CN108310615A - A kind of microneedle cutaneous device of photoinduction - Google Patents
A kind of microneedle cutaneous device of photoinduction Download PDFInfo
- Publication number
- CN108310615A CN108310615A CN201711474319.8A CN201711474319A CN108310615A CN 108310615 A CN108310615 A CN 108310615A CN 201711474319 A CN201711474319 A CN 201711474319A CN 108310615 A CN108310615 A CN 108310615A
- Authority
- CN
- China
- Prior art keywords
- module
- light emitting
- micropin
- photoinduction
- emitting module
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0023—Drug applicators using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0061—Methods for using microneedles
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Medical Informatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
The invention belongs to cutaneous penetration technical fields, and in particular to a kind of microneedle cutaneous device of photoinduction, including matrix, sensing module, light emitting module and light sensation micropin；The sensing module is set on matrix, for monitoring Human Physiology indication information；The light sensation micropin is detachably connected with matrix or sensing module；The light emitting module is set to the side of light sensation micropin, discharges drug for controlling light sensation micropin according to Human Physiology indication information.User, to indicate that control light sensation micropin discharges drug, solves the administration error problem that artificial subjective judgement easily causes according to Human Physiology indication information；In addition, without being administered manually, control light sensation micropin is controlled by light emitting module and discharges drug.
Description
Technical field
The invention belongs to cutaneous penetration technical fields, and in particular to a kind of microneedle cutaneous device of photoinduction.
Background technology
Cutaneous penetration refers to by being administered in skin surface, drug being made to pass through skin with constant speed or close to constant speed
Each layer generates whole body or a kind of administering mode of local therapeutic effects into body circulation.With the development of modern medicine science and technology, people
To be accurately administered and the convenience of administering mode, tolerance etc. more stringent requirements are proposed, so that cutaneous penetration is become new
The research hotspot of generation pharmaceutical preparation.But due to the barrier action of skin, the transmitance of most of preparation capable of permeating skin is low, is applied to
The drug of work(is confined to the fat-solubility non-electrolyte drug of small-molecular-weight.
In order to overcome this obstacle, in recent years, scientific research personnel develops new technologies and methods in succession；Wherein, a kind of combination skin
Microinvasion transdermal drug delivery system-micropin of lower injection and the dual drug release advantage of percutaneous plaster, it is sharp since micropin is thin, generally
Paracentesis depth only in cuticula, not in contact with to nerve endings, point degree has also substantially reduced needle point and has touched nerve endings
Probability, reduce the degree of injury to the corresponding affiliated group of body, show vast potential for future development.Micropin percutaneous plaster can
Increase the permeability of drug, especially it can be such that macromolecular drug (such as polypeptide, albumen and vaccine) percutaneous permeation significantly carries
Height can reach therapeutic effect.
It is well known that the ion, molecule or cell in human body in blood need to control in a normal horizontal extent
It can maintain the normal operation of function.For example, the concentration range of human body blood glucose under fasting state is 80~120mg/dL, due to drink
The difference of food and activity level, blood glucose level of the human body in one day are also always changing.If hypoglycemic drug is fast
It discharges fastly to human body, it is likely that cause another extreme reaction, i.e., hypoglycemia, hypoglycemia refer to that the blood glucose of human body is dense
Degree is consistently less than 60mg/dL, and serious and long-term hypoglycemia can cause nervous system injury and other complication.And it uses micro-
Needle Transdermal delivery systems can preferably solve the problems, such as that above-mentioned administration is too fast, but microneedle cutaneous mode is only limitted to artificially at present
Be administered and stop administration, depend entirely on subjective operation and the subjective judgement of people, easily cause that administration is insufficient or mistake
The problems such as amount, uneven administration, it is unable to reach good therapeutic effect.
Invention content
Aiming at the above shortcomings existing in the prior art, the present invention provides a kind of microneedle cutaneous device of photoinduction, should
Device can be administered according to the physical signs information of human body or stop administration.
In order to reach foregoing invention purpose, the present invention uses following technical scheme：
A kind of microneedle cutaneous device of photoinduction, including matrix, sensing module, light emitting module and light sensation micropin；It is described
Sensing module is set on matrix, for monitoring Human Physiology indication information；The light sensation micropin and matrix or sensing module are removable
Unload connection；The light emitting module is set to the side of light sensation micropin, is released for controlling light sensation micropin according to Human Physiology indication information
Put drug.User, to indicate that control light sensation micropin discharges drug, solves artificial subjective judgement according to Human Physiology indication information
The administration error problem easily caused；In addition, without being administered manually, control light sensation micropin is controlled by light emitting module and discharges medicine
Object.
Preferably, the sensing module includes temperature sensor, sodium ion sensor, potassium ion sensor, Portugal
One or more of grape sugar sensor and lactic acid sensor further include the reference electrode that circuit is constituted with sensor.Pass through biography
The setting of sensor ensures the accuracy for the Human Physiology index that monitoring obtains.
Preferably, the sensing module is ring-shaped structure, and sensor and reference electrode are uniformly distributed in annulus
The periphery of shape structure.The inner space of its ring-shaped structure improves the compactedness of apparatus structure for assembling other components.
Preferably, the transdermal delivery device further includes control module, control module and light emitting module, sensing mould
Block connects, and control module receives the Human Physiology indication information of sensing module monitoring, and is controlled according to Human Physiology indication information
Light emitting module opens or closes.By opening or closing for light emitting module drug or stopping release being discharged to control light sensation micropin
Drug, high degree of automation.
Preferably, the transdermal delivery device further includes memory module, and memory module is connect with control module, is deposited
Store up the preset human normal physical signs information of storage in module；It is described that light emitting module is controlled according to Human Physiology indication information
It opens or closes, including：Human Physiology indication information is matched with preset human normal physical signs information, if human body
Physical signs information and preset human normal physical signs information matches then keep or control light emitting module and close；If human body
Physical signs information is mismatched with preset human normal physical signs information, then controls light emitting module opening.In Human Physiology
When index occurs abnormal, light emitting module can be controlled in time and is opened to discharge drug；In Human Physiology index by being converted into extremely just
Chang Shi, moreover it is possible to which control light emitting module is closed to stop discharging drug in time, is realized administration and is stopped the free switching of administration.
Preferably, the transdermal delivery device further includes shading cover, and the shading cover is covered on matrix so that control
First side of molding block, light emitting module and sensing module is located in shading cover.The setting of shading cover, for protecting its internal device
Part, and light sensation micropin is protected not influenced by external light source.
Preferably, the light sensation micropin includes pedestal and syringe needle, the second side of the pedestal insertion sensing module
So that syringe needle is in outside；The syringe needle embedding light pyrexin and drug.It is triggered by photoinduction close red in light sensation micropin
The outer photic thermal transition factor generates heat and needle body thawing is made to release drug.
Preferably, the smooth pyrexin is near infrared light pyrexin；Correspondingly, the light emitting module is close
Infrared light light source.Using near infrared light light source without destructive and pollution-free.
Preferably, the transdermal delivery device further includes power module, power module and control module, luminous mould
Block, sensing module connection are to provide electric power support.Without external power supply module device, make the easy-to-use of transdermal delivery device.
Preferably, the power module is the button-type battery that voltage is 6V.
Preferably, described matrix is wristband type universal serial wear structure.It, only need to be by it when user uses transdermal delivery device
It is worn in wrist, user experience is good.
Preferably, the near infrared light light source is coated with transparency silica glass or organic glass；To near-infrared
Radiant is protected.
Preferably, near infrared light light source launch wavelength is the near infrared light of 808nm.
Compared with prior art, the present invention advantageous effect is：The microneedle cutaneous device of photoinduction of the present invention, can be to body
Interior all kinds of physical signs levels carry out intelligent response, can accelerate micropin needle body when it is higher than normal level and load releasing for drug
It puts, and the rate of release of drug can be slowed down when it is less than normal level, form a sensing diagnostic and drug controlled release is controlled
The circulating system for the treatment of realizes the increasingly automated and intelligent of drug supply, has more bright application prospect.
Description of the drawings
Fig. 1 is the structural schematic diagram of the microneedle cutaneous device of photoinduction of the embodiment of the present invention one；
Fig. 2 is the Structure explosion diagram of the microneedle cutaneous device of photoinduction of the embodiment of the present invention one；
Fig. 3 be the embodiment of the present invention one sensing module in the structural schematic diagram of each sensor and reference electrode；
Fig. 4 be the embodiment of the present invention one the microneedle cutaneous device of photoinduction in light sensation micropin detach structural representation
Figure；
Fig. 5 is structural schematic diagram when the microneedle cutaneous device of photoinduction of the embodiment of the present invention one is worn on wrist.
Specific implementation mode
Explanation is further described to technical scheme of the present invention below by specific embodiment.
In embodiment one, as shown in Figs. 1-5, the microneedle cutaneous device of photoinduction of the present embodiment, including matrix 1,
Sensing module 2, light emitting module 3, light sensation micropin 4, control module 5, power module 6 and shading cover 7, matrix 1 are dressed for wristband type universal serial
Structure, it is preferable that matrix 1 is Wristwatch-type wristband constructions, can be worn in wrist；The material of matrix 1 is flexible material, preferably
For thermoplasticity silicon rubber, thermoplasticity silicon rubber is the thermoplastic silicone bullet that sulphurated siliastic particle is formed on thermoplastic matrix
Property body；By the surface enrichment and hydrophobicity of organosilicon, the performance of thermoplastic elastomer (TPE) and thermoplastic sulfurized rubber is expanded, has been made
It is with excellent high temperature resistant property, low draftability and compressibility and good wearability, hydrolytic resistance when high temperature and resistance to
Chemistry；The resilience of material is good, softer than general thermoplastic polyurethane elastomer rubber TPU；Surface is not easy to adsorb dust, does not send out
It is viscous, and grease resistance and chemical resistance are good, it is not easy to pollute；Covering property is relatively good, with many thermoplastic engineering plastics such as PC, PC/
ABS, ABS, PA, PVC etc. have excellent cementability, convenient formation, can co-extrusion, double injection molding, quadric injection mould；It can also carve
Abundant pattern, can colour to obtain colorful wrist strap.
The sensing module 2 that ring-shaped structure is assembled at the position of the middle part dial plate of matrix 1, for monitoring Human Physiology index
Information；Sensing module 2 is ring-shaped structure, outer diameter 5cm, internal diameter 4cm；Include that the temperature configured close to human skin face passes
Sensor 24, sodium ion sensor 21, potassium ion sensor 22, glucose sensor 26, lactic acid sensor 27 and and sensor
Constitute the reference electrode in circuit, the composition for detecting sweat on skin, to obtain Human Physiology indication information, such as the body of human body
Table temperature, Na ion concentration are horizontal, lithium concentration is horizontal, concentration of glucose is horizontal and lactic acid concn is horizontal；Specifically, as schemed
Shown in 3, the salt in circuit detection sweat is constituted by potassium ion sensor 22, sodium ion sensor 21 and silver/silver chloride electrode 23
The concentration level of class is made of back glucose sensor 26, lactic acid sensor 27 and polyvinyl butyral PVB reference electrodes 25
The gentle lactate level of glucose water in sweat is detected on road, while being equipped with temperature sensor 24 for detecting shell temperature；On
It states sensor and reference electrode is uniformly distributed in the periphery of ring-shaped structure；By the setting of the sensor, guarantee monitors
The accuracy of the Human Physiology index arrived provides foundation for the controlled release of Subsequent pharmacological.
Sensing module 2 is connect with control module 5, and the Human Physiology indication information that sensing obtains is sent to by sensing module 2
Control module 5；Specifically, temperature sensor, sodium ion sensor, potassium ion sensor, glucose sensor, lactic acid sensor
It is connect with control module 5, in order to which the physical signs information that will respectively monitor is sent to control module 5.
Light sensation micropin 4 includes pedestal and syringe needle, and circular patch shape is made by high molecular material in pedestal, and high molecular material is selected
One or more of gelatin, sodium alginate, hyaluronic acid, polycaprolactone and tridecanoic acid；Syringe needle is distributed in pedestal with array
On, syringe needle with lower glass transition temperature or compared with the high molecular material of low melting point by being made, and embedding is close in it
Infrared light pyrexin and drug composition.Pedestal removably be embedded in ring-shaped structure 2 inner periphery of sensing module downside with
Syringe needle is set to be in lower side, it is in direct contact with the skin convenient for syringe needle；Being set as detachable connection can make light sensation micropin that can replace
It changes.Wherein, light pyrexin is near infrared light pyrexin, preferably Prussian blue.
Light emitting module 3 is arranged in the top of sensing module 2, and light emitting module 3 is near infrared light light source, using near infrared light light source
Without destructive and pollution-free；Near infrared light light source launch wavelength is the near infrared light of 808nm, for triggering photo-thermal factor Prussia
Indigo plant generates heat, so that syringe needle melts to discharge drug.In addition, near infrared light light source is externally provided with protective cover, protective cover is
Alum English glass or organic glass, protects near infrared light light source；Protective cover is resisted against the sensing module 2 of ring-shaped structure
Upside it is movable downwards to limit protective cover.Wherein, there are four near-infrared light sources for setting in protective cover.
The top of light emitting module 3 is arranged control module 5, i.e. the top of protective cover is arranged control module 5, control module 5 with
Light emitting module 3 connects, for, to indicate that control light sensation micropin discharges drug, solving artificial master according to Human Physiology indication information
See the administration error problem for judging to easily cause.Specifically, control module 5 carries out analysis to Human Physiology indication information and according to people
Body physical signs information control light emitting module opens or closes, to control light sensation micropin release drug or stop release medicine
Object.
The microneedle cutaneous device of photoinduction of the present embodiment further includes memory module, and memory module connects with control module 5
It connects, preset human normal physical signs information is stored in memory module, shell temperature, the sodium ion of such as above-mentioned human body are dense
Degree level, lithium concentration level, concentration of glucose level and lactic acid concn level etc..Control module 5 refers to according to Human Physiology
Opening or closing for mark information control light emitting module, specifically includes：By the Human Physiology indication information actually measured with it is preset
Human normal physical signs information is matched, if the Human Physiology indication information actually measured and preset human normal physiology
Indication information matches, and when light emitting module is in the open state, then closes light emitting module；When light emitting module is closed,
Then light emitting module is kept to close；If Human Physiology indication information is mismatched with default human normal physical signs information, control
Light emitting module is opened.When Human Physiology index occurs abnormal, light emitting module can be controlled in time and is opened to discharge drug；In human body
When physical signs by being converted into normal extremely, moreover it is possible in time control light emitting module close with stop discharge drug, realize administration and
Stop the free switching of administration.
Wherein, control module 5 can be the circuit board equipped with processor chips, be patrolled by the completion of various processor chips
Operation and operation are collected, for example, processor chips can be CPLD (Complex Programmable Logic Device, complexity
Programmable logic device) and FPGA (Field Programmable Gate Array, field programmable gate array).
Power module 6, power module 6 and control module 5, light emitting module 3, sensing module 2 is arranged in the top of control module 5
Connection is to provide electric power support；Without external power supply module device, keep the use of transdermal delivery device more convenient.Specifically,
Power module 6 is the button-type battery that voltage is 6V, power module 6 in control module 5, light emitting module 3 and sensing module 2
Various sensors electrical connection.
Shading cover 7 is that upper and lower end is open columnar structured, and the lower port of shading cover 7 sequentially passes through electricity from top to bottom
Source module 6, control module 5, light emitting module 3 are fixedly connected to the upside of sensing module 2 and with matrix 1；The mode being fixedly connected
To be threadedly coupled or snapping connection；The upper port of shading cover 7 is equipped with detachable lid, when cover cap is together in the upper of shading cover 7
When port, the power module 6, control module 5, light emitting module 3, sensing module 2 in shading cover 7 are up and down by limitation, to
Improve the structural compactness of the microneedle cutaneous device of photoinduction.The setting of shading cover, the device for also protecting it internal, and
Light sensation micropin is protected not influenced when in use by external light source.Wherein, lid is set as the detachable replacement convenient for battery.
The assemble flow of the microneedle cutaneous device of photoinduction of the present embodiment is as follows：Sensing module 2 is assemblied in matrix 1
Dial plate position at；Light emitting module 3 is right against sensing module 2 and is resisted against the top of sensing module 2；Control module 5 is put
It is placed in the top of light emitting module 3；Power module 6 is positioned over to the top of control module 5, is incited somebody to action after arranging corresponding connection
Blanking disc 7 from top to bottom by above-mentioned module cage in the inner, and shading cover is fixedly connected with matrix, by cover cap together in shading cover
Upper port；Finally, light sensation micropin 4 is embedded in the inner periphery of sensing module 2 to fix light sensation micropin 4；User uses should
It is easy to use as worn wrist-watch when the microneedle cutaneous device of photoinduction.Wherein, the assemble sequence of light sensation micropin 4
It does not limit specifically, can also be installed after having assembled sensing module 2.
The microneedle cutaneous device of photoinduction of the present invention is electric by micropin medicine-feeding technology, light-operated release drug technique and micro-nano
Sub- sensing technology is combined, realize can it is intelligent light-controlled release micropin load medicine, overcome a series of relevant problems；On the one hand,
Both the advantages of having remained drug pump (variable drug release) eliminates the complex pipeline connection between drug pump and patient, again
Chemotherapy, conventional subcutaneous can be avoided frequently to be administered to patient and cause body, spirit and multiple pressure economically；On the other hand,
Light-operated drug release can Effective Regulation drug rate of release, avoid drug too fast or cross On The Drug Release, to improve light-operated drug
The safety of release and validity；It also utilizes micro-electronic sensor technology to continue the variation of the internal all kinds of indexs of monitoring in real time, adjusts
The release of drug, the final target for realizing intelligent drug delivery.The microneedle cutaneous device of photoinduction of the present invention, can be chronic disease
More comfortable, an acceptable therapeutic modality is created in the treatment of disease.
In concrete application example, the sweat of skin surface is detected by the sensor, to blood glucose water
It is flat to be estimated, when blood glucose is higher than normal concentration, near infrared light light sensation micropin is utilized by control module, keeps light sensation micro-
The syringe needle of needle melts, and releases the drug of loading；When Drug controlled release and when blood glucose level being made to be restored to normal concentration, control
Molding block will control light source closing, to make light sensation micropin taper off thawing, stop the release of drug.For practical physiology
Situation is targetedly administered or stops administration, realizes the intelligentized control method of drug release.
As a preferred embodiment, the microneedle cutaneous device of the photoinduction of the present embodiment and the difference of embodiment one exist
In：Light sensation micropin is detachably connected with sensing module to be changed to light sensation micropin and is detachably connected with matrix, realizes photoinduction micropin
The structure diversification of transdermal delivery device.Other structures are with reference to embodiment one.
As a preferred embodiment, the microneedle cutaneous device of the photoinduction of the present embodiment and the difference of embodiment one exist
In：It is equipped with adhesive layer between light emitting module and sensing module, adhesive layer, power module are equipped between control module and light emitting module
It is equipped with adhesive layer between control module, improves the integrally-built stability of the microneedle cutaneous device of photoinduction.Other structures
With reference to embodiment one.
As a preferred embodiment, the microneedle cutaneous device of the photoinduction of the present embodiment and the difference of embodiment one exist
In：The microneedle cutaneous device of photoinduction further includes display module, and display module is connect with control module, for showing real-time prison
Every physical signs information of survey, allows a user to intuitively understand the physiological status of itself.Other structures are with reference to embodiment one.
It should be noted that above-described embodiment can be freely combined as needed.The above is only to the excellent of the present invention
Embodiment and principle is selected to be described in detail, for those of ordinary skill in the art, the thought provided according to the present invention,
It will change in specific implementation mode, and these changes should also be regarded as the scope of the invention.
Claims (10)
1. a kind of microneedle cutaneous device of photoinduction, which is characterized in that including matrix, sensing module, light emitting module and light sensation
Micropin；The sensing module is set on matrix, for monitoring Human Physiology indication information；The light sensation micropin and matrix or sensing
Module is detachably connected；The light emitting module is set to the side of light sensation micropin, for controlling light according to Human Physiology indication information
Feel micropin and discharges drug.
2. the microneedle cutaneous device of a kind of photoinduction according to claim 1, which is characterized in that the sensing module packet
Include one or more in temperature sensor, sodium ion sensor, potassium ion sensor, glucose sensor and lactic acid sensor
It is a, further include the reference electrode that circuit is constituted with sensor.
3. the microneedle cutaneous device of a kind of photoinduction according to claim 2, which is characterized in that the sensing module is
Ring-shaped structure, sensor and reference electrode are uniformly distributed in the periphery of ring-shaped structure.
4. the microneedle cutaneous device of a kind of photoinduction according to claim 1, which is characterized in that the cutaneous penetration dress
It further includes control module to set, and control module is connect with light emitting module, sensing module, and control module receives the people of sensing module monitoring
Body physical signs information, and opening or closing for light emitting module is controlled according to Human Physiology indication information.
5. the microneedle cutaneous device of a kind of photoinduction according to claim 4, which is characterized in that the cutaneous penetration dress
It further includes memory module to set, and memory module is connect with control module, the preset human normal physical signs of storage in memory module
Information；It is described that opening or closing for light emitting module is controlled according to Human Physiology indication information, including：By Human Physiology indication information
It is matched with preset human normal physical signs information, if Human Physiology indication information refers to preset human normal physiology
Information matches are marked, then keeps or controls light emitting module and close；If Human Physiology indication information refers to preset human normal physiology
It marks information to mismatch, then controls light emitting module opening.
6. the microneedle cutaneous device of a kind of photoinduction according to claim 4, which is characterized in that the cutaneous penetration dress
It further includes shading cover to set, the shading cover is covered on matrix so that control module, light emitting module and sensing module the first side position
In in shading cover.
7. the microneedle cutaneous device of a kind of photoinduction according to claim 6, which is characterized in that the light sensation micropin packet
Pedestal and syringe needle are included, the second side of the pedestal insertion sensing module is so that syringe needle is in outside；The syringe needle embeds photic heat
The factor and drug.
8. the microneedle cutaneous device of a kind of photoinduction according to claim 7, which is characterized in that the smooth pyrexin
For near infrared light pyrexin；Correspondingly, the light emitting module is near infrared light light source.
9. the microneedle cutaneous device of a kind of photoinduction according to claim 4, which is characterized in that the cutaneous penetration dress
It further includes power module to set, and power module is connect with control module, light emitting module, sensing module to provide electric power support.
10. the microneedle cutaneous device of a kind of photoinduction according to claim 1, which is characterized in that described matrix is hand
Ring type wear structure.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711474319.8A CN108310615B (en) | 2017-12-29 | 2017-12-29 | Photoinduction microneedle transdermal delivery device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711474319.8A CN108310615B (en) | 2017-12-29 | 2017-12-29 | Photoinduction microneedle transdermal delivery device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN108310615A true CN108310615A (en) | 2018-07-24 |
| CN108310615B CN108310615B (en) | 2021-06-08 |
Family
ID=62893407
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711474319.8A Active CN108310615B (en) | 2017-12-29 | 2017-12-29 | Photoinduction microneedle transdermal delivery device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108310615B (en) |
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110584633A (en) * | 2019-09-06 | 2019-12-20 | 湘南学院附属医院 | Hypertension real-time diagnosis and treatment integrated system capable of controlling drug release |
| EP3603508A1 (en) * | 2018-08-03 | 2020-02-05 | PKvitality | Multi-position capsule |
| EP3603489A1 (en) * | 2018-08-03 | 2020-02-05 | PKvitality | Body monitoring system with removable connection |
| CN111956948A (en) * | 2020-01-16 | 2020-11-20 | 广州医科大学 | Wearable remote control thermal response microneedle array patch and preparation method thereof |
| FR3097768A1 (en) * | 2019-06-28 | 2021-01-01 | Commissariat à l'Energie Atomique et aux Energies Alternatives | Patch-type device to be applied to the skin of a living being |
| CN112617749A (en) * | 2019-11-19 | 2021-04-09 | 奇异平台股份有限公司 | Physiological and biochemical monitoring device |
| WO2021094699A1 (en) * | 2019-11-15 | 2021-05-20 | Pkvitality | Body monitoring system |
| CN114081455A (en) * | 2021-10-10 | 2022-02-25 | 湖南云医链生物科技有限公司 | Traditional chinese medical science pulse-taking intelligence health management wrist-watch |
| CN114209976A (en) * | 2021-12-17 | 2022-03-22 | 北京理工大学 | Soluble micro-needle photodynamic therapy device |
| CN114376569A (en) * | 2022-01-19 | 2022-04-22 | 浙江大学 | Glucagon-carrying wearable device for treating hypoglycemia |
| EP4154814A1 (en) * | 2018-08-03 | 2023-03-29 | PKvitality | Body monitoring system |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2620957A (en) * | 2022-07-27 | 2024-01-31 | Shae Warwick Emily | A wearable transdermal-drug-delivery-device housing assembly |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5135479A (en) * | 1983-08-18 | 1992-08-04 | Drug Delivery Systems, Inc. | Programmable control and mounting system for transdermal drug applicator |
| CN105342599A (en) * | 2015-11-27 | 2016-02-24 | 杭州正负极工业设计有限公司 | Medical wristband |
| CN106860956A (en) * | 2017-03-17 | 2017-06-20 | 苏州艾伊帕微动力科技有限公司 | Portable Automatic monitoring/the doser of chronic disease that a kind of flexible Micropump drives |
| CN106943134A (en) * | 2017-03-15 | 2017-07-14 | 陶军 | A kind of wearable blood pressure regulation device |
| US20170304557A1 (en) * | 2016-04-21 | 2017-10-26 | Mayo Foundation For Medical Education And Research | Vaccination delivery system and method |
| CN107349518A (en) * | 2017-06-22 | 2017-11-17 | 浙江理工大学 | A kind of near infrared light sensitivity microneedle patch and preparation method thereof |
| CN206715039U (en) * | 2016-06-29 | 2017-12-08 | 莆田学院 | A kind of intelligent drug delivery device based on micropin |
-
2017
- 2017-12-29 CN CN201711474319.8A patent/CN108310615B/en active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5135479A (en) * | 1983-08-18 | 1992-08-04 | Drug Delivery Systems, Inc. | Programmable control and mounting system for transdermal drug applicator |
| CN105342599A (en) * | 2015-11-27 | 2016-02-24 | 杭州正负极工业设计有限公司 | Medical wristband |
| US20170304557A1 (en) * | 2016-04-21 | 2017-10-26 | Mayo Foundation For Medical Education And Research | Vaccination delivery system and method |
| CN206715039U (en) * | 2016-06-29 | 2017-12-08 | 莆田学院 | A kind of intelligent drug delivery device based on micropin |
| CN106943134A (en) * | 2017-03-15 | 2017-07-14 | 陶军 | A kind of wearable blood pressure regulation device |
| CN106860956A (en) * | 2017-03-17 | 2017-06-20 | 苏州艾伊帕微动力科技有限公司 | Portable Automatic monitoring/the doser of chronic disease that a kind of flexible Micropump drives |
| CN107349518A (en) * | 2017-06-22 | 2017-11-17 | 浙江理工大学 | A kind of near infrared light sensitivity microneedle patch and preparation method thereof |
Cited By (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3603508A1 (en) * | 2018-08-03 | 2020-02-05 | PKvitality | Multi-position capsule |
| EP3603489A1 (en) * | 2018-08-03 | 2020-02-05 | PKvitality | Body monitoring system with removable connection |
| WO2020025821A1 (en) * | 2018-08-03 | 2020-02-06 | Pkvitality | Body-monitoring system with separable link |
| WO2020025820A1 (en) * | 2018-08-03 | 2020-02-06 | Pkvitality | Multi-position capsule |
| US11998325B2 (en) | 2018-08-03 | 2024-06-04 | Pkvitality | Body-monitoring system with separable link |
| EP4154814A1 (en) * | 2018-08-03 | 2023-03-29 | PKvitality | Body monitoring system |
| FR3097768A1 (en) * | 2019-06-28 | 2021-01-01 | Commissariat à l'Energie Atomique et aux Energies Alternatives | Patch-type device to be applied to the skin of a living being |
| CN110584633A (en) * | 2019-09-06 | 2019-12-20 | 湘南学院附属医院 | Hypertension real-time diagnosis and treatment integrated system capable of controlling drug release |
| WO2021094699A1 (en) * | 2019-11-15 | 2021-05-20 | Pkvitality | Body monitoring system |
| FR3103099A1 (en) * | 2019-11-15 | 2021-05-21 | Pkvitality | BODY SURVEILLANCE SYSTEM |
| CN112617749A (en) * | 2019-11-19 | 2021-04-09 | 奇异平台股份有限公司 | Physiological and biochemical monitoring device |
| CN112617749B (en) * | 2019-11-19 | 2024-06-07 | 奇异平台股份有限公司 | Physiology and biochemistry monitoring device |
| CN111956948A (en) * | 2020-01-16 | 2020-11-20 | 广州医科大学 | Wearable remote control thermal response microneedle array patch and preparation method thereof |
| CN114081455A (en) * | 2021-10-10 | 2022-02-25 | 湖南云医链生物科技有限公司 | Traditional chinese medical science pulse-taking intelligence health management wrist-watch |
| CN114209976A (en) * | 2021-12-17 | 2022-03-22 | 北京理工大学 | Soluble micro-needle photodynamic therapy device |
| CN114376569A (en) * | 2022-01-19 | 2022-04-22 | 浙江大学 | Glucagon-carrying wearable device for treating hypoglycemia |
| CN114376569B (en) * | 2022-01-19 | 2023-10-13 | 浙江大学 | Glucagon-carrying wearable device for treating hypoglycemia |
Also Published As
| Publication number | Publication date |
|---|---|
| CN108310615B (en) | 2021-06-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN108310615A (en) | A kind of microneedle cutaneous device of photoinduction | |
| CN103702697B (en) | Promote the devices, systems and methods of medicine delivery and its management based on syringe | |
| CN207898735U (en) | Medicine delivery device | |
| KR20220132615A (en) | Redundant Staggered Glucose Sensor Disease Management System | |
| ES2807895T3 (en) | Wireless communication for medical devices on the body | |
| US6875195B2 (en) | Portable automatic insulin syringe device with blood sugar measuring function | |
| CN205626630U (en) | Portable injection device of intelligence insulin based on cloud calculates | |
| CN106860956B (en) | Portable automatic chronic disease monitoring/drug delivery device driven by flexible micropump | |
| JP6549615B2 (en) | Infusion pump with program key | |
| CN104784777A (en) | Ductless medicine fluid infusion device | |
| MX2012002762A (en) | Adhesive skin patch with pump for subcutaneous drug delivery. | |
| CN104622480A (en) | Single-needle integrated artificial pancreas | |
| EP0980688B1 (en) | Automatic insulin syringe device with doctor mode | |
| CN108989469A (en) | Medical care intelligent flexible based on NB-IOT communication shows bracelet and application method | |
| CN204050542U (en) | Injection of insulin alarm set | |
| CN109276778A (en) | A kind of multi-user's dynamic glucose and insulin pump monitor system | |
| CN204319415U (en) | The two merit treating diabetes pump of portable intelligent | |
| CN208229177U (en) | A kind of injection of insulin pump pressure monitoring device | |
| CN205339754U (en) | Novel insulin injection device | |
| CN205626617U (en) | Attached pump control system device of insulin | |
| CN106362238A (en) | Novel cloud intelligent insulin pump system | |
| CN206867472U (en) | A kind of novel insulin pump with external catheter needle monitoring function | |
| CN207912981U (en) | A kind of diabetes injection device and its fixing device | |
| KR101571782B1 (en) | Vein insertion type artificial port assisted pancreas | |
| CN210698400U (en) | Venous transfusion device capable of being used in dark environment |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |