CN116874608A - 嵌合抗原受体 - Google Patents

嵌合抗原受体 Download PDF

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Publication number
CN116874608A
CN116874608A CN202310693859.4A CN202310693859A CN116874608A CN 116874608 A CN116874608 A CN 116874608A CN 202310693859 A CN202310693859 A CN 202310693859A CN 116874608 A CN116874608 A CN 116874608A
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China
Prior art keywords
amino acid
acid sequence
cell
region
cells
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Pending
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CN202310693859.4A
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Chinese (zh)
Inventor
玉田耕治
佐古田幸美
石崎秀信
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Noile-Immune Biotech Inc
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Noile-Immune Biotech Inc
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3076—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties
    • C07K16/3084—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties against tumour-associated gangliosides
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • A61K40/10—Cellular immunotherapy characterised by the cell type used
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
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    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
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  • Developmental Biology & Embryology (AREA)
  • Virology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CN202310693859.4A 2017-03-27 2018-03-26 嵌合抗原受体 Pending CN116874608A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2017061461 2017-03-27
JP2017-061461 2017-03-27
CN201880020844.9A CN110461881B (zh) 2017-03-27 2018-03-26 嵌合抗原受体
PCT/JP2018/012194 WO2018181207A1 (ja) 2017-03-27 2018-03-26 キメラ抗原受容体

Related Parent Applications (1)

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CN201880020844.9A Division CN110461881B (zh) 2017-03-27 2018-03-26 嵌合抗原受体

Publications (1)

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CN116874608A true CN116874608A (zh) 2023-10-13

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CN201880020844.9A Active CN110461881B (zh) 2017-03-27 2018-03-26 嵌合抗原受体
CN202310693859.4A Pending CN116874608A (zh) 2017-03-27 2018-03-26 嵌合抗原受体

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US (2) US20210122831A1 (enExample)
EP (2) EP4495141A3 (enExample)
JP (2) JP6761113B2 (enExample)
KR (1) KR102333377B1 (enExample)
CN (2) CN110461881B (enExample)
AU (1) AU2018242408B2 (enExample)
BR (1) BR112019019941B1 (enExample)
CA (1) CA3057811A1 (enExample)
CL (1) CL2019002715A1 (enExample)
IL (1) IL269515B2 (enExample)
MX (1) MX2019011404A (enExample)
RU (1) RU2770002C2 (enExample)
SG (1) SG11201908659RA (enExample)
TW (1) TWI753141B (enExample)
WO (1) WO2018181207A1 (enExample)
ZA (1) ZA201906321B (enExample)

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