CN116635378A - 二环1,4-二氮杂环庚酮和其治疗用途 - Google Patents

二环1,4-二氮杂环庚酮和其治疗用途 Download PDF

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CN116635378A
CN116635378A CN202180074915.5A CN202180074915A CN116635378A CN 116635378 A CN116635378 A CN 116635378A CN 202180074915 A CN202180074915 A CN 202180074915A CN 116635378 A CN116635378 A CN 116635378A
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alkyl
compound
optionally substituted
pharmaceutically acceptable
acceptable salt
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Chinese (zh)
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B·P·摩根
C·埃文斯
P-P·卢
山崎诚
W·王
S·科利比
牧野拓也
土屋和之
黑崎寿夫
山木晋
本庄绘理子
小泉由佳
加藤直人
关冈竜一
栗胁生实
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Cytokinetics Inc
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Cytokinetics Inc
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    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
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    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
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    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
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  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN202180074915.5A 2020-11-06 2021-11-05 二环1,4-二氮杂环庚酮和其治疗用途 Pending CN116635378A (zh)

Applications Claiming Priority (3)

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US202063110776P 2020-11-06 2020-11-06
US63/110,776 2020-11-06
PCT/US2021/058260 WO2022099011A1 (en) 2020-11-06 2021-11-05 Bicyclic 1,4-diazepanones and therapeutic uses thereof

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CN116635378A true CN116635378A (zh) 2023-08-22

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US (3) US11981644B2 (https=)
EP (1) EP4240724A1 (https=)
JP (1) JP7825618B2 (https=)
KR (1) KR20230122002A (https=)
CN (1) CN116635378A (https=)
AR (1) AR124008A1 (https=)
AU (1) AU2021373814A1 (https=)
CL (1) CL2023001301A1 (https=)
IL (1) IL302665A (https=)
MX (1) MX2023004745A (https=)
WO (1) WO2022099011A1 (https=)

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US11981644B2 (en) 2020-11-06 2024-05-14 Cytokinetics, Inc. Bicyclic 1,4-diazepanones and therapeutic uses thereof
WO2024040190A1 (en) * 2022-08-18 2024-02-22 Cytokinetics, Incorporated Indane and coumaran derivatives as fast skeletal muscle myosin inhibitors
CN120202194A (zh) 2022-11-16 2025-06-24 巴斯夫欧洲公司 作为杀真菌剂的取代的四氢苯并二氮杂䓬
WO2024104815A1 (en) 2022-11-16 2024-05-23 Basf Se Substituted benzodiazepines as fungicides
CN120202196A (zh) 2022-11-16 2025-06-24 巴斯夫欧洲公司 作为杀真菌剂的取代的苯并二氮杂䓬类

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