CN110584633A - Hypertension real-time diagnosis and treatment integrated system capable of controlling drug release - Google Patents
Hypertension real-time diagnosis and treatment integrated system capable of controlling drug release Download PDFInfo
- Publication number
- CN110584633A CN110584633A CN201910839898.4A CN201910839898A CN110584633A CN 110584633 A CN110584633 A CN 110584633A CN 201910839898 A CN201910839898 A CN 201910839898A CN 110584633 A CN110584633 A CN 110584633A
- Authority
- CN
- China
- Prior art keywords
- blood pressure
- microneedle
- drug
- hypertension
- module
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/021—Measuring pressure in heart or blood vessels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
- A61B5/6802—Sensor mounted on worn items
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0023—Drug applicators using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/18—General characteristics of the apparatus with alarm
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3306—Optical measuring means
- A61M2205/3313—Optical measuring means used specific wavelengths
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2230/00—Measuring parameters of the user
- A61M2230/30—Blood pressure
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- General Health & Medical Sciences (AREA)
- Surgery (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Pathology (AREA)
- Biophysics (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Physiology (AREA)
- Dermatology (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
The invention discloses a hypertension real-time diagnosis and treatment integrated system capable of controlling drug release, and particularly relates to the technical field of medical treatment. According to the invention, the pressure generated by weak pulse is detected by utilizing the high sensitivity of the graphene sensor, the blood pressure is monitored in real time, the controllable release of antihypertensive drug molecules is realized by utilizing the photosensitive liposome nanoparticles, the blood pressure monitoring device and the microneedle type drug release device are organically combined together by utilizing the wireless transmission technology to form a diagnosis and treatment system, the required drug amount is immediately calculated when abnormal blood pressure is detected, and the corresponding drug amount is accurately released by controlling the illumination time and intensity, so that the real-time accurate regulation and control of the blood pressure are realized.
Description
Technical Field
The invention relates to the technical field of medical treatment, in particular to a hypertension real-time diagnosis and treatment integrated system capable of controlling drug release.
Background
In the prior art, with the gradual acceleration of modern life rhythm and the increasing of life pressure of people year by year, the number of people suffering from hypertension presents a remarkable rising trend, and the hypertension is characterized by the rising of arterial pressure and can be accompanied with systemic symptoms of functional or organic changes of organs such as heart, blood vessel, brain and kidney, and can cause diseases such as stroke, myocardial infarction, heart failure, hemangioma, renal failure and the like, even death in severe cases, and becomes a great public health problem in the global scope. Hypertension is a chronic disease, which is very difficult to completely cure, and the current clinical common treatment mode is to use antihypertensive drugs to control the blood pressure within a normal range for a long time, so as to effectively prevent hypertension complications. Diagnosis and treatment of hypertension thus involves long-term blood pressure monitoring and medication.
The current blood pressure measurement in clinical application mainly comprises consulting room blood pressure, dynamic blood pressure and home self-measuring blood pressure. The blood pressure and the dynamic blood pressure in a consulting room need to be carried out in a hospital, the former uses a traditional mercury sphygmomanometer or an automatic sphygmomanometer and needs to be operated by professional medical personnel or needs large professional equipment, the dynamic sphygmomanometer used in the latter is portable, but has a large volume, a cable needs to be wound on a patient, the measurement is still carried out through cuff pressurization, the comfort level is low, the influence on the normal life of the user is large, and the continuous use time is usually not more than 24 hours due to the reasons of electric quantity, sanitation and the like. The home self-testing of blood pressure is mainly realized through an electronic cuff or wrist sphygmomanometer, the price of the product is reasonable, the accuracy is high, the measurement still needs manual active operation, and the measurement frequency is difficult to guarantee in the current fast-paced life. Therefore, these blood pressure detection means cannot meet the requirements of high-frequency or real-time blood pressure detection in the treatment of hypertension, especially for acute hypertension and high-risk patients.
Conventional methods for treating hypertension include oral administration, sublingual administration, intravenous injection, and the like. Wherein, the oral administration is convenient, does not damage the skin and mucous membrane, and has lower price. However, oral administration is not regularly absorbed because the oral administration firstly enters blood after gastrointestinal digestion, for example, the antihypertensive drug nitroglycerin or sodium nitroprusside generally takes about 15-30 minutes to take effect when being taken orally, so that the drug effect cannot be achieved in a short time when the hypertensive emergency is treated, and people who are unconscious can easily suffocate due to taking the drug, so that the gold first aid is missed for 10 minutes; sublingual buccal is used as a common treatment method for hypertension, and the medicament directly enters blood through sublingual capillaries to finish an absorption process, so that the first pass effect of liver is avoided, the medicament is completely absorbed and has higher speed, but the dosage of sublingual buccal administration is limited; intravenous injections, however, are fast to absorb and can achieve higher doses, but they can only be achieved in hospitals or in the presence of medical professionals, and because of the high concentration of the drug reaching the plasma and tissues rapidly, the possibility of adverse reactions, as well as the inconvenience and skin trauma associated with intravenous injections, is increased. The treatment of hypertension is a long-term process, the simplest oral mode usually needs to take 1-2 times a day, while the treatment of acute hypertension and hypertension with multiple complications needs to take medicines more frequently, so that both the acute hypertension and the hypertension with multiple complications need to take medicines manually and actively for a long time, on time and quantitatively, and the treatment is a great problem in the hypertension treatment, namely, many patients do not insist on taking medicines or do not insist on correct taking medicines, so that the blood pressure regulation and treatment effect is poor, the blood pressure rises repeatedly, even serious complications occur, and the life is threatened. At present, there is still a lack of more automated administration methods requiring less manual intervention in the treatment of hypertension.
There are several new blood pressure monitoring and administration modes that are currently emerging. For example, a device for detecting blood pressure at high frequency by using a photoelectric method or a mechanical sensing method is available, but still has great problems, such as poor detection accuracy, only reflecting the trend of overall blood pressure change, failing to meet the clinical accuracy requirement of plus or minus 5mmHg error of a mercury sphygmomanometer, or satisfying accuracy, but having harsh wearing modes and using conditions and high price. In the aspect of drug delivery mode, related researches on transdermal drug delivery by using a microneedle device have appeared in recent years, and the characteristics of painless transdermal penetration and simple and easy use of the microneedle are utilized, but the control of drug dosage is still not accurate enough, and the drug dosage is difficult to adjust in time according to the change of blood pressure of a patient, so that the improvement is still not perfect. Meanwhile, a diagnosis and treatment system with blood pressure detection and drug administration functions is not available.
Therefore, it is necessary to provide a wearable integrated hypertension diagnosis and treatment system which monitors blood pressure in real time and accurately administers the medicine immediately when the blood pressure is abnormal, so as to solve the above problems.
Disclosure of Invention
In order to overcome the above defects in the prior art, embodiments of the present invention provide a hypertension real-time diagnosis and treatment integrated system with controllable drug release, which detects pressure generated by weak pulse by using high sensitivity of a graphene sensor, monitors blood pressure in real time, realizes controllable release of antihypertensive drug molecules by using photosensitive liposome nanoparticles, organically combines a blood pressure monitoring device and a microneedle type drug release device together by using a wireless transmission technology to form a diagnosis and treatment system, immediately calculates the required drug amount when abnormal blood pressure is detected, and accurately releases the corresponding drug amount by controlling illumination time and intensity, thereby realizing real-time accurate regulation and control of blood pressure, and solving the problems proposed in the background art.
In order to achieve the purpose, the invention provides the following technical scheme: a controllable drug release hypertension real-time diagnosis and treatment integrated system comprises a wearable blood pressure monitoring device and a micro-needle type controllable drug delivery device, wherein the wearable blood pressure monitoring device comprises a hand ring worn on a wrist part, and the micro-needle type controllable drug delivery device comprises an arm band worn on an arm part;
the device comprises a bracelet, a sensor, a pressure sensor, a signal processing module, a data storage module, a data transmission module and a battery, wherein the graphene pressure sensor, the signal processing module, the data storage module, the data transmission module and the battery are arranged in the bracelet, the signal processing module is used for carrying out digital-to-analog conversion on an electric signal, converting a corresponding radial artery pressure value and a corresponding blood pressure value, and judging whether a monitored blood pressure value is normal or not, the data storage module is used for storing the blood pressure value within a certain time, and the data transmission module is used for exporting monitoring data, sending a dosing instruction;
the arm band comprises a hypertension drug microneedle, an instruction receiving module, a controllable release module and a microneedle storage module, the hypertension drug microneedle comprises a microneedle substrate and a microneedle head, the instruction receiving module is used for receiving an instruction signal from the wearable blood pressure monitoring device, the controllable release module is used for reminding the replacement of the microneedle head in time, and the microneedle storage module is used for storing the microneedle head;
the micro-needle storage module is of a rotary drum structure, a plurality of storage spaces are arranged inside the micro-needle storage module, each storage space is internally provided with a piece of hypertension drug micro-needle, a counter is arranged inside the controllable release module, a micro vibrator is further arranged inside the controllable release module, a light-emitting diode light source is further arranged on one side of the arm band, and the light-emitting diode light source is matched with the micro-needle head.
Preferably, the system further comprises a machine learning server, wherein the machine learning server is used for collecting and analyzing the blood pressure value of the user, comparing, analyzing and learning the measured blood pressure to obtain an effective correction algorithm personalized for the specific user, regularly correcting, updating the correction algorithm and importing the correction algorithm into the bracelet signal processing module in the later use.
Preferably, the graphene pressure sensor is arranged in a corrugated graphene sheet structure, and the graphene pressure sensor is packaged in the wrist band portion of the bracelet.
Preferably, the microneedle substrate is composed of one of polydimethylsiloxane, photo-crosslinking polyethylene glycol monomethyl ether-methacrylate or photo-crosslinking trimethylolpropane triacrylate, the exterior of the microneedle is made of one of hydroxymethyl cellulose, polyvinylpyrrolidone, sodium alginate or hyaluronic acid materials, and photosensitive liposome nanoparticles are uniformly distributed in the interior of the microneedle.
Preferably, the photosensitive liposome nanoparticle sphere comprises a liposome nanoparticle, a gold nanorod and a pressure-reducing drug, wherein the pressure-reducing drug is wrapped inside the liposome nanoparticle and the gold nanorod.
Preferably, the specific working steps of the controllable release module are as follows:
s1, starting a light emitting diode light source according to the time and the intensity required by the instruction, irradiating the skin penetration part with the micro-needle point by the light source with the wavelength of 500-1000 nm, and calculating the content of the subcutaneous residual medicine according to the time and the intensity of illumination;
and S2, when the calculation result shows that the content of the drug which is not released subcutaneously is lower than 20% of the total content of the drug of the single microneedle, the micro vibrator vibrates to remind the user to replace the microneedle.
Preferably, the microneedle storage module is connected with a counter on the controllable release module and is used for triggering the counter on the controllable release module and updating the value of the content of the residual drug in the controllable release module.
The invention has the technical effects and advantages that:
1. the pressure generated by weak pulse is detected by utilizing the high sensitivity of a graphene sensor, the blood pressure is monitored in real time, the controllable release of blood pressure reducing drug molecules is realized by utilizing photosensitive liposome nanoparticles, a blood pressure monitoring device and a microneedle type drug release device are organically combined together by utilizing a wireless transmission technology to form a diagnosis and treatment system, the required drug amount is immediately calculated when abnormal blood pressure is detected, the corresponding drug amount is accurately released by controlling the time and the intensity of illumination, and the real-time accurate regulation and control of the blood pressure are realized;
2. through wearing bracelet and armlet at user's arm, can not influence user's normal activity, facilitate the use, graphite alkene pressure sensor sets up to the graphite alkene lamellar structure of fold form, and graphite alkene pressure sensor encapsulates in the wrist strap part of bracelet, can be convenient carry out accurate monitoring to blood pressure, and combine the machine learning, in time rectify the conversion algorithm of blood pressure value, make the real-time accurate monitoring blood pressure of graphite alkene pressure sensor, compare with prior art, detection error is little, the precision is high.
Drawings
Fig. 1 is a schematic view of the topology of the present invention.
Fig. 2 is a block diagram of the system architecture of the present invention.
Fig. 3 is a schematic structural diagram of an internal system of the microneedle storage module according to the present invention.
The reference signs are: the device comprises a bracelet 1, a graphene pressure sensor 11, a signal processing module 12, a data storage module 13, a data transmission module 14, a battery 15, an arm band 2, an instruction receiving module 21, a controllable release module 22 and a microneedle storage module 23.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The hypertension real-time diagnosis and treatment integrated system capable of controlling drug release shown in fig. 1-3 comprises a wearable blood pressure monitoring device and a micro-needle type controllable drug delivery device, wherein the wearable blood pressure monitoring device comprises a bracelet 1 worn on a wrist part, and the micro-needle type controllable drug delivery device comprises an arm band 2 worn on an arm part;
the bracelet 1 is internally provided with a graphene pressure sensor 11, a signal processing module 12, a data storage module 13, a data transmission module 14 and a battery 15, wherein the signal processing module 12 is used for performing digital-to-analog conversion on an electric signal, converting a corresponding radial artery pressure value and a corresponding blood pressure value, and judging whether the monitored blood pressure value is normal or not, the data storage module 13 is used for storing the blood pressure value within a certain time, and the data transmission module 14 is used for exporting monitoring data, sending an administration instruction and importing a blood pressure correction algorithm;
the arm band 2 comprises a hypertension drug microneedle, an instruction receiving module 21, a controllable release module 22 and a microneedle storage module 23 inside, the hypertension drug microneedle comprises a microneedle substrate and a microneedle head, the instruction receiving module 21 is used for receiving an instruction signal from the wearable blood pressure monitoring device, the controllable release module 22 is used for reminding the replacement of the microneedle head in time, and the microneedle storage module 23 is used for storing the microneedle head;
the micro-needle storage module 23 is of a rotary drum structure, a plurality of storage spaces are arranged in the micro-needle storage module 23, a piece of hypertension drug micro-needle is stored in each storage space, a counter is arranged in the controllable release module 22, a micro vibrator is further arranged in the controllable release module 22, a light-emitting diode light source is further arranged on one side of the arm band 2, and the light-emitting diode light source is matched with the micro-needle head;
the graphene pressure sensor 11 is of a corrugated graphene sheet structure, the graphene pressure sensor 11 is packaged on the wrist strap portion of the bracelet 1, the graphene pressure sensor converts pressure into an electric signal by utilizing a stretching-shrinking process of the graphene structure by the pressure generated by radial artery pulsation, and the graphene structure realizes accurate detection of a tiny pressure signal due to high electron mobility and large specific surface area;
the micro-needle substrate is composed of one of polydimethylsiloxane, photo-crosslinking polyethylene glycol monomethyl ether-methacrylate or photo-crosslinking trimethylolpropane triacrylate which have biocompatibility but are insoluble in water, the exterior of the micro-needle is made of one of hydroxymethyl cellulose, polyvinylpyrrolidone, sodium alginate or hyaluronic acid materials, and photosensitive liposome nanoparticle spheres which are uniformly distributed are arranged inside the micro-needle;
the photosensitive liposome nanoparticle ball comprises liposome nanoparticles, gold nanorods and a pressure-reducing drug, wherein the pressure-reducing drug is wrapped inside the liposome nanoparticles and the gold nanorods;
the specific working steps of the controllable release module 22 are as follows:
s1, starting a light emitting diode light source according to the time and the intensity required by the instruction, irradiating the skin penetration part with the micro-needle point by the light source with the wavelength of 500-1000 nm, and calculating the content of the subcutaneous residual medicine according to the time and the intensity of illumination;
s2, when the calculation result shows that the content of the drug which is not released subcutaneously is lower than 20% of the total content of the drug of a single microneedle, the micro vibrator vibrates to remind a user to replace the microneedle;
the microneedle storage module 23 is connected with the counter on the controllable release module 22 and is used for triggering the counter on the controllable release module 22 and updating the value of the content of the residual drug in the controllable release module 22;
the implementation mode is specifically as follows: the hand ring 1 and the arm band 2 are worn on the arm of a user, the pressure generated by weak pulse is detected by utilizing the high sensitivity of the graphene sensor 11, the blood pressure of the user is monitored in real time, the injection depressurization is carried out by utilizing photosensitive liposome nanoparticles, when the signal processing module 12 receives the pressure signal value sensed by the graphene sensor 11 and exceeds a set safety value, the data transmission module 14 sends a signal to the arm band 2, the instruction receiving module 21 receives an instruction signal, so that the hypertension drug is injected by the microneedle to realize the controllable release of the molecules of the depressurization drug, the blood pressure monitoring device and the microneedle type drug release device are organically combined together by utilizing the wireless transmission technology to form a diagnosis and treatment system, when abnormal blood pressure is detected, the required drug amount is immediately calculated, the corresponding drug amount is accurately released by controlling the time and the intensity of illumination, the real-time accurate regulation and control of the blood pressure are realized, and, according to the time and the intensity of illumination, the content of subcutaneous residual drugs is calculated, when the calculation result shows that the content of subcutaneous unreleased drugs is lower than 20% of the total content of single microneedle drugs, the micro vibrator vibrates to remind a user to replace microneedles, the drum structure is manually adjusted, so that the microneedle of the hypertension drugs in the storage space leaks to prepare for injection.
According to the integrated system for real-time diagnosis and treatment of hypertension with controllable drug release shown in fig. 1-3, the system further comprises a machine learning server, the machine learning server is used for collecting and analyzing the blood pressure value of a user, the blood pressure value collected and converted by the bracelet 1 is compared, analyzed and learned through the machine learning server and the dynamic sphygmomanometer 24 hours before the initial use, an effective correction algorithm personalized for the specific user is obtained, the correction algorithm is periodically corrected every 1 month in the later use, the correction algorithm is updated, the correction algorithm is introduced into the bracelet 1 signal processing module 12, and a high-accuracy blood pressure measurement value is obtained;
the implementation mode is specifically as follows: wear bracelet 1 and armlet 2 at user's arm, can not influence user's normal activity, facilitate the use, graphite alkene pressure sensor 11 sets up to the graphite alkene lamellar structure of fold form, and graphite alkene pressure sensor 11 encapsulates in bracelet 1's wrist strap part, can be convenient carry out accurate monitoring to blood pressure, and combine machine learning, the conversion algorithm of in time rectifying the blood pressure value realizes real-time accurate blood pressure monitoring, the problem that the blood pressure detection error that exists among the prior art is big has specifically been solved to this embodiment.
The working principle of the invention is as follows:
referring to the attached drawings 1-3 of the specification, the pressure generated by weak pulse is detected by using the high sensitivity of a graphene sensor 11, when a signal processing module 12 receives a pressure signal value sensed by the graphene sensor 11 and exceeds a set safety value, a data transmission module 14 sends a signal to an arm band 2, an instruction receiving module 21 receives an instruction signal, so that a high blood pressure drug microneedle injects a drug, a blood pressure monitoring device and a microneedle type drug release device are organically combined together by using a wireless transmission technology to form a diagnosis and treatment system, the required drug amount is immediately calculated when abnormal blood pressure is detected, the corresponding drug amount is accurately released by controlling the time and the intensity of illumination, a light emitting diode light source irradiates a transdermal part of a microneedle tip, the content of subcutaneous residual drug is calculated according to the time and the intensity of illumination, and when the calculation result shows that the content of the drug which is not released subcutaneously is lower than 20% of the total content, the micro vibrator vibrates to remind a user to replace the micro needle, and the drum type structure is manually adjusted to enable the micro needle of the hypertension drug in the storage space to leak out for injection preparation;
referring to the attached drawings 1-3 of the specification, the bracelet 1 and the arm band 2 are worn on the arm of a user, normal activities of the user cannot be affected, the use is convenient, the graphene pressure sensor 11 is of a corrugated graphene sheet structure, the graphene pressure sensor 11 is packaged on the wrist band portion of the bracelet 1, blood pressure can be conveniently and accurately monitored, and the conversion algorithm of the blood pressure value is timely corrected by combining machine learning, so that the graphene pressure sensor 11 can accurately monitor the blood pressure in real time.
The points to be finally explained are: first, in the description of the present application, it should be noted that, unless otherwise specified and limited, the terms "mounted," "connected," and "connected" should be understood broadly, and may be a mechanical connection or an electrical connection, or a communication between two elements, and may be a direct connection, and "upper," "lower," "left," and "right" are only used to indicate a relative positional relationship, and when the absolute position of the object to be described is changed, the relative positional relationship may be changed;
secondly, the method comprises the following steps: in the drawings of the disclosed embodiments of the invention, only the structures related to the disclosed embodiments are referred to, other structures can refer to common designs, and the same embodiment and different embodiments of the invention can be combined with each other without conflict;
and finally: the above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents, improvements and the like that are within the spirit and principle of the present invention are intended to be included in the scope of the present invention.
Claims (7)
1. The utility model provides a controllable drug release's hypertension integrated system of diagnosing in real time, includes wearing formula blood pressure monitoring device and the controllable device of dosing of micropin formula, its characterized in that: the wearable blood pressure monitoring device comprises a bracelet (1) worn on a wrist part, and the micro-needle type controllable drug delivery device comprises an arm band (2) worn on an arm part;
the bracelet (1) is internally provided with a graphene pressure sensor (11), a signal processing module (12), a data storage module (13), a data transmission module (14) and a battery (15), the signal processing module (12) is used for carrying out digital-to-analog conversion on an electric signal, converting out a corresponding radial artery pressure value and a corresponding blood pressure value, and judging whether the monitored blood pressure value is normal or not, the data storage module (13) is used for storing the blood pressure value within a certain time, the data transmission module (14) is used for exporting monitoring data, sending a dosing instruction and introducing a blood pressure correction algorithm;
the arm band (2) internally comprises a hypertension drug microneedle, an instruction receiving module (21), a controllable release module (22) and a microneedle storage module (23), the hypertension drug microneedle comprises a microneedle substrate and a microneedle head, the instruction receiving module (21) is used for receiving an instruction signal from the wearable blood pressure monitoring device, the controllable release module (22) is used for timely reminding the replacement of the microneedle head, and the microneedle storage module (23) is used for storing the microneedle head;
microneedle storage module (23) sets up to the rotary drum structure, microneedle storage module (23) inside is equipped with a plurality of storage spaces, every all store a slice hypertension medicine micropin in the storage space, the inside counter that is equipped with of controllable release module (22), the inside miniature vibrator that still is equipped with of controllable release module (22), arm area (2) one side still is equipped with the emitting diode light source, emitting diode light source and micropin head phase-match.
2. The integrated system for hypertension real-time diagnosis and treatment capable of controlling drug release according to claim 1, is characterized in that: the system also comprises a machine learning server, wherein the machine learning server is used for collecting and analyzing the blood pressure value of the user, comparing, analyzing and learning the measured blood pressure to obtain an effective correction algorithm personalized for the specific user, regularly correcting, updating the correction algorithm and importing the correction algorithm into the signal processing module (12) of the bracelet (1) in the later use.
3. The integrated system for hypertension real-time diagnosis and treatment capable of controlling drug release according to claim 1, is characterized in that: the graphene pressure sensor (11) is arranged to be of a corrugated graphene sheet structure, and the graphene pressure sensor (11) is packaged on the wrist strap portion of the wrist strap (1).
4. The integrated system for hypertension real-time diagnosis and treatment capable of controlling drug release according to claim 1, is characterized in that: the micro-needle substrate is composed of one of polydimethylsiloxane, photo-crosslinking polyethylene glycol monomethyl ether-methacrylate or photo-crosslinking trimethylolpropane triacrylate, the exterior of the micro-needle is made of one of hydroxymethyl cellulose, polyvinylpyrrolidone, sodium alginate or hyaluronic acid materials, and photosensitive liposome nano-particle balls which are uniformly distributed are arranged inside the micro-needle.
5. The integrated system for hypertension real-time diagnosis and treatment capable of controlling drug release according to claim 4, is characterized in that: the photosensitive liposome nanoparticle ball comprises liposome nanoparticles, gold nanorods and a pressure-reducing drug, wherein the pressure-reducing drug is wrapped inside the liposome nanoparticles and the gold nanorods.
6. The integrated system for hypertension real-time diagnosis and treatment capable of controlling drug release according to claim 1, is characterized in that: the specific working steps of the controllable release module (22) are as follows:
s1, starting a light emitting diode light source according to the time and the intensity required by the instruction, irradiating the skin penetration part with the micro-needle point by the light source with the wavelength of 500-1000 nm, and calculating the content of the subcutaneous residual medicine according to the time and the intensity of illumination;
and S2, when the calculation result shows that the content of the drug which is not released subcutaneously is lower than 20% of the total content of the drug of the single microneedle, the micro vibrator vibrates to remind the user to replace the microneedle.
7. The integrated system for hypertension real-time diagnosis and treatment capable of controlling drug release according to claim 1, is characterized in that: the microneedle storage module (23) is connected with a counter on the controllable release module (22) and used for triggering the counter on the controllable release module (22) and updating the value of the content of the residual drug in the controllable release module (22).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910839898.4A CN110584633A (en) | 2019-09-06 | 2019-09-06 | Hypertension real-time diagnosis and treatment integrated system capable of controlling drug release |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910839898.4A CN110584633A (en) | 2019-09-06 | 2019-09-06 | Hypertension real-time diagnosis and treatment integrated system capable of controlling drug release |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110584633A true CN110584633A (en) | 2019-12-20 |
Family
ID=68857856
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910839898.4A Pending CN110584633A (en) | 2019-09-06 | 2019-09-06 | Hypertension real-time diagnosis and treatment integrated system capable of controlling drug release |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110584633A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112870543A (en) * | 2021-02-26 | 2021-06-01 | 中山大学 | Drug release control device, control method thereof, and computer-readable storage medium |
| CN114081455A (en) * | 2021-10-10 | 2022-02-25 | 湖南云医链生物科技有限公司 | Traditional chinese medical science pulse-taking intelligence health management wrist-watch |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106943134A (en) * | 2017-03-15 | 2017-07-14 | 陶军 | A kind of wearable blood pressure regulation device |
| CN108310615A (en) * | 2017-12-29 | 2018-07-24 | 浙江理工大学 | A kind of microneedle cutaneous device of photoinduction |
| CN108619081A (en) * | 2018-05-22 | 2018-10-09 | 浙江理工大学 | A kind of photosensitive micropin and preparation method thereof, controlled release method |
| CN108671383A (en) * | 2018-06-01 | 2018-10-19 | 陶军 | The real-time diagnosis and treatment integral system of hypertension of wearable controlled drug release |
-
2019
- 2019-09-06 CN CN201910839898.4A patent/CN110584633A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106943134A (en) * | 2017-03-15 | 2017-07-14 | 陶军 | A kind of wearable blood pressure regulation device |
| CN108310615A (en) * | 2017-12-29 | 2018-07-24 | 浙江理工大学 | A kind of microneedle cutaneous device of photoinduction |
| CN108619081A (en) * | 2018-05-22 | 2018-10-09 | 浙江理工大学 | A kind of photosensitive micropin and preparation method thereof, controlled release method |
| CN108671383A (en) * | 2018-06-01 | 2018-10-19 | 陶军 | The real-time diagnosis and treatment integral system of hypertension of wearable controlled drug release |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112870543A (en) * | 2021-02-26 | 2021-06-01 | 中山大学 | Drug release control device, control method thereof, and computer-readable storage medium |
| CN112870543B (en) * | 2021-02-26 | 2022-06-21 | 中山大学 | Drug release control device, control method thereof, and computer-readable storage medium |
| CN114081455A (en) * | 2021-10-10 | 2022-02-25 | 湖南云医链生物科技有限公司 | Traditional chinese medical science pulse-taking intelligence health management wrist-watch |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US20230058052A1 (en) | Wearable band for health monitoring device | |
| US11963736B2 (en) | Wireless patient monitoring system | |
| US20230028745A1 (en) | Wearable device with physiological parameters monitoring | |
| CN108671383B (en) | Wearable hypertension real-time diagnosis and treatment integrated system capable of controlling drug release | |
| EP3920788B1 (en) | Wearable device with physiological parameters monitoring | |
| US9028407B1 (en) | Methods and apparatus for monitoring patient conditions | |
| US8636670B2 (en) | Circulatory monitoring systems and methods | |
| US8403881B2 (en) | Circulatory monitoring systems and methods | |
| US20160360971A1 (en) | Monitoring Health Status of People Suffering from Chronic Diseases | |
| US9107571B2 (en) | ECG acquisition and treatment-response system for treating abnormal cardiac function | |
| US20090292222A1 (en) | Circulatory monitoring systems and methods | |
| CN111050632A (en) | Monitoring markers by medical devices | |
| Khandpur | Compendium of Biomedical Instrumentation, 3 Volume Set | |
| CN113226448A (en) | Method and apparatus for a wearable electronic digital treatment device | |
| US20090287093A1 (en) | Circulatory monitoring systems and methods | |
| CN110584633A (en) | Hypertension real-time diagnosis and treatment integrated system capable of controlling drug release | |
| US20240074701A1 (en) | Wearable continuous emergency medical monitoring system | |
| US20090287110A1 (en) | Circulatory monitoring systems and methods | |
| US20090292214A1 (en) | Circulatory monitoring systems and methods | |
| CN110327025A (en) | A kind of multifunctional intellectual wrist strap | |
| US20090287094A1 (en) | Circulatory monitoring systems and methods | |
| CN107088070A (en) | A kind of wearable real-time Dynamic Blood Glucose Monitoring device | |
| CN106419848A (en) | Device and method for monitoring thyroid function | |
| US11759640B2 (en) | Methods for reducing the risk of strokes by pharmacotherapy to reduce the number and duration of atrial fibrillations | |
| US20090292213A1 (en) | Circulatory monitoring systems and methods |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20191220 |