CN116869887A - Spray and preparation method thereof - Google Patents
Spray and preparation method thereof Download PDFInfo
- Publication number
- CN116869887A CN116869887A CN202310947220.4A CN202310947220A CN116869887A CN 116869887 A CN116869887 A CN 116869887A CN 202310947220 A CN202310947220 A CN 202310947220A CN 116869887 A CN116869887 A CN 116869887A
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- Prior art keywords
- extract
- stirring
- mixture
- spray
- magnesium hydroxide
- Prior art date
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- 239000007921 spray Substances 0.000 title claims abstract description 34
- 238000002360 preparation method Methods 0.000 title claims abstract description 18
- 239000000284 extract Substances 0.000 claims abstract description 54
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims abstract description 51
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 39
- VTHJTEIRLNZDEV-UHFFFAOYSA-L magnesium dihydroxide Chemical compound [OH-].[OH-].[Mg+2] VTHJTEIRLNZDEV-UHFFFAOYSA-L 0.000 claims abstract description 30
- 239000000347 magnesium hydroxide Substances 0.000 claims abstract description 30
- 229910001862 magnesium hydroxide Inorganic materials 0.000 claims abstract description 30
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 30
- 241000755540 Indocalamus Species 0.000 claims abstract description 23
- 244000157072 Hylocereus undatus Species 0.000 claims abstract description 21
- 235000018481 Hylocereus undatus Nutrition 0.000 claims abstract description 20
- 229940087603 grape seed extract Drugs 0.000 claims abstract description 20
- 235000002532 grape seed extract Nutrition 0.000 claims abstract description 20
- 239000001717 vitis vinifera seed extract Substances 0.000 claims abstract description 20
- 239000008367 deionised water Substances 0.000 claims abstract description 18
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 18
- KWIUHFFTVRNATP-UHFFFAOYSA-N Betaine Natural products C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 claims abstract description 17
- KWIUHFFTVRNATP-UHFFFAOYSA-O N,N,N-trimethylglycinium Chemical compound C[N+](C)(C)CC(O)=O KWIUHFFTVRNATP-UHFFFAOYSA-O 0.000 claims abstract description 17
- 244000042430 Rhodiola rosea Species 0.000 claims abstract description 17
- 235000003713 Rhodiola rosea Nutrition 0.000 claims abstract description 17
- 229960003237 betaine Drugs 0.000 claims abstract description 17
- 235000011187 glycerol Nutrition 0.000 claims abstract description 17
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 claims abstract description 17
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 claims abstract description 17
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims abstract description 13
- 229920002674 hyaluronan Polymers 0.000 claims abstract description 13
- 229960003160 hyaluronic acid Drugs 0.000 claims abstract description 13
- DFPAKSUCGFBDDF-ZQBYOMGUSA-N [14c]-nicotinamide Chemical compound N[14C](=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-ZQBYOMGUSA-N 0.000 claims abstract description 8
- 238000003756 stirring Methods 0.000 claims description 43
- 239000000203 mixture Substances 0.000 claims description 41
- 238000006243 chemical reaction Methods 0.000 claims description 15
- 239000000243 solution Substances 0.000 claims description 15
- 239000002994 raw material Substances 0.000 claims description 11
- 238000000034 method Methods 0.000 claims description 10
- 238000002156 mixing Methods 0.000 claims description 10
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 9
- 239000011259 mixed solution Substances 0.000 claims description 9
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 claims description 8
- 238000001035 drying Methods 0.000 claims description 7
- 238000010438 heat treatment Methods 0.000 claims description 6
- 229960005336 magnesium citrate Drugs 0.000 claims description 6
- 239000004337 magnesium citrate Substances 0.000 claims description 6
- 235000002538 magnesium citrate Nutrition 0.000 claims description 6
- PLSARIKBYIPYPF-UHFFFAOYSA-H trimagnesium dicitrate Chemical compound [Mg+2].[Mg+2].[Mg+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O PLSARIKBYIPYPF-UHFFFAOYSA-H 0.000 claims description 6
- 229920002385 Sodium hyaluronate Polymers 0.000 claims description 5
- 238000007599 discharging Methods 0.000 claims description 5
- 229940010747 sodium hyaluronate Drugs 0.000 claims description 5
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims description 5
- 238000005303 weighing Methods 0.000 claims description 5
- 230000032683 aging Effects 0.000 claims description 4
- 229960003966 nicotinamide Drugs 0.000 claims description 4
- 235000005152 nicotinamide Nutrition 0.000 claims description 4
- 239000011570 nicotinamide Substances 0.000 claims description 4
- 239000000843 powder Substances 0.000 claims description 4
- 239000007787 solid Substances 0.000 claims description 4
- 238000005406 washing Methods 0.000 claims description 4
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 claims description 3
- 235000011114 ammonium hydroxide Nutrition 0.000 claims description 3
- 239000000395 magnesium oxide Substances 0.000 claims description 3
- CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 claims description 3
- AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 claims description 3
- 238000004321 preservation Methods 0.000 claims description 3
- 238000000967 suction filtration Methods 0.000 claims description 3
- 241001165494 Rhodiola Species 0.000 claims description 2
- 230000003020 moisturizing effect Effects 0.000 abstract description 13
- 231100000344 non-irritating Toxicity 0.000 abstract 1
- 230000000052 comparative effect Effects 0.000 description 12
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 11
- 150000004676 glycans Chemical class 0.000 description 11
- 229920001282 polysaccharide Polymers 0.000 description 11
- 239000005017 polysaccharide Substances 0.000 description 11
- 238000012360 testing method Methods 0.000 description 11
- LNTHITQWFMADLM-UHFFFAOYSA-N gallic acid Chemical compound OC(=O)C1=CC(O)=C(O)C(O)=C1 LNTHITQWFMADLM-UHFFFAOYSA-N 0.000 description 10
- BJRNKVDFDLYUGJ-RMPHRYRLSA-N hydroquinone O-beta-D-glucopyranoside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-RMPHRYRLSA-N 0.000 description 10
- 230000008859 change Effects 0.000 description 7
- 230000000694 effects Effects 0.000 description 6
- 229960000271 arbutin Drugs 0.000 description 5
- 229940074391 gallic acid Drugs 0.000 description 5
- 235000004515 gallic acid Nutrition 0.000 description 5
- BJRNKVDFDLYUGJ-UHFFFAOYSA-N p-hydroxyphenyl beta-D-alloside Natural products OC1C(O)C(O)C(CO)OC1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-UHFFFAOYSA-N 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 239000000047 product Substances 0.000 description 4
- 238000010298 pulverizing process Methods 0.000 description 4
- 238000002425 crystallisation Methods 0.000 description 3
- 230000008025 crystallization Effects 0.000 description 3
- 230000032798 delamination Effects 0.000 description 3
- 238000001914 filtration Methods 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 150000003254 radicals Chemical class 0.000 description 3
- 206010020751 Hypersensitivity Diseases 0.000 description 2
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 208000026935 allergic disease Diseases 0.000 description 2
- 230000007815 allergy Effects 0.000 description 2
- 238000007873 sieving Methods 0.000 description 2
- 238000005507 spraying Methods 0.000 description 2
- 238000013112 stability test Methods 0.000 description 2
- 239000006228 supernatant Substances 0.000 description 2
- 239000013589 supplement Substances 0.000 description 2
- YDNKGFDKKRUKPY-JHOUSYSJSA-N C16 ceramide Natural products CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)C=CCCCCCCCCCCCCC YDNKGFDKKRUKPY-JHOUSYSJSA-N 0.000 description 1
- 206010013786 Dry skin Diseases 0.000 description 1
- 235000010837 Echinocereus enneacanthus subsp brevispinus Nutrition 0.000 description 1
- 235000006850 Echinocereus enneacanthus var dubius Nutrition 0.000 description 1
- 206010014970 Ephelides Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 208000003351 Melanosis Diseases 0.000 description 1
- CRJGESKKUOMBCT-VQTJNVASSA-N N-acetylsphinganine Chemical compound CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC(C)=O CRJGESKKUOMBCT-VQTJNVASSA-N 0.000 description 1
- 208000012641 Pigmentation disease Diseases 0.000 description 1
- OUUQCZGPVNCOIJ-UHFFFAOYSA-M Superoxide Chemical compound [O-][O] OUUQCZGPVNCOIJ-UHFFFAOYSA-M 0.000 description 1
- 102000003425 Tyrosinase Human genes 0.000 description 1
- 108060008724 Tyrosinase Proteins 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 238000007605 air drying Methods 0.000 description 1
- 230000003064 anti-oxidating effect Effects 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 229940106189 ceramide Drugs 0.000 description 1
- ZVEQCJWYRWKARO-UHFFFAOYSA-N ceramide Natural products CCCCCCCCCCCCCCC(O)C(=O)NC(CO)C(O)C=CCCC=C(C)CCCCCCCCC ZVEQCJWYRWKARO-UHFFFAOYSA-N 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 230000037336 dry skin Effects 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 229940087559 grape seed Drugs 0.000 description 1
- 230000036074 healthy skin Effects 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 238000000643 oven drying Methods 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 230000001376 precipitating effect Effects 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 238000010025 steaming Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000013517 stratification Methods 0.000 description 1
- 230000001502 supplementing effect Effects 0.000 description 1
- 239000012747 synergistic agent Substances 0.000 description 1
- 238000002137 ultrasound extraction Methods 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/046—Aerosols; Foams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
- A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8147—Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Chemical & Material Sciences (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Emergency Medicine (AREA)
- Biotechnology (AREA)
- Inorganic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a spray and a preparation method thereof, wherein the spray comprises the following components in parts by weight: 2-5% of grape seed extract, 2-5% of propylene glycol, 3-8% of glycerin, 0.1-1.5% of betaine, 1-3% of nicotinamide, 0.0002-0.02% of magnesium hydroxide, 0.05-0.5% of sodium polyacrylate, 1-6% of indocalamus leaf extract, 2-5% of dragon fruit stem extract, 2-5% of rhodiola rosea extract, 0.01-0.1% of hyaluronic acid and the balance of deionized water. The spray prepared by the invention is rich in various natural components, is mild and non-irritating, and has the functions of moisturizing and protecting skin.
Description
Technical Field
The invention belongs to the technical field of daily chemicals, and particularly relates to a spray and a preparation method thereof.
Background
The moisture content of the skin is closely related to the aging degree of the skin, and the skin is affected by environmental factors such as ultraviolet rays, so that the skin is damaged by the protective barrier of the skin, and when the moisture content in the horny layer of the skin is too low, unhealthy conditions such as dry skin can occur. The related product with the moisturizing effect can supplement water to the skin and relieve skin pressure.
The spray is one of the popular skin care skins at present, and the advantages of convenient carrying, convenient use, comprehensive efficacy and the like make the skin care spray popular, especially for female consumers focusing on skin care. The components with the moisturizing effect are mainly substances such as hyaluronic acid or ceramide, and the substances can be combined with free water in the skin after being absorbed into the skin, so that the loss of the free water is avoided, and the moisturizing effect is further achieved. However, pure chemical components have low safety performance, unstable chemical properties and cause discomfort such as allergy.
Therefore, a spray with high stability, which has the functions of moisturizing and protecting skin, is highly demanded.
Disclosure of Invention
The invention aims to provide a spray and a preparation method, and the spray provided by the invention is convenient to use, safe, environment-friendly, simple and effective; can supplement moisture to facial skin and exert moisturizing effect for a long time; has effects of moisturizing and protecting skin. .
In order to solve the technical problems, the technical scheme of the invention is as follows:
the spray is prepared from the following raw materials in percentage by weight: 2-5% of grape seed extract, 2-5% of propylene glycol, 3-8% of glycerin, 0.1-1.5% of betaine, 1-3% of nicotinamide, 0.0002-0.02% of magnesium hydroxide, 0.05-0.5% of sodium polyacrylate, 1-6% of indocalamus leaf extract, 2-5% of dragon fruit stem extract, 2-5% of rhodiola rosea extract, 0.01-0.1% of hyaluronic acid and the balance of deionized water.
The grape seed extract added in the invention contains procyanidine, gallic acid and other components, has extremely strong antioxidation and free radical elimination effects, and can effectively eliminate superoxide anion free radicals and hydroxyl free radicals; the procyanidine has the effects of detumescence and dredging, and can strengthen capillary vessel, artery and vein vessel, reduce capillary vessel resistance and improve permeability, so that cells can absorb nutrients and remove wastes more easily, and cell activity is enhanced; the indocalamus leaf extract and the dragon fruit stem extract contain polysaccharide, can absorb a large amount of water and have a strong moisturizing effect; the rhodiola rosea extract contains arbutin, and can inhibit the generation of melanin by inhibiting the activity of tyrosinase in vivo, thereby reducing skin pigmentation, removing color spots and freckles, and simultaneously has the functions of sterilization and anti-inflammation.
Preferably, the spray is prepared from the following raw materials in percentage by weight: 2% of grape seed extract, 2% of propylene glycol, 5% of glycerin, 1.5% of betaine, 1% of nicotinamide, 0.001% of magnesium hydroxide, 0.05% of sodium polyacrylate, 2% of indocalamus leaf extract, 3% of dragon fruit stem extract, 1% of rhodiola rosea extract, 0.015% of hyaluronic acid and the balance of deionized water.
Preferably, the spray is prepared from the following raw materials in percentage by weight: grape seed extract 5%, propylene glycol 3%, glycerin 3%, betaine 1%, nicotinamide 2%, magnesium hydroxide 0.008%, sodium polyacrylate 0.2%, indocalamus leaf extract 6%, dragon fruit stem extract 5%, rhodiola root extract 5%, hyaluronic acid 0.1%, and deionized water in balance.
Preferably, the spray is prepared from the following raw materials in percentage by weight: 4% of grape seed extract, 5% of propylene glycol, 8% of glycerin, 0.1% of betaine, 3% of nicotinamide, 0.02% of magnesium hydroxide, 0.1% of sodium polyacrylate, 4% of indocalamus leaf extract, 2% of dragon fruit stem extract, 3% of rhodiola rosea extract, 0.05% of hyaluronic acid and the balance of deionized water.
The invention also provides a preparation method of the spray, which comprises the following steps:
step 1, accurately weighing glycerol, propylene glycol, sodium polyacrylate, sodium hyaluronate, betaine and deionized water, transferring into a reaction kettle, keeping the mixing temperature between 20 and 25 ℃, and stirring for 60 to 90 minutes until the mixture is uniformly dispersed to obtain a mixture A;
step 2, transferring the grape seed extract, the indocalamus leaf extract, the rhodiola rosea extract and the dragon fruit stem into another stirring kettle, keeping the mixing temperature between 20 and 25 ℃, stirring for 45 to 60 minutes until the mixture is uniformly dispersed, adding the mixture A, and continuously stirring for 30 to 45 minutes to obtain a mixture B;
and step 3, adding magnesium hydroxide into the mixture B, stirring for 30-45min until the mixture is uniformly dispersed, and discharging.
Preferably, the stirring speed in the step 1 is 300-500r/min, the stirring speed in the step 2 is 300-400r/min, and the stirring speed in the step 3 is 500-1000r/min.
Preferably, the magnesium hydroxide preparation method comprises the following steps:
step 1, taking a proper amount of magnesium oxide solid, adding a citric acid solution to prepare a mixed solution, transferring the mixed solution to a water bath kettle with the temperature of 60-90 ℃ for heating, and stirring for 60-80min to prepare a magnesium citrate solution;
step 2, transferring the magnesium citrate solution into another reaction container, adding 1.2mol/L ammonia water, stirring for 2-4h, transferring into a water bath kettle at 60-80 ℃ for heating, stirring and reacting for 40-60min, and ending the reaction;
and step 3, carrying out heat preservation and aging on the mixed solution obtained after the reaction is finished for 24-48 hours, and carrying out suction filtration, washing and drying to obtain magnesium hydroxide powder.
After the technical scheme is adopted, the invention has the beneficial effects that:
1. the magnesium hydroxide is added to serve as a synergistic agent, a certain amount of electrolyte is provided for spraying, the skin is protected to recover elasticity, and the magnesium hydroxide has a certain stabilizing effect on other components in spraying;
2. the magnesium hydroxide can be used as a carrier of the active ingredients, so that the coating and carrying of various ingredients are increased, the release speed of the active ingredients is increased, and the rapid water supplementing is realized;
3. the invention is added with various plant extracts, is rich in various active substances such as polysaccharide, procyanidine, gallic acid, arbutin and the like, is a pure natural component, can protect skin and reduce the damage of ultraviolet rays, can not generate any irritation reaction to the skin, and is safe and nontoxic and safe to use.
Detailed Description
The following examples are provided to illustrate a spray and method of preparation of the present invention in detail, but they should not be construed as limiting the scope of the invention. In the present invention, all the preparation materials are commercially available products well known to those skilled in the art unless specified otherwise.
Example 1
The preparation process of grape seed extract comprises the following steps: air drying grape seed, pulverizing with pulverizer, sieving to remove large granule impurities, extracting with 70% ethanol at 75deg.C for 5-8 hr, concentrating the extractive solution, and drying to obtain grape seed extract containing procyanidine and gallic acid;
the preparation process of the indocalamus leaf extract comprises the following steps: drying and pulverizing Indocalamus latiflorus, placing in deionized water, extracting with 300W ultrasonic wave at 55deg.C for 30min, and filtering to obtain supernatant as Indocalamus latiflorus polysaccharide extractive solution. Spin-steaming the extractive solution, adjusting to ethanol concentration of 90% with anhydrous ethanol, standing overnight at normal temperature, centrifuging to obtain precipitate, and oven drying to obtain indocalamus leaf polysaccharide, wherein the extract contains polysaccharide;
the preparation process of the dragon fruit stem extract comprises the following steps: pulverizing stem of Pitaya, sieving with 40 mesh sieve to obtain powder, ultrasonic extracting at 65deg.C for 15min at 250W, and filtering to obtain supernatant as Indocalamus leaf polysaccharide extractive solution; precipitating the extractive solution with 95% ethanol, filtering, washing, and lyophilizing to obtain dragon fruit stem extract containing polysaccharide;
the preparation process of the rhodiola rosea extract comprises the following steps: drying and pulverizing radix Rhodiolae, adding 65% ethanol, performing ultrasonic extraction under 300W power for 60min, concentrating the extractive solution, eluting with 75% ethanol, evaporating the eluate, concentrating, and drying to obtain radix Rhodiolae extract containing arbutin;
the preparation process of the magnesium hydroxide comprises the following steps:
step 1, taking a proper amount of magnesium oxide solid, adding a citric acid solution to prepare a mixed solution, transferring the mixed solution to a water bath kettle with the temperature of 60-90 ℃ for heating, and stirring for 60-80min to prepare a magnesium citrate solution;
step 2, transferring the magnesium citrate solution into another reaction container, adding 1.2mol/L ammonia water, stirring for 2-4h, transferring into a water bath kettle at 60-80 ℃ for heating, stirring and reacting for 40-60min, and ending the reaction;
and step 3, carrying out heat preservation and aging on the mixed solution obtained after the reaction is finished for 24-48 hours, and carrying out suction filtration, washing and drying to obtain magnesium hydroxide powder.
Example 2
The spray is prepared from the following raw materials in percentage by weight: grape seed extract (procyanidine, gallic acid) 2%, propylene glycol 2%, glycerin 5%, betaine 1.5%, nicotinamide 1%, magnesium hydroxide 0.001%, sodium polyacrylate 0.05%, indocalamus leaf extract (polysaccharide) 2%, dragon fruit stem extract (polysaccharide) 3%, rhodiola rosea extract (arbutin) 1%, hyaluronic acid 0.015%, and deionized water in balance. The method comprises the following steps:
step 1, accurately weighing glycerol, propylene glycol, sodium polyacrylate, sodium hyaluronate, betaine and deionized water, transferring into a reaction kettle, keeping the mixing temperature at 20 ℃, and controlling the rotating speed at 500r/min to stir for 60min until the mixture is uniformly dispersed to obtain a mixture A;
step 2, transferring the grape seed extract, the indocalamus leaf extract, the rhodiola rosea extract and the dragon fruit stem into another stirring kettle, keeping the mixing temperature at 20 ℃, controlling the rotating speed at 350r/min, stirring for 45min until the mixture is uniformly dispersed, adding the mixture A, and continuously stirring for 30min to obtain a mixture B;
and step 3, adding magnesium hydroxide into the mixture B, stirring for 30min at the rotating speed of 900r/min until the mixture is uniformly dispersed, and discharging.
Preferably, the stirring speed in the step 1 is 300-500r/min, the stirring speed in the step 2 is 300-400r/min, and the stirring speed in the step 3 is 500-1000r/min.
Example 3
The spray is prepared from the following raw materials in percentage by weight: grape seed extract (procyanidine, gallic acid) 5%, propylene glycol 3%, glycerin 3%, betaine 1%, nicotinamide 2%, magnesium hydroxide 0.008%, sodium polyacrylate 0.2%, indocalamus leaf extract (polysaccharide) 6%, dragon fruit stem (polysaccharide) 5%, rhodiola rosea extract (arbutin) 5%, hyaluronic acid 0.1%, and deionized water in balance. The method comprises the following steps:
step 1, accurately weighing glycerol, propylene glycol, sodium polyacrylate, sodium hyaluronate, betaine and deionized water, transferring into a reaction kettle, keeping the mixing temperature at 23 ℃, and controlling the rotating speed at 300r/min to stir for 90min until the mixture is uniformly dispersed to obtain a mixture A;
step 2, transferring the grape seed extract, the indocalamus leaf extract, the rhodiola rosea extract and the dragon fruit stem into another stirring kettle, keeping the mixing temperature at 23 ℃, controlling the rotating speed at 350r/min, stirring for 60min until the mixture is uniformly dispersed, adding the mixture A, and continuously stirring for 40min to obtain a mixture B;
and 3, adding magnesium hydroxide into the mixture B, controlling the rotating speed to be 500r/min, stirring for 40min until the mixture is uniformly dispersed, and discharging.
Example 4
The spray is prepared from the following raw materials in percentage by weight: 4% of grape seed extract, 5% of propylene glycol, 8% of glycerin, 0.1% of betaine, 3% of nicotinamide, 0.02% of magnesium hydroxide, 0.1% of sodium polyacrylate, 54% of indocalamus leaf extract, 2% of dragon fruit stem extract, 3% of rhodiola rosea extract, 0.05% of hyaluronic acid and the balance of deionized water. The method comprises the following steps:
step 1, accurately weighing glycerol, propylene glycol, sodium polyacrylate, sodium hyaluronate, betaine and deionized water, transferring into a reaction kettle, keeping the mixing temperature at 25 ℃, and controlling the rotating speed at 500r/min to stir for 75min until the mixture is uniformly dispersed to obtain a mixture A;
step 2, transferring the grape seed extract, the indocalamus leaf extract, the rhodiola rosea extract and the dragon fruit stem into another stirring kettle, keeping the mixing temperature at 25 ℃, controlling the rotating speed at 300r/min, stirring for 50min until the mixture is uniformly dispersed, adding the mixture A, and continuously stirring for 45min to obtain a mixture B;
and 3, adding magnesium hydroxide into the mixture B, stirring at the rotating speed of 700r/min for 45min until the mixture is uniformly dispersed, and discharging.
Comparative example 1
The spray of comparative example 1 was compared to example 2, except that no magnesium hydroxide was added to the formulation, and the remaining composition was unchanged. The preparation procedure is referred to above in the examples.
Comparative example 2
The spray of comparative example 2 was compared to example 3, except that no magnesium hydroxide was added to the formulation, and the remaining composition was unchanged. The preparation procedure is referred to above in the examples.
Comparative example 3
The spray of comparative example 3 is compared to example 4, except that no magnesium hydroxide is added to the formulation, and the rest of the composition is unchanged. The preparation procedure is referred to above in the examples.
Test examples
Stability test (one)
Cold resistance stability: standing the test sample in a refrigerator at 0-4 ℃ for 2 months, taking out, and observing the properties;
heat resistance stability: the sample was allowed to stand in an incubator at 40℃for 2 months, and the shape was observed after taking out.
The test results are shown in table 1:
TABLE 1 stability test results
| Experimental example | Cold resistance | Heat resistance |
| Example 2 | No obvious change | No obvious change |
| Example 3 | No obvious change | No obvious change |
| Example 4 | No obvious change | No obvious change |
| Comparative example 1 | Small amount of crystallization | Slight delamination |
| Comparative example 2 | Small amount of crystallization | Slight delamination |
| Comparative example 3 | Small amount of crystallization | Slight delamination |
As shown by the cold and heat resistance test results, the spray of examples 2-4 has no obvious change in 2 months, and has good cold and heat resistance. The sprays of comparative examples 1 to 3 showed solid precipitation and water-oil stratification in cold resistance test and heat resistance test, respectively, indicating poor cold resistance and heat resistance. The comparative test results show that the addition of magnesium hydroxide has a key effect on improving the cold resistance and heat resistance of spray.
And (II) selecting healthy skin, and selecting a group of subjects with no cosmetic allergy history, wherein the age is 20-35 years, and 70 men and 70 women are divided into 7 groups, 10 groups each, and half of men and women. Room temperature 25 ℃ +/-1 ℃; humidity 60% ± 5%. The face was cleaned during the test, and the time for cleansing the face was the same for each person, and after the skin was dried, the cheek portion of 4cm skin was selected as the test area, and the test area was used with the moisturizing spray products of examples 2 to 4, comparative examples 1 to 3, and the control group without using any moisturizing product, respectively. The test results are shown in Table 2.
TABLE 2 determination of moisture content
As can be seen from Table 2, the moisturizing spray of the present invention has good moisturizing effect and long moisturizing time, and can balance skin oil and water, and permanently moisturize and moisten skin when compared with the comparison example and the blank control group.
Claims (7)
1. The spray is characterized by being prepared from the following raw materials in percentage by weight: 2-5% of grape seed extract, 2-5% of propylene glycol, 3-8% of glycerin, 0.1-1.5% of betaine, 1-3% of nicotinamide, 0.0002-0.02% of magnesium hydroxide, 0.05-0.5% of sodium polyacrylate, 1-6% of indocalamus leaf extract, 2-5% of dragon fruit stem extract, 2-5% of rhodiola rosea extract, 0.01-0.1% of hyaluronic acid and the balance of deionized water.
2. A spray according to claim 1, characterized in that it is prepared from the following raw materials in weight percent: 2% of grape seed extract, 2% of propylene glycol, 5% of glycerin, 1.5% of betaine, 1% of nicotinamide, 0.001% of magnesium hydroxide, 0.05% of sodium polyacrylate, 2% of indocalamus leaf extract, 3% of dragon fruit stem extract, 1% of rhodiola rosea extract, 0.015% of hyaluronic acid and the balance of deionized water.
3. A spray according to claim 1, characterized in that it is prepared from the following raw materials in weight percent: grape seed extract 5%, propylene glycol 3%, glycerin 3%, betaine 1%, nicotinamide 2%, magnesium hydroxide 0.008%, sodium polyacrylate 0.2%, indocalamus leaf extract 6%, dragon fruit stem extract 5%, rhodiola root extract 5%, hyaluronic acid 0.1%, and deionized water in balance.
4. A spray according to claim 1, characterized in that it is prepared from the following raw materials in weight percent: 4% of grape seed extract, 5% of propylene glycol, 8% of glycerin, 0.1% of betaine, 3% of nicotinamide, 0.02% of magnesium hydroxide, 0.1% of sodium polyacrylate, 4% of indocalamus leaf extract, 2% of dragon fruit stem extract, 3% of rhodiola rosea extract, 0.05% of hyaluronic acid and the balance of deionized water.
5. A method of preparing a spray comprising the steps of:
step 1, accurately weighing glycerol, propylene glycol, sodium polyacrylate, sodium hyaluronate, betaine and deionized water, transferring into a reaction kettle, keeping the mixing temperature between 20 and 25 ℃, and stirring for 60 to 90 minutes until the mixture is uniformly dispersed to obtain a mixture A;
step 2, transferring the grape seed extract, the indocalamus leaf extract, the rhodiola rosea extract and the dragon fruit stem into another stirring kettle, keeping the mixing temperature between 20 and 25 ℃, stirring for 45 to 60 minutes until the mixture is uniformly dispersed, adding the mixture A, and continuously stirring for 30 to 45 minutes to obtain a mixture B;
and step 3, adding magnesium hydroxide into the mixture B, stirring for 30-45min until the mixture is uniformly dispersed, and discharging.
6. The method according to claim 5, wherein the stirring rate in the step 1 is 300-500r/min, the stirring rate in the step 2 is 300-400r/min, and the stirring rate in the step 3 is 500-1000r/min.
7. A method of preparing a spray as claimed in claim 5, wherein the magnesium hydroxide preparation method comprises the steps of:
step 1, taking a proper amount of magnesium oxide solid, adding a citric acid solution to prepare a mixed solution, transferring the mixed solution to a water bath kettle with the temperature of 60-90 ℃ for heating, and stirring for 60-80min to prepare a magnesium citrate solution;
step 2, transferring the magnesium citrate solution into another reaction container, adding 1.2mol/L ammonia water, stirring for 2-4h, transferring into a water bath kettle at 60-80 ℃ for heating, stirring and reacting for 40-60min, and ending the reaction;
and step 3, carrying out heat preservation and aging on the mixed solution obtained after the reaction is finished for 24-48 hours, and carrying out suction filtration, washing and drying to obtain magnesium hydroxide powder.
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| CN202310947220.4A CN116869887A (en) | 2023-07-31 | 2023-07-31 | Spray and preparation method thereof |
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