CN116898898B - Moxa stick with effects of promoting blood circulation, removing blood stasis and eliminating dampness and preparation method thereof - Google Patents
Moxa stick with effects of promoting blood circulation, removing blood stasis and eliminating dampness and preparation method thereof Download PDFInfo
- Publication number
- CN116898898B CN116898898B CN202311082275.XA CN202311082275A CN116898898B CN 116898898 B CN116898898 B CN 116898898B CN 202311082275 A CN202311082275 A CN 202311082275A CN 116898898 B CN116898898 B CN 116898898B
- Authority
- CN
- China
- Prior art keywords
- moxa
- adhesive
- powder
- poloxamer
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 230000000694 effects Effects 0.000 title claims abstract description 36
- 238000002360 preparation method Methods 0.000 title claims abstract description 30
- 230000017531 blood circulation Effects 0.000 title claims abstract description 14
- 239000008280 blood Substances 0.000 title claims description 15
- 210000004369 blood Anatomy 0.000 title claims description 15
- 230000001737 promoting effect Effects 0.000 title description 8
- 230000003213 activating effect Effects 0.000 claims abstract description 14
- 239000000843 powder Substances 0.000 claims description 95
- 230000001070 adhesive effect Effects 0.000 claims description 59
- 239000000853 adhesive Substances 0.000 claims description 58
- 238000002156 mixing Methods 0.000 claims description 42
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 38
- 238000001035 drying Methods 0.000 claims description 22
- 229920000742 Cotton Polymers 0.000 claims description 18
- 238000007873 sieving Methods 0.000 claims description 18
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims description 17
- 239000004863 Frankincense Substances 0.000 claims description 17
- 239000002671 adjuvant Substances 0.000 claims description 16
- 239000000463 material Substances 0.000 claims description 16
- 238000003825 pressing Methods 0.000 claims description 16
- 238000010298 pulverizing process Methods 0.000 claims description 16
- 238000003892 spreading Methods 0.000 claims description 15
- 230000007480 spreading Effects 0.000 claims description 15
- 241000717739 Boswellia sacra Species 0.000 claims description 14
- 238000005507 spraying Methods 0.000 claims description 14
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 claims description 12
- 229920001983 poloxamer Polymers 0.000 claims description 12
- 229960000502 poloxamer Drugs 0.000 claims description 12
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 claims description 9
- 238000010992 reflux Methods 0.000 claims description 9
- 125000004218 chloromethyl group Chemical group [H]C([H])(Cl)* 0.000 claims description 8
- 229920002509 Poloxamer 182 Polymers 0.000 claims description 6
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims description 6
- 238000010438 heat treatment Methods 0.000 claims description 6
- 229940093426 poloxamer 182 Drugs 0.000 claims description 6
- 238000001914 filtration Methods 0.000 claims description 5
- 239000000203 mixture Substances 0.000 claims description 4
- 238000006068 polycondensation reaction Methods 0.000 claims description 4
- 238000009835 boiling Methods 0.000 claims description 3
- 238000006243 chemical reaction Methods 0.000 claims description 3
- 238000001816 cooling Methods 0.000 claims description 3
- 238000003756 stirring Methods 0.000 claims description 3
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims description 3
- 238000005406 washing Methods 0.000 claims description 3
- 238000012545 processing Methods 0.000 abstract description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 21
- 241000511009 Eustoma exaltatum subsp. russellianum Species 0.000 description 21
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 16
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 16
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 16
- 239000000469 ethanolic extract Substances 0.000 description 13
- 230000000052 comparative effect Effects 0.000 description 11
- 238000000034 method Methods 0.000 description 9
- 239000003814 drug Substances 0.000 description 8
- 208000002193 Pain Diseases 0.000 description 7
- 244000223760 Cinnamomum zeylanicum Species 0.000 description 6
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 6
- 235000017803 cinnamon Nutrition 0.000 description 6
- 238000000605 extraction Methods 0.000 description 6
- 230000008569 process Effects 0.000 description 6
- 240000000249 Morus alba Species 0.000 description 5
- 235000008708 Morus alba Nutrition 0.000 description 5
- 229940079593 drug Drugs 0.000 description 5
- 239000000284 extract Substances 0.000 description 5
- 208000024891 symptom Diseases 0.000 description 5
- 244000061520 Angelica archangelica Species 0.000 description 4
- 241000382455 Angelica sinensis Species 0.000 description 4
- 235000001287 Guettarda speciosa Nutrition 0.000 description 4
- 238000001467 acupuncture Methods 0.000 description 4
- 235000019658 bitter taste Nutrition 0.000 description 4
- 230000002175 menstrual effect Effects 0.000 description 4
- 238000004806 packaging method and process Methods 0.000 description 4
- 235000019633 pungent taste Nutrition 0.000 description 4
- 229940126680 traditional chinese medicines Drugs 0.000 description 4
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 description 3
- 235000003261 Artemisia vulgaris Nutrition 0.000 description 3
- 240000006891 Artemisia vulgaris Species 0.000 description 3
- 235000003717 Boswellia sacra Nutrition 0.000 description 3
- 240000007551 Boswellia serrata Species 0.000 description 3
- 235000012035 Boswellia serrata Nutrition 0.000 description 3
- GAWIXWVDTYZWAW-UHFFFAOYSA-N C[CH]O Chemical group C[CH]O GAWIXWVDTYZWAW-UHFFFAOYSA-N 0.000 description 3
- 241000112528 Ligusticum striatum Species 0.000 description 3
- 229940116229 borneol Drugs 0.000 description 3
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 description 3
- 238000002485 combustion reaction Methods 0.000 description 3
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 description 3
- 230000001976 improved effect Effects 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 238000006467 substitution reaction Methods 0.000 description 3
- 238000010792 warming Methods 0.000 description 3
- 230000008901 benefit Effects 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 230000000740 bleeding effect Effects 0.000 description 2
- 230000004087 circulation Effects 0.000 description 2
- 235000009508 confectionery Nutrition 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 239000000706 filtrate Substances 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 230000001939 inductive effect Effects 0.000 description 2
- 230000005906 menstruation Effects 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 230000000638 stimulation Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- 235000019640 taste Nutrition 0.000 description 2
- 241000173529 Aconitum napellus Species 0.000 description 1
- 241000132012 Atractylodes Species 0.000 description 1
- 206010008479 Chest Pain Diseases 0.000 description 1
- 241000218176 Corydalis Species 0.000 description 1
- 244000163122 Curcuma domestica Species 0.000 description 1
- 235000003392 Curcuma domestica Nutrition 0.000 description 1
- 244000150195 Cyperus longus Species 0.000 description 1
- 235000018109 Cyperus longus Nutrition 0.000 description 1
- 244000075634 Cyperus rotundus Species 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 241000893536 Epimedium Species 0.000 description 1
- 241000511010 Eustoma Species 0.000 description 1
- 241000628997 Flos Species 0.000 description 1
- 244000303040 Glycyrrhiza glabra Species 0.000 description 1
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 description 1
- 241000212322 Levisticum officinale Species 0.000 description 1
- 241001673966 Magnolia officinalis Species 0.000 description 1
- 241000157491 Morinda Species 0.000 description 1
- 241000237502 Ostreidae Species 0.000 description 1
- 244000236658 Paeonia lactiflora Species 0.000 description 1
- 235000008598 Paeonia lactiflora Nutrition 0.000 description 1
- 235000004347 Perilla Nutrition 0.000 description 1
- 244000124853 Perilla frutescens Species 0.000 description 1
- 229920000175 Pistacia lentiscus Polymers 0.000 description 1
- 244000197580 Poria cocos Species 0.000 description 1
- 235000008599 Poria cocos Nutrition 0.000 description 1
- 241000405414 Rehmannia Species 0.000 description 1
- 235000005010 Scirpus paludosus Nutrition 0.000 description 1
- 241001078983 Tetradium ruticarpum Species 0.000 description 1
- 244000273928 Zingiber officinale Species 0.000 description 1
- 235000006886 Zingiber officinale Nutrition 0.000 description 1
- 229940023019 aconite Drugs 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 229940107666 astragalus root Drugs 0.000 description 1
- 238000010009 beating Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 238000000748 compression moulding Methods 0.000 description 1
- 235000003373 curcuma longa Nutrition 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 239000003640 drug residue Substances 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 235000018905 epimedium Nutrition 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 235000008397 ginger Nutrition 0.000 description 1
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000010409 ironing Methods 0.000 description 1
- 239000001645 levisticum officinale Substances 0.000 description 1
- 235000011477 liquorice Nutrition 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 235000017524 noni Nutrition 0.000 description 1
- 235000020636 oyster Nutrition 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 230000002040 relaxant effect Effects 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- 230000036548 skin texture Effects 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 239000002341 toxic gas Substances 0.000 description 1
- 235000013976 turmeric Nutrition 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
- A61H39/00—Devices for locating or stimulating specific reflex points of the body for physical therapy, e.g. acupuncture
- A61H39/06—Devices for heating or cooling such points within cell-life limits
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
- A61K36/324—Boswellia, e.g. frankincense
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/486—Millettia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The invention discloses a moxa stick with the effects of activating blood circulation, removing stasis and eliminating dampness and a preparation method thereof, and relates to the technical field of moxa stick processing.
Description
Technical field:
the invention relates to the technical field of moxa stick processing, in particular to moxa sticks with the effects of activating blood circulation, removing blood stasis and eliminating dampness and a preparation method thereof.
The background technology is as follows:
moxibustion, otherwise known as moxibustion or moxibustion, is a treatment method which uses moxa sticks and moxa sticks made of mugwort leaves to generate Ai Reci which excites acupoints or specific parts of a human body and adjusts physiological and biochemical functions of human body disorders by exciting activities of menstrual qi so as to achieve the aim of preventing and treating diseases. The moxibustion action mechanism is similar to that of acupuncture and has complementary treatment effect with acupuncture, and has the advantages of simple operation, low cost, obvious effect and the like.
The moxa stick is a cylindrical long roll made by wrapping moxa with roll paper, and the moxa column is a relatively short moxa stick. The choice of moxa stick or moxa stick is mainly determined by the moxibustion device. If the moxibustion device is relatively large, moxa sticks are usually selected; if the moxibustion device is small, a moxa stick is usually selected.
The mugwort floss is obtained by repeatedly sun-drying and pestle, beating, pulverizing, sieving to remove impurities and dust, and has soft and flammable nature, no flame and aromatic smell. Moxa is a raw material for manufacturing moxa sticks, is also a main material for moxibustion, and has the effects of dredging and activating channels and collaterals, warming channels and stopping bleeding, dispelling cold and relieving pain, and preserving health. The moxa stick made of the pure moxa has the stimulation effect of burning and ironing the acupoints, and has certain health care effect, but the curative effect is not obvious and the treatment course is longer due to insufficient stimulation and permeability.
The patent CN114306563A discloses a gynaecologic climacteric menstrual Fang Aijiu, which comprises mugwort leaf, cinnamon, white peony root, dried ginger, liquorice, dragon bone, oyster, morinda root, epimedium, prepared aconite root, evodia rutaecarpa, poria cocos, magnolia officinalis, katsumadai seed, angelica, szechuan lovage rhizome, bighead atractylodes rhizome, perilla leaf, astragalus root, prepared rhizome of rehmannia, dried orange peel, dangshen, nutgrass galingale rhizome, rhizoma corydalis, frankincense and turmeric root-tuber, and the preparation method comprises the following steps: s1, weighing the components according to a formula, cleaning, drying and crushing to obtain crude drug powder; s2, blending the crude powder obtained in the step S1 with moxa; and S3, hydraulic pressing, cutting and packaging the blend obtained in the step S2 to obtain a finished product. According to the moxa stick, a plurality of traditional Chinese medicines are added in moxa to improve the treatment effect of moxa moxibustion on various symptoms of gynaecology climacteric, but dry crude drug powder and moxa are adopted to be physically mixed, so that the compression molding property is poor, the prepared moxa stick has the problems that crude drug powder is easy to scatter and cannot achieve an expected curative effect in the packaging and transportation processes, and the potential safety hazard of scalding caused by the fact that drug residues are easy to fall off in the combustion process in the moxa moxibustion process is caused.
The invention comprises the following steps:
the moxa stick takes moxa as a main material, and traditional Chinese medicines with the effects of activating blood and dissolving stasis are added, so that the moxa stick cost is reduced and the moxibustion effect is improved under the condition of simplifying a traditional Chinese medicine formula, and the treatment course is greatly shortened.
The technical problems to be solved by the invention are realized by adopting the following technical scheme:
the first aim of the invention is to provide a preparation method of moxa stick with the effects of activating blood circulation, removing blood stasis and eliminating dampness, which comprises the following preparation steps:
(1) Selecting aged moxa which is yellow or golden in color, soft like cotton, fine and fluffy and Ai Wei mellow;
(2) Mixing radix Angelicae sinensis, rhizoma Ligustici Chuanxiong, caulis Spatholobi, olibanum, cortex Cinnamomi and Borneolum Syntheticum at a certain proportion, pulverizing into fine powder, and sieving to obtain medicinal powder;
(3) Spraying adhesive into the medicinal powder, and mixing to obtain adjuvant;
(4) Adding adjuvants into moxa, mixing, spreading on roll paper, pressing into long strip, and drying to obtain moxa stick.
Preferably, the mass ratio of the angelica, the ligusticum wallichii, the caulis spatholobi, the frankincense, the cinnamon and the borneol is (5-20), the mass ratio of the angelica is (5-20), the mass ratio of the cinnamon is (5-10), the mass ratio of the angelica is (1-10), the mass ratio of the cinnamon is (0.5-5).
Preferably, the mesh number of the screen is 100 to 200 mesh.
Preferably, the mass ratio of the powder to the adhesive is 1 (1-2).
Preferably, the adhesive is prepared by adding water into hydroxyethyl cellulose, the mass concentration is 5-10%, and the preparation temperature is 80-90 ℃.
Further preferably, the hydroxyethyl cellulose has a hydroxyethyl molar substitution of 1.8 to 2.0.
Preferably, the mass ratio of the moxa to the medicinal powder is 100 (1-10).
Preferably, the roll paper is one of moxa paper, mulberry paper and cotton paper.
Preferably, the drying temperature is 50-60 ℃ so that the water content of the moxa stick is reduced to below 5%.
The second aim of the invention is to provide a preparation method of moxa stick with the effects of activating blood circulation, removing blood stasis and eliminating dampness, which comprises the following preparation steps:
(1) Selecting aged moxa which is yellow or golden in color, soft like cotton, fine and fluffy and Ai Wei mellow;
(2) Mixing radix Angelicae sinensis, rhizoma Ligustici Chuanxiong, caulis Spatholobi, olibanum, cortex Cinnamomi, borneolum Syntheticum and Eustoma grandiflorum ethanol extract at a certain ratio, pulverizing into fine powder, and sieving to obtain medicinal powder;
(3) Spraying adhesive into the medicinal powder, and mixing to obtain adjuvant;
(4) Adding adjuvants into moxa, mixing, spreading on roll paper, pressing into long strip, and drying to obtain moxa stick.
Preferably, the mass ratio of the ethanol extract of the angelica sinensis, the ligusticum wallichii, the caulis spatholobi, the frankincense, the cinnamon, the borneol and the eustoma grandiflorum is (5-20), the ethanol extract of the angelica sinensis is (5-20), the ethanol extract of the eustoma grandiflorum is (1-10), the ethanol extract of the angelica sinensis is (0.5-5), and the ethanol extract of the eustoma grandiflorum is (0.01-0.1).
Eustoma grandiflorum is a herbal plant of the genus Eustoma of the family gentiaceae, and the efficacy of promoting blood circulation and removing blood stasis of moxa sticks is enhanced by adding an appropriate amount of an alcohol extract of Eustoma grandiflorum.
Preferably, the preparation method of the eustoma grandiflorum ethanol extract comprises the following steps: reflux-extracting dried petals of Eustoma grandiflorum with ethanol, filtering, mixing filtrates, concentrating under reduced pressure, lyophilizing, and pulverizing to obtain Eustoma grandiflorum ethanol extract.
Further preferably, the ethanol is an ethanol solution with the concentration of 75-85 Vol%, the reflux extraction times are 2-3 times, the ethanol consumption in each reflux extraction is 5-10 times of the dry weight of the eustoma grandiflorum petals, and the reflux extraction time is 1-5 hours.
Preferably, the mesh number of the screen is 100 to 200 mesh.
Preferably, the mass ratio of the powder to the adhesive is 1 (1-2).
Preferably, the adhesive is prepared by adding water into hydroxyethyl cellulose, the mass concentration is 5-10%, and the preparation temperature is 80-90 ℃.
Further preferably, the hydroxyethyl cellulose has a hydroxyethyl molar substitution of 1.8 to 2.0.
Preferably, the mass ratio of the moxa to the medicinal powder is 100 (1-10).
Preferably, the roll paper is one of moxa paper, mulberry paper and cotton paper.
Preferably, the drying temperature is 50-60 ℃ so that the water content of the moxa stick is reduced to below 5%.
Although the adhesive prepared by adding water into the hydroxyethyl cellulose can promote the uniform dispersion of the medicinal powder on the moxa, the viscosity of the adhesive is obviously reduced after the adhesive is dried, and the firm adhesion of the medicinal powder on the moxa cannot be ensured, so that the problem that crude drug powder is easy to scatter and cannot achieve the expected curative effect in the packaging and transportation process of moxa sticks cannot be thoroughly solved, and the potential safety hazard of scalding caused by easy dropping of medicinal residues in the combustion process of moxa sticks is avoided. Therefore, the invention also prepares another adhesive, can realize the even and firm attachment of the medicinal powder on moxa under the condition of the same concentration and dosage of the adhesive, and well solves the technical problems existing in the process of packaging and transporting moxa sticks and moxibustion; and no toxic gas is generated during full combustion, so that the use safety of the moxa stick is not affected.
Preferably, the adhesive is prepared by adding water into poloxamer terminated polycondensate, the mass concentration is 5-10%, and the preparation temperature is 80-90 ℃.
Further preferably, the poloxamer terminated polycondensate is prepared by polycondensation of poloxamer and 1, 3-bis (chloromethyl) -1, 3-tetramethyldisiloxane.
The third object of the invention is to provide a moxa stick with the effects of activating blood circulation, removing blood stasis and eliminating dampness, which is prepared by the preparation method.
Moxa: bitter and pungent taste, warm nature, and has the effects of dredging meridian passage, warming meridian, stopping bleeding, dispelling cold and relieving pain.
Chinese angelica root: pungent and sweet in taste and warm in nature, has the effects of replenishing blood, activating blood, regulating menstruation, relieving pain, and relaxing bowel.
Ligusticum wallichii: pungent and warm in nature, has the effects of promoting blood circulation, relieving pain, promoting qi circulation, resolving stagnation, dispelling pathogenic wind and removing dampness.
Caulis Spatholobi: bitter and sweet in taste, warm in nature, has the effects of activating blood, tonifying blood, regulating menstruation, relieving pain, and soothing channels and activating collaterals.
Mastic gum: pungent and bitter taste and warm nature, has the effects of promoting blood circulation, promoting qi circulation, relieving pain, relieving swelling and promoting granulation.
Cinnamon: pungent and bitter taste and strong heat property, has the effects of warming and activating meridians, dispelling cold and relieving pain, and inducing fire to supplement primordial energy.
Borneol: pungent and bitter taste and slightly cold nature, has the effects of inducing resuscitation and refreshing mind, can increase skin permeation, stimulates acupoints when moxa sticks are burnt, stimulates menstrual flow, opens local skin texture, and introduces medicines into the menstrual flow, and promotes qi and blood circulation.
The beneficial effects of the invention are as follows: according to the invention, high-quality moxa is taken as a main material, traditional Chinese medicines with the effects of activating blood circulation, removing stasis and eliminating dampness are added as auxiliary materials, and a simple and easy operation process is adopted to process and prepare the moxa stick, so that under the condition of simplifying a traditional Chinese medicine formula, the cost of the moxa stick can be reduced, the moxibustion curative effect can be improved, and the technical problems of the traditional method for directly adding traditional Chinese medicine powder into the moxa to improve the moxibustion curative effect can be solved, and the utilization rate of the traditional Chinese medicines and the moxibustion safety can be improved.
The specific embodiment is as follows:
the invention is further described in connection with the following embodiments in order to make the technical means, the creation features, the achievement of the purpose and the effect of the invention easy to understand.
The sources of the raw materials in the following examples and comparative examples are illustrated:
aged moxa was purchased from the biological product of san-yang Shennong moxa company, product grade SN06.
The hydroxyethyl cellulose is purchased from Shandong Tex chemical industry Co., ltd, the model is HE-40000S, and the molar substitution degree of the hydroxyethyl is 1.8-2.0.
Preparation of eustoma grandiflorum alcohol extract: reflux-extracting 500g of dried eustoma grandiflorum petals with ethanol, wherein the ethanol is an ethanol solution with concentration of 80Vol%, the reflux extraction times are 3 times, the ethanol consumption is 5 times of the dry weight of the eustoma grandiflorum petals during each reflux extraction, the reflux extraction time is 3 hours, filtering, mixing the filtrates, concentrating under reduced pressure, freeze-drying, and pulverizing into fine powder to obtain eustoma grandiflorum ethanol extract.
Poloxamer 182 was purchased from south-pass algo chemical industry limited and had an average molecular weight of 2500.
Synthesis of poloxamer-terminated polycondensate a: adding 0.2mol of poloxamer 182 and 0.1mol of 1, 3-bis (chloromethyl) -1, 3-tetramethyl disiloxane into tetrahydrofuran, stirring and dissolving completely, adding 0.2mol of triethylamine, heating to boiling state, refluxing for reaction, stopping heating after TLC monitors that 1, 3-bis (chloromethyl) -1, 3-tetramethyl disiloxane is completely reacted, naturally cooling to room temperature, washing with water for three times at normal temperature, filtering, drying filter residues at 80 ℃, crushing into fine powder, sieving with a 100-mesh sieve, and obtaining the poloxamer terminated polycondensate A.
Synthesis of poloxamer-terminated polycondensate B: adding 0.2mol of poloxamer 182 and 0.1mol of diethyl ether into tetrahydrofuran, stirring and dissolving completely, adding 0.2mol of triethylamine, heating to boiling state, refluxing for reaction, stopping heating after TLC monitors that the diethyl ether is completely reacted, naturally cooling to room temperature, washing with water at normal temperature for three times, filtering, drying filter residues at 80 ℃, crushing into fine powder, and sieving with a 100-mesh sieve to obtain the poloxamer terminated polycondensate B.
Example 1
(1) Selecting aged moxa with yellow or golden color, softness like cotton, fineness and fluffiness and Ai Wei mellow.
(2) Mixing radix Angelicae sinensis, rhizoma Ligustici Chuanxiong, caulis Spatholobi, olibanum, cortex Cinnamomi and Borneolum Syntheticum at a ratio of 15:15:15:5:3:0.5, pulverizing into fine powder, and sieving with 100 mesh sieve to obtain medicinal powder.
(3) Spraying adhesive into the medicinal powder, wherein the mass ratio of the medicinal powder to the adhesive is 1:1, the adhesive is prepared by adding water into hydroxyethyl cellulose, the mass concentration is 10%, the preparation temperature is 80 ℃, and the auxiliary materials are obtained by uniformly mixing.
(4) Adding adjuvants into moxa, mixing with the powder at a mass ratio of 100:5, spreading on moxa paper, pressing into long strips, and drying at 60deg.C to reduce the water content of moxa strip to below 5% to obtain moxa strip.
Example 2
(1) Selecting aged moxa with yellow or golden color, softness like cotton, fineness and fluffiness and Ai Wei mellow.
(2) Mixing radix Angelicae sinensis, rhizoma Ligustici Chuanxiong, caulis Spatholobi, olibanum, cortex Cinnamomi and Borneolum Syntheticum at a ratio of 15:20:10:4:4:0.5, pulverizing into fine powder, and sieving with 100 mesh sieve to obtain medicinal powder.
(3) Spraying adhesive into the medicinal powder, wherein the mass ratio of the medicinal powder to the adhesive is 1:2, the adhesive is prepared by adding water into hydroxyethyl cellulose, the mass concentration is 5%, the preparation temperature is 85 ℃, and the auxiliary materials are obtained by uniformly mixing.
(4) Adding adjuvants into moxa, mixing with the powder at a mass ratio of 100:5, spreading on mulberry paper, pressing into long strips, and drying at 50deg.C to reduce the water content of moxa to below 5% to obtain moxa stick.
Example 3
(1) Selecting aged moxa with yellow or golden color, softness like cotton, fineness and fluffiness and Ai Wei mellow.
(2) Mixing radix Angelicae sinensis, rhizoma Ligustici Chuanxiong, caulis Spatholobi, olibanum, cortex Cinnamomi and Borneolum Syntheticum at a ratio of 20:10:15:3:4:0.5, pulverizing into fine powder, and sieving with 100 mesh sieve to obtain medicinal powder.
(3) Spraying adhesive into the medicinal powder, wherein the mass ratio of the medicinal powder to the adhesive is 1:2, the adhesive is prepared by adding water into hydroxyethyl cellulose, the mass concentration is 5%, the preparation temperature is 80 ℃, and the auxiliary materials are obtained by uniformly mixing.
(4) Adding adjuvants into moxa, mixing with the powder at a mass ratio of 100:8, spreading on mulberry paper, pressing into long strips, and drying at 55deg.C to reduce the water content of moxa to below 5% to obtain moxa stick.
Example 4
(1) Selecting aged moxa with yellow or golden color, softness like cotton, fineness and fluffiness and Ai Wei mellow.
(2) Mixing radix Angelicae sinensis, rhizoma Ligustici Chuanxiong, caulis Spatholobi, olibanum, cortex Cinnamomi and Borneolum Syntheticum at a ratio of 15:10:20:4:3:0.5, pulverizing into fine powder, and sieving with 100 mesh sieve to obtain medicinal powder.
(3) Spraying adhesive into the medicinal powder, wherein the mass ratio of the medicinal powder to the adhesive is 1:1, the adhesive is prepared by adding water into hydroxyethyl cellulose, the mass concentration is 10%, the preparation temperature is 90 ℃, and the auxiliary materials are obtained by uniformly mixing.
(4) Adding adjuvants into moxa, mixing with the powder at a mass ratio of 100:8, spreading on cotton paper, pressing into long strips, and drying at 60deg.C to reduce the water content of moxa to below 5% to obtain moxa stick.
Example 5
(1) Selecting aged moxa with yellow or golden color, softness like cotton, fineness and fluffiness and Ai Wei mellow.
(2) Mixing radix Angelicae sinensis, rhizoma Ligustici Chuanxiong, caulis Spatholobi, olibanum, cortex Cinnamomi and Borneolum Syntheticum at a ratio of 20:15:10:3:3:0.5, pulverizing into fine powder, and sieving with 100 mesh sieve to obtain medicinal powder.
(3) Spraying adhesive into the medicinal powder, wherein the mass ratio of the medicinal powder to the adhesive is 1:1, the adhesive is prepared by adding water into hydroxyethyl cellulose, the mass concentration is 8%, the preparation temperature is 80 ℃, and the auxiliary materials are obtained by uniformly mixing.
(4) Adding adjuvants into moxa, mixing with the powder at a mass ratio of 100:5, spreading on mulberry paper, pressing into long strips, and drying at 55deg.C to reduce the water content of moxa to below 5% to obtain moxa stick.
Example 6
Example 6 differs from example 1 in that in step (2) an alcohol extract of eustoma grandiflorum was also added.
(1) Selecting aged moxa with yellow or golden color, softness like cotton, fineness and fluffiness and Ai Wei mellow.
(2) Mixing radix Angelicae sinensis, rhizoma Ligustici Chuanxiong, caulis Spatholobi, olibanum, cortex Cinnamomi, borneolum Syntheticum, and radix Eustoma grandiflorum ethanol extract at a mass ratio of 15:15:15:5:3:0.5:0.03, and sieving with 100 mesh sieve to obtain medicinal powder.
(3) Spraying adhesive into the medicinal powder, wherein the mass ratio of the medicinal powder to the adhesive is 1:1, the adhesive is prepared by adding water into hydroxyethyl cellulose, the mass concentration is 10%, the preparation temperature is 80 ℃, and the auxiliary materials are obtained by uniformly mixing.
(4) Adding adjuvants into moxa, mixing with the powder at a mass ratio of 100:5, spreading on moxa paper, pressing into long strips, and drying at 60deg.C to reduce the water content of moxa strip to below 5% to obtain moxa strip.
Example 7
Example 7 differs from example 1 in that in step (2) an alcohol extract of eustoma grandiflorum was also added.
(1) Selecting aged moxa with yellow or golden color, softness like cotton, fineness and fluffiness and Ai Wei mellow.
(2) Mixing radix Angelicae sinensis, rhizoma Ligustici Chuanxiong, caulis Spatholobi, olibanum, cortex Cinnamomi, borneolum Syntheticum, and radix Eustoma grandiflorum ethanol extract at a mass ratio of 15:15:15:5:3:0.5:0.05, pulverizing into fine powder, and sieving with 100 mesh sieve to obtain medicinal powder.
(3) Spraying adhesive into the medicinal powder, wherein the mass ratio of the medicinal powder to the adhesive is 1:1, the adhesive is prepared by adding water into hydroxyethyl cellulose, the mass concentration is 10%, the preparation temperature is 80 ℃, and the auxiliary materials are obtained by uniformly mixing.
(4) Adding adjuvants into moxa, mixing with the powder at a mass ratio of 100:5, spreading on moxa paper, pressing into long strips, and drying at 60deg.C to reduce the water content of moxa strip to below 5% to obtain moxa strip.
Example 8
Example 8 differs from example 1 in that in step (2) an alcohol extract of eustoma grandiflorum was also added.
(1) Selecting aged moxa with yellow or golden color, softness like cotton, fineness and fluffiness and Ai Wei mellow.
(2) Mixing radix Angelicae sinensis, rhizoma Ligustici Chuanxiong, caulis Spatholobi, olibanum, cortex Cinnamomi, borneolum Syntheticum, and radix Eustoma grandiflorum ethanol extract at a mass ratio of 15:15:15:5:3:0.5:0.1, pulverizing into fine powder, and sieving with 100 mesh sieve to obtain medicinal powder.
(3) Spraying adhesive into the medicinal powder, wherein the mass ratio of the medicinal powder to the adhesive is 1:1, the adhesive is prepared by adding water into hydroxyethyl cellulose, the mass concentration is 10%, the preparation temperature is 80 ℃, and the auxiliary materials are obtained by uniformly mixing.
(4) Adding adjuvants into moxa, mixing with the powder at a mass ratio of 100:5, spreading on moxa paper, pressing into long strips, and drying at 60deg.C to reduce the water content of moxa strip to below 5% to obtain moxa strip.
Comparative example 1
Comparative example 1 differs from example 1 in that no medicinal powder was added.
Selecting aged moxa with yellow or golden color, softness like cotton, fineness and fluffiness and Ai Wei mellow, spreading on moxa paper, pressing into long strips, and drying at 60deg.C to reduce the water content of moxa strip to below 5% to obtain moxa strip.
Example 9
Example 9 differs from example 1 in that the hydroxyethyl cellulose used to formulate the adhesive is replaced by an equivalent amount of poloxamer terminated polycondensate a.
(1) Selecting aged moxa with yellow or golden color, softness like cotton, fineness and fluffiness and Ai Wei mellow.
(2) Mixing radix Angelicae sinensis, rhizoma Ligustici Chuanxiong, caulis Spatholobi, olibanum, cortex Cinnamomi and Borneolum Syntheticum at a ratio of 15:15:15:5:3:0.5, pulverizing into fine powder, and sieving with 100 mesh sieve to obtain medicinal powder.
(3) Spraying adhesive into the medicinal powder, wherein the mass ratio of the medicinal powder to the adhesive is 1:1, the adhesive is prepared by adding water into poloxamer-terminated polycondensate A, the mass concentration is 10%, the preparation temperature is 80 ℃, and the mixture is uniformly mixed to obtain auxiliary materials.
(4) Adding adjuvants into moxa, mixing with the powder at a mass ratio of 100:5, spreading on moxa paper, pressing into long strips, and drying at 60deg.C to reduce the water content of moxa strip to below 5% to obtain moxa strip.
1000 patients with symptoms of chest distress, short breath and deficiency of qi and blood with different degrees are randomly selected, the average of the patients is divided into 10 groups, 100 patients in each group are respectively half of men and women, each group is used for respectively moxibustion moxa sticks prepared in the above embodiment and comparative example, 3 acupuncture points (Hegu acupoint, sanyinjiao acupoint and Xuehai acupoint) are subjected to moxibustion every day, each acupuncture point is subjected to moxibustion for 15min every time, one treatment course is carried out every day, 4 treatment courses are carried out in continuous moxibustion, and the results are shown in table 1.
Judging curative effect:
and (3) curing: the symptoms completely disappeared;
improvement: the symptoms are obviously relieved;
the method is characterized in that: the symptoms were not significantly altered.
TABLE 1
As can be seen from table 1, the addition of eustoma grandiflorum ethanol extract to the powder when preparing moxa sticks can improve the moxibustion effect, and the adhesive prepared by adding water to poloxamer-terminated polycondensate a (prepared by polycondensation reaction of poloxamer and 1, 3-bis (chloromethyl) -1, 3-tetramethyldisiloxane) does not adversely affect the moxibustion effect.
Comparative example 2
Comparative example 2 differs from example 9 in that the poloxamer-terminated polycondensate a used to formulate the adhesive was replaced with an equivalent amount of poloxamer-terminated polycondensate B.
(1) Selecting aged moxa with yellow or golden color, softness like cotton, fineness and fluffiness and Ai Wei mellow.
(2) Mixing radix Angelicae sinensis, rhizoma Ligustici Chuanxiong, caulis Spatholobi, olibanum, cortex Cinnamomi and Borneolum Syntheticum at a ratio of 15:15:15:5:3:0.5, pulverizing into fine powder, and sieving with 100 mesh sieve to obtain medicinal powder.
(3) Spraying adhesive into the medicinal powder, wherein the mass ratio of the medicinal powder to the adhesive is 1:1, the adhesive is prepared by adding water into poloxamer-terminated polycondensate B, the mass concentration is 10%, the preparation temperature is 80 ℃, and the mixture is uniformly mixed to obtain auxiliary materials.
(4) Adding adjuvants into moxa, mixing with the powder at a mass ratio of 100:5, spreading on moxa paper, pressing into long strips, and drying at 60deg.C to reduce the water content of moxa strip to below 5% to obtain moxa strip.
Comparative example 3
Comparative example 3 differs from example 9 in that the poloxamer-terminated polycondensate a used to formulate the adhesive was replaced with an equal amount of poloxamer 182.
(1) Selecting aged moxa with yellow or golden color, softness like cotton, fineness and fluffiness and Ai Wei mellow.
(2) Mixing radix Angelicae sinensis, rhizoma Ligustici Chuanxiong, caulis Spatholobi, olibanum, cortex Cinnamomi and Borneolum Syntheticum at a ratio of 15:15:15:5:3:0.5, pulverizing into fine powder, and sieving with 100 mesh sieve to obtain medicinal powder.
(3) Spraying adhesive into the medicinal powder, wherein the mass ratio of the medicinal powder to the adhesive is 1:1, the adhesive is prepared by adding poloxamer 182 into water, the mass concentration is 10%, the preparation temperature is 80 ℃, and the auxiliary materials are obtained by uniformly mixing.
(4) Adding adjuvants into moxa, mixing with the powder at a mass ratio of 100:5, spreading on moxa paper, pressing into long strips, and drying at 60deg.C to reduce the water content of moxa strip to below 5% to obtain moxa strip.
The adhesive prepared by adding water into the poloxamer-terminated polycondensate plays a role of bridging between moxa and the medicinal powder by utilizing the viscosity of the adhesive, and improves the adhesive force and the adhesive uniformity of the medicinal powder on the moxa, so that the poloxamer-terminated polycondensate with the adhesive effect is required to simultaneously show good viscosity to the moxa and the medicinal powder. Because the physical properties of the surfaces of moxa and the medicinal powder are completely different, although the adhesive prepared by adding water into hydroxyethyl cellulose or poloxamer also has certain viscosity, the medicinal powder with a given adding amount is not enough to be firmly and uniformly attached to the moxa, and particularly, after the prepared moxa stick is dried and dehydrated, the moxa stick can not be dried, so that the moxa stick is difficult to burn or burns very slowly due to overlarge humidity, the moxa moxibustion time is too long, and the moxa moxibustion effect can be influenced.
Moxa sticks with the length of 100mm prepared in the above examples and comparative examples are respectively selected, rolled paper outside the moxa sticks is torn off, the moxa sticks are then placed in a vibrating screen provided with a single-layer screen, the screening granularity is 0.15mm, the amplitude is 5mm, the vibration frequency is 960r/min, and the quality of the screened objects is weighed after 5 min. The test was repeated 3 times, and the average value was taken to calculate the powder falling rate, and the result is shown in Table 2. The calculation formula of the powder dropping rate is as follows:
powder falling rate = (amount of undersize/amount of powder contained in moxa stick) ×100%
TABLE 2
| Powder falling rate/% | |
| Example 1 | 40.3 |
| Example 2 | 41.5 |
| Example 3 | 42.6 |
| Example 4 | 39.2 |
| Example 5 | 38.7 |
| Example 9 | 15.4 |
| Comparative example 2 | 52.8 |
| Comparative example 3 | 47.6 |
As can be seen from Table 2, the powder was firmly attached to moxa only by using an adhesive prepared by adding water to poloxamer-terminated polycondensate A (prepared by polycondensation of poloxamer and 1, 3-bis (chloromethyl) -1, 3-tetramethyldisiloxane).
The foregoing has shown and described the basic principles and main features of the present invention and the advantages of the present invention. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, and that the above embodiments and descriptions are merely illustrative of the principles of the present invention, and various changes and modifications may be made without departing from the spirit and scope of the invention, which is defined in the appended claims. The scope of the invention is defined by the appended claims and equivalents thereof.
Claims (2)
1. The preparation method of the moxa stick with the effects of activating blood circulation to dissipate blood stasis and eliminating dampness is characterized by comprising the following preparation steps of:
(1) Selecting aged moxa which is yellow or golden in color, soft like cotton, fine and fluffy and Ai Wei mellow;
(2) Mixing radix Angelicae sinensis, rhizoma Ligustici Chuanxiong, caulis Spatholobi, olibanum, cortex Cinnamomi and Borneolum Syntheticum at a ratio of 15:15:5:3:0.5, pulverizing into fine powder, and sieving with 100 mesh sieve to obtain medicinal powder;
(3) Spraying an adhesive into the medicinal powder, wherein the mass ratio of the medicinal powder to the adhesive is 1:1, the adhesive is prepared by adding water into a poloxamer-terminated polycondensate A, the mass concentration is 10%, the preparation temperature is 80 ℃, and the mixture is uniformly mixed to obtain auxiliary materials;
(4) Adding adjuvants into moxa, mixing with the powder at a mass ratio of 100:5, spreading on moxa paper, pressing into long strips, and drying at 60deg.C to reduce the water content of moxa strip to below 5% to obtain moxa strip;
the poloxamer terminated polycondensate A is prepared by polycondensation reaction of poloxamer and 1, 3-bis (chloromethyl) -1, 3-tetramethyl disiloxane: adding 0.2mol of poloxamer 182 and 0.1mol of 1, 3-bis (chloromethyl) -1, 3-tetramethyl disiloxane into tetrahydrofuran, stirring and dissolving completely, adding 0.2mol of triethylamine, heating to boiling state, refluxing for reaction, stopping heating after TLC monitors that 1, 3-bis (chloromethyl) -1, 3-tetramethyl disiloxane is completely reacted, naturally cooling to room temperature, washing with water for three times at normal temperature, filtering, drying filter residues at 80 ℃, crushing into fine powder, sieving with a 100-mesh sieve, and obtaining the poloxamer terminated polycondensate A.
2. The moxa stick with the effects of activating blood circulation, removing blood stasis and eliminating dampness, which is prepared by the preparation method according to claim 1.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202311082275.XA CN116898898B (en) | 2023-08-27 | 2023-08-27 | Moxa stick with effects of promoting blood circulation, removing blood stasis and eliminating dampness and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202311082275.XA CN116898898B (en) | 2023-08-27 | 2023-08-27 | Moxa stick with effects of promoting blood circulation, removing blood stasis and eliminating dampness and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN116898898A CN116898898A (en) | 2023-10-20 |
| CN116898898B true CN116898898B (en) | 2024-01-26 |
Family
ID=88366861
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202311082275.XA Active CN116898898B (en) | 2023-08-27 | 2023-08-27 | Moxa stick with effects of promoting blood circulation, removing blood stasis and eliminating dampness and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN116898898B (en) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101732685A (en) * | 2009-12-15 | 2010-06-16 | 林庆学 | Skin surface infiltration Chinese medicinal preparation for acupuncture and moxibustion |
| CN104173509A (en) * | 2014-08-28 | 2014-12-03 | 桂林市艾康科技有限公司 | Moxa stick for treating dysmenorrhea |
| CN105412938A (en) * | 2015-12-23 | 2016-03-23 | 北京夏央投资管理有限公司 | Moxa stick, moxa stick fabrication method and moxibustion device |
| CN108498584A (en) * | 2018-06-26 | 2018-09-07 | 谢鑫 | A kind of Chinese medicine moxa stick and preparation method thereof for benefiting qi and raising yang |
| CN109847041A (en) * | 2019-04-25 | 2019-06-07 | 陕西中医药大学附属医院 | A kind of plaster for treating cervical spondylosis, lumbar vertebra disease and osteoproliferation |
-
2023
- 2023-08-27 CN CN202311082275.XA patent/CN116898898B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101732685A (en) * | 2009-12-15 | 2010-06-16 | 林庆学 | Skin surface infiltration Chinese medicinal preparation for acupuncture and moxibustion |
| CN104173509A (en) * | 2014-08-28 | 2014-12-03 | 桂林市艾康科技有限公司 | Moxa stick for treating dysmenorrhea |
| CN105412938A (en) * | 2015-12-23 | 2016-03-23 | 北京夏央投资管理有限公司 | Moxa stick, moxa stick fabrication method and moxibustion device |
| CN108498584A (en) * | 2018-06-26 | 2018-09-07 | 谢鑫 | A kind of Chinese medicine moxa stick and preparation method thereof for benefiting qi and raising yang |
| CN109847041A (en) * | 2019-04-25 | 2019-06-07 | 陕西中医药大学附属医院 | A kind of plaster for treating cervical spondylosis, lumbar vertebra disease and osteoproliferation |
Non-Patent Citations (1)
| Title |
|---|
| 无烟灸条;关吉多;曹国彬;黄迪君;;成都中医药大学学报(第02期);68-69 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN116898898A (en) | 2023-10-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102688144B (en) | Production method of smokeless attapulgite moxibustion sticks | |
| CN104666579A (en) | Traditional Chinese medicine composition for treating gonarthromeningitis and preparation method of traditional Chinese medicine composition | |
| CN111840405A (en) | Sleep-aiding foot patch and preparation method thereof | |
| CN103405636A (en) | Drug for treating insomnia and preparation method thereof | |
| CN102631655B (en) | Medicine for treating coronary heart disease and preparation method for medicine | |
| CN116898898B (en) | Moxa stick with effects of promoting blood circulation, removing blood stasis and eliminating dampness and preparation method thereof | |
| CN103272207B (en) | Traditional Chinese medicine for treating nerve headaches and preparation method of traditional Chinese medicine | |
| CN104306618A (en) | Traditional Chinese medicine composition for treating rhinitis and preparation method thereof | |
| CN104042981A (en) | Medicament for treating postnatal constipation and preparation method thereof | |
| CN114129670A (en) | Aquilaria sinensis sleep-aiding herbal atomized composition and preparation method and application thereof | |
| CN103751648B (en) | For the goods of cyclomastopathy patient | |
| CN102366543A (en) | Chinese herbal medicine for treating blood deficiency, blood heat and blood dryness | |
| CN107334996B (en) | Anti-aging rejuvenation pill | |
| CN104623559A (en) | Agent with effects of invigorating blood circulation and removing stasis for eliminating breast lump | |
| CN105311306A (en) | Medicine for treating severe body odor | |
| CN114712470B (en) | Medicine for treating deficiency of kidney of men and preparation method thereof | |
| CN105748932A (en) | Traditional Chinese medicine tablets for treating self-biting behavior of minks and preparation method thereof | |
| CN108142566A (en) | A kind of walnut powder having effect of relieving insomnia and preparation method | |
| CN112791155A (en) | Rose foot patch and preparation method thereof | |
| CN105056071A (en) | Traditional Chinese medicine prescription for prevention and treatment of arrhythmia and preparation method thereof | |
| CN105233134B (en) | A kind of Chinese medicine composition and preparation method thereof for treating menopausal syndrome | |
| CN104707003B (en) | The Chinese medicinal capsule for the treatment of hypertension, hyperlipidemia | |
| CN104688985A (en) | Traditional Chinese medicine composition for treating insomnia and preparation method thereof | |
| CN117617716A (en) | Health-preserving mattress containing cornel and mugwort wool of secret herbal medicine combination powder and preparation method of health-preserving mattress | |
| CN104173815B (en) | Treat neurasthenic Chinese medicine composition and preparation method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |