CN108619081A - A kind of photosensitive micropin and preparation method thereof, controlled release method - Google Patents
A kind of photosensitive micropin and preparation method thereof, controlled release method Download PDFInfo
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- CN108619081A CN108619081A CN201810496974.1A CN201810496974A CN108619081A CN 108619081 A CN108619081 A CN 108619081A CN 201810496974 A CN201810496974 A CN 201810496974A CN 108619081 A CN108619081 A CN 108619081A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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Abstract
The invention belongs to microneedle cutaneous technical fields, and in particular to a kind of photosensitive micropin and preparation method thereof, controlled release method.Wherein, photosensitive micropin, including matrix and be attached to several syringe needles of matrix, the syringe needle include material of main part, pharmaceutical agent and the photothermal conversion factor, and the material of main part hybrid medicine factor and the photothermal conversion factor simultaneously cure；The syringe needle coats low melting point phase change materials.The photosensitive micropin of the present invention, using low melting point phase change materials as the face coat of syringe needle, the photothermal conversion factor in syringe needle can absorb near infrared light and be converted into heat to melt the coating of needle surface, and syringe needle is made to absorb body fluid and gradually dissolve or degrade and release the pharmaceutical agent being embedded in syringe needle.
Description
Technical field
The invention belongs to microneedle cutaneous technical fields, and in particular to a kind of photosensitive micropin and preparation method thereof, controllable
Method for releasing.
Background technology
" diabetes " are easy the excessive chronic disease of accumulation as a kind of glucose in blood, are with " hyperglycemia " clinically
Main feature.The control of blood glucose is lifelong with diabetic, due to hypoinsulinism or has insulin resistance, leads to pancreas
Island element is opposite or absolutely shortage, subcutaneous or intravenous injection insulin are presently the most and directly effectively control blood sugar in diabetic patients water
Flat administering mode.However, there are many deficiencies for this administering mode：Such as, insulin (3~5 points of half-life short in blood
Clock), through blood circulation of human body, only small part can enter liver performance hypoglycemic effect；Long-term, frequent insulin injection is needed,
To cause body, spirit and multiple pressure economically to patient.It is asked relative to many present in injection of insulin administration
Topic, it is microneedle cutaneous more convenient, safer, gradually cause the concern of international scholar and medical worker, it has also become future
The important research direction for the treatment of of diabetes research.
Ideal micropin drug-loading system should be able to autonomous regulating medicine rate of release.In recent years, micropin drug delivery system has
Prodigious development, but to realize that it is applied to still face lot of challenges in clinic, such as：The quick sensitive response of drug in micropin
Release；The biocompatibility etc. of micropin material.Near infrared light (600~900nm) has good biological tissue's penetrability, and right
Tissue is almost without damage；And optical-thermal conversion material can absorb near infrared light and be converted to heat, under near infrared light
The photo-thermal effect of generation, causes local temperature to increase.Optical-thermal conversion material is loaded in micropin, it is likely that realize using close
The program mode of infrared light active drive drug discharges.Selection has good biocompatibility, biological degradability and low melting point phase transformation
Material of main part of the polymer as micropin, it is compound with drug and optical-thermal conversion material, and in certain infrared light stimulus in the external world
Micropin can be made to heat under effect, it is expected to the active release for realizing drug, to meet the difference demand of Different Individual.
Invention content
Based on above-mentioned deficiency existing in the prior art, the present invention provides a kind of photosensitive micropin and preparation method thereof, controllable
Method for releasing.
In order to reach foregoing invention purpose, the present invention uses following technical scheme：
A kind of photosensitive micropin, including matrix and several syringe needles for being attached to matrix, the syringe needle includes material of main part, drug
The factor and the photothermal conversion factor, the material of main part hybrid medicine factor and the photothermal conversion factor simultaneously cure；The syringe needle coating
Low melting point phase change materials.
Preferably, the low melting point phase change materials are lauric acid or tridecanoic acid or polycaprolactone.
Preferably, the material of main part is hydrophilic material.
Preferably, the material of main part selects polyvinylpyrrolidone, polyvinyl alcohol, gelatin, carboxymethyl fine
It is one or more in the plain sodium of dimension.
Preferably, the syringe needle is pyramid structure, and the whole height of syringe needle is 400~600 μm, syringe needle
Head diameter is 5~20 μm.
Preferably, the photothermal conversion factor selects bismuth nano-quantum point, Jenner's grain of rice, carbon nanotube, Pu Lu
It is one or more in scholar's indigo plant, lanthanum hexaboride.
Preferably, the photothermal conversion factor is bismuth nano-quantum point, and grain size is less than 10nm.
Preferably, the pharmaceutical agent is Metformin hydrochloride or acetylsalicylic acid.
The present invention also provides a kind of methods preparing the photosensitive micropin described in either a program as above, include the following steps：
S1, in microneedles template die cavity addition include material of main part, the photothermal conversion factor and pharmaceutical agent mixture；
S2, high-molecular gel is added again in the die cavity of microneedles template, solidification, demoulding are made matrix and are attached to matrix
Syringe needle；
S3, low melting point phase change materials are sprayed in the location of syringe needle, photosensitive micropin is made.
The present invention also provides a kind of controlled release methods of the photosensitive micropin described in any one scheme as above, including walk as follows
Suddenly：
Utilize photosensitive micropin described near infrared light；
Low melting point phase change materials are controlled release of the flowable state to realize to pharmaceutical agent by Solid State Transformation.
Compared with prior art, the present invention advantageous effect is：
The photosensitive micropin of the present invention, using low melting point phase change materials as the face coat of syringe needle, the photo-thermal in syringe needle
Conversion factor can absorb near infrared light and be converted into heat to melt the coating of needle surface, and syringe needle is made to absorb body fluid and gradually dissolve
Or it degrades and releases the pharmaceutical agent being embedded in syringe needle.
The preparation method of the photosensitive micropin of the present invention, method is simple, convenient for being prepared on a large scale.
The controlled release method of the photosensitive micropin of the present invention, can accurately control the release of drug.
Description of the drawings
Fig. 1 is the preparation flow figure of the photosensitive micropin of application type of the embodiment of the present invention one；
Fig. 2 is the scanning electron microscope (SEM) photograph of the photosensitive micropin of application type of the embodiment of the present invention one；
Fig. 3 is the photosensitive micropin of application type of the different Bi contents of the embodiment of the present invention one in 1.6W/cm2808nm near-infrareds
Temperature distribution history (A) under light irradiation and the cycle heating curve (B) under 0.044wt%Bi contents；
Fig. 4 is the photosensitive micropin of the photosensitive micropin of application type and uncoated low melting point phase change materials of the embodiment of the present invention one
Whether the pattern being pierced under near infrared light illumination before and after skin changes comparison diagram.
Fig. 5 is that the photosensitive micropin of the presence or absence of embodiment of the present invention one coating (R6G substitutes melbine as model drug) exists
Whether the histotomy comparison diagram after skin is applied under illumination.
Specific implementation mode
In order to illustrate the embodiments of the present invention more clearly, below by the specific implementation mode of the control description of the drawings present invention.
It should be evident that drawings in the following description are only some embodiments of the invention, those of ordinary skill in the art are come
It says, without creative efforts, other drawings may also be obtained based on these drawings, and obtains other real
Apply mode.
Embodiment one：
By liquid polydimethylsiloxane prepolymer object (PDMS) and curing agent in mass ratio 10：After 1 mixing, it is cast in PMMA
On micropin formpiston, removing bubble is first vacuumized later, is subsequently placed under 80 DEG C of environment of normal pressure and heats 6h, and finally demoulding obtains PDMS
Micropin former.
0.5g polyvinylpyrrolidones (PVP) are taken to be mixed into 0.1g calcium carbonate (CaCO3), 0.3g Metformin hydrochlorides (Met)
And 0.4g (0.044wt%) photo-thermal factor bismuth nano-quantum point (Bi) be dissolved in 1mL deionized waters stir evenly with obtain carry medicine it is micro-
The syringe needle mixture of needle.Wherein, the grain size of bismuth nano-quantum point is less than 10nm.
Separately need the pure PVP hydrogels of configuration quality score 40wt% as micropin basis material.
The syringe needle mixture 6mg for pipetting load medicine micropin is poured into PDMS template cavitys, and then 10000rpm centrifuges 15min.
Then 40wt%PVP hydrogels are pipetted and are poured into template inner cavity again until tamping completely, then are taken out through 8000rpm centrifugations 5min
Entire mold is positioned over room temperature environment natural air drying, and finally demoulding is obtained without the photosensitive micropin Bi-Met/CaCO of coating3/PVP。
Low melting point phase change materials lauric acid (LA) is dissolved by solvent of ethyl acetate, to configure the uniform molten of 0.25g/mL
Liquid, as a kind of spray solution.Then, by nano-spray instrument with the height away from photosensitive micropin 10cm towards the location of syringe needle
5s is sprayed, then places and air-dries at room temperature, obtain the photosensitive micropin LA/Bi-Met/CaCO of application type3/PVP.Last low temperature is dry
The photosensitive micropin of application type obtained by dry preservation, it is spare.
Fig. 1 is the preparation flow figure of the photosensitive micropin of the present embodiment application type.As shown in Figure 1, whole preparation process includes pouring
Coating structure is presented in three note, centrifugation and spraying key steps, the micropin of gained, and inner end is hydrophilic, the low melting point phase transition of outer layer
Material layer is hydrophobic.Entire microneedle array is by the molten gel support of no-load liquid medicine.
Fig. 2 is scanning electron microscope diagram (different angle, the difference times of the photosensitive micropin of application type manufactured in the present embodiment
Number).As shown in Figure 2, gained micropin syringe needle present pyramid structure, the whole height of syringe needle between 450~550 μm,
Between the head diameter of syringe needle is 10~20 μm, the spacing between syringe needle is about 600 μm, and entire coating surface is more coarse.
Fig. 3 is the photosensitive micropin of application type of the present embodiment difference Bi contents under 1.6W/cm2 808nm near infrared lights
Temperature distribution history (A) and 0.044wt%Bi contents under cycle heating curve (B).From the figure 3, it may be seen that photosensitive microneedle surface
Temperature gradually rises with the increase of Bi contents, and the 0.044wt%Bi contents of 47 DEG C of maximum temperature are the most suitable, and with excellent
Recycle light thermal property.
Fig. 4 be the photosensitive micropin of application type and the uncoated low melting point phase change materials of the embodiment photosensitive micropin whether
The pattern variation comparison diagram being pierced under near infrared light illumination before and after skin.As shown in Figure 4, it when there is no near infrared light, compares
In the photosensitive micropin of application type, the photosensitive micropins of the uncoated low melting point phase change materials part caused by interstitial fluid acts on is molten
Solution is pierced into front and back pattern and significant change occurs.And when the photosensitive micropin of the application type of the present embodiment is exposed under near infrared light, it is micro-
Needle surface layer heats, and variation just takes place in pattern.Therefore, the photosensitive micropin of the application type of the present embodiment realizes controlled release.
Fig. 5 be the present embodiment whether there is or not coat photosensitive micropin (R6G substitutes melbine as model drug) whether illumination
It is applied to the histotomy comparison diagram after skin down.As shown in Figure 5, compared to without the photosensitive micropin of coating, the coating of the present embodiment
The photosensitive micropin of type hardly releases fluorescent material R6G because of hydrophobic skins structure.And when skin specimen is exposed to 90s under near infrared light
When, histotomy shows a large amount of fluorescent material R6G, therefore shows that the photosensitive micropin of application type has drug controlled release behavior.
Wherein, the addition of calcium carbonate increases the structural strength of syringe needle, to penetrate skin histology.
Embodiment two：
Microneedles template is prepared with embodiment one.
0.6g polyvinylpyrrolidones (PVP) are taken to be mixed into 0.05g calcium carbonate (CaCO3), 0.3g melbine (Met) and
0.2g (0.022wt%) photo-thermal factor bismuth quantum dot (Bi) is dissolved in 1mL deionized waters and stirs evenly to obtain the needle for carrying medicine micropin
Head mixture.
Separately need the pure PVP hydrogels of configuration quality score 30wt% as micropin basis material.
The syringe needle mixture 8mg for pipetting load medicine micropin is poured into PDMS template cavitys, and then 8000rpm centrifuges 10min.It connects
It and pipettes 30wt%PVP hydrogels and be poured into template inner cavity again until tamp completely, then taken out through 6000rpm centrifugations 10min
Entire mold is positioned over room temperature environment natural air drying, and finally demoulding is obtained without the photosensitive micropin Bi-Met/CaCO of coating3/PVP。
Low melting point phase change materials lauric acid (LA) is dissolved to configure the uniform molten of 0.20g/mL by solvent of ethyl acetate
Liquid, as a kind of spray solution.Then, by nano-spray instrument with the height away from photosensitive micropin 8cm towards the location of syringe needle
10s is sprayed, is then placed at room temperature for air-dried, obtains the photosensitive micropin LA/Bi-Met/CaCO of application type3/PVP.Last low temperature drying is protected
The gained photosensitive micropin of application type is deposited, it is spare.
Embodiment three：
Microneedles template is prepared with embodiment one.
0.7g polyvinyl alcohol (PVA) is taken to be mixed into 0.1g calcium carbonate (CaCO3), 0.2g melbine and 0.8g
(0.089wt%) photo-thermal factor bismuth quantum dot (Bi) be dissolved in 1mL deionized waters stir evenly with obtain carry medicine micropin syringe needle it is mixed
Close object.
Separately need the pure PVA hydrogels of configuration quality score 20wt% as micropin basis material.
The syringe needle mixture 10mg for pipetting load medicine micropin is poured into PDMS template cavitys, and then 8000rpm centrifuges 8min.It connects
It and pipettes 20wt%PVA hydrogels and be poured into template inner cavity again until tamp completely, then taken out through 8000rpm centrifugations 10min
Entire mold is positioned over room temperature environment natural air drying, and finally demoulding is obtained without the photosensitive micropin Bi-Met/CaCO3/PVP of coating.
Low melting point phase change materials polycaprolactone (PCL) is dissolved to configure the uniform of 0.30g/mL by solvent of dichloromethane
Solution, as a kind of spray solution.Then, by nano-spray instrument with the height away from photosensitive micropin 12cm towards the position residing for syringe needle
Spraying 8s is set, is then placed at room temperature for air-dried, obtains coating photosensitive micropin PCL/Bi-Met/CaCO3/PVP.Last low temperature drying is protected
It deposits gained and coats photosensitive micropin to prevent spare.
Example IV：
Microneedles template is prepared with embodiment one.
0.8g Sodium Hyaluronates (HA) are taken to be mixed into 0.08g calcium carbonate (CaCO3), 0.25g melbine and 0.4g
(0.044wt%) photothermal conversion factor bismuth nano-quantum point (Bi) is dissolved in 1mL deionized waters and stirs evenly to obtain load medicine micropin
Syringe needle mixture.
Separately need the pure HA hydrogels of configuration quality score 30wt% as micropin basis material.
It pipettes micropin substrate mixture 7mg and is poured into PDMS template cavitys, then 12000rpm centrifuges 5min.Then it pipettes
30wt%PVP hydrogels are poured into template inner cavity until tamping completely again, then take out entire mould through 6000rpm centrifugations 10min
Tool is positioned over room temperature environment natural air drying, and finally demoulding is obtained without the photosensitive micropin Bi-Met/CaCO of coating3/PVP。
Low melting point phase change materials tridecanoic acid (TA) is dissolved to configure the uniform molten of 0.25g/mL by solvent of chloroform
Liquid, as a kind of spray solution.Then, by nano-spray instrument with the height away from photosensitive micropin 10cm towards the location of syringe needle
10s is sprayed, is then placed at room temperature for air-dried, obtains coating photosensitive micropin TA/Bi-Met/CaCO3/PVP.Last low temperature drying preserves
Gained coats photosensitive micropin to prevent spare.
In above-described embodiment and its alternative, the selection of the photothermal conversion factor can also select bismuth nano-quantum point,
It is Jenner's grain of rice, carbon nanotube, Prussian blue, one or more in lanthanum hexaboride.
In above-described embodiment and its alternative, the size of spray distance can also be 5cm, 6cm, 7cm, 9cm,
11cm。
In above-described embodiment and its alternative, the length of spray time can also be 6s, 7s, 9s, 11s, 12s.
In above-described embodiment and its alternative, the size of centrifugal rotational speed can also be 7000rpm, 9000rpm,
11000rpm。
In above-described embodiment and its alternative, the syringe needle whole height of micropin can also be 400~600 μm, syringe needle
Head diameter can also be 5~20 μm, can specifically be obtained according to the size adjusting of microneedles template inside cavity.
In above-described embodiment and its alternative, pharmaceutical agent can also be the drugs such as acetylsalicylic acid.
The material of main part of the syringe needle can also select polyvinylpyrrolidone, polyvinyl alcohol, gelatin, carboxymethyl cellulose
It is one or more in plain sodium.
Embodiment five：
The photosensitive micropin of application type of the present embodiment based on above-described embodiment provides a kind of realizing controlled-release of the photosensitive micropin of application type
Method is put, is included the following steps：
The photosensitive micropin of application type is affixed at skin histology, syringe needle penetrates skin histology；
Utilize the photosensitive micropin of near infrared light application type；The photothermal conversion factor in syringe needle absorbs near infrared light and generates heat
Amount；
Low melting point phase change materials absorb heat by Solid State Transformation be flowable state, the material of main part absorptive tissue liquid of syringe needle and
Dissolving, drug release；When near infrared light is withdrawn, the stopping of low melting point phase change materials is changed into flowable state, slows down releasing for drug
The release for putting or stopping drug, to realize the controlled release to pharmaceutical agent.
Since the coating material of needle surface is water-insoluble, under the action of no near infrared light, the painting of needle surface
Layer material does not melt the entrance that can prevent body fluid, prevents the drug in syringe needle from discharging.By the irradiation for controlling near infrared light
The controlled release of drug may be implemented.In addition, can according to actual needs, by adjust the photothermal conversion factor type, dosage with
And the different photosensitive micropin of Intensity Design of near infrared light, realize further accurate administration.
The above is only that the preferred embodiment of the present invention and principle are described in detail, to the common skill of this field
For art personnel, the thought provided according to the present invention will change in specific implementation mode, and these changes should also regard
For protection scope of the present invention.
Claims (10)
1. a kind of photosensitive micropin, including matrix and several syringe needles for being attached to matrix, which is characterized in that the syringe needle includes main body
Material, pharmaceutical agent and the photothermal conversion factor, the material of main part hybrid medicine factor and the photothermal conversion factor simultaneously cure；It is described
Syringe needle coats low melting point phase change materials.
2. a kind of photosensitive micropin according to claim 1, which is characterized in that the low melting point phase change materials are lauric acid
Or tridecanoic acid or polycaprolactone.
3. a kind of photosensitive micropin according to claim 1, which is characterized in that the material of main part is hydrophilic material.
4. a kind of photosensitive micropin according to claim 3, which is characterized in that the material of main part selects polyvinylpyrrolidine
It is one or more in alkanone, polyvinyl alcohol, gelatin, sodium carboxymethylcellulose.
5. a kind of photosensitive micropin according to claim 1, which is characterized in that the syringe needle is pyramid structure, syringe needle
Whole height be 400~600 μm, the head diameter of syringe needle is 5~20 μm.
6. a kind of photosensitive micropin according to claim 1, which is characterized in that the photothermal conversion factor selects bismuth nanometer amount
It is sub- point, Jenner's grain of rice, carbon nanotube, Prussian blue, one or more in lanthanum hexaboride.
7. a kind of photosensitive micropin according to claim 6, which is characterized in that the photothermal conversion factor is bismuth Nano quantum
Point, grain size are less than 10nm.
8. a kind of photosensitive micropin according to claim 1, which is characterized in that the pharmaceutical agent be Metformin hydrochloride or
Acetylsalicylic acid.
9. a kind of preparing the method such as the photosensitive micropin of claim 1-8 any one of them, which is characterized in that including walking as follows
Suddenly：
S1, in microneedles template die cavity addition include material of main part, the photothermal conversion factor and pharmaceutical agent mixture；
S2, high-molecular gel is added again in the die cavity of microneedles template, solidification, demoulding are made matrix and are attached to the syringe needle of matrix；
S3, low melting point phase change materials are sprayed in the location of syringe needle, photosensitive micropin is made.
10. a kind of controlled release method of such as photosensitive micropin of claim 1-8 any one of them, which is characterized in that including such as
Lower step：
Utilize photosensitive micropin described near infrared light；
Low melting point phase change materials are controlled release of the flowable state to realize to pharmaceutical agent by Solid State Transformation.
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Cited By (7)
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|---|---|---|---|---|
| CN109621181A (en) * | 2018-11-02 | 2019-04-16 | 华南理工大学 | A kind of compound micropin of photothermal response and preparation method thereof |
| CN110584633A (en) * | 2019-09-06 | 2019-12-20 | 湘南学院附属医院 | Hypertension real-time diagnosis and treatment integrated system capable of controlling drug release |
| CN111136841A (en) * | 2019-12-16 | 2020-05-12 | 深圳市中科先见医疗科技有限公司 | Preparation method of hydrogel microneedle mould and hydrogel microneedle mould |
| CN111378080A (en) * | 2020-04-02 | 2020-07-07 | 山东圣佑高科新材料有限公司 | Nano micro needle and photosensitive material composition for micro needle array production and preparation method thereof |
| CN111529920A (en) * | 2020-04-09 | 2020-08-14 | 四川大学 | Microneedle drug delivery device, manufacturing method thereof and skin disease treatment device |
| CN114272374A (en) * | 2021-12-29 | 2022-04-05 | 广州纳丽生物科技有限公司 | Photosensitive controlled-release microneedle and preparation method thereof |
| CN114470235A (en) * | 2022-01-18 | 2022-05-13 | 山东大学 | Application of bismuth-based metal organic framework material as light-operated drug carrier |
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Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109621181A (en) * | 2018-11-02 | 2019-04-16 | 华南理工大学 | A kind of compound micropin of photothermal response and preparation method thereof |
| CN110584633A (en) * | 2019-09-06 | 2019-12-20 | 湘南学院附属医院 | Hypertension real-time diagnosis and treatment integrated system capable of controlling drug release |
| CN111136841A (en) * | 2019-12-16 | 2020-05-12 | 深圳市中科先见医疗科技有限公司 | Preparation method of hydrogel microneedle mould and hydrogel microneedle mould |
| CN111136841B (en) * | 2019-12-16 | 2022-08-09 | 深圳市中科先见医疗科技有限公司 | Preparation method of hydrogel microneedle mould and hydrogel microneedle mould |
| CN111378080A (en) * | 2020-04-02 | 2020-07-07 | 山东圣佑高科新材料有限公司 | Nano micro needle and photosensitive material composition for micro needle array production and preparation method thereof |
| CN111529920A (en) * | 2020-04-09 | 2020-08-14 | 四川大学 | Microneedle drug delivery device, manufacturing method thereof and skin disease treatment device |
| CN111529920B (en) * | 2020-04-09 | 2022-04-29 | 四川大学 | Microneedle drug delivery device, manufacturing method thereof and skin disease treatment device |
| CN114272374A (en) * | 2021-12-29 | 2022-04-05 | 广州纳丽生物科技有限公司 | Photosensitive controlled-release microneedle and preparation method thereof |
| CN114272374B (en) * | 2021-12-29 | 2022-08-02 | 广州纳丽生物科技有限公司 | Photosensitive controlled-release microneedle and preparation method thereof |
| CN114470235A (en) * | 2022-01-18 | 2022-05-13 | 山东大学 | Application of bismuth-based metal organic framework material as light-operated drug carrier |
| CN114470235B (en) * | 2022-01-18 | 2023-05-30 | 山东大学 | Application of bismuth-based metal organic framework material as light-operated drug carrier |
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Application publication date: 20181009 |