CN116585492A - 用于治疗肌纤蛋白(myoc)青光眼的腺伴随病毒载体 - Google Patents

用于治疗肌纤蛋白(myoc)青光眼的腺伴随病毒载体 Download PDF

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Publication number
CN116585492A
CN116585492A CN202211533202.3A CN202211533202A CN116585492A CN 116585492 A CN116585492 A CN 116585492A CN 202211533202 A CN202211533202 A CN 202211533202A CN 116585492 A CN116585492 A CN 116585492A
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Prior art keywords
myoc
aav
mammal
raav
eye
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Pending
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CN202211533202.3A
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English (en)
Chinese (zh)
Inventor
P·佩汉
A·斯卡利亚
J·阿丁格
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Genzyme Corp
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Genzyme Corp
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Priority claimed from PCT/US2015/050515 external-priority patent/WO2016044478A1/en
Publication of CN116585492A publication Critical patent/CN116585492A/zh
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    • A61K48/0058—Nucleic acids adapted for tissue specific expression, e.g. having tissue specific promoters as part of a contruct
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CN202211533202.3A 2014-09-16 2015-09-16 用于治疗肌纤蛋白(myoc)青光眼的腺伴随病毒载体 Pending CN116585492A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201462051299P 2014-09-16 2014-09-16
US62/051,299 2014-09-16
PCT/US2015/050515 WO2016044478A1 (en) 2014-09-16 2015-09-16 Adeno-associated viral vectors for treating myocilin (myoc) glaucoma
CN201580061882.5A CN107001436B (zh) 2014-09-16 2015-09-16 用于治疗肌纤蛋白(myoc)青光眼的腺伴随病毒载体

Related Parent Applications (1)

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CN201580061882.5A Division CN107001436B (zh) 2014-09-16 2015-09-16 用于治疗肌纤蛋白(myoc)青光眼的腺伴随病毒载体

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CN116585492A true CN116585492A (zh) 2023-08-15

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CN201580061882.5A Active CN107001436B (zh) 2014-09-16 2015-09-16 用于治疗肌纤蛋白(myoc)青光眼的腺伴随病毒载体
CN202211533202.3A Pending CN116585492A (zh) 2014-09-16 2015-09-16 用于治疗肌纤蛋白(myoc)青光眼的腺伴随病毒载体

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CN201580061882.5A Active CN107001436B (zh) 2014-09-16 2015-09-16 用于治疗肌纤蛋白(myoc)青光眼的腺伴随病毒载体

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US (1) US10821193B2 (https=)
EP (1) EP3194601B1 (https=)
JP (2) JP6673923B2 (https=)
KR (3) KR102612871B1 (https=)
CN (2) CN107001436B (https=)
AU (2) AU2015317756B2 (https=)
BR (1) BR112017005235B1 (https=)
CA (2) CA3280614A1 (https=)
IL (1) IL251178B (https=)
MX (2) MX2017003426A (https=)
RU (2) RU2718047C2 (https=)
SG (3) SG11201702055PA (https=)
ZA (1) ZA201701881B (https=)

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SG11201702055PA (en) 2014-09-16 2017-04-27 Genzyme Corp Adeno-associated viral vectors for treating myocilin (myoc) glaucoma
WO2019155833A1 (ja) * 2018-02-07 2019-08-15 学校法人日本医科大学 改良型アデノ随伴ウイルスベクター
WO2019165241A1 (en) * 2018-02-22 2019-08-29 University Of South Florida Grp94 inhibitors to treat steroid-induced ocular hypertensions and glaucomas
US20220047618A1 (en) 2019-02-28 2022-02-17 Regeneron Pharmaceuticals, Inc. Adeno-associated virus vectors for the delivery of therapeutics
KR20230117177A (ko) * 2020-12-03 2023-08-07 유니버시티 오브 매사추세츠 진행성 골화성 섬유이형성증을 위한 신규 유전자 치료제의개발
CN113032010B (zh) * 2021-03-12 2022-09-20 歌尔科技有限公司 命令的传输控制方法、终端及计算机可读存储介质
WO2023278406A1 (en) * 2021-06-28 2023-01-05 Alnylam Pharmaceuticals, Inc. Compositions and methods for silencing myoc expression
KR20240117571A (ko) 2021-12-08 2024-08-01 리제너론 파마슈티칼스 인코포레이티드 돌연변이 마이오실린 질환 모델 및 이의 용도
US20250087355A1 (en) * 2021-12-16 2025-03-13 Peter Koulen A machine learning based framework using electroretinography for detecting early stage glaucoma
CN117343152B (zh) * 2023-04-18 2024-06-04 上海本导基因技术有限公司 一种用于治疗青光眼疾病的慢病毒样颗粒
CN118546217B (zh) * 2024-07-25 2024-10-29 广州译码基因科技有限公司 靶向小梁网、角膜缘及rpe的aav衣壳蛋白及其应用
CN121449764A (zh) * 2026-01-07 2026-02-03 山东伯桢生物科技有限公司 抑制Wnt信号通路的融合蛋白及其应用

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GB0403600D0 (en) * 2004-02-18 2004-03-24 Trinity College Dublin Methods and reagents for treating disease
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JP6673923B2 (ja) 2020-03-25
ZA201701881B (en) 2023-09-27
KR20260019013A (ko) 2026-02-09
AU2022202413A1 (en) 2022-05-05
KR20230172610A (ko) 2023-12-22
SG10201913430VA (en) 2020-03-30
MX2017003426A (es) 2017-07-28
JP2020105194A (ja) 2020-07-09
EP3194601B1 (en) 2021-10-27
RU2718047C2 (ru) 2020-03-30
US10821193B2 (en) 2020-11-03
IL251178B (en) 2022-07-01
RU2746991C2 (ru) 2021-04-23
EP3194601A1 (en) 2017-07-26
CA2961523A1 (en) 2016-03-24
AU2015317756B2 (en) 2022-01-13
CN107001436B (zh) 2023-01-06
SG10201902285SA (en) 2019-04-29
BR112017005235A2 (pt) 2017-12-12
KR102916865B1 (ko) 2026-01-23
IL251178A0 (en) 2017-05-29
RU2020111038A (ru) 2020-04-29
JP2017529395A (ja) 2017-10-05
RU2017112972A3 (https=) 2019-04-16
CA2961523C (en) 2026-01-13
JP7097398B2 (ja) 2022-07-07
US20170304465A1 (en) 2017-10-26
RU2017112972A (ru) 2018-10-17
CN107001436A (zh) 2017-08-01
MX2023005998A (es) 2023-06-08
RU2020111038A3 (https=) 2020-10-15
SG11201702055PA (en) 2017-04-27
AU2015317756A1 (en) 2017-04-13
BR112017005235B1 (pt) 2023-10-31
KR102612871B1 (ko) 2023-12-13
CA3280614A1 (en) 2026-03-02
KR20170054493A (ko) 2017-05-17

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