CN217180948U - Full-automatic chemiluminescence immunoassay analyzer with high compactness - Google Patents

Abstract

The utility model discloses a full-automatic chemiluminescence immunoassay analyzer with high compactness, a reagent system is in a circular structure, and a sample system concentric ring surrounds the circumferential outer side of the reagent system; the detection module comprises a circular tray which is rotatably arranged and a light-emitting detection assembly positioned outside the circular tray, and detection gaps for mounting reaction cups are distributed on the circumferential edge of the circular tray; the incubation module is integrated in the central area of the circular tray; a transfer module is arranged between the washing module and the detection module and used for placing a reaction cup, the washing module, the transfer module and the detection module are positioned on the same straight line, and a mechanical clamping arm is transversely arranged above the transfer module; the filling system is positioned between the sample system and the transfer module and comprises an upright post and a cantilever arranged at the top end of the upright post, and a filling needle sliding along the length direction of the cantilever is arranged at the lower end of the cantilever. The utility model has the advantages that: reasonable structural layout is adopted among the modules, and the compactness of the structure of the analyzer is guaranteed.

Description

Full-automatic chemiluminescence immunoassay analyzer with high compactness

Technical Field

The utility model relates to a medical science detects technical field, concretely relates to full-automatic chemiluminescence immunoassay appearance with high compactness.

Background

Chemiluminescence immunoassay (CLIA) is a detection and analysis technique for various antigens, haptens, antibodies, hormones, enzymes, fatty acids, vitamins, drugs and the like by combining a chemiluminescence assay technique with high sensitivity and high specificity immunoreaction. Is a latest immunoassay technology developed after radioimmunoassay, enzyme immunoassay, fluoroimmunoassay and time-resolved fluoroimmunoassay.

In order to avoid the influence of uncertain factors such as complex operation, long sample turnover period, man-made interference and the like in the traditional biomedical inspection, the chemiluminescence immunoassay device is developing towards the full-automatic direction, namely, the chemiluminescence immunoassay device is an integrated analyzer capable of realizing links such as filling, shaking, diluting, incubating, washing, detecting and the like.

In the prior art, although some full-automatic chemiluminescence immune analyses are already available on the market, the internal module of the analyzer still has the technical problem of poor layout compactness, and the moving span and the moving track of the mechanical hand grip are complex, so that the detection efficiency is reduced and the equipment volume is increased.

SUMMERY OF THE UTILITY MODEL

In view of this, the present invention provides a fully automatic chemiluminescence immunoassay analyzer with high compactness to solve the technical problems pointed out by the background art.

In order to achieve the above purpose, the utility model discloses technical scheme as follows:

the utility model provides a full-automatic chemiluminescence immunoassay appearance with high compactness, includes the equipment frame, be equipped with sample system, reagent system, washing module, incubation module, detection module and filling system in the equipment frame, its key lies in:

the reagent system is in a circular configuration, the sample system concentric about a circumferentially outer side of the reagent system;

the detection module comprises a circular tray which is rotatably arranged and a light-emitting detection assembly positioned outside the circular tray, and detection gaps for mounting reaction cups are distributed on the circumferential edge of the circular tray; the incubation module is integrally arranged in the central area of the circular tray;

a transfer module is arranged between the washing module and the detection module and used for placing a reaction cup, the washing module, the transfer module and the detection module are positioned on the same straight line, and a mechanical clamping arm is transversely arranged above the transfer module;

the filling system is positioned between the sample system and the transfer module and comprises an upright post and a cantilever arranged at the top end of the upright post, a filling needle is fixedly arranged at the lower part of the far end of the cantilever, and the filling needle rotates around the axis of the upright post along with the cantilever and slides along the axis direction of the upright post.

Preferably, the method comprises the following steps: the cup arranging system comprises a guide rail mechanism which is obliquely arranged above the detection module, the lower end of the guide rail mechanism is in butt joint with the transfer module, and the upper end of the guide rail mechanism is provided with a hopper.

Preferably, the method comprises the following steps: the transfer module comprises a positioning ring and a turntable which is rotatably arranged in the positioning ring, at least two groups of positioning grooves are arranged on the edge of the turntable, cup guide grooves are arranged on the guide rail mechanism, and transition notches which are in butt joint with the lower ends of the cup guide grooves are arranged on the positioning ring.

Preferably, the method comprises the following steps: arrange the backup pad of cup system still includes vertical setting, guide rail mechanism and hopper are located the backup pad both sides respectively, wherein, the hopper bottom has the bottom plate that the slope set up, have the clearance between bottom plate and the backup pad, install the piece that lifts that can reciprocate in this clearance, the upper end of lifting the piece has the bearing diagonal face, forms sharp angular groove between the lateral wall of this bearing diagonal face and backup pad.

Preferably, the method comprises the following steps: the washing module comprises a base, the base is provided with a chamber with an open upper end, a supporting plate is rotatably arranged in the chamber, and supporting holes are distributed on the supporting plate in a circumferential array manner;

the lower part of the base is provided with a shaking mechanism which is arranged below one of the supporting holes in a way of moving up and down through a lifting component.

Preferably, the method comprises the following steps: the base is internally embedded with a plurality of magnetic blocks, the magnetic blocks are distributed in an array mode along the circumferential direction where the supporting plate is located, and the height of each magnetic block is gradually reduced along the circumferential direction of the supporting plate.

Preferably, the method comprises the following steps: the sample system and the reagent system are integrated together through the inner container component, wherein the reagent system is rotatably arranged in the inner region of the inner container component, the sample system is sleeved on the periphery of the inner container component in a ring mode, and the equipment frame is internally provided with a gear driving mechanism and a belt driving mechanism which are respectively used for driving the sample system and the reagent system to rotate.

Preferably, the method comprises the following steps: the detection module comprises a shell seat with an annular structure, the circular tray is rotatably arranged inside the shell seat, the light-emitting detection assembly is fixed outside the shell seat, the shell seat is provided with a detection channel at a position corresponding to the light-emitting detection assembly, the shell seat is provided with an elastic sheet at a position above the detection channel, when a reaction cup in the detection gap stops at the position of the detection channel, the elastic sheet can enable the reaction cup to be tightly attached to the inner wall of the detection gap, and the relative position of the reaction cup keeps consistent every time.

Preferably, the method comprises the following steps: the shell fragment level sets up, and its both ends all rigid coupling is on the inside lateral wall of casing seat.

Preferably, the method comprises the following steps: the filling needle extends in the vertical direction and is mounted at the lower end of the cantilever through a linear module.

Compared with the prior art, the beneficial effects of the utility model are that:

1. the sample system and the reagent system are integrated together in a rotation concentric mode, the incubation module is integrated in the central area of the circular tray of the detection module, and the washing module and the detection module are linearly connected through the transfer module, so that the chemiluminescence immunoassay analyzer is more compact in internal structure and smaller in occupied space.

2. The transfer module is arranged to serve as a temporary placing position of the reaction cup, so that the moving range and the moving track of the mechanical clamping arm can be greatly reduced, the mechanical clamping arm can only move linearly to transfer the reaction cup, and the detection efficiency of equipment is guaranteed.

Drawings

Fig. 1 is a schematic diagram showing the distribution relationship of a sample system 2, a reagent system 3, a washing module 4, an incubation module 5, a detection module 6, a filling system 7 and a transfer module 8 in a full-automatic chemiluminescence immunoassay analyzer;

FIG. 2 is a schematic diagram of the structure of a full-automatic chemiluminescence immunoassay analyzer;

FIG. 3 is another schematic diagram of the structure of the full-automatic chemiluminescence immunoassay analyzer;

FIG. 4 is a schematic structural diagram of the cup arranging system 1 and the transfer module 8;

FIG. 5 is a schematic structural view of the cup arranging system 1 after an outer baffle 1e is hidden;

FIG. 6 is a partial schematic structural view showing the positional relationship of the support plate, the hopper and the lifting block in the cup arranging system 1;

FIG. 7 is a schematic structural diagram of the detection module 6;

fig. 8 is a schematic structural view of the housing seat 6d of the detection module 6;

FIG. 9 is a cross-sectional view of detection module 6;

fig. 10 is a cross-sectional view of the wash module 4;

fig. 11 is a schematic perspective view of the washing module 4 after the base 4a is hidden;

FIG. 12 is a schematic view showing the installation of the support plate 4b inside the base 4a and the lifting assembly 4dd at the bottom of the base 4 a;

FIG. 13 is a schematic structural view of the hidden base 4a in FIG. 12;

fig. 14 is a schematic diagram of the structures of the sample system 2 and the reagent system 3.

Detailed Description

The present invention will be further described with reference to the following examples and accompanying drawings.

As shown in fig. 1 and 2, a full-automatic chemiluminescence immunoassay analyzer structurally comprises an apparatus frame a, wherein a cup arranging system 1, a sample system 2, a reagent system 3, a washing module 4, an incubation module 5, a detection module 6, a filling system 7 and a transfer module 8 are arranged in the apparatus frame a.

As shown in fig. 1, the reagent system 3 is of a circular structure, the sample system 2 is concentrically surrounded on the circumferential outer side of the reagent system 3, the sample system 2 and the reagent system 3 are integrated together in a revolving concentric layout mode, the occupied space is small, the structure compactness is high, and the chemiluminescence immunoassay analyzer is beneficial to realizing the compact and miniaturized design.

Further, referring to fig. 14, the sample system 2 and the reagent system 3 are integrated together through the inner container member 11, wherein the reagent system 3 is rotatably installed in an inner region of the inner container member 11, the sample system 2 is annularly sleeved on a circumference of the inner container member 11, a gear driving mechanism 12 and a belt driving mechanism 13 are installed in the apparatus frame a, and the gear driving mechanism 12 and the belt driving mechanism 13 can independently drive the sample system 2 and the reagent system 3 to rotate.

As shown in fig. 7 again, the detection module 6 includes a circular tray 6a and a light-emitting detection assembly 6b, the circular tray 6a is rotatably disposed, detection notches 6c for installing reaction cups a are distributed on the circumferential edge of the circular tray 6a, the reaction cups a are installed in the detection notches 6c one by one, and along with the rotation of the circular tray 6a, the reaction cups a in the detection notches 6c can pass through the light-emitting detection assembly 6b one by one, so that the detection is completed.

In this embodiment, the middle area of the circular tray 6a is provided with two circles of incubation holes 5a distributed in an annular array, that is, the incubation module 5 is integrally arranged in the central area of the circular tray 6a of the detection module 6, so that the design can make full use of the space of the circular tray 6a, integrate the incubation module 5 and the detection module 6 of the analyzer together, reduce the total space occupied by the incubation module 5 and the detection module 6 in the chemiluminescence immunoassay, and is favorable for the compact and miniaturized design of the product.

Further, as shown in fig. 8 and 9, the detection module 6 further includes a casing seat 6d with an annular structure, the circular tray 6a is rotatably disposed inside the casing seat 6d, the light-emitting detection assembly 6b is fixed outside the casing seat 6d, the casing seat 6d is provided with a detection channel 6e at a position corresponding to the light-emitting detection assembly 6b, the casing seat 6d is provided with an elastic sheet 6f at a position above the detection channel 6e, in this embodiment, the elastic sheet 6f is horizontally disposed, and two ends of the elastic sheet are fixedly connected to an inner side wall of the casing seat 6 d. When detecting the reaction cup a in breach 6c and stopping when surveying passageway 6e position, luminous determine module 6b carries out the analysis and detection to reaction cup a through surveying passageway 6e, and meanwhile, shell fragment 6f can fix reaction cup a in detecting breach 6c, can not take place to rock, makes reaction cup a and detection breach 6c inner wall hug closely and the position unanimous to guarantee that the distance between luminous determine module 6b and the reaction cup a is invariable, help guaranteeing the detection precision of analysis appearance.

As shown in fig. 1, the transfer module 8 is disposed between the washing module 4 and the detection module 6, and by providing the transfer module 8, the transfer module can be used to temporarily hold the cuvette a as a transfer station for adding reagents and samples, so as to prevent the filling needle of the filling system 7 from moving to the washing module 4 or the incubation module to add the reagents and the samples, and significantly reduce the complexity of the mechanism and optimize the movement trajectory of the filling needle 7c of the filling system 7, thereby ensuring that the analyzer has high compactness.

Furthermore, the washing module 4, the transfer module 8 and the detection module 6 are positioned on the same straight line, and the mechanical clamping arm 9 is transversely arranged above the straight line, so that the movement track of the mechanical clamping arm 9 is simplified, and the transfer of the reaction cup among the washing module 4, the transfer module 8 and the detection module 6 can be realized only by one group of straight line driving modules. Such a design in turn helps to ensure compactness of the analyzer device.

As shown in fig. 1 and 2, the filling system 7 is located between the sample system 2 and the relay module 8, the filling system 7 includes a column 7a and a cantilever 7b disposed at a top end of the column 7a, a filling needle 7c is fixedly mounted at a lower portion of a distal end of the cantilever 7b, and the filling needle 7c rotates along an axis of the column 7a along with the cantilever 7b and slides along an axis of the column 7a, so that the blood sample of the sample system 2 and the detection reagent of the reagent system 3 can be added into the reaction cup on the relay module 8. By adopting the movement mode to fill the sample and the reagent, the complexity of the device can be reduced, and the device is further compact.

As shown in fig. 3 and 4, the cup arranging system 1 includes a guide rail mechanism 1a obliquely disposed above the detecting module 6, a lower end of the guide rail mechanism 1a is abutted to the relay module 8, and a hopper 1b is disposed at an upper end thereof, and the guide rail mechanism 1a can move the cuvettes one by one to the relay module 8 after the cuvettes a are put into the hopper 1 b. The guide rail mechanism 1a of the cup arranging system 1 is obliquely arranged above the detection module 6, so that the upper space of the analyzer can be fully utilized, and the compact and small-sized design of the product is facilitated.

The implementation structure of the cup arranging system 1 for realizing automatic cup arrangement is as follows:

referring to fig. 5 and 6, the cup arranging system 1 further includes a supporting plate 1c vertically disposed, and the guiding rail mechanism 1a and the hopper 1b are respectively disposed at two sides of the supporting plate 1c, wherein the bottom of the hopper 1b has a bottom plate 1b1 obliquely disposed, a gap is provided between the bottom plate 1b1 and the supporting plate 1c, a lifting block 1d capable of moving up and down is installed in the gap, an upper end of the lifting block 1d has a inclined supporting surface 1d1, and an acute angle groove c is formed between the inclined supporting surface 1d1 and a side wall of the supporting plate 1 c. The other guide rail mechanism 1a is provided with a cup guide groove 1a 1.

Referring to fig. 5, the reaction cup a to be arranged of the cup arranging system 1 has a cylindrical structure as a whole, and an annular step b is formed at the upper part thereof. Based on the structural characteristics of the reaction cups a, after an operator randomly grabs a large number of reaction cups a into the hopper 1b, at least one or two reaction cups a slide into the acute angle groove c at the upper end of the lifting block 1d from the bottom plate 1b1, the lifting block 1d is lifted along the side wall of the supporting plate 1c under the action of an external driving mechanism, when the top end of the lifting block 1d is level with the upper end of the supporting plate 1c, the reaction cups a in the acute angle groove c slide into the guide rail mechanism 1a at the other side from the top end of the supporting plate 1c, and finally, the reaction cups a are aligned on the guide groove 1a1 of the guide rail mechanism 1a in a vertical posture under the action of self gravity, so that automatic cup arrangement is realized.

As shown in fig. 4, in the present embodiment, the relay module 8 includes a positioning ring 8a and a rotating disc 8b rotatably installed inside the positioning ring 8a, at least two sets of positioning grooves 8c are disposed on the edge of the rotating disc 8b, a transition gap 8d is disposed on the positioning ring 8a, and the lower end of the cup guiding groove 1a1 of the guiding rail mechanism 1a is butted with the transition gap 8 d. Based on this, when the rotating disc 8b rotates to one of the positioning slots 8c to align with the transition notch 8d, the reaction cup a on the material guiding chute 1a1 will automatically slide into the positioning slot 8c under the action of gravity. At this time, the rotating disc 8b rotates again to bring the reaction cup a out, thereby facilitating the filling or the mechanical clamping arm 9 to grab the reaction cup.

As shown in fig. 10, 12 and 13, in this embodiment, the washing module 4 includes a base 4a, the base 4a is a rectangular block structure, the upper end of the base is provided with a chamber 4b1 with a circular structure, a supporting plate 4b is rotatably mounted in the chamber 4b1, the supporting plate 4b is provided with supporting holes 4b1 distributed in a circumferential array, and the supporting holes 4b1 are used for positioning and mounting the reaction cups a. The base 4a is provided at a lower portion thereof with a shaking mechanism 4c, and the shaking mechanism 4c is provided below one of the support holes 4b1 so as to be movable up and down by a lifting unit 4 d.

When the reaction cup a rotates to the position above the shaking mechanism 4c, the lifting component 4d drives the shaking mechanism 4c to move upwards, so that the bottom of the reaction cup a enters the shaking mechanism 4c, the shaking mechanism 4c is started to complete shaking work, after shaking is finished, the lifting component 4d drives the shaking mechanism 4c to return downwards, and the supporting disk 4b further rotates forwards.

As shown in FIG. 10, a liquid supply system 14 is provided above the base 4a for filling the reaction cup a with liquid or extracting waste liquid to thereby effect washing. Set up supporting disk 4b with the gyration mode, on satisfying conventional filling and imbibition function, washing module 4 can also realize that reaction cup a liquid shakes evenly, has avoided mechanical arm lock 9 frequently to shift the reaction cup among the washing process, can show the detection precision that promotes the analysis appearance, also helps the product to realize compactification, miniaturized design simultaneously.

Referring to fig. 12, a specific structure for realizing the lifting function of the shaking mechanism is as follows:

the lifting assembly 4d comprises a support plate e positioned below the base 4a, a motor f fixed on the support plate e and a nut sleeve h fixed on the lower portion of the base 4a, two guide rods d are arranged at two ends of the lower portion of the base 4a, two ends of the support plate e are sleeved on the guide rods d in a vertically sliding mode, a lead screw g is arranged on an output shaft of the motor f and in threaded connection with the nut sleeve h, and the shaking-up mechanism 4c is fixedly installed on the support plate e. Based on this, the motor f rotates forward and backward to drive the shaking mechanism 4c to move up and down. The working principle of the shaking mechanism 4c is a mature technical means in the technical field of chemiluminescence immunoassay, and is not further described here.

As shown in fig. 11, a plurality of magnetic blocks 4e are embedded in the base 4a, each magnetic block 4e is distributed in an array along the circumferential direction of the supporting plate 4b, and the height of each magnetic block 4e gradually decreases along the circumferential direction of the supporting plate 4 b. After the reaction cups a are installed in the supporting holes 4b1 on the supporting plate 4b, each reaction cup can pass through the side part of each magnet 4e along with the rotation of the supporting plate 4b, and because the height of each magnet in the circumferential direction of the supporting plate is gradually reduced, after the reaction cups pass through the side parts of all the magnets 4e, magnetic particles in the reaction cups a can be gradually guided to the bottom of the reaction cups by the magnetism of each magnet 4e, so that all effective substances in the reaction cups are all sunk to the bottom of the reaction cups, the effective substances in the liquid are prevented from being sucked away by the liquid supply system 14 along with waste liquid, and the accuracy of immunoassay detection is further improved.

Finally, it should be noted that the above description is only a preferred embodiment of the present invention, and those skilled in the art can make various similar representations without departing from the spirit and the scope of the present invention.

Claims (9)

1. A full-automatic chemiluminescence immunoassay analyzer with high compactness comprises an equipment frame (A), wherein a sample system (2), a reagent system (3), a washing module (4), an incubation module (5), a detection module (6) and a filling system (7) are arranged in the equipment frame (A), and the full-automatic chemiluminescence immunoassay analyzer is characterized in that:

the reagent system (3) is of circular configuration, the sample system (2) concentrically surrounding the reagent system (3) circumferentially outside;

the detection module (6) comprises a circular tray (6a) which is rotatably arranged and a light-emitting detection assembly (6b) which is positioned outside the circular tray (6a), and detection gaps (6c) for mounting reaction cups are distributed on the circumferential edge of the circular tray (6 a); the incubation module (5) is integrated in the central area of the circular tray (6 a);

a transfer module (8) is arranged between the washing module (4) and the detection module (6), the transfer module (8) is used for placing the reaction cup, the washing module (4), the transfer module (8) and the detection module (6) are positioned on the same straight line, and a mechanical clamping arm (9) is transversely arranged above the transfer module (8);

the filling system (7) is located between the sample system (2) and the transfer module (8) and comprises an upright post (7a) and a cantilever (7b) arranged at the top end of the upright post (7a), a filling needle (7c) is fixedly installed at the lower part of the far end of the cantilever (7b), and the filling needle (7c) rotates along the axis of the upright post (7a) along with the cantilever (7b) and slides along the axis direction of the upright post (7 a).

2. The full-automatic chemiluminescent immunoassay analyzer of claim 1 having high compactness, characterized in that: the cup discharging device is characterized by further comprising a cup discharging system (1), wherein the cup discharging system (1) comprises a guide rail mechanism (1a) which is obliquely arranged above the detection module (6), the lower end of the guide rail mechanism (1a) is in butt joint with the transfer module (8), and the upper end of the guide rail mechanism is provided with a hopper (1 b).

3. The full-automatic chemiluminescent immunoassay analyzer of claim 2 having high compactness, characterized in that: transfer module (8) include holding ring (8a) and rotate and install carousel (8b) at holding ring (8a) inside, be equipped with at least two sets of constant head tank (8c) on carousel (8b) edge, be equipped with guide cup groove (1a1) on guide rail mechanism (1a), be equipped with on holding ring (8a) with guide cup groove (1a1) lower extreme butt joint transition breach (8 d).

4. The full-automatic chemiluminescent immunoassay analyzer of claim 2 having high compactness, characterized in that: arrange cup system (1) and still include the backup pad (1c) of vertical setting, rail mechanism (1a) and hopper (1b) are located backup pad (1c) both sides respectively, wherein, hopper (1b) bottom has bottom plate (1b1) that the slope set up, bottom plate (1b1) and backup pad (1c) between have the clearance, install lifting block (1d) that can reciprocate in this clearance, the upper end of lifting block (1d) has bearing surface (1d1) to one side, forms sharp angle groove (c) between the lateral wall of this bearing surface (1d1) and backup pad (1c) to one side.

5. The full-automatic chemiluminescent immunoassay analyzer of claim 1 having high compactness, characterized in that: the washing module (4) comprises a base (4a), the base (4a) is provided with a chamber (4a1) with an open upper end, a supporting disc (4b) is rotatably mounted in the chamber (4a1), and supporting holes (4b1) are distributed on the supporting disc (4b) in a circumferential array;

the lower part of the base (4a) is provided with a shaking mechanism (4c), and the shaking mechanism (4c) is arranged below one of the supporting holes (4b1) in a way that the shaking mechanism can move up and down through a lifting component (4 d).

6. The full-automatic chemiluminescence immunoassay analyzer with high compactness according to claim 5, characterized in that: a plurality of magnetic blocks (4e) are embedded in the base (4a), the magnetic blocks (4e) are distributed in an array mode along the circumferential direction where the supporting plate (4b) is located, and the height of each magnetic block (4e) is gradually reduced along the circumferential direction of the supporting plate (4 b).

7. The full-automatic chemiluminescent immunoassay analyzer of claim 1 having high compactness, characterized in that: the sample system (2) and the reagent system (3) are integrated together through an inner container component (11), wherein the reagent system (3) is rotatably installed in the inner area of the inner container component (11), the sample system (2) is sleeved on the periphery of the inner container component (11) in a ring mode, and a gear driving mechanism (12) and a belt driving mechanism (13) are installed in the equipment frame (A) and are respectively used for driving the sample system (2) and the reagent system (3) to rotate.

8. The full-automatic chemiluminescent immunoassay analyzer of claim 1 having high compactness, characterized in that: detection module (6) are including casing seat (6d) of annular structure, circular tray (6a) rotate to set up inside casing seat (6d), luminous detection subassembly (6b) are fixed in casing seat (6d) outside, casing seat (6d) are equipped with in the position that corresponds luminous detection subassembly (6b) and are surveyed passageway (6e), shell fragment (6f) are installed in the position that lies in above surveying passageway (6e) in casing seat (6d), when detecting the reaction cup in breach (6c) and stop in surveying passageway (6e) position, shell fragment (6f) can make reaction cup and detection breach (6c) inner wall hug closely.

9. The full-automatic chemiluminescent immunoassay analyzer of claim 8 having high compactness, characterized in that: the elastic sheet (6f) is horizontally arranged, and two ends of the elastic sheet are fixedly connected to the inner side wall of the shell seat (6 d).

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