylitol, and trichlorogalactose.

Preferably, the sweetener is sodium saccharin.

Preferably, the foaming agent comprises one or more of sodium lauroyl glutamate, sodium laurylsulfate and sodium lauroyl sarcosinate.

Preferably, the foaming agent is sodium lauroyl glutamate.

Preferably, the surface active foaming agent comprises one or more of poloxamer 407, poloxamer 105 and poloxamer 123.

Preferably, the surfactant foaming agent is poloxamer 407.

Preferably, the supplementary bacteriostat comprises the following components in percentage by mass: 0.03-0.1% sodium citrate, 0.01-0.02% silver sulfate, 0.01-0.02% silver, 0.2-0.8% sodium dodecyl benzene sulfonate, and water for the rest to 100%.

In a second aspect, the present application provides a preparation method of a gum protecting toothpaste, which adopts the following technical scheme:

a preparation method of gum-protecting toothpaste comprises the following steps:

mixing sweetener, antiseptic, cetylpyridinium chloride, foaming agent, 45-55% of supplementary antiinflammatory agent, and camphor root/stem extract with water, dissolving, and then adding humectant and supplementary antibacterial agent to obtain primary mixture;

mixing the thickener, the carrageenan extract, the friction agent, the surfactant and the colorant, and then mixing with the primary mixed material to obtain a middle mixed material;

adding the aromatic, the rest of the supplementary anti-inflammatory agent and the mint extract into the mixture, and uniformly mixing to obtain a finished product.

By adopting the technical scheme, various raw materials are mixed by adopting a specific feeding sequence, and the various raw materials have better mixing effect, so that the matching effect is fully exerted.

Preferably, when the primary mixed material is prepared, the vacuum degree is controlled to be more than or equal to-0.06 MPa; when mixing materials in preparation, the vacuum degree is controlled to be more than or equal to-0.08 MPa.

Through adopting above-mentioned technical scheme, the vacuum degree when further limiting the mixing, the bubble that produces when making the material mix reduces to minimum, obtains finer and smooth toothpaste to can fully, comprehensive contact with the tooth, increase the contact effect of active substance and tooth, thereby form more stable membrane, exert better whitening, antibacterial anti-inflammatory effect.

In summary, the present application has the following beneficial effects:

1. the application reduces the dosage of cetylpyridinium chloride in the gum-protecting toothpaste and reduces the irritation; meanwhile, camphor tree root/stem extract and mint extract are selected, and under the cooperation of the camphor tree root/stem extract and mint extract, the camphor tree root/stem extract has an effect on lipopolysaccharide, reduces inflammation, and assists cetylpyridinium chloride in diminishing inflammation and inhibiting bacteria.

2. Under the common coordination of the carrageenan extract, the mint extract and the camphor root/stem extract, part of effective substances can also pass through enamel and dentin and move between enamel pillars, so that pigment molecules in the teeth can be rapidly decomposed and removed. The active substances which do not penetrate through enamel and dentin can make tea stains and smoke stains fluffy, and the tea stains and the smoke stains are matched with a friction agent together, so that the tea stains and the smoke stains can fall off more easily, whitening is realized on the surface of teeth and the inside of teeth, and the influence of cetylpyridinium chloride on tooth staining is relieved.

3. Under the common cooperation of the carrageenan extract, the mint extract and the camphor root/stem extract, a layer of film with ion selectivity can be generated on the surface of teeth, so that the residence time of effective substances on enamel, dentin and the surface of teeth can be prolonged, external harmful substances can be isolated, and the whitening, antibacterial and anti-inflammatory effects of the gum-protecting toothpaste can be improved from multiple aspects.

Detailed Description

The present application is described in further detail below with reference to examples.

The raw materials used in the following examples and comparative examples are all commercially available products.

Preparation example

Preparation example 1

A supplemental bacteriostatic agent comprising the following components: 0.05kg sodium citrate, 0.01kg silver sulfate, 0.02kg silver, 0.6kg sodium dodecyl benzene sulfonate, 99.32kg water.

Mixing the above materials, and stirring to obtain the final product.

Examples

Example 1

A gum-protecting toothpaste, which comprises the following components: moisturizer, thickener, carrageenan (CHONDRUS CRISPUS) extract, abrasive, sweetener, preservative, aromatic, peppermint (MENTHAPLOCALYX) extract, foaming agent, surfactant foaming agent, cetylpyridinium chloride, supplemental anti-inflammatory agent, supplemental bacteriostatic agent, colorant, camphor tree (CINNAMOMUM CAMPHORA) root/stem extract, and water.

The humectant is sorbitol and glycerol.

The thickener is cellulose gum, xanthan gum, which is purchased from well-known Weiyi technology Co.

The abrasive is hydrated silica.

The sweetener is saccharin sodium.

The preservative is sodium benzoate.

The aromatic is essence.

The foaming agent is sodium lauroyl glutamate.

The surfactant foaming agent is poloxamer 407.

The supplementary antiinflammatory agent is honokiol and paeonol.

The supplementary bacteriostat obtained in preparation example 1 is adopted.

The colorant is CI 77891.

The Chondrus crispus extract was purchased from Guangzhou Jiahui chemical Co., ltd, the peppermint extract was purchased from Guangzhou Jihui flavor Co., ltd, and the camphor root/stem extract was purchased from Siam Heshun biotechnology Co.

The specific amounts of the raw materials are shown in Table 1.

The application also provides a preparation method of the gum-protecting toothpaste, which comprises the following steps:

1. starting a vacuum pump valve, and when the vacuum degree reaches-0.06 Mpa, opening a feed valve, and dissolving saccharin sodium, sodium benzoate, cetylpyridinium chloride, sodium lauroyl glutamate, paeonol, and Cinnamomum camphora root/stem extract in water.

2. After dissolution, sorbitol, glycerol and supplemental bacteriostat are added into the material in step 1 to be mixed, thus obtaining a primary mixed material.

3. When the vacuum degree is increased to-0.08 Mpa, a scraper is started (slow stirring), and the powder, cellulose gum, xanthan gum, carrageenan extract, hydrated silica, poloxamer 407 and CI 77891 are stirred and mixed with the primary mixed material to obtain the middle mixed material.

The powder is fed by a feeding valve, and 5 times of feeding are performed in the feeding process.

4. The mixed materials are continuously stirred for 28 minutes, and the mixed materials are uniformly mixed and stirred.

5. Mixing essence, honokiol and herba Menthae extract, and stirring for 5 min.

6. Vacuumizing until the paste is uniform and fine, and obtaining the finished product.

Example 2

A gum-protecting toothpaste, which is different from example 1 in that the mass ratio of the carrageenan extract, the peppermint extract and the camphor root/stem extract is 1.5:0.4:1.3. the use amount of the carrageenan extract was 1.5kg, the use amount of the mint extract was 0.4kg, and the use amount of the camphor root/stem extract was 1.3kg.

The thickener is cellulose gum and xanthan gum, and the mass ratio of the cellulose gum to the xanthan gum is 1:1. the amount of cellulose gum used was 0.6kg and that of xanthan gum was 0.6kg.

The mass ratio of honokiol to paeonol is 1:1.5, the dosage of honokiol is 0.03kg, and the dosage of paeonol is 0.045kg.

The amount of water used was 22.925kg.

The specific amounts are summarized in Table 1.

Example 3

A gum-protecting toothpaste, which is different from example 1 in that the mass ratio of the carrageenan extract, the peppermint extract and the camphor root/stem extract is 2.5:0.2:0.8. the use amount of the carrageenan extract was 2.5kg, the use amount of the mint extract was 0.2kg, and the use amount of the camphor root/stem extract was 0.8kg.

The thickener is cellulose gum and xanthan gum, and the mass ratio of the cellulose gum to the xanthan gum is 1:3. the amount of cellulose gum used was 0.6kg and that of xanthan gum was 1.8kg.

The mass ratio of honokiol to paeonol is 1:0.8, the dosage of honokiol is 0.03kg, and the dosage of paeonol is 0.024kg.

The amount of water used was 21.446kg.

The specific amounts are summarized in Table 1.

Example 4

A gum-protecting toothpaste, which is different from example 1 in that the mass ratio of the carrageenan extract, the peppermint extract and the camphor root/stem extract is 2.9:0.1:0.5. the use amount of the carrageenan extract was 2.9kg, the use amount of the mint extract was 0.1kg, and the use amount of the camphor root/stem extract was 0.5kg.

Example 5

A gum-protecting toothpaste, which is different from example 1 in that the thickener is cellulose gum, xanthan gum, and the mass ratio of the cellulose gum to the xanthan gum is 1:9. the amount of cellulose gum used was 0.6kg and that of xanthan gum was 5.4kg.

The amount of water used was 17.84kg.

Example 6

The gum-protecting toothpaste is different from example 1 in that the amounts of the raw materials are different, and the details are shown in Table 1.

Example 7

TABLE 1

Comparative example

Comparative example 1

A gum-protecting toothpaste is different from example 1 in that the extract of Chondrus crispus is replaced with ALOE (Aloe VERA) extract, the amount of the extract of Chondrus crispus is 0kg, and the amount of the extract of Aloe is 2kg.

Aloe extract was purchased from guangzhou Hua biosciences limited.

Comparative example 2

A gum protecting toothpaste is different from example 1 in that the peppermint extract is replaced with stevia (STEVIA REBAUDIANA) extract, the amount of peppermint extract used is 0kg, and the amount of stevia extract used is 0.3kg.

Stevia rebaudiana extract is purchased from mountain yang-linked biosciences, inc.

Comparative example 3

The gum-protecting toothpaste is different from example 1 in that the extract of the root/stem of the camphor tree is replaced with the extract of the bark of the white birch (BETULA ALBA), the amount of the extract of the root/stem of the camphor tree used is 0kg, and the amount of the extract of the white birch bark used is 1.2kg.

The white birch bark extract was purchased from Shaanxi Sihe Biotechnology Inc.

Comparative example 4

The gum-protecting toothpaste is different from example 1 in that the use amount of the carrageenan extract is 0.05kg, the use amount of the peppermint extract is 3.2kg, and the use amount of the camphor root/stem extract is 0.25kg.

Performance test

1. Anti-inflammatory effect:

1) Test article: gingiva protection toothpastes of examples 1 to 7 and comparative examples 1 to 4.

2) Experimental animals and feeding environment:

SPF-grade KM mice, 48 females, 18-22g, were supplied by the medical laboratory animal center in Guangdong province.

Feed was provided by the medical laboratory animal center in Guangdong province.

After purchasing animals, raising the animals in a barrier animal house, and using the animals after quarantine is qualified; the temperature of the animal house is 20-26 ℃ and the humidity is 40-70%.

3) The test method comprises the following steps:

mice were divided into 12 groups of 4 mice each; there were 11 groups for corresponding detection of one test, the 11 mice were the test groups, and the remaining 1 group served as the model control group.

The left ear of the mouse is not treated to be used as a background value, 30 mu L of xylene solution is coated on the inner side and the outer side of the right ear together, after 30min, a model control group is not treated, 100 mu L of corresponding test objects are coated on the two sides of the right ear of the mouse of the test group, after the test objects are coated for 1h, the mouse is killed at the cervical dislocation position, the test objects are wiped off, the ears are cut off, and the weighing record of the ear pieces (the same parts of the left ear and the right ear) with the diameter of 8mm is taken. The weight of the left and right ears of the same mouse is the swelling degree.

The swelling inhibition was calculated according to the following formula.

2. Antibacterial effect: the gingiva-protecting toothpastes of examples 1 to 7 and comparative examples 1 to 4 were tested according to WS/T650-2019, antibacterial and bacteriostatic effect evaluation method, and the bacteriostatic rates against Escherichia coli, staphylococcus aureus, and Candida albicans were recorded.

3. Whitening effect:

test article: gingiva protection toothpastes of examples 1 to 7 and comparative examples 1 to 4.

The test method comprises the following steps:

1) Manufacturing a tooth grinding block: bovine incisors were cut into enamel blocks approximately 5 x 2mm in size and embedded in polymethyl methacrylate resin. The labial surface of the tooth enamel is polished by using 180-mesh abrasive paper wetted by water, and the tooth enamel surface with an arc-shaped structure is polished to be flat. After rinsing the sample with water, the enamel surface was polished smooth with 600 mesh sandpaper by wetting with water. The solution was rinsed with deionized water in an ultrasonic bath for 15 minutes.

2) Acid etching: immersing the tooth grinding block in 1% hydrochloric acid, stirring for 60s, taking out, and washing with clear water; then immersing in saturated sodium carbonate solution, stirring for 60s, taking out, and washing with clear water; finally, immersing the mixture into 1% phytic acid solution, stirring for 60s, taking out, and washing with clear water.

3) Preparing a staining solution: dissolving gastric mucin with hot water, adding coffee, soy sauce and black tea, stirring, standing, and cooling. FeCl stored at 4 ℃ is added before use ₃ A solution. Final concentration of each component: gastric mucin 2.5g/L, coffee 4.0g/L, soy sauce 4.0g/L, black tea 4.0g/L and ferric chloride 0.05g/L.

4) Staining of dental grinding blocks: and (5) placing the tooth grinding block with the acid etching into a dyeing machine for dyeing for 12 days. The stained dental abrasive blocks were numbered and labeled, and the color of enamel was measured with a colorimeter (L x _{Before brushing teeth} ) Dental abrasive blocks with L values of 30-50 were selected, randomly allocated, and each group of subjects was brushed with 5 dental abrasive blocks.

5) Preparation of test sample slurry: according to 1:1.6 (toothpaste: water) a certain weight of toothpaste (test object) to be tested and deionized water are weighed, and stirred by a glass rod to disperse the toothpaste, and then stirred by a magnetic stirrer to be homogenized for standby.

6) Simulating a tooth brushing process: the tooth grinding block is placed into a sample fixing groove of an automatic mechanical tooth brushing machine for fixing, so that the tooth grinding block is higher than the sample fixing groove by about 2mm, and a screw is screwed down for fixing the tooth grinding block. The toothbrush head was mounted so that the bristles vertically contacted the enamel surface, and the total weight of the toothbrush head and the stem was 150g. About 70g of the sample slurry to be measured was weighed and added to a fixed mounting toothbrush head so that the bristles vertically contact the enamel surface, the total weight of the toothbrush head and the rod being 150g. About 70g of the sample slurry to be measured is weighed and added into a grinding liquid bottle, and the grinding liquid bottle is fixed on a tooth brushing machine, so that the slurry is buried in tooth grinding blocks, and tooth brushing is carried out for 800 times. After the tooth brushing is finished, the tooth grinding block is taken out from the tooth brushing machine, washed clean by water, sucked by paper towel and dried.

7) Determination of enamel colour after brushing L _{After brushing the teeth} And the difference between the values of L before and after brushing was calculated and noted as Δl.

4. Irritation detection: 55 volunteers with healthy teeth and 25-35 years old were selected and divided into 11 groups of 5 persons, and one group of toothpaste for protecting gingiva corresponding to one of examples 1-7 and comparative examples 1-4.

The volunteers brushed their teeth with the corresponding gum-protecting toothpaste in the morning and evening for 5 days and the sum of the number of times all volunteers felt uncomfortable during the test period was recorded.

The above detection results are shown in Table 2.

TABLE 2

Comparative examples 1 to 3 are toothpastes obtained by replacing any one of the extracts of carrageenan, peppermint, and camphor tree root/stem with the other plant extracts on the basis of example 1. As can be seen from comparison of the test data of example 1 and comparative examples 1 to 3 in Table 2, the toothpaste prepared in comparative examples 1 to 3 had a much lower inhibition rate of ear swelling at about 10%, than that of example 1 at 22.61%; in the antibacterial test, the toothpastes of comparative examples 1 to 3 only show the degree of antibacterial effect on various bacteria, which is less remarkable than the strong antibacterial effect of example 1; in terms of irritation, volunteers using the toothpaste of comparative examples 1-3 had more dental discomfort than example 1. From the detection data, the toothpaste of example 1 can keep mildness and has good anti-inflammatory and antibacterial effects. In the whitening test, although the toothpaste of comparative examples 1-3 was used to whiten the color of the dental pad, the degree of whitening was significantly less than in example 1. According to the technical scheme, under the cooperation of the carrageenan extract, the mint extract and the camphor tree root/stem extract, cetylpyridinium chloride can be assisted to have a good effect, and teeth can be whitened in a mode of being attached to the surfaces of the teeth, penetrating enamel dentin and the like. If the special combination of the three is destroyed, the ideal effect cannot be achieved.

Comparative example 4 is based on example 1, the use ratio of the extract of carrageenan, the extract of peppermint and the extract of root/stem of camphor tree was greatly destroyed, and the amounts of the three were changed to be out of a specific limit range. Example 4 was obtained by disrupting the ratio of the extract of carrageenan, the extract of peppermint and the extract of camphor tree root/stem on the basis of example 1, but the amount of the extract was still within a specific limit, and examples 2 and 3 were obtained by limiting the ratio of the extract of carrageenan, the extract of peppermint and the extract of camphor tree root/stem on the basis of a specific limit. As is clear from the comparison of the test data of comparative examples 4 and examples 2 to 4, comparative example 4 shows better effects than comparative examples 1 to 3 in the detection of the anti-inflammatory effect, the antibacterial effect and the whitening effect, but the effects are significantly inferior to those of examples 1 and 4. The toothpaste of example 4 was tested for anti-inflammatory, bacteriostatic, whitening etc. and, although better than comparative examples 1-4, it was slightly inferior to example 1. Examples 2-3 have better results than example 4, comparative example 4. The method further limits the use proportion and the use amount range of the carrageenan extract, the mint extract and the camphor root/stem extract, and can more fully and effectively realize the special matching effect among the three. The amount of the three materials is changed or the proportion of the three materials is destroyed, and the obtained toothpaste can not generate beneficial effects in the given direction.

Example 5 is that the amount and proportion of the thickener are changed based on example 1, and the performance of the prepared toothpaste is better than that of example 1 in the detection of anti-inflammation, bacteriostasis, whitening and the like. The specific dosage and proportion of the thickening agent can influence the dispersion and suspension of the whole system, thereby influencing the compounding effect of the carrageenan extract, the peppermint extract and the camphor tree root/stem extract.

The present embodiment is merely illustrative of the present application and is not intended to be limiting, and those skilled in the art, after having read the present specification, may make modifications to the present embodiment without creative contribution as required, but is protected by patent laws within the scope of the claims of the present application.

Claims

1. The gum-protecting toothpaste is characterized by comprising the following components in percentage by mass: 50-65% humectant, 0.1-6% thickener, 0.1-4.5% carrageenan extract, 10-20% abrasive, 0.1-0.5% sweetener, 0-0.5% preservative, 0-1.5% flavoring, 0.1-0.5% peppermint extract, 0.1-0.5% foaming agent, 1-3% surfactant foaming agent, 0.1-0.15% cetylpyridinium chloride, 0.054-0.2% supplemental anti-inflammatory agent, 1.5-2% supplemental antibacterial agent, 0-0.2% colorant, 0.5-1.5% camphor root/stem extract, water supplemental balance to 100%;

the mass ratio of the carrageenan extract to the mint extract to the camphor tree root/stem extract is (1.5-2.5): (0.2-0.4): (0.8-1.3);

the thickener is cellulose gum and xanthan gum, and the mass ratio of the cellulose gum to the xanthan gum is 1: (1-3) based on the mass of the cellulose gum;

the supplementary anti-inflammatory agent is honokiol and paeonol, and the mass ratio of honokiol to paeonol is 1: (0.8-1.5) based on the mass of honokiol;

the humectant comprises one or more of sorbitol, glycerol, polyethylene glycol-8 and propylene glycol;

the friction agent comprises one or more of hydrated silica, dibasic calcium phosphate dihydrate and aluminum hydroxide;

the foaming agent comprises one or more of sodium lauroyl glutamate, sodium laurylsulfate and sodium lauroyl sarcosinate;

the surface active foaming agent comprises one or more of poloxamer 407, poloxamer 105 and poloxamer 123;

the supplementary bacteriostat comprises the following components in percentage by mass: 0.03-0.1% sodium citrate, 0.01-0.02% silver sulfate, 0.01-0.02% silver, 0.2-0.8% sodium dodecyl benzene sulfonate, and water for the rest to 100%.

2. A method for preparing a gum-protecting toothpaste according to claim 1, comprising the steps of:

3. The method for preparing the gum-protecting toothpaste according to claim 2, wherein: when the primary mixed material is prepared, the vacuum degree is controlled to be more than or equal to-0.06 MPa; when mixing materials in preparation, the vacuum degree is controlled to be more than or equal to-0.08 MPa.