CN116723850A - Glp-1/glp-2双重激动剂的药物组合物 - Google Patents

Glp-1/glp-2双重激动剂的药物组合物 Download PDF

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Publication number
CN116723850A
CN116723850A CN202180079922.4A CN202180079922A CN116723850A CN 116723850 A CN116723850 A CN 116723850A CN 202180079922 A CN202180079922 A CN 202180079922A CN 116723850 A CN116723850 A CN 116723850A
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CN
China
Prior art keywords
glp
composition
concentration
aspects
present
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202180079922.4A
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English (en)
Chinese (zh)
Inventor
杰斯珀·斯科博格·维拉德森
利塞·吉姆
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zealand Pharma AS
Original Assignee
Zealand Pharma AS
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Filing date
Publication date
Application filed by Zealand Pharma AS filed Critical Zealand Pharma AS
Publication of CN116723850A publication Critical patent/CN116723850A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/186—Quaternary ammonium compounds, e.g. benzalkonium chloride or cetrimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Inorganic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Dermatology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
CN202180079922.4A 2020-12-16 2021-12-16 Glp-1/glp-2双重激动剂的药物组合物 Pending CN116723850A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP20214558.7 2020-12-16
EP20214558 2020-12-16
PCT/EP2021/086148 WO2022129312A1 (en) 2020-12-16 2021-12-16 Pharmaceutical composition of glp-1/glp-2 dual agonists

Publications (1)

Publication Number Publication Date
CN116723850A true CN116723850A (zh) 2023-09-08

Family

ID=74141273

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202180079922.4A Pending CN116723850A (zh) 2020-12-16 2021-12-16 Glp-1/glp-2双重激动剂的药物组合物

Country Status (13)

Country Link
US (1) US20230405088A1 (https=)
EP (1) EP4262746A1 (https=)
JP (1) JP2023553563A (https=)
KR (1) KR20230121824A (https=)
CN (1) CN116723850A (https=)
AU (1) AU2021401137B2 (https=)
CA (1) CA3196989A1 (https=)
CL (1) CL2023001745A1 (https=)
IL (1) IL301891A (https=)
MX (1) MX2023006280A (https=)
TW (1) TW202241491A (https=)
WO (1) WO2022129312A1 (https=)
ZA (1) ZA202304233B (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116669752A (zh) * 2020-12-16 2023-08-29 西兰制药公司 Glp-1/glp-2双重激动剂的药物组合物

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11202111311WA (en) 2019-06-14 2021-12-30 Zealand Pharma As Pharmaceutical parenteral composition of dual glp1/2 agonist
JP2024533153A (ja) * 2021-09-03 2024-09-12 ジーランド ファーマ エー／エス 投薬レジーム

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110023329A (zh) * 2016-12-02 2019-07-16 赛诺菲 作为肽类三重glp1/胰高血糖素/gip受体激动剂的新化合物
CN110088125A (zh) * 2016-12-09 2019-08-02 西兰制药公司 酰化的glp-1/glp-2双重激动剂
KR20200080331A (ko) * 2012-07-23 2020-07-06 질랜드 파마 에이/에스 글루카곤 유사체

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU723268B2 (en) 1996-09-09 2000-08-24 Zealand Pharma A/S Improved solid-phase peptide synthesis and agent for use in such synthesis
UA95235C2 (en) * 2005-05-04 2011-07-25 Зииланд Фарма А/С Glucagon-like-peptide-2 (glp-2) analogues
IN2015DN00544A (https=) * 2012-07-23 2015-06-26 Zealand Pharma As
JP6822839B2 (ja) * 2013-09-13 2021-01-27 ザ・スクリップス・リサーチ・インスティテュート 修飾された治療剤、及びその組成物
KR102455171B1 (ko) * 2013-12-18 2022-10-14 더 스크립스 리서치 인스티튜트 변형된 치료제, 스테이플드 펩티드 지질 접합체, 및 이의 조성물

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20200080331A (ko) * 2012-07-23 2020-07-06 질랜드 파마 에이/에스 글루카곤 유사체
CN110023329A (zh) * 2016-12-02 2019-07-16 赛诺菲 作为肽类三重glp1/胰高血糖素/gip受体激动剂的新化合物
CN110088125A (zh) * 2016-12-09 2019-08-02 西兰制药公司 酰化的glp-1/glp-2双重激动剂

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116669752A (zh) * 2020-12-16 2023-08-29 西兰制药公司 Glp-1/glp-2双重激动剂的药物组合物
CN116669752B (zh) * 2020-12-16 2025-11-07 西兰制药公司 Glp-1/glp-2双重激动剂的药物组合物

Also Published As

Publication number Publication date
WO2022129312A1 (en) 2022-06-23
US20230405088A1 (en) 2023-12-21
KR20230121824A (ko) 2023-08-21
AU2021401137B2 (en) 2024-09-05
CL2023001745A1 (es) 2024-01-19
TW202241491A (zh) 2022-11-01
ZA202304233B (en) 2025-08-27
IL301891A (en) 2023-06-01
AU2021401137A1 (en) 2023-06-08
MX2023006280A (es) 2023-06-13
JP2023553563A (ja) 2023-12-22
EP4262746A1 (en) 2023-10-25
CA3196989A1 (en) 2022-06-23

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