CN116889627A - 用固醇调节元件结合转录因子1(srebf1)抑制剂治疗脂质水平升高 - Google Patents

用固醇调节元件结合转录因子1(srebf1)抑制剂治疗脂质水平升高 Download PDF

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Publication number
CN116889627A
CN116889627A CN202310867404.XA CN202310867404A CN116889627A CN 116889627 A CN116889627 A CN 116889627A CN 202310867404 A CN202310867404 A CN 202310867404A CN 116889627 A CN116889627 A CN 116889627A
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China
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seq
srebf1
position corresponding
nucleotide sequence
nucleic acid
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CN202310867404.XA
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Chinese (zh)
Inventor
A·舒尔迪纳
N·戈萨利亚
C·范霍特
龚大为
J·A·佩里
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Regeneron Pharmaceuticals Inc
University of Maryland, Baltimore
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Regeneron Pharmaceuticals Inc
University of Maryland, Baltimore
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Publication of CN116889627A publication Critical patent/CN116889627A/zh
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    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
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CN202310867404.XA 2019-03-20 2020-03-19 用固醇调节元件结合转录因子1(srebf1)抑制剂治疗脂质水平升高 Pending CN116889627A (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201962820893P 2019-03-20 2019-03-20
US62/820,893 2019-03-20
US201962879138P 2019-07-26 2019-07-26
US62/879,138 2019-07-26
PCT/US2020/023532 WO2020191141A1 (en) 2019-03-20 2020-03-19 Treatment of increased lipid levels with sterol regulatory element binding transcription factor 1 (srebf1) inhibitors
CN202080030927.3A CN113727732B (zh) 2019-03-20 2020-03-19 用固醇调节元件结合转录因子1(srebf1)抑制剂治疗脂质水平升高

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CN116889627A true CN116889627A (zh) 2023-10-17

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CN202080030927.3A Active CN113727732B (zh) 2019-03-20 2020-03-19 用固醇调节元件结合转录因子1(srebf1)抑制剂治疗脂质水平升高

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EP (1) EP3942048A1 (enExample)
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CA (1) CA3133000A1 (enExample)
WO (1) WO2020191141A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4259279A1 (en) 2020-12-14 2023-10-18 Regeneron Pharmaceuticals, Inc. Methods of treating metabolic disorders and cardiovascular disease with inhibin subunit beta e (inhbe) inhibitors
CN116583291A (zh) * 2020-12-14 2023-08-11 雷杰纳荣制药公司 用抑制素亚基βE(INHBE)抑制剂治疗代谢病症和心血管疾病的方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003033656A2 (en) * 2001-10-16 2003-04-24 Exelixis, Inc. MSREBPs AS MODIFIERS OF THE SREBP PATHWAY AND METHODS OF USE
US20080249040A1 (en) * 2001-05-18 2008-10-09 Sirna Therapeutics, Inc. RNA interference mediated inhibition of sterol regulatory element binding protein 1 (SREBP1) gene expression using short interfering nucleic acid (siNA)
CN102124107A (zh) * 2006-07-17 2011-07-13 瑟纳治疗公司 使用短干扰核酸(siNA)的RNA干扰介导的前蛋白转化酶枯草杆菌蛋白酶Kexin9(PCSK9)基因表达的抑制

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5688787A (en) 1991-07-23 1997-11-18 Schering Corporation Substituted β-lactam compounds useful as hypochlesterolemic agents and processes for the preparation thereof
AU670818B2 (en) 1992-04-03 1996-08-01 Cosmoferm B.V. Selective N-acylation of amino alcohols
LT3595B (en) 1993-01-21 1995-12-27 Schering Corp Spirocycloalkyl-substituted azetidinones useful as hypocholesterolemic agents
US5631365A (en) 1993-09-21 1997-05-20 Schering Corporation Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents
FR2710337B1 (fr) 1993-09-23 1995-12-08 Gerard Coquerel Procédé de dédoublement de deux antipodes optiques par entraînement polythermique programmé et autoensemencé.
US5633246A (en) 1994-11-18 1997-05-27 Schering Corporation Sulfur-substituted azetidinone compounds useful as hypocholesterolemic agents
US5624920A (en) 1994-11-18 1997-04-29 Schering Corporation Sulfur-substituted azetidinone compounds useful as hypocholesterolemic agents
US5656624A (en) 1994-12-21 1997-08-12 Schering Corporation 4-[(heterocycloalkyl or heteroaromatic)-substituted phenyl]-2-azetidinones useful as hypolipidemic agents
US5756470A (en) 1996-10-29 1998-05-26 Schering Corporation Sugar-substituted 2-azetidinones useful as hypocholesterolemic agents
US6602710B1 (en) 1998-08-27 2003-08-05 Chugai Seiyaku Kabushiki Kaisha Screening method for SREBP pathway-specific inhibitors
GB9916757D0 (en) 1999-07-17 1999-09-15 Glaxo Group Ltd Method
IL156550A0 (en) 2000-12-21 2004-01-04 Aventis Pharma Gmbh Novel 1,2-diphenzylazetidinones, method for producing the same, medicaments containing said compounds, and the use thereof for treating disorders of the lipid metabolism
TWI291957B (en) 2001-02-23 2008-01-01 Kotobuki Pharmaceutical Co Ltd Beta-lactam compounds, process for repoducing the same and serum cholesterol-lowering agents containing the same
AU2002320621A1 (en) 2001-07-20 2003-03-03 Incyte Genomics, Inc. Structural and cytoskeleton-associated proteins
US20050014177A1 (en) * 2003-05-19 2005-01-20 Koustubh Ranade Human sterol response element binding protein 1 (SREBP1) single nucleotide polymorphisms
WO2008036638A2 (en) 2006-09-18 2008-03-27 Alnylam Pharmaceuticals, Inc. Rnai modulation of scap and therapeutic uses thereof
JP2010053122A (ja) * 2008-07-31 2010-03-11 Hayashibara Biochem Lab Inc 脂質合成阻害剤
US9187746B2 (en) 2009-09-22 2015-11-17 Alnylam Pharmaceuticals, Inc. Dual targeting siRNA agents
JP2013515085A (ja) 2009-12-22 2013-05-02 ジ・アドミニストレイターズ・オブ・ザ・チユレーン・エデユケーシヨナル・フアンド 肥満症および糖尿病を治療するための組成物および方法
WO2015100257A1 (en) 2013-12-23 2015-07-02 The General Hospital Corporation Methods and assays for determining reduced brca1 pathway function in a cancer cell
EP3387129A1 (en) 2015-12-10 2018-10-17 Alnylam Pharmaceuticals, Inc. STEROL REGULATORY ELEMENT BINDING PROTEIN (SREBP) CHAPERONE (SCAP) iRNA COMPOSITIONS AND METHODS OF USE THEREOF
CN105441454B (zh) 2015-12-23 2018-12-11 北京大学人民医院 Scap基因突变体及其应用
WO2017191165A1 (en) 2016-05-03 2017-11-09 Lonza Ltd Modulation of lipid metabolism for protein production
EP3740573A1 (en) * 2018-01-18 2020-11-25 Roche Innovation Center Copenhagen A/S Antisense oligonucleotides targeting srebp1
TW201940165A (zh) 2018-01-29 2019-10-16 美商卡普勒斯療法有限責任公司 包含6員中心環的srebp抑制劑
KR102995657B1 (ko) 2018-03-29 2026-07-28 테크니온 리서치 엔드 디벨로프먼트 화운데이션 엘티디. Pten 억제제를 포함하는 소포 및 이의 용도
CN109536610B (zh) 2018-12-05 2020-10-16 西南大学 Setdb1在调控胆固醇途径中的应用

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080249040A1 (en) * 2001-05-18 2008-10-09 Sirna Therapeutics, Inc. RNA interference mediated inhibition of sterol regulatory element binding protein 1 (SREBP1) gene expression using short interfering nucleic acid (siNA)
WO2003033656A2 (en) * 2001-10-16 2003-04-24 Exelixis, Inc. MSREBPs AS MODIFIERS OF THE SREBP PATHWAY AND METHODS OF USE
CN102124107A (zh) * 2006-07-17 2011-07-13 瑟纳治疗公司 使用短干扰核酸(siNA)的RNA干扰介导的前蛋白转化酶枯草杆菌蛋白酶Kexin9(PCSK9)基因表达的抑制

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CN113727732B (zh) 2023-08-08
WO2020191141A1 (en) 2020-09-24
EP3942048A1 (en) 2022-01-26
US20200297752A1 (en) 2020-09-24
CA3133000A1 (en) 2020-09-24
US20230263821A1 (en) 2023-08-24
US11504390B2 (en) 2022-11-22
CN113727732A (zh) 2021-11-30
JP7574206B2 (ja) 2024-10-28
JP2022525545A (ja) 2022-05-17

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