CN116617552B - Photo-thermal response microneedle device with health care function - Google Patents
Photo-thermal response microneedle device with health care functionInfo
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- CN116617552B CN116617552B CN202310351009.6A CN202310351009A CN116617552B CN 116617552 B CN116617552 B CN 116617552B CN 202310351009 A CN202310351009 A CN 202310351009A CN 116617552 B CN116617552 B CN 116617552B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
- A61H39/00—Devices for locating or stimulating specific reflex points of the body for physical therapy, e.g. acupuncture
- A61H39/06—Devices for heating or cooling such points within cell-life limits
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
- A61H39/00—Devices for locating or stimulating specific reflex points of the body for physical therapy, e.g. acupuncture
- A61H39/08—Devices for applying needles to such points, i.e. for acupuncture ; Acupuncture needles or accessories therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
- A61N5/0619—Acupuncture
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
- A61N5/0625—Warming the body, e.g. hyperthermia treatment
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0023—Drug applicators using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0046—Solid microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0632—Constructional aspects of the apparatus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0658—Radiation therapy using light characterised by the wavelength of light used
- A61N2005/0659—Radiation therapy using light characterised by the wavelength of light used infrared
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Animal Behavior & Ethology (AREA)
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- Radiology & Medical Imaging (AREA)
- Physical Education & Sports Medicine (AREA)
- Pathology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Medical Informatics (AREA)
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- Heart & Thoracic Surgery (AREA)
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- Radiation-Therapy Devices (AREA)
- Finger-Pressure Massage (AREA)
Abstract
本发明公开了一种具有保健功能的光热响应微针装置，包括：带底座的光热响应微针贴片；红外照射器，所述带底座的光热响应微针贴片由聚合物实心微针构成，聚合物实心微针连接于所述红外照射器的五指透光台上；所述红外照射器包括底板、壳体以及连接在所述壳体上的五指透光台、一个支撑台，所述五指透光台的上表面的中心位置处设置有便于连接微针贴片的凹槽，其两侧表面的棱线处分别均布一个第一极和一个第二极，其中一侧的表面均设置有散热孔，第一极与第二极之间电性连接一个红外线灯管。本发明提供的一种具有保健功能的光热响应微针装置，可有效穿透指尖表皮进而达到刺激十宣穴的目的，经常使用该微针装置可以达到保健的效果。
This invention discloses a photothermal responsive microneedle device with health-care functions, comprising: a photothermal responsive microneedle patch with a base; and an infrared irradiator. The photothermal responsive microneedle patch with the base is composed of polymer solid microneedles, which are connected to the five-finger light-transmitting platform of the infrared irradiator. The infrared irradiator includes a base plate, a housing, and a five-finger light-transmitting platform and a support platform connected to the housing. A groove for connecting the microneedle patch is provided at the center of the upper surface of the five-finger light-transmitting platform. A first electrode and a second electrode are evenly distributed along the ridges of both sides of the platform. One side of the platform has heat dissipation holes. An infrared lamp is electrically connected between the first electrode and the second electrode. This invention provides a photothermal responsive microneedle device with health-care functions, which can effectively penetrate the epidermis of the fingertips to stimulate the ten acupoints. Regular use of this microneedle device can achieve health-care effects.
Description
Technical Field
The invention relates to a medical apparatus, in particular to a photo-thermal response microneedle device with a health care function.
Background
The mode of stimulating the Shi Xuan acupoint to treat diseases has a long history, and is widely recorded in ancient Chinese medical books. The Ling Pivot indicates that the stimulation of Shi Xuan points can regulate emotion, happy mind and strengthen brain. The book of changes refers to the "under-heart fullness" corresponding to "blockage of heart, no pain and fast" and can be relieved by stimulating the Shi Xuan point. The "Qianjin Fang of preparing Ji" indicates that shock, shortness of breath and other conditions can stimulate the Shi Xuan point. It is also mentioned in the "Jiuzhu Daquan" that ten Xuan Shi point acupuncture treatment is selected for treating heart convulsion and mania.
Modern researches show that the stimulation of the Shi Xuan acupoint can improve the microcirculation and the neurotrophic function of local tissues and reduce the permeability of local capillaries, so that the normal functions of the local nerve vessels of limbs are recovered, and the brain cell vitality is stimulated, awakened and recovered through the nerve reflex function. Therefore, the acupoint is stimulated, the effects of clearing heat, soothing nerves and inducing resuscitation can be achieved, and the health care effect is achieved.
The micropins are micro-needle devices arranged in an array and are made of materials such as metal or high molecular polymers. The microneedle can precisely penetrate through the stratum corneum without touching the pain nerve, can avoid skin injury and pain, and simultaneously has the function of promoting drug permeation. In recent years, with the development of high molecular polymer materials, polymer microneedles have become a new research hotspot. The polymeric microneedles gradually dissolve after piercing the stratum corneum, thereby releasing the drug. Compared with the traditional micro-needle, the polymer micro-needle not only can avoid the risk of biological pollution, but also can not cause larger damage to human body after being dissolved in the skin.
The traditional methods for stimulating the ten Xuan points include massage, moxibustion and three-edged needle punching, but have certain disadvantages. The moxa stick is used for stimulating the Shixuan acupoint, and the temperature of the moxa stick is difficult to control, if the moxibustion method is improper, skin can be bleb and ulcerated, cancerogenic substances can be generated when the moxa stick is burnt, and the lung of a person can be greatly injured, so that the compliance of a patient is not high. The method of the three-edged needle point needling is not suitable for patients suffering from thrombocytopenia, hemophilia, dizziness and the like, and has the problems of easy wound infection, difficult treatment of medical waste of sharp instruments and the like.
It can be seen that the existing treatment methods still have defects and need to be improved. Therefore, the invention combines the percutaneous administration of the micro-needle and the meridian point, utilizes the ten Xuan point to absorb the medicine, and then leads the relevant viscera to obtain good curative effect through the operation of the meridian, and plays the roles of health care and disease treatment under the double effects of the micro-needle and the meridian effect. Compared with the traditional three-edged needle point needling, moxibustion and other modes, the treatment method can avoid risks such as pain, lung injury or skin scald and the like, and can also enhance the effect of drug delivery. The microneedle device is often used, can play roles in clearing heat, soothing nerves, restoring consciousness, inducing resuscitation and the like, and achieves the effect of health care.
Disclosure of Invention
In view of the above, the invention provides a photo-thermal response microneedle device with health care function, which can control temperature and time, can be reused, and is efficient and accurate.
In order to achieve the above object, an aspect of the present invention provides a photothermal response microneedle device with health care function, comprising:
The infrared irradiator comprises a bottom plate, a shell, and a five-finger light-transmitting table and a supporting table which are connected to the shell, wherein the five-finger light-transmitting table is arranged on the upper portion of the shell, and the supporting table is arranged in the middle of the shell. The five-finger light-transmitting table is provided with five light-transmitting tables internally provided with infrared lamp tubes, grooves which are convenient to connect with the microneedle patches are formed in the central position of the upper surface of the five-finger light-transmitting table, a first pole and a second pole are uniformly distributed on edge lines of the two side surfaces of the five-finger light-transmitting table, a radiating hole is formed in the surface of one side of the five-finger light-transmitting table, the infrared lamp tubes are electrically connected between the first pole and the second pole, the front side surface of the shell is provided with a light intensity control knob and a time control knob, the upper surface of the shell is provided with a charging port, the infrared lamp tubes are used for providing infrared light sources, the five-finger light-transmitting table supports ten-Xuan holes, and the supporting table supports the palm.
The photo-thermal response micro-needle patch with the base is of a polymer solid micro-needle structure, and the polymer solid micro-needle structure is connected to the five-finger light-transmitting table of the infrared irradiator. The polymeric solid microneedle structure includes a substrate and a needle body. The substrate of the photo-thermal response microneedle patch with the base is made of a polymer containing 2D MXene material, and the needle body is made of a polymer containing mugwort and ginger extracts.
Preferably, the photo-thermal response micro-needle patch with the base is composed of a micro-needle array with the height of 200-600 microns, a single solid needle body of the photo-thermal response micro-needle patch with the base is conical or triangular pyramid, the diameter of a needle point is 5-60 microns, and the diameter of the bottom end of the needle body is 200-500 microns.
Preferably, the lower side edge of the bottom plate is provided with a wire slot which facilitates the layout of the conductive wires.
Preferably, the upper surface of the five-finger light-transmitting table adopts light-transmitting heat-resistant glass, and a sealing ring is arranged between the five-finger light-transmitting table and the shell.
Preferably, the light intensity control knob of the infrared irradiator has three gears, including a low gear, a middle gear and a high gear, and the adjustment range of the time control knob is 0-20 min.
Compared with the existing treatment modes, the invention has the following advantages:
(1) The invention has novel structure, applies the microneedle technology to the field of traditional Chinese medicine, in particular to a photo-thermal response microneedle device which can promote the release of medicines under the irradiation of infrared light and can effectively penetrate the epidermis of a fingertip so as to achieve the purpose of stimulating ten Xuan points;
(2) The photo-thermal response microneedle patch adopted by the invention has no repeated use problem, reduces the risk of cross infection, has no sharp instrument after use, and is easier to treat medical waste;
(3) The invention can play a role in supporting the Shi Xuan acupoint, and can realize the complete fitting of the acupoint and the microneedle patch when the drug delivery device is used, and finally achieve the effect of accurate drug delivery;
(4) The invention is safe and effective, has wide applicable crowd and is convenient for popularization and use in a large range.
It is to be understood that both the foregoing general description and the following detailed description are exemplary and explanatory only and are not restrictive of the disclosure.
This document provides an overview of various implementations or examples of the technology described in this disclosure, and is not a comprehensive disclosure of the full scope or all of the features of the technology disclosed.
Drawings
Fig. 1 is a schematic perspective view of a photo-thermal response microneedle device with health care function according to the present invention.
Fig. 2 is a schematic diagram of a three-dimensional explosion structure of a photo-thermal response microneedle device with health care function according to the present invention.
The main reference numerals:
1-photo-thermal response microneedle patch with base, 2-infrared irradiator, 21-light-transmitting table, 22-first pole, 23-second pole, 24-heat-radiating hole, 25-infrared lamp tube, 26-supporting table, 27-light intensity control knob, 28-base plate, 29-charging port, 211-shell, 212-time control traveling button and 213-wire slot.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present disclosure more apparent, the technical solutions of the embodiments of the present disclosure will be clearly and completely described below with reference to the accompanying drawings of the embodiments of the present disclosure.
It will be apparent that the described embodiments are some, but not all, of the embodiments of the present disclosure. All other embodiments, which can be made by one of ordinary skill in the art without the need for inventive faculty, are within the scope of the present disclosure, based on the described embodiments of the present disclosure.
As shown in fig. 1 and 2, a photo-thermal response microneedle device with health care function according to an embodiment of the present invention includes:
The photo-thermal response micro-needle patch 1 with the base is of a replaceable structure, and can be replaced by a new micro-needle patch after being used, so that the repeated utilization is realized, and the cost is reduced. The polymer microneedle material is soluble base materials such as PVP (polyvinylpyrrolidone), HA (hyaluronic acid), PVA (polyvinyl alcohol) and the like, and a composite material thereof. PVA HAs higher strength, high biological solubility and good HA water-containing effect, and combines the advantages of the two materials, thereby achieving better effect. Thus, the present invention employs HA/PVA polymers to prepare microneedles. The photo-thermal response micro-needle patch 1 comprises a substrate and a needle body, wherein the substrate of the photo-thermal response micro-needle patch 1 with a base is made of a polymer containing a 2D MXene material, and the photo-thermal material 2D MXene can quickly and nearly hundred percent convert absorbed light energy into heat energy, promote the dissolution of the micro-needle and accelerate the release of drugs. The needle body of the photo-thermal response microneedle patch 1 with the base is conical, the maximum height of the needle body is 600 mu m, the maximum diameter of the needle tip is 60 mu m, and the maximum diameter of the bottom end of the needle body is 500 mu m in order to avoid bleeding caused by puncturing the dermis layer of the skin. The needle body of the photo-thermal response microneedle patch 1 with the base is made of a polymer containing mugwort and ginger extracts, and the medicine has the effects of dredging channels and collaterals and promoting blood circulation. In summary, the photo-thermal response microneedle patch 1 with the base can stimulate the Shi Xuan acupoint;
The infrared irradiator 2, the infrared irradiator 2 includes a bottom plate 28, a housing 211, five light-transmitting tables 21 with built-in infrared lamp tubes 25 fixed on the housing 211, and a supporting table 26, the infrared lamp tubes 25 are used for providing infrared light sources, the five-finger light-transmitting tables 21 support the ten Xuan acupoints, and the supporting table 26 supports the palms. In summary, the main function of the infrared illuminator 2 is to provide an infrared light source and support the hand. In particular, the invention is superior to any acupuncture point micro-needle for the treatment of the Shi Xuan acupoint, because the radian of the epidermis at the Shi Xuan acupoint is larger, the existing acupuncture point micro-needle is difficult to realize complete fitting with the epidermis at the Shi Xuan acupoint, and the treatment effect is poor.
As described above, in the technical solution of the present invention, the temperature of the photo-thermal response microneedle patch is raised under the effect of the infrared light, so in order to prevent the internal temperature of the five-finger transparent table 21 from being high, the right surface of the five-finger transparent table 21 should be provided with the heat dissipation holes 24. In order to improve the utilization rate of the infrared light, the upper surface of the five-finger transparent table 21 should be made of a transparent material. In view of safety, the light-transmitting portion is not suitably made of a polymer material in the present invention, but heat-resistant glass is preferable. The groove on the upper surface of the five-finger light-transmitting table 21 is matched with the base of the photo-thermal response micro-needle patch 1 with the base, and the side length of the base of the photo-thermal response micro-needle patch 1 is slightly larger than that of the groove by utilizing a size difference locking structure. In view of structural stability, a sealing ring (not shown) is disposed between the five-finger transparent table 21 and the housing 211. Considering that the device relies on electricity, the lower side edge of the base plate 28 is provided with a wire slot 213 facilitating the routing of the conductive wires. In addition, in this embodiment of the present invention, a second pole 23 is uniformly distributed on the edge line of the left surface of the five-finger transparent table 21, a first pole 22 corresponding to the second pole 23 is respectively disposed on the edge line of the right surface of the five-finger transparent table 21, and an infrared lamp tube 25 is electrically connected between the first pole 22 and the second pole 23. The infrared lamp 25 may in fact be chosen to be similar to the lamp power of conventional infrared lamp equipment.
The function of the photo-thermal response microneedle device with the health care function is based on the following principle:
(1) A photosensitive drug release method of microneedles. This method is to control the drug release in the microneedle patch by varying the intensity of the infrared illuminator. Under the irradiation of near infrared light, the photo-thermal material 2D MXene can quickly and nearly hundred percent convert absorbed light energy into heat energy, promote the dissolution of the micro-needle and accelerate the release of the medicine.
(2) Microneedle forced-through method. The microneedle technology provides an important and advanced mode for disease treatment, can effectively realize subcutaneous administration, and promotes rapid absorption of drugs, thereby remarkably improving the treatment effect. The method combines the percutaneous administration of the micro-needle and the meridian point, absorbs the medicine by using the ten Xuan point, and enables the relevant viscera to obtain good curative effect through the operation of the meridian, thereby playing the roles of health care and disease treatment under the dual functions of the micro-needle and the meridian effect.
The operation method of the photo-thermal response microneedle device with the health care function is as follows:
s1, mounting a photo-thermal response microneedle patch 1 with a base on a five-finger light-transmitting table 21;
And S2, the charging port 29 is connected, the light intensity control knob 27 is adjusted, and the treatment effect of the middle grade is best, or the patient feels comfortable. When the infant care device is used for infants, a low gear can be selected;
S3, adjusting a time control knob 212, wherein the recommended use time range is 8-10 min for a low gear, 5-8 min for a medium gear and 3-5 min for a high gear;
S4, enabling the fingertip to be perpendicular to the photo-thermal response microneedle patch 1, and placing the metacarpophalangeal joint on the supporting table 26;
s5, closing the equipment and removing the used microneedle patch;
s6, suggesting to use 1-3 times per week;
s7, if the fingers show any bad signs in the using process, the device is immediately stopped.
Compared with the prior art, the microneedle drug delivery device can effectively penetrate the epidermis of the fingertip to stimulate ten Xuan acupoints, avoid pain caused by the pricking of the triangular needle, avoid the damage of moxibustion to the lung of a human body and the risk of scalding the skin, enhance the effect of drug delivery, play roles in clearing heat, soothing the nerves and restoring consciousness and inducing resuscitation, and can achieve the effect of health care by frequently using the microneedle device.
The above embodiments are only exemplary embodiments of the present invention and are not intended to limit the present invention, the scope of which is defined by the claims. Various modifications and equivalent arrangements of this invention will occur to those skilled in the art, and are intended to be within the spirit and scope of the invention.
Claims (3)
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| CN202310351009.6A CN116617552B (en) | 2023-04-04 | 2023-04-04 | Photo-thermal response microneedle device with health care function |
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| CN202310351009.6A CN116617552B (en) | 2023-04-04 | 2023-04-04 | Photo-thermal response microneedle device with health care function |
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| CN113797439A (en) * | 2021-09-27 | 2021-12-17 | 山东大学 | A near-infrared responsive hydrogel microneedle patch and preparation method thereof |
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| CN113975619B (en) * | 2021-11-11 | 2023-02-10 | 浙江大学 | Device and method for controlling microneedle penetration based on light |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20140105686A (en) * | 2013-02-23 | 2014-09-02 | 박도영 | Microneedle Patch of stimulating Meridian Points |
| CN113797439A (en) * | 2021-09-27 | 2021-12-17 | 山东大学 | A near-infrared responsive hydrogel microneedle patch and preparation method thereof |
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