CN116655504A - 一种二芳基硫醚化合物的制备方法 - Google Patents
一种二芳基硫醚化合物的制备方法 Download PDFInfo
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- CN116655504A CN116655504A CN202310639325.3A CN202310639325A CN116655504A CN 116655504 A CN116655504 A CN 116655504A CN 202310639325 A CN202310639325 A CN 202310639325A CN 116655504 A CN116655504 A CN 116655504A
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- China
- Prior art keywords
- bis
- mmol
- sulfide compound
- diphenylphosphine
- palladium
- Prior art date
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- -1 diaryl sulfide compound Chemical class 0.000 title claims abstract description 49
- 238000002360 preparation method Methods 0.000 title claims abstract description 12
- 238000006243 chemical reaction Methods 0.000 claims abstract description 56
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 claims abstract description 42
- 239000003054 catalyst Substances 0.000 claims abstract description 35
- 239000003446 ligand Substances 0.000 claims abstract description 24
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 claims abstract description 22
- XYFCBTPGUUZFHI-UHFFFAOYSA-N Phosphine Chemical compound P XYFCBTPGUUZFHI-UHFFFAOYSA-N 0.000 claims abstract description 22
- 229910052751 metal Inorganic materials 0.000 claims abstract description 13
- 239000002184 metal Substances 0.000 claims abstract description 12
- 238000000034 method Methods 0.000 claims abstract description 12
- 229910000073 phosphorus hydride Inorganic materials 0.000 claims abstract description 11
- 229910052763 palladium Inorganic materials 0.000 claims abstract description 9
- 239000003960 organic solvent Substances 0.000 claims abstract description 7
- 229910052759 nickel Inorganic materials 0.000 claims abstract description 5
- 150000007530 organic bases Chemical class 0.000 claims abstract description 4
- 239000003638 chemical reducing agent Substances 0.000 claims abstract description 3
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims description 42
- LZWQNOHZMQIFBX-UHFFFAOYSA-N lithium;2-methylpropan-2-olate Chemical compound [Li+].CC(C)(C)[O-] LZWQNOHZMQIFBX-UHFFFAOYSA-N 0.000 claims description 21
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims description 21
- 239000010948 rhodium Substances 0.000 claims description 13
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims description 11
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims description 9
- 238000004519 manufacturing process Methods 0.000 claims description 8
- RIOQSEWOXXDEQQ-UHFFFAOYSA-N triphenylphosphine Chemical compound C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 RIOQSEWOXXDEQQ-UHFFFAOYSA-N 0.000 claims description 8
- PIBWKRNGBLPSSY-UHFFFAOYSA-L palladium(II) chloride Chemical compound Cl[Pd]Cl PIBWKRNGBLPSSY-UHFFFAOYSA-L 0.000 claims description 7
- NFHFRUOZVGFOOS-UHFFFAOYSA-N palladium;triphenylphosphane Chemical compound [Pd].C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 NFHFRUOZVGFOOS-UHFFFAOYSA-N 0.000 claims description 7
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 7
- WQDUMFSSJAZKTM-UHFFFAOYSA-N Sodium methoxide Chemical compound [Na+].[O-]C WQDUMFSSJAZKTM-UHFFFAOYSA-N 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 6
- 229910052703 rhodium Inorganic materials 0.000 claims description 6
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims description 5
- 239000003513 alkali Substances 0.000 claims description 5
- 125000003118 aryl group Chemical group 0.000 claims description 5
- GPAYUJZHTULNBE-UHFFFAOYSA-N diphenylphosphine Chemical compound C=1C=CC=CC=1PC1=CC=CC=C1 GPAYUJZHTULNBE-UHFFFAOYSA-N 0.000 claims description 5
- QMMRZOWCJAIUJA-UHFFFAOYSA-L nickel dichloride Chemical compound Cl[Ni]Cl QMMRZOWCJAIUJA-UHFFFAOYSA-L 0.000 claims description 5
- MHOVAHRLVXNVSD-UHFFFAOYSA-N rhodium atom Chemical compound [Rh] MHOVAHRLVXNVSD-UHFFFAOYSA-N 0.000 claims description 5
- 125000004434 sulfur atom Chemical group 0.000 claims description 5
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims description 4
- KTWOOEGAPBSYNW-UHFFFAOYSA-N ferrocene Chemical compound [Fe+2].C=1C=C[CH-]C=1.C=1C=C[CH-]C=1 KTWOOEGAPBSYNW-UHFFFAOYSA-N 0.000 claims description 4
- ZCSHNCUQKCANBX-UHFFFAOYSA-N lithium diisopropylamide Chemical compound [Li+].CC(C)[N-]C(C)C ZCSHNCUQKCANBX-UHFFFAOYSA-N 0.000 claims description 4
- 125000001624 naphthyl group Chemical group 0.000 claims description 4
- 229910052760 oxygen Inorganic materials 0.000 claims description 4
- 229910052697 platinum Inorganic materials 0.000 claims description 4
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 claims description 4
- 230000008569 process Effects 0.000 claims description 4
- XINWHKIKKFDJLM-UHFFFAOYSA-N butane;diphenylphosphane Chemical compound CCCC.C=1C=CC=CC=1PC1=CC=CC=C1.C=1C=CC=CC=1PC1=CC=CC=C1 XINWHKIKKFDJLM-UHFFFAOYSA-N 0.000 claims description 3
- IYSKRFPTDIFGIE-UHFFFAOYSA-N diphenylphosphane;ethane Chemical compound CC.C=1C=CC=CC=1PC1=CC=CC=C1.C=1C=CC=CC=1PC1=CC=CC=C1 IYSKRFPTDIFGIE-UHFFFAOYSA-N 0.000 claims description 3
- URBPOYVAEJMMOH-UHFFFAOYSA-N diphenylphosphane;hexane Chemical compound CCCCCC.C=1C=CC=CC=1PC1=CC=CC=C1.C=1C=CC=CC=1PC1=CC=CC=C1 URBPOYVAEJMMOH-UHFFFAOYSA-N 0.000 claims description 3
- SBOQCPPINFMCBH-UHFFFAOYSA-N diphenylphosphane;methane Chemical compound C.C=1C=CC=CC=1PC1=CC=CC=C1.C=1C=CC=CC=1PC1=CC=CC=C1 SBOQCPPINFMCBH-UHFFFAOYSA-N 0.000 claims description 3
- STCDDNDGEFVYKE-UHFFFAOYSA-N diphenylphosphane;propane Chemical compound CCC.C=1C=CC=CC=1PC1=CC=CC=C1.C=1C=CC=CC=1PC1=CC=CC=C1 STCDDNDGEFVYKE-UHFFFAOYSA-N 0.000 claims description 3
- YNESATAKKCNGOF-UHFFFAOYSA-N lithium bis(trimethylsilyl)amide Chemical compound [Li+].C[Si](C)(C)[N-][Si](C)(C)C YNESATAKKCNGOF-UHFFFAOYSA-N 0.000 claims description 3
- JILPJDVXYVTZDQ-UHFFFAOYSA-N lithium methoxide Chemical compound [Li+].[O-]C JILPJDVXYVTZDQ-UHFFFAOYSA-N 0.000 claims description 3
- AZVCGYPLLBEUNV-UHFFFAOYSA-N lithium;ethanolate Chemical compound [Li+].CC[O-] AZVCGYPLLBEUNV-UHFFFAOYSA-N 0.000 claims description 3
- ZBRJXVVKPBZPAN-UHFFFAOYSA-L nickel(2+);triphenylphosphane;dichloride Chemical group [Cl-].[Cl-].[Ni+2].C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 ZBRJXVVKPBZPAN-UHFFFAOYSA-L 0.000 claims description 3
- LPNYRYFBWFDTMA-UHFFFAOYSA-N potassium tert-butoxide Chemical compound [K+].CC(C)(C)[O-] LPNYRYFBWFDTMA-UHFFFAOYSA-N 0.000 claims description 3
- QDRKDTQENPPHOJ-UHFFFAOYSA-N sodium ethoxide Chemical compound [Na+].CC[O-] QDRKDTQENPPHOJ-UHFFFAOYSA-N 0.000 claims description 3
- 125000001424 substituent group Chemical group 0.000 claims description 3
- WLPUWLXVBWGYMZ-UHFFFAOYSA-N tricyclohexylphosphine Chemical compound C1CCCCC1P(C1CCCCC1)C1CCCCC1 WLPUWLXVBWGYMZ-UHFFFAOYSA-N 0.000 claims description 3
- JRTIUDXYIUKIIE-KZUMESAESA-N (1z,5z)-cycloocta-1,5-diene;nickel Chemical compound [Ni].C\1C\C=C/CC\C=C/1.C\1C\C=C/CC\C=C/1 JRTIUDXYIUKIIE-KZUMESAESA-N 0.000 claims description 2
- GSNUFIFRDBKVIE-UHFFFAOYSA-N DMF Natural products CC1=CC=C(C)O1 GSNUFIFRDBKVIE-UHFFFAOYSA-N 0.000 claims description 2
- 229910021585 Nickel(II) bromide Inorganic materials 0.000 claims description 2
- 229910021586 Nickel(II) chloride Inorganic materials 0.000 claims description 2
- 239000007983 Tris buffer Substances 0.000 claims description 2
- 125000001931 aliphatic group Chemical group 0.000 claims description 2
- 125000000217 alkyl group Chemical group 0.000 claims description 2
- 229910052782 aluminium Inorganic materials 0.000 claims description 2
- WXMZPPIDLJRXNK-UHFFFAOYSA-N butyl(diphenyl)phosphane Chemical compound C=1C=CC=CC=1P(CCCC)C1=CC=CC=C1 WXMZPPIDLJRXNK-UHFFFAOYSA-N 0.000 claims description 2
- 125000001309 chloro group Chemical group Cl* 0.000 claims description 2
- WMKGGPCROCCUDY-PHEQNACWSA-N dibenzylideneacetone Chemical compound C=1C=CC=CC=1\C=C\C(=O)\C=C\C1=CC=CC=C1 WMKGGPCROCCUDY-PHEQNACWSA-N 0.000 claims description 2
- HASCQPSFPAKVEK-UHFFFAOYSA-N dimethyl(phenyl)phosphine Chemical compound CP(C)C1=CC=CC=C1 HASCQPSFPAKVEK-UHFFFAOYSA-N 0.000 claims description 2
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 claims description 2
- 125000000623 heterocyclic group Chemical group 0.000 claims description 2
- XGZVUEUWXADBQD-UHFFFAOYSA-L lithium carbonate Chemical compound [Li+].[Li+].[O-]C([O-])=O XGZVUEUWXADBQD-UHFFFAOYSA-L 0.000 claims description 2
- 229910052808 lithium carbonate Inorganic materials 0.000 claims description 2
- UJNZOIKQAUQOCN-UHFFFAOYSA-N methyl(diphenyl)phosphane Chemical compound C=1C=CC=CC=1P(C)C1=CC=CC=C1 UJNZOIKQAUQOCN-UHFFFAOYSA-N 0.000 claims description 2
- IPLJNQFXJUCRNH-UHFFFAOYSA-L nickel(2+);dibromide Chemical compound [Ni+2].[Br-].[Br-] IPLJNQFXJUCRNH-UHFFFAOYSA-L 0.000 claims description 2
- YCWSUKQGVSGXJO-NTUHNPAUSA-N nifuroxazide Chemical group C1=CC(O)=CC=C1C(=O)N\N=C\C1=CC=C([N+]([O-])=O)O1 YCWSUKQGVSGXJO-NTUHNPAUSA-N 0.000 claims description 2
- YJVFFLUZDVXJQI-UHFFFAOYSA-L palladium(ii) acetate Chemical compound [Pd+2].CC([O-])=O.CC([O-])=O YJVFFLUZDVXJQI-UHFFFAOYSA-L 0.000 claims description 2
- INIOZDBICVTGEO-UHFFFAOYSA-L palladium(ii) bromide Chemical compound Br[Pd]Br INIOZDBICVTGEO-UHFFFAOYSA-L 0.000 claims description 2
- CLSUSRZJUQMOHH-UHFFFAOYSA-L platinum dichloride Chemical compound Cl[Pt]Cl CLSUSRZJUQMOHH-UHFFFAOYSA-L 0.000 claims description 2
- SYKXNRFLNZUGAJ-UHFFFAOYSA-N platinum;triphenylphosphane Chemical compound [Pt].C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 SYKXNRFLNZUGAJ-UHFFFAOYSA-N 0.000 claims description 2
- 229910000027 potassium carbonate Inorganic materials 0.000 claims description 2
- 230000035484 reaction time Effects 0.000 claims description 2
- FCQRKDSALKMOGU-UHFFFAOYSA-K rhodium(3+);triphenylphosphane;trichloride Chemical compound Cl[Rh](Cl)Cl.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 FCQRKDSALKMOGU-UHFFFAOYSA-K 0.000 claims description 2
- 229910000029 sodium carbonate Inorganic materials 0.000 claims description 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 2
- 229910052725 zinc Inorganic materials 0.000 claims description 2
- ZGNHTTAQNUXEPJ-UHFFFAOYSA-N C(C1=CC=CC=C1)=C1C(C(C=CC(C)=O)=CC=C1)=CC1=CC=CC=C1 Chemical compound C(C1=CC=CC=C1)=C1C(C(C=CC(C)=O)=CC=C1)=CC1=CC=CC=C1 ZGNHTTAQNUXEPJ-UHFFFAOYSA-N 0.000 claims 1
- YNHIGQDRGKUECZ-UHFFFAOYSA-N dichloropalladium;triphenylphosphanium Chemical compound Cl[Pd]Cl.C1=CC=CC=C1[PH+](C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1[PH+](C=1C=CC=CC=1)C1=CC=CC=C1 YNHIGQDRGKUECZ-UHFFFAOYSA-N 0.000 claims 1
- ONDPGJBEBGWAKI-UHFFFAOYSA-N diphenylphosphane;propane Chemical compound CCC.C=1C=CC=CC=1PC1=CC=CC=C1 ONDPGJBEBGWAKI-UHFFFAOYSA-N 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 238000005859 coupling reaction Methods 0.000 abstract description 5
- 239000002994 raw material Substances 0.000 abstract description 5
- 239000003153 chemical reaction reagent Substances 0.000 abstract description 4
- 230000008878 coupling Effects 0.000 abstract description 4
- 238000010168 coupling process Methods 0.000 abstract description 4
- 238000003786 synthesis reaction Methods 0.000 abstract description 4
- 238000006477 desulfuration reaction Methods 0.000 abstract description 3
- 230000023556 desulfurization Effects 0.000 abstract description 3
- 150000001875 compounds Chemical class 0.000 abstract description 2
- 229910052736 halogen Inorganic materials 0.000 abstract description 2
- 150000002367 halogens Chemical class 0.000 abstract description 2
- 238000000746 purification Methods 0.000 abstract description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 38
- 238000002474 experimental method Methods 0.000 description 28
- BCJVBDBJSMFBRW-UHFFFAOYSA-N 4-diphenylphosphanylbutyl(diphenyl)phosphane Chemical compound C=1C=CC=CC=1P(C=1C=CC=CC=1)CCCCP(C=1C=CC=CC=1)C1=CC=CC=C1 BCJVBDBJSMFBRW-UHFFFAOYSA-N 0.000 description 20
- 238000004440 column chromatography Methods 0.000 description 19
- 229910052757 nitrogen Inorganic materials 0.000 description 19
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 18
- GUUVPOWQJOLRAS-UHFFFAOYSA-N Diphenyl disulfide Chemical compound C=1C=CC=CC=1SSC1=CC=CC=C1 GUUVPOWQJOLRAS-UHFFFAOYSA-N 0.000 description 16
- 239000000460 chlorine Substances 0.000 description 15
- 239000007788 liquid Substances 0.000 description 11
- LTYMSROWYAPPGB-UHFFFAOYSA-N diphenyl sulfide Chemical compound C=1C=CC=CC=1SC1=CC=CC=C1 LTYMSROWYAPPGB-UHFFFAOYSA-N 0.000 description 9
- 238000000926 separation method Methods 0.000 description 8
- 239000007787 solid Substances 0.000 description 7
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 6
- KZPYGQFFRCFCPP-UHFFFAOYSA-N 1,1'-bis(diphenylphosphino)ferrocene Chemical compound [Fe+2].C1=CC=C[C-]1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=C[C-]1P(C=1C=CC=CC=1)C1=CC=CC=C1 KZPYGQFFRCFCPP-UHFFFAOYSA-N 0.000 description 5
- UCKMPCXJQFINFW-UHFFFAOYSA-N Sulphide Chemical compound [S-2] UCKMPCXJQFINFW-UHFFFAOYSA-N 0.000 description 5
- 239000007858 starting material Substances 0.000 description 5
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- 239000011593 sulfur Substances 0.000 description 4
- 229910052717 sulfur Inorganic materials 0.000 description 4
- LVEYOSJUKRVCCF-UHFFFAOYSA-N 1,3-Bis(diphenylphosphino)propane Substances C=1C=CC=CC=1P(C=1C=CC=CC=1)CCCP(C=1C=CC=CC=1)C1=CC=CC=C1 LVEYOSJUKRVCCF-UHFFFAOYSA-N 0.000 description 3
- FWXAUDSWDBGCMN-UHFFFAOYSA-N 3-diphenylphosphanylbutan-2-yl(diphenyl)phosphane Chemical compound C=1C=CC=CC=1P(C=1C=CC=CC=1)C(C)C(C)P(C=1C=CC=CC=1)C1=CC=CC=C1 FWXAUDSWDBGCMN-UHFFFAOYSA-N 0.000 description 3
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 229910052698 phosphorus Inorganic materials 0.000 description 3
- 239000011574 phosphorus Substances 0.000 description 3
- XGCDBGRZEKYHNV-UHFFFAOYSA-N 1,1-bis(diphenylphosphino)methane Chemical compound C=1C=CC=CC=1P(C=1C=CC=CC=1)CP(C=1C=CC=CC=1)C1=CC=CC=C1 XGCDBGRZEKYHNV-UHFFFAOYSA-N 0.000 description 2
- QFMZQPDHXULLKC-UHFFFAOYSA-N 1,2-bis(diphenylphosphino)ethane Chemical compound C=1C=CC=CC=1P(C=1C=CC=CC=1)CCP(C=1C=CC=CC=1)C1=CC=CC=C1 QFMZQPDHXULLKC-UHFFFAOYSA-N 0.000 description 2
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 2
- AFCARXCZXQIEQB-UHFFFAOYSA-N N-[3-oxo-3-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)propyl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C(CCNC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)N1CC2=C(CC1)NN=N2 AFCARXCZXQIEQB-UHFFFAOYSA-N 0.000 description 2
- UFWIBTONFRDIAS-UHFFFAOYSA-N Naphthalene Chemical compound C1=CC=CC2=CC=CC=C21 UFWIBTONFRDIAS-UHFFFAOYSA-N 0.000 description 2
- 101150003085 Pdcl gene Proteins 0.000 description 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 2
- VSCWAEJMTAWNJL-UHFFFAOYSA-K aluminium trichloride Chemical compound Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 230000003197 catalytic effect Effects 0.000 description 2
- 238000006555 catalytic reaction Methods 0.000 description 2
- MVPPADPHJFYWMZ-UHFFFAOYSA-N chlorobenzene Chemical compound ClC1=CC=CC=C1 MVPPADPHJFYWMZ-UHFFFAOYSA-N 0.000 description 2
- 229910052802 copper Inorganic materials 0.000 description 2
- 239000010949 copper Substances 0.000 description 2
- YWWZCHLUQSHMCL-UHFFFAOYSA-N diphenyl diselenide Chemical compound C=1C=CC=CC=1[Se][Se]C1=CC=CC=C1 YWWZCHLUQSHMCL-UHFFFAOYSA-N 0.000 description 2
- VRLFOXMNTSYGMX-UHFFFAOYSA-N diphenyl ditelluride Chemical compound C=1C=CC=CC=1[Te][Te]C1=CC=CC=C1 VRLFOXMNTSYGMX-UHFFFAOYSA-N 0.000 description 2
- HHEAADYXPMHMCT-UHFFFAOYSA-N dpph Chemical compound [O-][N+](=O)C1=CC([N+](=O)[O-])=CC([N+]([O-])=O)=C1[N]N(C=1C=CC=CC=1)C1=CC=CC=C1 HHEAADYXPMHMCT-UHFFFAOYSA-N 0.000 description 2
- KFBKRCXOTTUAFS-UHFFFAOYSA-N nickel;triphenylphosphane Chemical compound [Ni].C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 KFBKRCXOTTUAFS-UHFFFAOYSA-N 0.000 description 2
- 238000005839 oxidative dehydrogenation reaction Methods 0.000 description 2
- 125000001037 p-tolyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C([H])([H])[H] 0.000 description 2
- RMVRSNDYEFQCLF-UHFFFAOYSA-N phenyl mercaptan Natural products SC1=CC=CC=C1 RMVRSNDYEFQCLF-UHFFFAOYSA-N 0.000 description 2
- 238000001308 synthesis method Methods 0.000 description 2
- 230000002194 synthesizing effect Effects 0.000 description 2
- CXNIUSPIQKWYAI-UHFFFAOYSA-N xantphos Chemical compound C=12OC3=C(P(C=4C=CC=CC=4)C=4C=CC=CC=4)C=CC=C3C(C)(C)C2=CC=CC=1P(C=1C=CC=CC=1)C1=CC=CC=C1 CXNIUSPIQKWYAI-UHFFFAOYSA-N 0.000 description 2
- 239000011701 zinc Substances 0.000 description 2
- CYPYTURSJDMMMP-WVCUSYJESA-N (1e,4e)-1,5-diphenylpenta-1,4-dien-3-one;palladium Chemical group [Pd].[Pd].C=1C=CC=CC=1\C=C\C(=O)\C=C\C1=CC=CC=C1.C=1C=CC=CC=1\C=C\C(=O)\C=C\C1=CC=CC=C1.C=1C=CC=CC=1\C=C\C(=O)\C=C\C1=CC=CC=C1 CYPYTURSJDMMMP-WVCUSYJESA-N 0.000 description 1
- MJEPOVIWHVRBIT-UHFFFAOYSA-N 1-chloro-4-(4-chlorophenyl)sulfanylbenzene Chemical compound C1=CC(Cl)=CC=C1SC1=CC=C(Cl)C=C1 MJEPOVIWHVRBIT-UHFFFAOYSA-N 0.000 description 1
- ZSSCTTQONPHGRA-UHFFFAOYSA-N 1-methyl-2-(2-methylphenyl)disulfanylbenzene Chemical compound CC1=CC=CC=C1SSC1=CC=CC=C1C ZSSCTTQONPHGRA-UHFFFAOYSA-N 0.000 description 1
- GVEDOIATHPCYGS-UHFFFAOYSA-N 1-methyl-3-(3-methylphenyl)benzene Chemical group CC1=CC=CC(C=2C=C(C)C=CC=2)=C1 GVEDOIATHPCYGS-UHFFFAOYSA-N 0.000 description 1
- SUPMWVVVBKKGEL-UHFFFAOYSA-N 2-(naphthalen-2-yldisulfanyl)naphthalene Chemical compound C1=CC=CC2=CC(SSC=3C=C4C=CC=CC4=CC=3)=CC=C21 SUPMWVVVBKKGEL-UHFFFAOYSA-N 0.000 description 1
- FECNOIODIVNEKI-UHFFFAOYSA-N 2-[(2-aminobenzoyl)amino]benzoic acid Chemical class NC1=CC=CC=C1C(=O)NC1=CC=CC=C1C(O)=O FECNOIODIVNEKI-UHFFFAOYSA-N 0.000 description 1
- WZFUQSJFWNHZHM-UHFFFAOYSA-N 2-[4-[2-(2,3-dihydro-1H-inden-2-ylamino)pyrimidin-5-yl]piperazin-1-yl]-1-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)ethanone Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)N1CCN(CC1)CC(=O)N1CC2=C(CC1)NN=N2 WZFUQSJFWNHZHM-UHFFFAOYSA-N 0.000 description 1
- YJLUBHOZZTYQIP-UHFFFAOYSA-N 2-[5-[2-(2,3-dihydro-1H-inden-2-ylamino)pyrimidin-5-yl]-1,3,4-oxadiazol-2-yl]-1-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)ethanone Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)C1=NN=C(O1)CC(=O)N1CC2=C(CC1)NN=N2 YJLUBHOZZTYQIP-UHFFFAOYSA-N 0.000 description 1
- YLZOPXRUQYQQID-UHFFFAOYSA-N 3-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)-1-[4-[2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidin-5-yl]piperazin-1-yl]propan-1-one Chemical compound N1N=NC=2CN(CCC=21)CCC(=O)N1CCN(CC1)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F YLZOPXRUQYQQID-UHFFFAOYSA-N 0.000 description 1
- 101150030352 Arsi gene Proteins 0.000 description 1
- BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 description 1
- RWSOTUBLDIXVET-UHFFFAOYSA-N Dihydrogen sulfide Chemical compound S RWSOTUBLDIXVET-UHFFFAOYSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- ZQRRBZZVXPVWRB-UHFFFAOYSA-N [S].[Se] Chemical compound [S].[Se] ZQRRBZZVXPVWRB-UHFFFAOYSA-N 0.000 description 1
- 150000004982 aromatic amines Chemical class 0.000 description 1
- 150000001502 aryl halides Chemical class 0.000 description 1
- 239000012298 atmosphere Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- NXQGGXCHGDYOHB-UHFFFAOYSA-L cyclopenta-1,4-dien-1-yl(diphenyl)phosphane;dichloropalladium;iron(2+) Chemical compound [Fe+2].Cl[Pd]Cl.[CH-]1C=CC(P(C=2C=CC=CC=2)C=2C=CC=CC=2)=C1.[CH-]1C=CC(P(C=2C=CC=CC=2)C=2C=CC=CC=2)=C1 NXQGGXCHGDYOHB-UHFFFAOYSA-L 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000003009 desulfurizing effect Effects 0.000 description 1
- 150000004833 diarylthioethers Chemical class 0.000 description 1
- UOPIRNHVGHLLDZ-UHFFFAOYSA-L dichlororhodium Chemical compound Cl[Rh]Cl UOPIRNHVGHLLDZ-UHFFFAOYSA-L 0.000 description 1
- AAXGWYDSLJUQLN-UHFFFAOYSA-N diphenyl(propyl)phosphane Chemical compound C=1C=CC=CC=1P(CCC)C1=CC=CC=C1 AAXGWYDSLJUQLN-UHFFFAOYSA-N 0.000 description 1
- XIMIGUBYDJDCKI-UHFFFAOYSA-N diselenium Chemical compound [Se]=[Se] XIMIGUBYDJDCKI-UHFFFAOYSA-N 0.000 description 1
- PXJJSXABGXMUSU-UHFFFAOYSA-N disulfur dichloride Chemical compound ClSSCl PXJJSXABGXMUSU-UHFFFAOYSA-N 0.000 description 1
- JPIIVHIVGGOMMV-UHFFFAOYSA-N ditellurium Chemical compound [Te]=[Te] JPIIVHIVGGOMMV-UHFFFAOYSA-N 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 238000005265 energy consumption Methods 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 description 1
- 229910000041 hydrogen chloride Inorganic materials 0.000 description 1
- 229910000037 hydrogen sulfide Inorganic materials 0.000 description 1
- 239000011261 inert gas Substances 0.000 description 1
- 239000008204 material by function Substances 0.000 description 1
- UCFFGYASXIPWPD-UHFFFAOYSA-N methyl hypochlorite Chemical compound COCl UCFFGYASXIPWPD-UHFFFAOYSA-N 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 229920000620 organic polymer Polymers 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 239000000575 pesticide Substances 0.000 description 1
- ORQWTLCYLDRDHK-UHFFFAOYSA-N phenylselanylbenzene Chemical compound C=1C=CC=CC=1[Se]C1=CC=CC=C1 ORQWTLCYLDRDHK-UHFFFAOYSA-N 0.000 description 1
- XTCBHFKSTRGVMZ-UHFFFAOYSA-N phenyltellanylbenzene Chemical compound C=1C=CC=CC=1[Te]C1=CC=CC=C1 XTCBHFKSTRGVMZ-UHFFFAOYSA-N 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000002910 solid waste Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 229910052714 tellurium Inorganic materials 0.000 description 1
- PORWMNRCUJJQNO-UHFFFAOYSA-N tellurium atom Chemical compound [Te] PORWMNRCUJJQNO-UHFFFAOYSA-N 0.000 description 1
- 229910052723 transition metal Inorganic materials 0.000 description 1
- 238000007832 transition metal-catalyzed coupling reaction Methods 0.000 description 1
- 150000003624 transition metals Chemical class 0.000 description 1
- 239000002912 waste gas Substances 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C391/00—Compounds containing selenium
- C07C391/02—Compounds containing selenium having selenium atoms bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C395/00—Compounds containing tellurium
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/70—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/34—Sulfur atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
本发明公开了一种二芳基硫醚化合物的制备方法,属于有机合成技术领域。该发明以廉价易得的二芳基二硫醚为单一原料,在镍或钯催化剂、膦配体、金属还原剂、有机碱以及有机溶剂中发生脱硫反应,经提纯处理后得到相应的二芳基硫醚。本方法具有原料廉价易得、不使用含卤化合物和预官能团化的偶联试剂、催化剂量低、产率高、操作便捷等优点,具有较高的工业应用前景。
Description
技术领域
本发明涉及有机合成技术领域,更具体地说,涉及一种二芳基硫醚化合物的制备方法。
背景技术
二芳基硫醚化合物在生物医药、农药、染料中间体、有机高分子功能材料等领域有着广泛的应用。合成二苯硫醚方法主要有以下几种:1)将苯和氯化硫在三氯化铝的催化下制备二苯硫醚,此过程三废量大,如释放氯化氢、硫化氢废气和三氯化铝络合物等固废,污染、耗能严重(0rg.Synth.1934,14,36);2)也可通过苯/氯苯和硫磺反应制备二苯硫醚;3)过渡金属催化的偶联反应合成二芳基硫醚,具体包括由芳基卤素ArX(X=Cl、Br、I)、芳基胺ArNR2、芳基酚衍生物ArOR、芳基硼烷ArB(OH)2、芳基金属(ArZnX、ArMgBr)、芳基硅ArSi(OEt)3等偶联试剂试剂与芳基硫酚ArSH、芳基硫钠ArSNa、二芳基二硫醚ArSSAr等含硫偶联试剂在过渡金属(Pd、Ni、Cu等)催化下发生偶联反应制备二芳基硫醚ArSAr(Mini-Reviewsin Organic Chemistry,2017,14,407-431);
以上合成方法都是用到多种起始原料、预官能团化试剂制备芳基硫醚。最近有文献报道了一种铜催化二芳基二硫醚直接发生脱硫反应合成二芳基硫醚(ACS Catal.2020,10,2707-2712)的方法,使用的铜催化剂(20mol%剂量)和配体量(40mol%剂量)消耗量都较大,且S原子是以SO2形式脱去,环境污染隐患较大。
发明内容
本发明的目的在于提供一种二芳基二硫醚Ar1SSAr2高效脱硫制备二芳基硫醚类化合物Ar1SAr2的方法,该方法,其中对称二硫醚原料Ar1SSAr1通过芳基硫分Ar1SH氧化脱氢即可制备,底物适用范围广、操作便捷、催化剂使用量低、反应产率高、成本低廉、污染小。
以解决上述背景技术中提出的问题。
为实现上述目的,本发明提供如下技术方案:
一种二芳基硫醚化合物的制备方法,包括以下步骤:
S1:无水无氧环境下,如手套箱中,在惰性气体或氮气气氛下,在反应器如施莱克反应管内加入如式(I)所示结构的二芳基二硫醚、催化剂、配体;
S2:再向S1内加入碱、金属、有机溶剂;密封环境内,一定温度下反应经后处理柱层析分离、纯化处理得到如式(II)所示结构的二芳基硫醚类化合物;
式(I);
式(II);
其中,Ar1和Ar2分别独立为取代或未取代的苯基、取代或未取代的萘基和取代或未取代的含N、O、S原子的杂环芳基;Ar1和Ar2相同或不同;
苯基、萘基和含N、O、S原子的杂环芳基上,取代的基团包括邻、间、对的一取代或多取代的C6-C20的长链烷基,或者包括邻、间、对的一取代或多取代的C6-C20的支链烷基,或者包括邻、间、对的一取代或多取代的C6-C20的长链烷氧基,或者包括邻、间、对的一取代或多取代的C6-C20的支链的烷氧基,或者包括氯、脂基、醛基、三氟甲基、氰基、氨基和苯基中的一种或多种;进一步的,所述芳香环的取代基团为邻、间、对位的甲基、甲氧基、氯、苯基中的一种或多种。
优选的,所述二芳基二硫醚至二芳基硫醚类化合物的反应结构式如式(III):
式(III)。
优选的,所述金属还原剂为Zn、Mg、Cu、Fe和Al中的一种或多种,优选Zn。
优选的,所述反应温度为50℃-150℃,反应时间4-24h。
优选的,所述催化剂选自镍、钯、铂和铑催化剂中的任意一种或两种混合;
优选的,所述镍催化剂为双三苯基磷二氯化镍Ni(Ph3P)2Cl2、(1,1’-双(二苯基膦)二茂铁)二氯化镍Ni(dppf)Cl2、1,3-双(二苯基膦丙烷)二氯化镍Ni(dppp)Cl2、双-(1,5-环辛二烯)镍Ni(cod)2、四(三苯基膦)镍Ni(Ph3P)4、氯化镍NiCl2和溴化镍NiBr2中的任意一种或多种;;进一步的,所述镍催化剂为双三苯基磷二氯化镍Ni(Ph3P)2Cl2和四(三苯基膦)镍Ni(Ph3P)4中的任意一种或两种;
优选的,所述钯催化剂为三(二亚苄,基丙酮)二钯Pd2(dba)3、(二亚苄基丙酮)钯Pd(dba)2、四(三苯基膦)钯Pd(Ph3P)4、醋酸钯Pd(OAc)2、氯化钯PdCl2、溴化钯PdBr2、1,1’-二(二苯膦基)二茂铁二氯化钯(II)Pd(dppf)Cl2、1,4-双(二苯基膦丁烷)二氯化钯Pd(dppb)Cl2和双三苯基膦二氯化钯Pd(Ph3P)2Cl2中的任意一种或多种;;进一步的,所述钯催化剂为三(二亚苄,基丙酮)二钯Pd2(dba)3和四(三苯基膦)钯Pd(Ph3P)4和双三苯基膦二氯化钯Pd(Ph3P)2Cl2中的任意一种或多种。
优选的,所述铂催化剂为氯化铂PtCl2和四(三苯基膦)铂Pt(Ph3P)4中的一种或两种;
优选的,所述铑催化剂为三(三苯基膦)氯化铑Rh(PPh3)3Cl、四羰基二氯化二铑Rh2(CO)4Cl2和三(二亚苄基丙酮)铑Rh(dba)3中的一种或多种。
优选的,所述金属催化剂与二芳基二硫醚的摩尔比为0.1%-20%。
优选的,所述配体包括三齿配体、双齿膦配体和单齿膦配体中的一种或多种;
优选的,单齿膦配体包括三苯基膦(Ph3P)、三环己基膦(Cy3P)、二苯基甲基膦(MePPh2)和苯基二甲基膦(Me2PPh)中的一种或多种;双齿膦配体包括双二苯基膦甲烷(dppm)、双二苯基膦乙烷(dppe)、双二苯基膦丙烷(dppp)、双二苯基膦丁烷(dppb)、双二苯基膦己烷(dpph)、1,1’-双(二苯基膦)二茂铁(dppf)、双齿膦配体包括1,1’-联萘-2,2’-双二苯膦(BINAP)和4,5-双二苯基膦-9,9-二甲基氧杂蒽(Xantphos)中的一种或多种;进一步的,双齿膦配体包括双二苯基膦甲烷(dppm)、双二苯基膦乙烷(dppe)、双二苯基膦丙烷(dppp)、双二苯基膦丁烷(dppb)、双二苯基膦己烷(dpph)和1,1’-双(二苯基膦)二茂铁(dppf)中的一种或多种;
配体能够调节催化剂金属中心的电性、从而改变其催化活性,还有调节氧化加成和还原消除的反应历程等;也可不加配体,收率相对于加上配体略微低一些。
优选的,所述碱为有机碱,有机碱选自叔丁醇锂、甲醇锂、乙醇锂、六甲基二硅基胺基锂、二异丙基胺基锂、叔丁醇钾、叔丁醇钠、碳酸钠、碳酸钾、碳酸锂、甲醇钠和乙醇钠中的一种或多种组合;进一步的,所述有机碱选自叔丁醇锂、甲醇锂、乙醇锂、叔丁醇钾、叔丁醇钠、甲醇钠和乙醇钠中的一种或多种组合;或其他常见的有机碱中的一种。
优选的,所述有机溶剂选自四氢呋喃、乙腈和DMF中的一种或任意多种混合。
与现有技术相比,本发明的有益效果是:
本发明所提供的二芳基二硫醚的合成方法开辟了新的合成催化体系和芳基硫醚的合成路径;克服了通过多种起始原料进行制备的缺陷;通过单一起始原料即可得到二芳基硫醚类化合物;而且单一起始原料获取简单,通过芳基硫分ArSH氧化脱氢即可制备;不使用含卤化合物和预官能团化的偶联试剂、目标产物产率均较高;反应条件温和,操作简便,成本低廉,无污染气体产生,具有较高的工业应用前景。
附图说明
图1为本发明制备方法具体反应结构过程示意图;
图2为本发明二芳基二硫醚示意图;
图3为本发明二芳基硫醚类化合物示意图。
具体实施方式
实施例1:
本发明提供一种技术方案:
通过剂量放大反应实验,检测相同反应条件和反应材料下,不同材料的剂量对反应结果的影响:
剂量为1.0mmol时:
在氮气保护下,于25mL的施莱克反应管中依次加入二苯基二硫醚(1.0mmol)、Pd2(dba)3(0.01mmol)、dppb(0.02mmol)、叔丁醇锂(2.0mmol)、锌粉(2.0mmol)和四氢呋喃(2.0mL),混合搅拌后,在70℃下反应4小时,反应完成后,经柱层析分离得到目标产物二苯基硫醚,无色液体,产率为86%。
剂量为10mmol时:
在氮气保护下,于250mL的施莱克反应管中依次加入二苯基二硫醚(10.0mmol)、Pd2(dba)3(0.1mmol)、dppb(0.2mmol)、叔丁醇锂(20.0mmol)、锌粉(20.0mmol)和四氢呋喃mmol(20mL),混合搅拌后,在70℃环境下反应12小时,反应完成后,经柱层析分离得到目标产物二苯基硫醚,无色液体,产率为87%。
从上述实验可知,相同的材料和实验条件下,二苯基二硫醚化合物中提取的二苯基硫醚均为无色液体,产率分别为86%和87%,随着剂量的增加,产率还有1%的提高,剂量对本发明的制备方法影响微乎其微;由此可知,本发明的制备方法具备进行大规模量产的前景,且产率并不会下降。
实施例2:
原料中Ar1=Ar2,且为不同种类时产率情况,每个实验中的取代基均选择在产率最高的条件下进行反应;
实验1:
在氮气保护下,于25mL的施莱克反应管中依次加入4,4’-二甲基二苯二硫醚(1.0mmol)、Pd2(dba)3(0.02mmol)、dppb(0.04mmol)、叔丁醇锂(2.0mmol)、锌粉(2.0mmol)和四氢呋喃(2.0mL),混合搅拌后,在90℃环境下反应24小时,反应完成后,经柱层析分离得到目标产物4,4’-二甲基二苯硫醚,白色固体,产率为97%。
实验2:
在氮气保护下,于25mL的施莱克反应管中依次加入3,3’-二甲基二苯二硫醚(1.0mmol)、Pd2(dba)3(0.02mmol)、dppb(0.04mmol)、叔丁醇锂(2.0mmol)、锌粉(2.0mmol)和四氢呋喃mmol(2.0mL),混合搅拌后,在90℃环境下反应24小时,反应完成后,经柱层析分离得到目标产物3,3’-二甲基二苯硫醚,无色液体,产率为86%。
实验3:
在氮气保护下,于25mL的施莱克反应管中依次加入2,2’-二甲基二苯二硫醚(1.0mmol)、Pd2(dba)3(0.02mmol)、dppb(0.04mmol)、叔丁醇锂(2.0mmol)、锌粉(2.0mmol)和四氢呋喃mmol(2mL),混合搅拌后,在90℃环境下反应24小时,反应完成后,经柱层析分离得到目标产物2,2’-二甲基二苯硫醚(1.0mmol),白色固体,产率为95%。
实验4:
在氮气保护下,于25mL的施莱克反应管中依次加入4,4’-二甲氧基二苯二硫醚(1.0mmol)、Pd2(dba)3(0.02mmol)、dppb(0.04mmol)、叔丁醇锂(2.0mmol)、锌粉(2.0mmol)和四氢呋喃mmol(2mL),混合搅拌后,在90℃环境下反应24小时,反应完成后,经柱层析分离得到目标产物,4’-二甲氧基二苯硫醚,白色固体,产率为97%。
实验5:
在氮气保护下,于25mL的施莱克反应管中依次加入4,4’-二氯二苯二硫醚(1.0mmol)、Pd2(dba)3(0.01mmol)、dppb(0.02mmol)、叔丁醇锂(2.0mmol)、锌粉(2.0mmol)和四氢呋喃mmol(2mL),混合搅拌后,在90℃环境下反应22小时,反应完成后,经柱层析分离得到目标产物4,4’-二氯二苯硫醚,无色液体,产率为88%。
实验6:
在氮气保护下,于25mL的施莱克反应管中依次加入2-萘二硫醚(1.0mmol)、Pd2(dba)3(0.02mmol)、dppb(0.04mmol)、叔丁醇锂(2.0mmol)、锌粉(2.0mmol)和四氢呋喃mmol(2mL),混合搅拌后,在90℃环境下反应21小时,反应完成后,经柱层析分离得到目标产物2-萘硫醚,白色固体,产率为89%。
实验7:
在氮气保护下,于25mL的施莱克反应管中依次加入2-噻吩二硫醚(1.0mmol)、Pd2(dba)3(0.04mmol)、dppb(0.08mmol)、叔丁醇锂(2.2mmol)、锌粉(2.2mmol)和四氢呋喃mmol(2mL),混合搅拌后,在90℃环境下反应4小时,反应完成后,经柱层析分离得到目标产物2-噻吩硫醚,无色液体,产率为50%。
实验8:
在氮气保护下,于25mL的施莱克反应管中依次加入2-吡啶二硫醚(1.0mmol)、Pd2(dba)3(0.02mmol)、dppb(0.04mmol)、叔丁醇锂(2.0mmol)、锌粉(2.0mmol)和四氢呋喃mmol(2mL),混合搅拌后,在70℃环境下反应4小时,反应完成后,经柱层析分离得到目标产物2-吡啶硫醚,黄色固体,产率为88%。
实验9:
在氮气保护下,于25mL的施莱克反应管中依次加入二苯二硒醚(1.0mmol)、Pd2(dba)3(0.02mmol)、dppb(0.04mmol)、叔丁醇锂(2.0mmol)、锌粉(2.0mmol)和四氢呋喃mmol(2mL),混合搅拌后,在90℃环境下反应23小时,反应完成后,经柱层析分离得到目标产物二苯硒醚,黄色固体,产率为89%。
实验10:
在氮气保护下,于25mL的施莱克反应管中依次加入二苯二碲醚(1.0mmol)、Pd2(dba)3(0.02mmol)、dppb(0.04mmol)、叔丁醇锂(2.0mmol)、锌粉(2.0mmol)和四氢呋喃mmol(2mL),混合搅拌后,在90℃环境下反应23小时,反应完成后,经柱层析分离得到目标产物二苯碲醚(1.0mmol),黄色固体,产率为80%。
实验9和实验10中加入的是二苯二硒醚和二苯二碲醚,由于硫硒碲是同一主族元素,性质和反应相似,因此将脱硫的策略应用于二硒醚和二碲醚的制备中。
实施例2-1:
在实施例1中实验1中同样条件下,将有机碱叔丁醇锂替换为六甲基二硅基胺基锂,产率为38%。
实施例2-2:
在实施例1中实验1中同样条件下,将双齿磷配体双二苯基膦丁烷(dppb)替换为1,1’-联萘-2,2’-双二苯膦(BINAP),产率为64%。
实施例2-3:
在实施例1中实验1中同样条件下,将双齿磷配体双二苯基膦丁烷(dppb)替换为三苯基膦(Ph3P),产率为56%。
实施例2-4:
在实施例1中实验1中同样条件下,将双齿磷配体双二苯基膦丁烷(dppb)替换为三环己基膦(Cy3P),产率为44%。
实施例2-5:
在实施例1中实验1中同样条件下,将有机溶剂四氢呋喃替换为乙腈,产率为76%。
实施例2-6:
在实施例1中实验1中同样条件下,将有机溶剂四氢呋喃替换为DMF,产率为56%。
实施例2-7:
在实施例1中实验1中同样条件下,将Pd2(dba)3(0.02mmol)替换为PdCl2(0.04mmol),产率为82%。
实施例2-8:
在实施例1中实验1中同样条件下,将Pd2(dba)3(0.02mmol)替换为Pd(OAc)2(0.04mmol),产率为65%。
实施例3:
原料中Ar1≠Ar2,且为不同种类时产率情况:
实验1:
在氮气保护下,于25mL的施莱克反应管中依次加入1-苯基-2-(4-甲基苯基)二硫醚(1.0mmol)、Pd2(dba)3(0.02mmol)、dppb(0.04mmol)、叔丁醇锂(2.0mmol)、锌粉(2.0mmol)和四氢呋喃mmol(2mL),混合搅拌后,在90℃环境下反应20小时,反应完成后,经柱层析分离得到目标产物1-苯基-2-(4-甲基苯基)硫醚,无色液体,产率为82%。
实验2:
在氮气保护下,于25mL的施莱克反应管中依次加入1-(4-甲基苯基)-2-(4-甲氧基苯基)二硫醚(1.0mmol)、Pd2(dba)3(0.02mmol)、dppb(0.04mmol)、叔丁醇锂(2.0mmol)、锌粉(2.0mmol)和四氢呋喃mmol(2mL),混合搅拌后,在90℃环境下反应20小时,反应完成后,经柱层析分离得到目标产物1-(4-甲基苯基)-2-(4-甲氧基苯基)硫醚(1.0mmol),无色液体,产率为85%。
由实施例3两个实验可知,即使原料中Ar1≠Ar2,且为不同种类时产率仍然保持较高的水平。
实施例4:
当催化剂使用Ni催化剂时的情况:
在氮气保护下,于25mL的施莱克反应管中依次加入二苯基二硫醚(1.0mmol)、Ni(Ph3P)2Cl2(0.05mmol)、叔丁醇锂(2.0mmol)、锌粉(4.0mmol)和四氢呋喃(2.0mL),混合搅拌后,在90℃下反应4小时,反应完成后,经柱层析分离得到目标产物二苯基硫醚,无色液体,产率为39%。
实施例4-1:
在实施例4中同样条件下,将金属催化剂Ni(Ph3P)2Cl2替换为Ni(cod)2,产率为40%。
实施例5:
当催化剂使用Pt催化剂时的情况:
实验1:在氮气保护下,于25mL的施莱克反应管中依次加入二苯基二硫醚(1.0mmol)、Pt(Ph3P)4(0.05mmol)、叔丁醇锂(2.2mmol)、锌粉(2.0mmol)和四氢呋喃(2.0mL),混合搅拌后,在90℃下反应过夜,反应完成后,经柱层析分离得到目标产物二苯基硫醚,无色液体,产率为10%。
实验2:在氮气保护下,于25mL的施莱克反应管中依次加入二苯基二硫醚(1.0mmol)、PtCl2(0.05mmol)、叔丁醇锂(2.2mmol)、锌粉(2.0mmol)和四氢呋喃(2.0mL),混合搅拌后,在90℃下反应过夜,反应完成后,经柱层析分离得到目标产物二苯基硫醚,无色液体,产率为15%。
实施例6:
当催化剂使用Rh催化剂时的情况:
在氮气保护下,于25mL的施莱克反应管中依次加入二苯基二硫醚(1.0mmol)、Rh(Ph3P)3Cl(0.05mmol)、叔丁醇锂(2.2mmol)、锌粉(2.0mmol)和四氢呋喃(2.0mL),混合搅拌后,在90℃下反应过夜,反应完成后,经柱层析分离得到目标产物二苯基硫醚,无色液体,产率为28%。
实施例6-1:
在实施例6中同样条件下,将金属催化剂Rh(Ph3P)3Cl替换为Rh(dba)3,产率为30%。
由实施例4、实施例5和实施例6可知,当金属催化剂为Ni催化剂、Pt催化剂和Rh催化剂时,仍然能有一定的产率;使得金属催化剂的选择更多样。
以上仅为本发明的优选实施例而已,并不用于限制本发明,凡在本发明的精神和原则之内,所作的任何修改、等同替换、改进等,均应包含在本发明的保护范围之内。
Claims (10)
1.一种二芳基硫醚化合物的制备方法,其特征在于:包括以下步骤:
S1:无水无氧环境下,在反应器内加入如式(I)所示结构的二芳基二硫醚、催化剂和配体;
S2:再向S1内加入碱、金属和有机溶剂;密封环境内,一定温度下反应后经后处理得到如式(II)所示结构的二芳基硫醚类化合物;
其中,Ar1和Ar2分别独立为取代或未取代的苯基、取代或未取代的萘基和取代或未取代的含N、O、S原子的杂环芳基;Ar1和Ar2相同或不同;
苯基、萘基和含N、O、S原子的杂环芳基上,取代的基团包括邻、间、对的一取代或多取代的C6-C20的长链烷基,或者包括邻、间、对的一取代或多取代的C6-C20的支链烷基,或者包括邻、间、对的一取代或多取代的C6-C20的长链烷氧基,或者包括邻、间、对的一取代或多取代的C6-C20的支链的烷氧基,或者包括氯、脂基、醛基、三氟甲基、氰基、氨基和苯基中的一种或多种。
2.根据权利要求1所述的一种二芳基硫醚化合物的制备方法,其特征在于:所述催化剂与二芳基二硫醚的摩尔比为0.1%-20%。
3.根据权利要求2所述的一种二芳基硫醚化合物的制备方法,其特征在于:所述催化剂为镍、钯、铂和铑金属催化剂中的任意一种或两种混合。
4.根据权利要求3所述的一种二芳基硫醚化合物的制备方法,其特征在于:所述镍催化剂选自双三苯基磷二氯化镍、(1,1’-双(二苯基膦)二茂铁)二氯化镍、1,3-双(二苯基膦丙烷)二氯化镍、双-(1,5-环辛二烯)镍2、四(三苯基膦)镍、氯化镍和溴化镍中的任意一种或多种;
所述钯催化剂为三(二亚苄,基丙酮)二钯、(二亚苄基丙酮)钯、四(三苯基膦)钯、醋酸钯、氯化钯、溴化钯、1,1’-二(二苯膦基)二茂铁二氯化钯(II)、1,4-双(二苯基膦丁烷)二氯化钯和双三苯基膦二氯化钯中的任意一种或多种;
所述铂催化剂为氯化铂和四(三苯基膦)铂中的任意一种或两种;
所述铑催化剂为三(三苯基膦)氯化铑、四羰基二氯化二铑和三(二亚苄基丙酮)铑中的任意一种或多种。
5.根据权利要求1所述的一种二芳基硫醚化合物的制备方法,其特征在于:所述配体包括三齿配体、双齿膦配体和单齿膦配体中的一种或多种;单齿膦配体包括三苯基膦、三环己基膦、二苯基甲基膦和苯基二甲基膦中的一种或多种;双齿膦配体包括双二苯基膦甲烷、双二苯基膦乙烷、双二苯基膦丙烷、双二苯基膦丁烷、双二苯基膦己烷、1,1’-双(二苯基膦)二茂铁、1,1’-联萘-2,2’-双二苯膦和4,5-双二苯基膦-9,9-二甲基氧杂蒽中的一种或多种。
6.根据权利要求1所述的一种二芳基硫醚化合物的制备方法,其特征在于:所述有机碱为叔丁醇锂、甲醇锂、乙醇锂、六甲基二硅基胺基锂、二异丙基胺基锂、叔丁醇钾、叔丁醇钠、碳酸钠、碳酸钾、碳酸锂、甲醇钠和乙醇钠中的一种或多种组合。
7.根据权利要求1所述的一种二芳基硫醚化合物的制备方法,其特征在于:所述金属还原剂为Zn、Mg、Cu、Fe和Al中的一种或多种。
8.根据权利要求1所述的一种二芳基硫醚化合物的制备方法,其特征在于:所述有机溶剂选自四氢呋喃、乙腈和DMF中的一种或任意多种混合。
9.根据权利要求1所述的一种二芳基硫醚化合物的制备方法,其特征在于:所述反应温度为50℃-150℃,反应时间4-24h。
10.根据权利要求1-9任意所述的一种二芳基硫醚化合物的制备方法,其特征在于:所述二芳基二硫醚至二芳基硫醚类化合物的反应结构式如式(III):
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