CN116669753A - Glp-1和胰淀素受体的共激动剂 - Google Patents

Glp-1和胰淀素受体的共激动剂 Download PDF

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Publication number
CN116669753A
CN116669753A CN202180085551.0A CN202180085551A CN116669753A CN 116669753 A CN116669753 A CN 116669753A CN 202180085551 A CN202180085551 A CN 202180085551A CN 116669753 A CN116669753 A CN 116669753A
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CN
China
Prior art keywords
receptor
glp
seq
amino
amino acid
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Pending
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CN202180085551.0A
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English (en)
Chinese (zh)
Inventor
T·克鲁瑟
A·L·B·柯达尔
J·马德森
S·奥斯特加德
W·F·J·霍根多夫
C·W·托尔诺埃
L·谢弗
A·R·马德森
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Novo Nordisk AS
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Novo Nordisk AS
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Publication of CN116669753A publication Critical patent/CN116669753A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Obesity (AREA)
  • General Chemical & Material Sciences (AREA)
  • Child & Adolescent Psychology (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Immunology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN202180085551.0A 2020-12-18 2021-12-17 Glp-1和胰淀素受体的共激动剂 Pending CN116669753A (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
EP20215291.4 2020-12-18
EP20215291 2020-12-18
EP21154668 2021-02-02
EP21154668.4 2021-02-02
EP21179810.3 2021-06-16
EP21179810 2021-06-16
PCT/EP2021/086494 WO2022129526A1 (en) 2020-12-18 2021-12-17 Co-agonists of the glp-1 and amylin receptors

Related Child Applications (3)

Application Number Title Priority Date Filing Date
CN202610109721.9A Division CN121991249A (zh) 2020-12-18 2021-12-17 Glp-1和胰淀素受体的共激动剂
CN202610110419.5A Division CN121991202A (zh) 2020-12-18 2021-12-17 Glp-1和胰淀素受体的共激动剂
CN202610110158.7A Division CN121975020A (en) 2020-12-18 2021-12-17 Co-agonists of GLP-1 and the amylin receptor

Publications (1)

Publication Number Publication Date
CN116669753A true CN116669753A (zh) 2023-08-29

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Family Applications (1)

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CN202180085551.0A Pending CN116669753A (zh) 2020-12-18 2021-12-17 Glp-1和胰淀素受体的共激动剂

Country Status (15)

Country Link
US (2) US12054528B2 (https=)
EP (1) EP4263581A1 (https=)
JP (1) JP7554928B2 (https=)
KR (3) KR20250165665A (https=)
CN (1) CN116669753A (https=)
AU (2) AU2021403851B2 (https=)
CA (1) CA3201088A1 (https=)
CL (1) CL2023001714A1 (https=)
CO (1) CO2023008866A2 (https=)
IL (2) IL303127A (https=)
MX (2) MX2023005707A (https=)
MY (1) MY209195A (https=)
PE (1) PE20231659A1 (https=)
TW (2) TWI850611B (https=)
WO (1) WO2022129526A1 (https=)

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IL318291A (en) * 2022-08-05 2025-03-01 Univ Indiana Res & Tech Corp Glucagon-like peptide 1 receptor antibodies
US12116388B2 (en) 2022-12-22 2024-10-15 Novo Nordisk A/S Amylin receptor agonists
WO2024179606A1 (zh) * 2023-03-02 2024-09-06 甘李药业股份有限公司 一种glp-1化合物的医药用途
KR20240176455A (ko) 2023-06-15 2024-12-24 노보 노르디스크 에이/에스 시클로덱스트린을 포함하는 약학적 제형
TW202540155A (zh) 2023-11-30 2025-10-16 丹麥商諾佛 儂迪克股份有限公司 Glp-1、gip及澱粉素受體之三重促效劑
AU2025214636A1 (en) * 2024-01-29 2026-01-29 Immunwork Inc. Pharmaceutical formulation of glucagon-like peptide -1 receptor agonist peptide for sublingual delivery
EP4721760A1 (en) 2024-10-07 2026-04-08 Adocia Composition comprising a peptide having an isoelectric point of less than 6.5 and a co-polyamino acid bearing carboxylate charges and hydrophobic radicals
WO2025172605A1 (en) 2024-02-16 2025-08-21 Adocia Composition comprising a peptide having an isoelectric point of less than 6.5 and a co-polyamino acid bearing carboxylate charges and hydrophobic radicals
EP4721761A1 (en) 2024-10-07 2026-04-08 Adocia Composition comprising semaglutide, cagrilintide and a co-polyamino acid bearing carboxylate charges and hydrophobic radicals
EP4603079A1 (en) 2024-02-16 2025-08-20 Adocia Composition comprising a peptide having an isoelectric point of less than 6.5 and a co-polyamino acid bearing carboxylate charges and hydrophobic radicals
EP4684802A1 (en) 2024-07-23 2026-01-28 Adocia Composition comprising a peptide having an isoelectric point of less than 6.5 and a co-polyamino acid bearing carboxylate charges and hydrophobic radicals
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WO2025172606A1 (en) 2024-02-16 2025-08-21 Adocia Composition comprising semaglutide, cagrilintide and a co-polyamino acid bearing carboxylate charges and hydrophobic radicals
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Publication number Publication date
US20240279299A1 (en) 2024-08-22
IL303127A (en) 2023-07-01
US20230331803A1 (en) 2023-10-19
KR102667196B1 (ko) 2024-05-27
PE20231659A1 (es) 2023-10-17
AU2025248685A1 (en) 2025-10-30
CL2023001714A1 (es) 2024-01-05
AU2021403851B2 (en) 2025-09-25
KR20230019499A (ko) 2023-02-08
JP2023553591A (ja) 2023-12-25
IL325793A (en) 2026-03-01
TW202227474A (zh) 2022-07-16
KR20240074867A (ko) 2024-05-28
TWI850611B (zh) 2024-08-01
CA3201088A1 (en) 2022-06-23
WO2022129526A1 (en) 2022-06-23
AU2021403851A9 (en) 2025-03-20
US12054528B2 (en) 2024-08-06
MX2023005707A (es) 2023-07-31
CO2023008866A2 (es) 2023-10-09
KR102884383B1 (ko) 2025-11-14
KR20250165665A (ko) 2025-11-26
JP7554928B2 (ja) 2024-09-20
EP4263581A1 (en) 2023-10-25
AU2021403851A1 (en) 2023-06-15
TW202440619A (zh) 2024-10-16
MY209195A (en) 2025-06-26
MX2025000872A (es) 2025-03-07

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