CN116802194A - 包含冠状病毒刺突蛋白的受体结合结构域的嵌合蛋白以及包含其的组合物 - Google Patents

包含冠状病毒刺突蛋白的受体结合结构域的嵌合蛋白以及包含其的组合物 Download PDF

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Publication number
CN116802194A
CN116802194A CN202180088951.7A CN202180088951A CN116802194A CN 116802194 A CN116802194 A CN 116802194A CN 202180088951 A CN202180088951 A CN 202180088951A CN 116802194 A CN116802194 A CN 116802194A
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CN
China
Prior art keywords
hbcag
protein
crbdh6
rbd
ser
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Pending
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CN202180088951.7A
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English (en)
Chinese (zh)
Inventor
G·契尼亚圣地亚哥
A·M·马丁敦
D·冈萨雷斯罗什
M·利蒙塔费尔南德斯
E·埃格莱西亚斯佩莱兹
M·贝奎特罗梅罗
H·桑塔纳米莲
G·J·马克斯佩雷拉
A·穆萨基奥拉萨
A·卡布拉莱斯里克
G·E·古兰尼托
M·阿亚拉维拉
E·皮曼特尔瓦兹奎兹
G·罗哈斯多兰特斯
V·胡尔塔加林多
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centro de Ingenieria Genetica y Biotecnologia CIGB
Original Assignee
Centro de Ingenieria Genetica y Biotecnologia CIGB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Centro de Ingenieria Genetica y Biotecnologia CIGB filed Critical Centro de Ingenieria Genetica y Biotecnologia CIGB
Publication of CN116802194A publication Critical patent/CN116802194A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6075—Viral proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/735—Fusion polypeptide containing domain for protein-protein interaction containing a domain for self-assembly, e.g. a viral coat protein (includes phage display)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/20011—Coronaviridae
    • C12N2770/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/20011—Coronaviridae
    • C12N2770/20071—Demonstrated in vivo effect

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Mycology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN202180088951.7A 2020-11-04 2021-11-03 包含冠状病毒刺突蛋白的受体结合结构域的嵌合蛋白以及包含其的组合物 Pending CN116802194A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CU2020000081A CU24665B1 (es) 2020-11-04 2020-11-04 Proteína quimérica que comprende el dominio de unión al receptor de la proteína de la espiga de coronavirus y composiciones que las comprenden
CU2020-0081 2020-11-04
PCT/CU2021/050010 WO2022096039A1 (es) 2020-11-04 2021-11-03 Proteina quimerica que comprende el dominio de union al receptor de la proteina de la espiga de corona virus y composiciones que las comprenden

Publications (1)

Publication Number Publication Date
CN116802194A true CN116802194A (zh) 2023-09-22

Family

ID=79164940

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202180088951.7A Pending CN116802194A (zh) 2020-11-04 2021-11-03 包含冠状病毒刺突蛋白的受体结合结构域的嵌合蛋白以及包含其的组合物

Country Status (12)

Country Link
US (1) US20230405106A1 (https=)
EP (1) EP4242222A1 (https=)
JP (1) JP2023548205A (https=)
CN (1) CN116802194A (https=)
AR (1) AR123998A1 (https=)
AU (1) AU2021373188A1 (https=)
CA (1) CA3197024A1 (https=)
CO (1) CO2023004963A2 (https=)
CU (1) CU24665B1 (https=)
MX (1) MX2023005211A (https=)
WO (1) WO2022096039A1 (https=)
ZA (1) ZA202304779B (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2025519107A (ja) * 2022-05-23 2025-06-24 バクスディグム カンパニー，リミティド ウイルスヌクレオカプシドを用いた結晶性タンパク質ベースの標的タンパク質融合自己組織化ナノ粒子製造プラットフォーム
WO2023229330A1 (ko) * 2022-05-23 2023-11-30 주식회사 백스다임 바이러스 뉴클레오캡시드를 이용한 오량체형 독소 단백질 기반 목적 단백질 융합 오량체 제조 플랫폼

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111217918B (zh) * 2020-03-04 2020-11-10 中山大学 一种基于2,4-二氧四氢喋啶合酶的新型冠状病毒s蛋白双区域亚单位纳米疫苗
CN111366734B (zh) * 2020-03-20 2021-07-13 广州市康润生物科技有限公司 双指标筛选新冠病毒及预判重型肺炎的方法
CN111620952A (zh) * 2020-06-17 2020-09-04 苏州米迪生物技术有限公司 基于嵌合型病毒样颗粒的新型冠状病毒疫苗
CN111676248A (zh) * 2020-07-02 2020-09-18 军事科学院军事医学研究院军事兽医研究所 表达新型冠状病毒S基因与流感M1基因嵌合SARS-CoV-2 VLP的构建

Also Published As

Publication number Publication date
CA3197024A1 (en) 2022-05-12
CU24665B1 (es) 2023-06-13
US20230405106A1 (en) 2023-12-21
AR123998A1 (es) 2023-02-01
MX2023005211A (es) 2023-05-16
EP4242222A1 (en) 2023-09-13
JP2023548205A (ja) 2023-11-15
AU2021373188A1 (en) 2023-06-01
CO2023004963A2 (es) 2023-06-20
WO2022096039A1 (es) 2022-05-12
AU2021373188A9 (en) 2024-10-10
ZA202304779B (en) 2024-09-25
CU20200081A7 (es) 2022-06-06

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