CN116600642A - 用于施加到皮肤上的消毒的、皮肤耐受的、护理且保湿的制剂 - Google Patents
用于施加到皮肤上的消毒的、皮肤耐受的、护理且保湿的制剂 Download PDFInfo
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- CN116600642A CN116600642A CN202180059377.2A CN202180059377A CN116600642A CN 116600642 A CN116600642 A CN 116600642A CN 202180059377 A CN202180059377 A CN 202180059377A CN 116600642 A CN116600642 A CN 116600642A
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Abstract
本发明涉及一种含有一种或多种消毒性活性物质的用于施加到皮肤上或处理皮肤的消毒的、皮肤耐受的、护理且保湿的制剂。根据本发明，将水溶性氯衍生物和/或醇掺入基础基质中并且还含有用于掩盖所述消毒材料的气味的物质混合物。
Description
本发明涉及一种包含一种或多种消毒性活性物质的用于施加到皮肤上的和用于处理皮肤的消毒的、皮肤耐受的、护理且保湿(rückfettendes)的制剂，基于这种制剂的洗剂以及具有根据独立权利要求所教导的消毒剂和消毒剂相关洗剂的分配器、罐、管或包装。
可以施加到皮肤上并且通过施加到皮肤上导致消毒、减少细菌的效果的产品是已知的。已知的制剂基于活性物质异丙醇、乙醇或其他醇类。
除了液体产品之外，凝胶是已知的，其中酒精被增稠。
为了在此产生足够的消毒效果，酒精的浓度必须至少为70％。这种浓度很容易用凝胶实现。就这种浓度而言，无法制造乳霜或洗剂。
因此，至今已知的用于消毒的含有酒精的洗剂在医学意义上以及从卫生学的角度来看是不够的，并且它们的有效性是有限的。如前所述，为了产生足够的消毒效果，酒精的浓度必须至少为70体积％。如果有必要在这种高酒精含量的情况下添加油润性成分，从DE10 2006 043 245 A1中已知含氯胺的伤口处理剂。
在那里，通过喷洒氯胺-T溶液获得含10％氯胺的伤口敷料。与物理加载的沸石组分和液体可通透的覆盖材料一起，所提出的系统主要适用于流血伤口，同时通过氯胺水溶液进行护理消毒。
关于用于皮肤护理和抗微生物处理的制剂，EP 1 955 591 A1提到苯扎氯铵作为乳霜基质中的消毒剂和抗微生物皮肤处理剂。这种乳霜中唯一的药物活性物质是所述苯扎氯铵。在与之相关的软膏的情况下，使用粘性至固体石蜡、羊毛蜡和/或白凡士林作为基材。根据EP 1 955 591 A1的制剂还应该适用于皮肤护理消毒，特别是对于医生或医务人员是适用的。
综上所述，本发明的任务是提供一种进一步开发的、消毒的、皮肤耐受的、护理且保湿的制剂，特别是洗剂，用于施加到皮肤上，其除了具有良好的皮肤耐受性和护理以及油润性效果，还有明显足够的消毒效果，因此它主要不是用于伤口消毒，而是用于日用的手部消毒并由此打破可能的感染链。
从医学的角度来看，乳霜或洗液是一种使其内容物可施用的水包油乳液或油包水乳液。乳霜的粘度低于软膏，即液体较多，并且容易被皮肤吸收。乳化剂或乳化稳定剂常用于乳霜中。用通俗的说法，洗剂也被描述为非医用、纯护理的产品。
根据所描述的任务，这是通过根据权利要求1的特征组合的用于施加到皮肤上或用于处理皮肤的消毒的、皮肤耐受的、护理且保湿的制剂，根据权利要求4的洗剂或根据权利要求8所述的分配器、罐、管或包装解决的。
与已知的解决方案不同，根据本发明的制剂除了酒精之外还使用氯衍生物作为消毒性活性物质。当作为消毒剂施加到皮肤上时，推荐并适合具有适当浓度的此类活性物质。
在根据本发明的配方中所使用的氯衍生物易溶于水并且可以以推荐的浓度很好地掺入到洗剂中。
用根据本发明的洗剂对志愿者进行的测试证明了杀菌效果，同时具有良好的皮肤耐受性。
因此，所述消毒的、皮肤耐受的、护理制剂基于一种或多种水溶性氯衍生物、醇或作为消毒性活性物质提及的组分的混合物。
所述一种或多种消毒材料被掺入到基础基质中。
此外，洗剂含有用于掩盖消毒材料气味的物质混合物，否则这些气味是可以通过气味感知的。
所述制剂具有至少一种香料或香料混合物或用于粘度调节的增稠剂。
在本发明的进一步发展中，可以将规定量的功能性活性物质添加到所述给定的配制剂中。在此可以例如是乳化剂、护理性D-泛醇、一种用于保湿或防止有害辐射(尤其是紫外线辐射)的活性物质。
基于所说明的制剂的本发明的洗剂的特征在于所用的氯衍生物(特别是氯胺-T)的量，基本上最多5重量％，优选并且特别是最多2重量％。
基础基质至少含有甘油酯、凡士林和硬脂酸酯。
就消毒性成分而言，即氯衍生物，如前所述优选为氯胺-T、次氯酸钠或类似物质。
根据本发明，还有一种分配器、罐、管或类似包装，其具有所提出的制剂或用于不同应用的相应洗剂，特别是用于施加到人皮肤上的应用。
下面将使用示例性实施例更详细地解释本发明。
所使用的基础基质结合了护肤所需的所有内容物，并且确保洗剂的油润的和同时护理的效果。
所述消毒性活性物质尤其是基于水溶性氯衍生物，它们是公认的消毒剂并符合官方要求。
用于掩盖气味的物质混合物是经皮肤病学认可的组分的混合物，目的是遮盖消毒性活性物质释放的气味。
可使用的香料赋予洗剂令人愉悦的气味。在此可以是精油或其他香料或由它们制成的混合物。
就功能性活性物质而言可以例如使用尿素，以达到额外的保湿效果。同样，也可以使用吸收紫外线辐射的制剂。
可商购的产品特别是可用于基础基质。
这种基础基质包括以下示例性内容物：
单硬脂酸甘油酯60、鲸蜡醇、中链甘油三酯、白凡士林、聚乙二醇-20-单硬脂酸甘油酯、丙二醇和纯净水。
消毒性活性物质使用如乙醇或异丙醇等醇类和/或例如氯胺-T或次氯酸钠等氯衍生物。特别是对于氯胺-T，在乳霜中的浓度为2重量％。在此涉及无顾虑的上限，在该上限时可以证明具有足够的消毒效果。
聚丙烯酸酯、纤维素衍生物、聚乙烯吡咯烷酮或这些化合物的共聚物用作增稠剂。
掩盖气味的物质混合物可采用商购可得的产品。
以下组成是示例性的：
内容物混合物A：
2,6-二甲基辛-7-烯-2-醇，3,7-二甲基辛烷-3-醇，l-(1,2,3,4,5,6,7,8-八氢-2,3,8,8-四甲基-2-萘基)乙烷-l-酮,苯戊醇,bmethyl-,异戊基水杨酸酯,3-(p-乙基苯基)-2,2-二甲基丙醛,3,7-二甲基辛烷-3-基乙酸酯,苯丙醇,.beta.,.beta.,3-三甲基-,2-苯乙醇,茴香醛,(E)-4-(2,6,6-三甲基-环己烯-1-基)-3丁烯-2-酮,氧杂环十六碳烯-2-酮,胡椒醛,l,4-二氧杂环十七烷-5,17-二酮,十五烷-15-内酯,乙酸己酯,3-(o-乙基苯基)-2,2-二甲基丙醛,l-甲基-4-(4甲基戊基)环己3-烯-l-甲醛1；
内容物混合物B：
水杨酸己酯，3,7-二甲基辛-3-醇，l-(l,2,3,4,5,6,7,8-八氢-2,3,8,8-四甲基-2萘基)乙烷-l-酮,2H-吡喃-4-醇,四氢-4-甲基-2(2-甲基丙基)-,苯戊醇,bmethyl-,苯丙醇,.beta.,.beta.,3-三甲基-,十五烷-15-内酯,2,6-二甲基辛-7-烯-2醇,α-甲基-1,3-苯并二唑-5-丙醛,4-(4-甲基-3戊基)环己-3烯-1-甲醛,(E)-茴香脑,2-乙基-4-(2,2,3三甲基-3-环戊烯基)-2-丁烯-1-醇,1,2,3,5,6,7-六氢-1,1,2,3,3-五甲基-4H-茚-4-酮,3-(p-乙基苯基)-2,2二甲基丙醛,木庚醇,胡椒醛,氧杂环十六碳烯-2-酮,4-甲基-3-癸-5-醇,3-(o-乙基苯基)-2,2二甲基丙醛,烯丙基环己基氧基)乙酸酯,2,4-二羟基-3,6-二甲基苯甲酸甲酯,2,6-二甲基庚-5-烯醛,八氢-7-甲基-1,4-甲萘-6(2H)-二酮,甲基碳酸顺-己-3-烯-1-基酯
精油如玫瑰油、薰衣草油等或这些精油的混合物用作香料。
提到的功能性活性物质不必是所述水剂的成分，但它们可以提高其效果并确保进一步的应用。
作为抗紫外线防护剂可掺入二氧化钛到所述水剂中，以保证相应的防晒系数。
作为消毒的、皮肤耐受的和护理的制剂，即售型水剂至少包括基础基质和消毒性活性物质。
通过添加用于掩盖气味的物质混合物，所述应用更容易被接受，因为所述消毒性活性物质所使用的一种或多种氯衍生物的令人不快的氯气味被包裹起来。
根据本发明的洗剂在制备和制造后进行填充。可以在合适的分配器、罐、管或类似包装中进行填充。
通过施加到皮肤上和轻轻揉搓应用水剂，由此同时发挥消毒和护理作用。
所提供的洗剂可以单独使用，也可以用于后续的皮肤护理。
具有高酒精含量的已知凝胶在添加油润性或保湿成分时会出现问题，因为存在絮凝的风险。其根据本发明经此避免，即，添加增稠剂，优选聚丙烯酸酯的聚合物和交联聚合物。已证明有利的是，在搅拌组分时遵守顺序。
本发明的另一个设想是提供添加到洗剂中的胶囊化活性物质。这导致胶囊漂浮在水剂中。当施加到皮肤上时，胶囊被破坏并释放胶囊中的活性物质。通过封装方法和形成更小的小球意味着也可以以有针对性和剂量的方式添加不会被水剂容纳的活性物质。
Claims (8)
1.具有一种或多种消毒性活性物质，用于施加到皮肤上或用于处理皮肤的消毒的、皮肤耐受的、护理且保湿的制剂，
其特征在于，
将水溶性氯衍生物和/或醇掺入基础基质中，并另外包含用于掩盖消毒材料的气味的物质混合物。
2.根据权利要求1所述的消毒的、皮肤耐受的、护理制剂，其特征在于，
这包含至少一种香料或香料混合物。
3.根据权利要求1或2所述的消毒的、皮肤耐受的、护理制剂，
其特征在于，
它在预定的配方中具有功能性活性物质，例如用于润湿或防止有害辐射。
4.基于根据权利要求1至3中任一项的制剂的洗剂，其特征在于，
氯衍生物的量基本上至多5重量％，特别是至多2重量％。
5.基于根据权利要求1至3中任一项的制剂的洗剂，其特征在于，
所述基础基质至少含有甘油酯、凡士林和硬脂酸酯。
6.根据前述权利要求中任一项所述的制剂或洗剂，其特征在于，
含有氯胺-T、次氯酸钠或类似的氯衍生物作为消毒成分。
7.根据前述权利要求中任一项的制剂或洗剂，其特征在于，
就所述消毒性活性物质而言，以至少为70体积％的浓度包含酒精。
8.具有根据前述权利要求中的一项或多项所述的制剂或洗剂的分配器、罐、管或包装。
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| PCT/EP2021/069011 WO2022017816A1 (de) | 2020-07-24 | 2021-07-08 | Desinfizierendes, hautverträgliches, pflegendes und rückfettendes mittel zum auftragen auf die haut |
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