CN116660567A - Reaction rotary table unit, incubation plate device and photo-excitation chemiluminescence detector - Google Patents

Reaction rotary table unit, incubation plate device and photo-excitation chemiluminescence detector Download PDF

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Publication number
CN116660567A
CN116660567A CN202310609990.8A CN202310609990A CN116660567A CN 116660567 A CN116660567 A CN 116660567A CN 202310609990 A CN202310609990 A CN 202310609990A CN 116660567 A CN116660567 A CN 116660567A
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CN
China
Prior art keywords
reaction
cup
incubation
radial
turntable
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Pending
Application number
CN202310609990.8A
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Chinese (zh)
Inventor
方泉
练子富
李临
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Kemei Diagnostic Technology Suzhou Co ltd
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Kemei Diagnostic Technology Suzhou Co ltd
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Priority to CN202310609990.8A priority Critical patent/CN116660567A/en
Publication of CN116660567A publication Critical patent/CN116660567A/en
Pending legal-status Critical Current

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/025—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having a carousel or turntable for reaction cells or cuvettes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G01N2035/0401—Sample carriers, cuvettes or reaction vessels
    • G01N2035/0412—Block or rack elements with a single row of samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G01N2035/0439—Rotary sample carriers, i.e. carousels
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N2035/1027—General features of the devices

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  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)

Abstract

The embodiment of the application provides a reaction turntable unit which is applied to an incubation disk device and comprises a reaction turntable and a circumferential guide ring. A plurality of radial sliding grooves are formed in the reaction turntable; the circumferential guide ring is provided with a plurality of circumferential guide grooves, and the plurality of radial sliding grooves are intersected with and communicated with the plurality of circumferential guide grooves to form a plurality of reaction cup positioning grooves distributed along the circumferential direction and the radial direction in an array manner. The application also discloses a laser engraving device adopting the laser module focusing component. The application also provides an incubation plate device adopting the reaction rotary plate unit and a light-activated chemiluminescence detector.

Description

Reaction rotary table unit, incubation plate device and photo-excitation chemiluminescence detector
Technical Field
The application belongs to the technical field of detection equipment, and particularly relates to a reaction turntable unit, an incubation tray device adopting the reaction turntable unit and a photo-excitation chemiluminescence detector.
Background
Chemiluminescent immunoassay is a non-radioactive immunoassay technology which has been rapidly developed in recent years, and the principle is that a chemiluminescent substance is utilized to amplify a signal of a sample, and the light-emitting intensity of the chemiluminescent substance is utilized to directly measure an immune binding process, so that the method has become one of important directions of immunological detection.
At present, chemiluminescence immunoassay is generally carried out by a light-activated chemiluminescence detector, wherein one or more incubation trays are arranged on the detector, and reaction cups required for testing are arranged on the incubation trays. The reaction systems of the reaction cup are two types commonly, the steps of sample adding, reagent adding, incubation, uniform mixing, light detection and the like of the reaction cup are separated, a more complex reaction cup transfer system is needed, a three-dimensional space gripper is used, the structure is complex, and the reliability is low; in another mode, the steps of sample adding, reagent adding, incubation, mixing, light detection and the like of the reaction cups are combined on one reaction disc, but the reaction cups of the reaction disc are arranged in a single circle, the energy of the detector is limited, and if the energy is increased, the incubation disc device has the problem of larger volume.
Disclosure of Invention
The application provides a reaction turntable unit with small volume and large energy, an incubation tray device using the turntable unit and a photo-excitation chemiluminescence detector.
In a first aspect, embodiments of the present application provide a reaction carousel unit for use in an incubation carousel apparatus, comprising a reaction carousel and a circumferential guide ring. A plurality of radial sliding grooves are formed in the reaction turntable; the circumferential guide ring is provided with a plurality of circumferential guide grooves, and the plurality of radial sliding grooves are intersected with and communicated with the plurality of circumferential guide grooves to form a plurality of reaction cup positioning grooves distributed along the circumferential direction and the radial direction in an array manner.
In one embodiment, the plurality of radial sliding grooves penetrate through the outer side surface and the inner side surface of the reaction turntable along the radial direction.
In one embodiment, the plurality of radial sliding grooves are formed in the upper surface of the reaction turntable, an annular accommodating groove is formed in the lower surface of the reaction turntable, and the circumferential guide ring is embedded in the annular accommodating groove.
In one embodiment, an annular rotating connection plate is arranged on the inner side of the reaction turntable and is used for being connected with a rotating connection shaft.
In one embodiment, an annular reinforcing plate is further connected to the outer side of the lower end of the reaction turntable, and is used for reinforcing the strength of the reaction turntable, and an installation inlet of the annular accommodating groove is formed between the reinforcing plate and the rotating connecting plate.
In one embodiment, the circumferential guide ring comprises a plurality of concentric ring members, and annular guide grooves which limit the radial direction of the reaction cup are formed between the adjacent concentric ring members so as to enable the reaction cup to move along the circumferential direction.
In one embodiment, each concentric ring member is provided with a through notch, and the through notches are opposite to each other in sequence along the same radial direction to form a sliding channel extending along a radial direction.
In one embodiment, the circumferential guide ring further comprises a radial stop, which is switchable between a state of extending into the sliding channel and a state of removing the sliding channel.
In one embodiment, the radial stop member comprises a base and a plurality of stop blocks protruding from the base, the number of the stop blocks corresponds to the number of the concentric rings, and when the reaction cup is required to be stopped in the radial direction, the stop blocks respectively extend into the corresponding through gaps.
In one embodiment, the radial stop further comprises a positioning guide and a linear driver, wherein an output shaft end part of the linear driver is connected with the base to drive the base and the stop block to move up and down, the positioning guide is connected with the linear driver and provided with limiting guide holes, the number of the limiting guide holes is the same as that of the stop blocks, the stop blocks penetrate through the corresponding limiting guide holes and can move along the axial direction of the limiting guide holes, and the limiting guide holes are used for preventing the stop blocks from bending or deflecting in the radial direction and guiding the stop blocks to move along the axial direction of the stop blocks.
In another aspect, an embodiment of the present application provides an incubation tray apparatus, including an incubation tray body, a rotation driving assembly, and a reaction turntable unit according to any one of claims 1 to 10 disposed in the incubation tray body, where the rotation driving assembly is configured to drive a reaction turntable of the reaction turntable unit to rotate.
In one embodiment, the rotary driving assembly comprises a driver assembly, a rotary connecting shaft and a rotary connecting plate, wherein the driver assembly is used for providing rotary driving force of the rotary connecting shaft, the rotary connecting shaft is connected with the rotary connecting plate so as to drive the rotary connecting plate to rotate, and the rotary connecting plate is connected with the reaction turntable so as to drive the reaction turntable to rotate.
In one embodiment, the incubation tray device further comprises a plurality of second support columns, one ends of the support columns are connected with the bottom of the circumferential guide ring, and the other ends of the support columns are connected with the bottom plate of the incubation tray body.
In one embodiment, the incubation tray device further comprises a cup discarding slide way, wherein the cup discarding slide way is arranged on the inner side of the reaction turntable and is provided with a cup discarding slide way communicated with the radial slide way and in butt joint, and the end part of the cup discarding slide way is adjacent to the cup discarding channel and is communicated with the interior of the cup discarding channel.
In one embodiment, the incubation tray device further comprises an upper cup slide, the upper cup slide is disposed radially outside the incubation tray body and has an upper cup chute for communicating with and docking with the radial chute.
In one embodiment, the incubation tray device further comprises an upper cup moving and discarding assembly, the upper cup moving and discarding assembly comprises a reaction cup pushing module and a pushing driving module, and the pushing driving module is used for driving the reaction cup pushing module to move along the extending direction of the upper cup slideway and the discarding slideway.
In another aspect, embodiments of the present application provide a photoexcitation chemiluminescent detector including an incubation plate device as described above.
In this embodiment, through the cooperation of reaction carousel and circumference direction circle, form the reaction cup constant head tank that is used for acceping the reaction cup of radial array's multirow, for the single round design of prior art, greatly increased detector's detection energy, and because along multirow design, need not to increase the diameter of reaction dish device to can keep the unchangeable circumstances of reaction dish device volume, increase detector's detection energy. Furthermore, through the matching design of the through notch and the radial stop piece, the reaction cup can not shift during rotation, and can move or move out of the through notch when the cup is required to be moved or discarded, so that the convenience of operation is greatly improved.
Drawings
In order to more clearly illustrate the embodiments of the application or the technical solutions in the prior art, the drawings that are necessary for the description of the embodiments or the prior art will be briefly described, it being obvious that the drawings in the following description are only some embodiments of the application and that other drawings may be obtained from them without inventive effort for a person skilled in the art.
FIG. 1 is a schematic structural view of a reaction turntable unit according to a first embodiment of the present application;
FIG. 2 is a schematic view of the reaction turntable unit of FIG. 1 from another perspective;
FIG. 3 is a schematic cross-sectional view of a reaction cup carried by the reaction carousel unit of FIG. 1;
FIG. 4 is a schematic view showing the combined structure of the components of the reaction turntable unit of FIG. 1;
FIG. 5 is a schematic view showing the construction of an incubation tray apparatus according to a second embodiment of the application;
FIG. 6 is a schematic illustration of the cooperation of the reaction turntable and the upper cup removal and cup discarding assembly of the incubator disk assembly of FIG. 5;
FIG. 7 is a schematic diagram of a photo-activated chemiluminescent detector according to a third embodiment of the present application.
Reference numerals:
Detailed Description
The present application will be described in further detail with reference to the drawings and examples, in order to make the objects, technical solutions and advantages of the present application more apparent. It should be understood that the specific embodiments described herein are for purposes of illustration only and are not intended to limit the scope of the application.
Referring to fig. 1 to 4, a first embodiment of the present application provides a reaction turntable unit 100, which can be used as an incubation plate of a photo-activated chemiluminescent detector, comprising a reaction turntable 10 and a circumferential guide ring 12; the reaction turntable 10 is provided with a plurality of radial sliding grooves 104, the circumferential guide ring 12 is arranged on the reaction turntable 10 and is provided with a plurality of circumferential guide grooves 122, and the plurality of radial sliding grooves 104 are intersected with and communicated with the plurality of circumferential guide grooves 122 to form a plurality of reaction cup positioning grooves 132 which are arrayed along the circumferential direction and the radial direction.
In this embodiment, the reaction turntable 10 is annular, the upper surface 102 of the reaction turntable 10 is provided with a plurality of radial sliding grooves 104 extending along the radial direction, and the plurality of radial sliding grooves 104 penetrate through the radially outer side surface and the radially inner side surface of the reaction turntable 10, in this embodiment, the plurality of radial sliding grooves 104 are distributed along the circumferential direction of the reaction turntable 10 at equal angles, and the number of the radial sliding grooves 104 can be set according to actual needs, which is 69 in this embodiment. The lower surface 106 of the reaction turntable 10 is provided with an annular receiving groove 108, the annular receiving groove 108 is concentric with the reaction turntable 10 and is communicated with the radial sliding groove 104, and the annular receiving groove 108 is used for embedding the circumferential guide ring 12 so as to receive the circumferential guide ring 12. The inner side of the reaction turntable 10 is provided with an annular rotating connection plate 110, as shown in fig. 5, the rotating connection plate 110 is used for being connected with a rotating connection shaft 344, so that the rotating connection shaft 344 rotates to drive the reaction turntable 10 to rotate, and in this embodiment, the rotating connection plate 110 is connected to the inner side of the lower end of the reaction turntable 10. The outer side of the lower end of the reaction turntable 10 is further connected with an annular reinforcing plate 112 for reinforcing the strength of the reaction turntable 10, a mounting inlet 114 of the annular receiving groove 108 is formed between the reinforcing plate 112 and the rotary connecting plate 110, and the circumferential guide ring 12 is mounted in the annular receiving groove 108 from the mounting inlet 114.
The circumferential guide ring 12 includes a plurality of concentric ring members 120, and annular guide grooves 122 are formed between adjacent concentric ring members 120, which radially limit the reaction cup 20 to move the reaction cup 20 along the circumferential direction, and the plurality of concentric ring members 120 are connected by connecting ribs (not shown) so as to realize connection and fixation, wherein the connecting ribs are disposed at bottoms of the plurality of concentric ring members 120, in this embodiment, the plurality of concentric ring members 120 are equal in height, and the top ends and the bottom ends are all flush with each other.
The circumferential guide ring 12 is embedded into the annular accommodating groove 108, the top end of the circumferential guide ring is adjacent to the upper surface 102 of the reaction turntable 10, the space position where the radial sliding groove 104 extending in the radial direction crosses the guide groove 122 extending in the circumferential direction is a reaction cup positioning groove 132 for arranging the reaction cup 20, and the periphery of the reaction cup 20 is limited by the reaction turntable 10 and the circumferential guide ring 12, so that the reaction turntable 10 can be driven to move along the circumferential direction. As shown in fig. 3, the reaction cup 20 includes a cup 201 and a shoulder 202 disposed at an upper portion of the cup 201 and protruding radially outward along the cup 201, and generally, the shoulder 202 is a protruding structure surrounding a circumference of the cup 201, the width, i.e., the diameter, of the shoulder 202 is larger than the width of the radial chute 104, and the width of the cup 201 is smaller than the width of the radial chute 104 and the guide groove 122, so that the cup 201 is received in the radial chute 104 and the guide groove 122, and the shoulder 202 is supported by the upper surface 102 of the reaction turntable 10.
Each concentric ring 120 has a through-hole 126, and the through-holes 126 are opposite to each other in sequence along a same radial direction, so as to form a sliding channel extending along a radial direction. The circumferential guide ring 12 further comprises a radial stop 128, the radial stop 128 can be switched between a state of extending into the sliding channel and a state of moving out of the sliding channel, when the reaction cup 20 is driven to rotate by the reaction turntable 10, the radial stop 128 extends into the sliding channel, and a stop wall is formed at the through gaps 126 of the concentric rings 120 to stop the radial movement of the reaction cup 20, so that the reaction cup 20 is limited in the reaction cup positioning groove 132; when the reaction cup 20 is required to move in the radial direction, the radial stopper 128 is separated from the through notch 126, so that the reaction cup 20 can pass through the through notch 126 in the radial direction after being separated from the limit of the radial stopper 128.
Specifically, the radial stopper 128 includes a base 1280 and a plurality of stoppers 1282 protruding from the base 1280, the number and shape of the stoppers 1282 correspond to the number of the concentric rings 120, and when the reaction cup 20 is required to be stopped radially, the stoppers 1282 extend into the corresponding through-holes 126. The radial stopper 128 may further include a positioning guide 1284 and a linear driver 1286, an output shaft end of the linear driver 1286 is connected with the base 1280 to drive the base 1280 and the stopper 1282 to move up and down, the positioning guide 1284 may be connected with the linear driver 1286 and have the same number of corresponding limiting guide holes 1288 as the number of the stoppers 1282, the stoppers 1282 may pass through the corresponding limiting guide holes 1288 and may move along the axial direction of the limiting guide holes 1288, and the limiting guide holes 1288 are used to prevent the stoppers 1282 from bending or deflecting in the radial direction and guide the stoppers 1282 to move along the axial direction thereof.
In this embodiment, by the mutual cooperation of the reaction turntable 10 and the circumferential guide ring 12, a plurality of rows of reaction cup positioning grooves 132 for accommodating the reaction cups 20 are formed, which are arranged in the radial direction, so that the detection energy of the detector is greatly increased compared with the single-ring design in the prior art, and the detection energy of the detector can be increased without increasing the diameter of the reaction disk device due to the adoption of the multi-row design, so that the detection energy of the detector can be increased under the condition that the volume of the reaction disk device is kept unchanged. Further, through the matching design of the through notch 126 and the radial stopper 128, the reaction cup 20 can not shift during rotation, and can be moved or removed from the through notch when the cup is required to be moved or discarded, so that the convenience of operation is greatly improved.
Referring to fig. 5 and 6, a second embodiment of the application provides an incubation tray apparatus 200, which includes an incubation tray body 30, a body support portion 32, a rotation driving assembly 34, an upper cup moving and discarding assembly 40, and a reaction turntable unit 100 according to the first embodiment. The body support portion 32 is used for supporting the incubation tray body 30, the reaction tray unit 100 is disposed in the incubation tray body 30, the rotation driving assembly 34 is used for driving the reaction tray 10 to rotate around its central axis, and the upper cup moving and discarding assembly 40 is used for moving the upper cup of the reaction cup 20 to the reaction tray 10 and performing cup moving and discarding operations on the reaction cup 20 in the reaction tray 10.
The incubation tray body 30 includes a cylindrical side plate 302 and a bottom plate 304 connected to the bottom end of the cylindrical side plate 302, so as to define an incubation cavity 306, and a through hole 308 is formed in the center of the bottom plate 304 to allow a rotation connection shaft 344 of the rotation driving assembly 34 to pass through. In this embodiment, the body supporting portion 32 includes a plurality of first supporting columns 322, and the plurality of first supporting columns 322 are connected to the outer bottom of the incubation tray body 30 to support and fix the incubation tray body 30. The rotary driving assembly 34 includes a driver assembly 342, a rotary connecting shaft 344 and a rotary connecting plate 346, wherein the driver assembly 342 is used for providing a rotary driving force of the rotary connecting shaft 344, the rotary connecting shaft 344 is connected to the rotary connecting plate 346 to drive the rotary connecting plate 346 to rotate, and the rotary connecting plate 346 is connected to the reaction turntable 10 to drive the reaction turntable 10 to rotate.
In this embodiment, the driver component 342 is disposed on the bottom side of the incubation plate body 30, and includes a driving motor 3422 and a transmission turntable 3424, wherein an output shaft of the driving motor 3422 is connected to the transmission turntable 3424 through a transmission belt 3426, that is, the transmission belt 3426 is tightly sleeved on the output shaft of the driving motor 3422 and the transmission turntable 3424, so that the driving motor 3422 drives the transmission turntable 3424 to rotate, and preferably the driving motor 3422 is a stepper motor; the outer diameter of the transmission turntable 3424 is larger than the outer diameter of the output shaft of the driving motor 3422, so that the angular velocity of the transmission turntable 3424 is smaller than the angular velocity of the output shaft of the driving motor 3422 to more precisely control the rotational angular velocity of the transmission turntable 3424. The rotary connecting shaft 344 passes through the through hole 308 from the outer side of the bottom of the incubation tray body 30 and extends into the incubation tray body 30, one end of the rotary connecting shaft 344 is fixedly connected with the central shaft of the transmission turntable 3424, the other end of the rotary connecting shaft 344 is connected with the rotary connecting plate 346, and the rotary connecting plate 346 is fixedly connected with the rotary connecting plate 110 on the inner side of the reaction turntable 10, so that the aim of driving the rotary connecting shaft 344 to rotate through the driver component 342 and further driving the reaction turntable 10 to rotate is fulfilled.
The incubation plate device 200 further includes a plurality of second support columns 35, wherein one end of each support column 35 is connected to the bottom of the circumferential guide ring 12, and the other end is connected to the inner side of the bottom plate 304, so as to fix the circumferential guide ring 12 in the incubation plate body 30.
The incubation tray apparatus 200 further includes a discard channel 36, a discard chute 37, an upper chute 38, and a disposing tray 39. The cup discarding channel 36 is arranged at the central axis of the incubation plate apparatus 200; specifically, the rotary connecting shaft 344 is cylindrical, the cup discarding channel 36 is a fixed shaft further disposed in the rotary connecting shaft 344, and when the rotary connecting shaft 344 rotates, the cup discarding channel 36 is fixed at a circumferential position; the discard cup channel 36 is also cylindrical, and has a discard cup hole 362 formed therein, and the discard reaction cup 20 after completion of reaction and detection is discarded through the discard cup hole 362.
The cup discarding slideway 37 is arranged on the inner side of the reaction turntable 10 and is provided with a cup discarding slideway 372 which is communicated and butted with the radial slideway 104 and the innermost through notch 126 of the circumferential guide ring 12, when the cup discarding is needed, the inner side end part of the radial slideway 104 is butted and communicated with the cup discarding slideway 372; the end of the discard cup chute 37 is disposed adjacent to the discard cup channel 36, and the discard cup chute 37 is in communication with the discard cup aperture 362, such that when a discard cup is desired, the reaction cup 20 slides within the discard cup chute 372 and eventually moves into the discard cup aperture 362 for discarding.
The upper cup slide 38 is arranged on the radial outer side of the incubation plate body 30 and is provided with an upper cup slide 382 which is communicated and butted with the radial slide groove 104, and when the upper cup is needed, the outer end part of the radial slide groove 104 is butted and communicated with the upper cup slide 382; in this embodiment, the extending directions of the upper cup slide 38 and the discard cup slide 37 are on the same straight line.
The cup arranging seat 39 is arranged adjacent to the upper cup slideway 38, the cup outlet chute 392 of the cup arranging seat 39 is communicated with the upper cup chute 382, the reaction cup 20 is arranged in the cup arranging seat 39 and then slides to the upper cup position of the upper cup chute 382 through the cup outlet chute 392, and at this time, the upper cup of the reaction cup 20 can be carried out, namely, the reaction cup 20 is moved to the corresponding position in the radial chute 104.
The incubation tray apparatus 200 further includes an upper cup transfer and discard cup assembly 40 that includes a reaction cup pusher module 402 and a pusher drive module 404, the pusher drive module 404 being configured to drive the reaction cup pusher module 402 to move along the radial direction of the reaction carousel, i.e., in the direction of extension of the upper cup slide 38 and discard cup slide 37. The reaction cup push module 402 includes a discard cup push handle 4022 and an upper cup push handle 4024, and the discard cup push handle 4022 and the upper cup push handle 4024 are movable in a vertical direction, so that the discard cup push handle 4022 and the upper cup push handle 4024 can be switched between an idle position and a working position. The pusher drive module 404 includes a slide assembly 4042 and a pusher drive assembly 4044, the pusher drive assembly 4044 being configured to drive the cuvette pusher module 402 to move on the slide assembly 4042 in a direction that is the extension of the upper cup slide 38 and the discard cup slide 37.
The principle of operation of the incubation disc device 200 is as follows:
when the reaction cup 20 is required to be placed on the cup, the reaction cup 20 of the cup arranging seat 39 moves to the upper cup chute 382 of the upper cup chute 38 through the cup outlet chute 392, at this time, the reaction cup 20 is positioned at the upper cup position, the upper cup moving push hand 4024 moves to the working position, and the reaction cup 20 is driven by the push hand driving assembly 4044 to move to the preset position on the reaction turntable 10; the reaction turntable 10 rotates in a predetermined manner, and the addition of a sample, a reagent, and the like to the cuvette 20 is achieved during the rotation.
When the reaction cup 20 is required to be discarded, that is, when the reaction cup 20 in the innermost reaction cup positioning groove 132 is discarded to the discard cup hole 362, the discard cup moving push hand 4022 moves to the upper part of the to-be-discarded reaction cup 20 under the driving of the push hand driving assembly 4044, moves downwards to a working position, and then the discard cup moving push hand 4022 pushes the reaction cup 20 to move to the discard cup sliding groove 372 under the driving of the push hand driving assembly 4044 and continues pushing along the discard cup sliding groove 372 until the reaction cup 20 slides into the discard cup hole 362.
When the reaction cup 20 is required to be moved, that is, the reaction cup 20 is moved from the outer reaction cup positioning groove 132 to the inner reaction cup positioning groove 132, the embodiment will be described by taking the reaction cup 20 in the reaction cup positioning grooves 132a, 132b, 132c as an example to be moved to the reaction cup positioning grooves 132b, 132c, 132d, wherein 132a, 132b, 132c, 132d are respectively reaction cup positioning grooves sequentially arranged from the outer side to the inner side: under the drive of the pusher driving assembly 4044, the cup discarding and moving pusher 4022 and the upper cup moving pusher 4024 move to the upper parts of the reaction cup positioning grooves 132a, 132b and 132c, the cup discarding and moving pusher 4022 and the upper cup moving pusher 4024 move downwards to the working positions, the cup discarding and moving pusher 4022 and the upper cup moving pusher 4024 are respectively provided with two poking heads 4032, the reaction cups 20 in the reaction cup positioning grooves 132a, 132b and 132c are respectively clamped between the poking heads 4032 of the cup discarding and moving pusher 4022, between the adjacent poking heads 4032 of the cup discarding and moving pusher 4022 and the upper cup moving pusher 4024, and between the poking heads 4032 of the upper cup moving pusher 4024; the cuvette 20 in the cuvette positioning slots 132a, 132b, 132c is moved to the cuvette positioning slots 132b, 132c, 132d, respectively, by the pushing hands driving unit 4044.
In the present embodiment, the incubation plate apparatus 200 employs the reaction turntable unit 100, and since a plurality of reaction cup positioning grooves 132 for receiving the reaction cups 20 are formed in a plurality of rows arranged in a radial direction, the detection energy of the detector can be increased relative to the single-turn design of the related art while maintaining the volume of the reaction plate apparatus unchanged. Moreover, under the cooperation of the reaction turntable unit 100 and the upper cup moving and discarding assembly 40, the upper cup moving and discarding is realized on the same slideway, so that the construction and the detection flow of the incubation tray device 200 are greatly simplified.
Referring further to fig. 7, a third embodiment of the present application provides a photo-activated chemiluminescent detector 300 comprising an incubation plate apparatus 200 according to the second embodiment; the photo-excitation chemiluminescence detector 300 further comprises a sample loading assembly 50, a first reagent loading assembly 52, a second reagent loading assembly 53 and a photo-detection module 54, wherein the sample loading assembly 50, the first reagent loading assembly 52 and the second reagent loading assembly 53 are all arranged on the outer side of the incubation tray body 30 and are respectively arranged at preset positions according to requirements and are respectively used for loading samples, a first reagent and a second reagent. The sample application component 50, the first reagent application component 52, the second reagent application component 53 and the light detection module 54 are all conventional structures in the chemiluminescent detection field, and are not described herein.
The photoexcitation chemiluminescent detector 300 of the embodiment adopts the incubation plate device 200, and the plurality of rows of reaction cup positioning grooves 132 for accommodating the reaction cups 20 are formed along the radial direction, so that the detection energy of the detector can be increased under the condition of keeping the volume of the reaction plate device unchanged compared with the single-circle design in the prior art. Moreover, under the cooperation of the reaction turntable unit 100 and the upper cup moving and discarding assembly 40, the upper cup moving and discarding is realized on the same slideway, so that the construction and the detection flow of the incubation tray device 200 are greatly simplified.
The same or similar reference numerals in the drawings of the present embodiment correspond to the same or similar components; in the description of the present application, it should be understood that, if there is an azimuth or positional relationship indicated by terms such as "upper", "lower", "left", "right", etc., based on the azimuth or positional relationship shown in the drawings, it is only for convenience of describing the present application and simplifying the description, but it is not indicated or implied that the apparatus or element referred to must have a specific azimuth, be constructed and operated in a specific azimuth, and thus terms describing the positional relationship in the drawings are merely illustrative and should not be construed as limitations of the present patent, and specific meanings of the terms described above may be understood by those skilled in the art according to specific circumstances.
The foregoing description of the preferred embodiments of the application is not intended to be limiting, but rather is intended to cover all modifications, equivalents, and alternatives falling within the spirit and principles of the application.

Claims (18)

1. A reaction carousel unit (100) for use in an incubation tray apparatus, comprising:
a reaction rotary disc (10) provided with a plurality of radial sliding grooves (104); a kind of electronic device with high-pressure air-conditioning system
The circumferential guide ring (12) is arranged on the reaction turntable (10) and is provided with a plurality of circumferential guide grooves (122), and the plurality of radial sliding grooves (104) are intersected with and communicated with the plurality of circumferential guide grooves (122) to form a plurality of reaction cup positioning grooves (132) which are distributed along the circumferential direction and the radial direction in an array manner.
2. The reaction turntable unit (100) of claim 1, wherein the plurality of radial runners (104) extend through radially outer and inner sides of the reaction turntable (10).
3. The reaction turntable unit (100) according to claim 2, wherein the plurality of radial sliding grooves (104) are formed in an upper surface of the reaction turntable (10), an annular receiving groove (108) is formed in a lower surface (106) of the reaction turntable (10), and the circumferential guide ring (12) is embedded in the annular receiving groove (108).
4. A reaction carousel unit (100) according to claim 3, wherein the inside of the reaction carousel (10) is provided with an annular rotating connection plate (110) for connection with a rotating connection shaft (344).
5. The reaction turntable unit (100) according to claim 4, wherein an annular reinforcing plate (112) is further connected to the outer side of the lower end of the reaction turntable (10) for reinforcing the strength of the reaction turntable (10), and an installation inlet (114) of the annular receiving groove (108) is formed between the reinforcing plate (112) and the rotation connection plate (110).
6. The reaction turntable unit (100) of claim 1, wherein the circumferential guide ring (12) comprises a plurality of concentric ring members (120), and wherein annular guide grooves (122) radially spacing the reaction cups (20) to move the reaction cups (20) in the circumferential direction are formed between adjacent concentric ring members (120).
7. The reaction turntable unit (100) of claim 6, wherein each of the concentric rings (120) is provided with a through-gap (126), and a plurality of the through-gaps (126) are sequentially opposite in a same radial direction to form a sliding channel extending in a radial direction.
8. The reaction turntable unit (100) of claim 7, wherein the circumferential guide ring (12) further comprises a radial stop (128), the radial stop (128) being switchable between a state of extending into the sliding channel and a state of removing the sliding channel.
9. The reaction turntable unit (100) of claim 8, wherein the radial stop (128) comprises a base (1280) and a plurality of stop blocks (1282) protruding from the base (1280), the number of stop blocks (1282) corresponds to the number of concentric rings (120), and when the reaction cup (20) is required to be stopped radially, the plurality of stop blocks (1282) respectively extend into the corresponding through-gaps (126).
10. The reaction turntable unit (100) of claim 9, wherein the radial stopper (128) further comprises a positioning guide (1284) and a linear driver (1286), an output shaft end of the linear driver (1286) being connected to the base (1280) to drive the base (1280) and stopper (1282) to move up and down, the positioning guide (1284) being connected to the linear driver (1286) and having the same number of limiting guide holes (1288) as the number of stopper (1282), the stopper (1282) passing through the corresponding limiting guide holes (1288) and being movable in an axial direction of the limiting guide holes (1288), the limiting guide holes (1288) being for preventing the stopper (1282) from being bent or deflected in a radial direction and guiding the stopper (1282) to move in an axial direction thereof.
11. An incubation tray device (200) comprising an incubation tray body (30), a rotation driving assembly (34) and a reaction carousel unit (100) according to any one of claims 1-10 arranged in the incubation tray body (30), the rotation driving assembly (34) being configured to drive a reaction carousel (10) of the reaction carousel unit (100) to rotate.
12. The incubation plate apparatus (200) of claim 11, wherein the rotary drive assembly (34) comprises a drive assembly (342), a rotary connection shaft (344) and a rotary connection plate (346), the drive assembly (342) is configured to provide a rotary driving force for the rotary connection shaft (344), the rotary connection shaft (344) is connected to the rotary connection plate (346) to rotate the rotary connection plate (346), and the rotary connection plate (346) is connected to the reaction turntable (10) to rotate the reaction turntable (10).
13. Incubation plate arrangement (200) according to claim 12, wherein the incubation plate arrangement (200) further comprises a plurality of second support columns (35), one end of the support columns (35) being connected to the bottom of the circumferential guide ring (12) and the other end being connected to the inner side of the bottom plate (304) of the incubation plate body (30).
14. The incubation tray arrangement (200) according to claim 13, wherein the incubation tray arrangement (200) further comprises a cup-discarding channel (36), the cup-discarding channel (36) being arranged at a central axis of the incubation tray arrangement (200), the rotation connection shaft (344) being tubular, the cup-discarding channel (36) being a stationary shaft further arranged in the rotation connection shaft (344), the cup-discarding channel (36) being stationary in a circumferential position when the rotation connection shaft (344) is rotated.
15. Incubation plate device (200) according to claim 14, wherein the incubation plate device (200) further comprises a discard cup slide (37), the discard cup slide (37) being arranged inside the reaction carousel (10) and having a discard cup slide (372) for communicating with and abutting against the radial slide (104), an end of the discard cup slide (37) being arranged adjacent to the discard cup channel (36) and communicating with the interior of the discard cup channel (36).
16. Incubation tray arrangement (200) according to claim 14, wherein the incubation tray arrangement (200) further comprises an upper cup slide (38), the upper cup slide (38) being arranged radially outside the incubation tray body (30) and having an upper cup slide (382) for communicating with and interfacing with the radial slide (104).
17. Incubation tray arrangement (200) according to claim 16, wherein the incubation tray arrangement (200) further comprises an upper cup transfer and discard assembly (40), the upper cup transfer and discard assembly (40) comprising a reaction cup pusher module (402) and a pusher drive module (404), the pusher drive module (404) being adapted to drive the reaction cup pusher module (402) to move in the extension direction of the upper cup slide (38) and discard slide (37).
18. A photo-activated chemiluminescent detector (300) comprising an incubation tray arrangement (200) according to any one of claims 11-17.
CN202310609990.8A 2023-05-26 2023-05-26 Reaction rotary table unit, incubation plate device and photo-excitation chemiluminescence detector Pending CN116660567A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202310609990.8A CN116660567A (en) 2023-05-26 2023-05-26 Reaction rotary table unit, incubation plate device and photo-excitation chemiluminescence detector

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202310609990.8A CN116660567A (en) 2023-05-26 2023-05-26 Reaction rotary table unit, incubation plate device and photo-excitation chemiluminescence detector

Publications (1)

Publication Number Publication Date
CN116660567A true CN116660567A (en) 2023-08-29

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