CN116710446B - Glp-1r激动剂的晶型及其用途 - Google Patents

Glp-1r激动剂的晶型及其用途 Download PDF

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Publication number
CN116710446B
CN116710446B CN202180082321.9A CN202180082321A CN116710446B CN 116710446 B CN116710446 B CN 116710446B CN 202180082321 A CN202180082321 A CN 202180082321A CN 116710446 B CN116710446 B CN 116710446B
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disease
compound
crystalline form
diabetes
condition
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Chinese (zh)
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CN116710446A (zh
Inventor
钟文革
郭巍
Z·J·李
姜夏伟
陈鹏源
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Shanghai Qilu Ruige Pharmaceutical R & D Co ltd
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Shanghai Qilu Ruige Pharmaceutical R & D Co ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Endocrinology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
CN202180082321.9A 2020-10-14 2021-10-13 Glp-1r激动剂的晶型及其用途 Active CN116710446B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CNPCT/CN2020/120814 2020-10-14
CN2020120814 2020-10-14
PCT/CN2021/123387 WO2022078352A1 (en) 2020-10-14 2021-10-13 Crystal forms of glp-1r agonists and uses thereof

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CN116710446A CN116710446A (zh) 2023-09-05
CN116710446B true CN116710446B (zh) 2024-10-18

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CN202180082321.9A Active CN116710446B (zh) 2020-10-14 2021-10-13 Glp-1r激动剂的晶型及其用途

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US (1) US20230382899A1 (enExample)
EP (1) EP4228753B1 (enExample)
JP (1) JP7769695B2 (enExample)
CN (1) CN116710446B (enExample)
AU (1) AU2021359493A1 (enExample)
CA (1) CA3195264A1 (enExample)
ES (1) ES3041328T3 (enExample)
TW (1) TW202227421A (enExample)
WO (1) WO2022078352A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES3010351T3 (en) * 2019-12-02 2025-04-02 Hyundai Pharm Co Ltd Glp-1 receptor agonist
AU2022349020A1 (en) 2021-09-27 2024-05-09 Terns Pharmaceuticals, Inc. Benzimidazole carboxylic acids as glp-1r agonists
AU2022375634A1 (en) 2021-10-25 2024-06-06 Terns Pharmaceuticals, Inc. Compounds as glp-1r agonists
JP2025508812A (ja) 2022-02-23 2025-04-10 ターンズ・ファーマシューティカルズ・インコーポレイテッド Ｇｌｐ－１ｒアゴニストとしての化合物
CN117362282A (zh) * 2022-07-07 2024-01-09 杭州德睿智药科技有限公司 Glp-1r激动剂的盐及其制备方法和应用
JP2025523988A (ja) * 2022-07-18 2025-07-25 徳睿智薬（蘇州）新薬研発有限公司 Ｇｌｐ－１ｒアゴニストの結晶多形物並びにその製造方法及び使用
KR20250166323A (ko) 2023-04-07 2025-11-27 테른스 파마슈티칼스, 인크. 간 장애 또는 심장대사 질환의 치료에 사용하기 위한 thr베타 효현제 및 glp-1r 효현제를 포함하는 조합
US12234236B1 (en) 2023-09-14 2025-02-25 Ascletis Pharma (China) Co., Limited GLP-1R agonist and therapeutic method thereof
TW202521534A (zh) 2023-11-24 2025-06-01 香港商歌禮製藥(中國)有限公司 Glp-1r 激動劑及其治療方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106109469A (zh) * 2010-11-15 2016-11-16 贝林格尔·英格海姆国际有限公司 保护血管及保护心脏的抗糖尿病性治疗
WO2019239371A1 (en) * 2018-06-15 2019-12-19 Pfizer Inc. Glp-1 receptor agonists and uses thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
US4485045A (en) 1981-07-06 1984-11-27 Research Corporation Synthetic phosphatidyl cholines useful in forming liposomes
US4544545A (en) 1983-06-20 1985-10-01 Trustees University Of Massachusetts Liposomes containing modified cholesterol for organ targeting
US5013556A (en) 1989-10-20 1991-05-07 Liposome Technology, Inc. Liposomes with enhanced circulation time
JP5382952B2 (ja) 2008-03-07 2014-01-08 トランス テック ファーマ，インコーポレイテッド 糖尿病の治療のためのオキサジアゾアントラセン化合物
CN110325530B (zh) 2016-12-16 2022-01-11 辉瑞大药厂 Glp-1受体激动剂及其用途
EP3883928A4 (en) * 2018-11-22 2022-06-29 Qilu Regor Therapeutics Inc. Glp-1r agonists and uses thereof
PH12021552557A1 (en) 2019-04-12 2022-07-04 Qilu Regor Therapeutics Inc Glp-1r agonists and uses thereof
US10954221B2 (en) * 2019-04-12 2021-03-23 Qilu Regor Therapeutics Inc. GLP-1R agonists and uses thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106109469A (zh) * 2010-11-15 2016-11-16 贝林格尔·英格海姆国际有限公司 保护血管及保护心脏的抗糖尿病性治疗
WO2019239371A1 (en) * 2018-06-15 2019-12-19 Pfizer Inc. Glp-1 receptor agonists and uses thereof

Also Published As

Publication number Publication date
TW202227421A (zh) 2022-07-16
CA3195264A1 (en) 2022-04-21
WO2022078352A1 (en) 2022-04-21
US20230382899A1 (en) 2023-11-30
EP4228753C0 (en) 2025-07-30
EP4228753B1 (en) 2025-07-30
ES3041328T3 (en) 2025-11-11
EP4228753A1 (en) 2023-08-23
AU2021359493A1 (en) 2023-06-15
JP2023546125A (ja) 2023-11-01
JP7769695B2 (ja) 2025-11-13
CN116710446A (zh) 2023-09-05
AU2021359493A9 (en) 2025-01-09

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