CN116568179A - 面膜组合物和方法 - Google Patents
面膜组合物和方法 Download PDFInfo
- Publication number
- CN116568179A CN116568179A CN202080107573.8A CN202080107573A CN116568179A CN 116568179 A CN116568179 A CN 116568179A CN 202080107573 A CN202080107573 A CN 202080107573A CN 116568179 A CN116568179 A CN 116568179A
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- China
- Prior art keywords
- mask
- hydrogel
- layer
- skin
- gum
- Prior art date
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/737—Galactomannans, e.g. guar; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/48—Thickener, Thickening system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/95—Involves in-situ formation or cross-linking of polymers
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (1)
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PCT/CN2020/132880 WO2022110183A1 (fr) | 2020-11-30 | 2020-11-30 | Composition de masque et procédé |
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CN116568179A true CN116568179A (zh) | 2023-08-08 |
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CN202080107573.8A Pending CN116568179A (zh) | 2020-11-30 | 2020-11-30 | 面膜组合物和方法 |
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CN (1) | CN116568179A (fr) |
FR (1) | FR3116725B1 (fr) |
WO (1) | WO2022110183A1 (fr) |
Families Citing this family (4)
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US20220354753A1 (en) * | 2021-05-10 | 2022-11-10 | Alps South, LLC | Hydrogel-Fabric Composite For Cosmetic Applications |
WO2023212908A1 (fr) * | 2022-05-06 | 2023-11-09 | L'oreal | Composition de soin pour matériaux kératiniques et masque la contenant |
WO2024034324A1 (fr) * | 2022-08-08 | 2024-02-15 | L'oreal | Produit cosmétique de type feuille |
FR3140539A1 (fr) * | 2022-10-10 | 2024-04-12 | L'oreal | Produit cosmétique de type feuille |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2017034115A1 (fr) * | 2015-08-25 | 2017-03-02 | 충남대학교 산학협력단 | Hydrogel comprenant des zestes de mandarine ou d'orange raffinés à l'état humide, feuille de stratification associée et son procédé de préparation |
KR20170022757A (ko) * | 2015-08-21 | 2017-03-02 | (주)진코스텍 | 하이드로겔화 알지네이트 부직포 마스크팩 |
KR20180065849A (ko) * | 2016-12-08 | 2018-06-18 | 손주연 | 이중 베이스를 포함하는 마스크팩 및 그 제조 방법 |
WO2019059696A1 (fr) * | 2017-09-21 | 2019-03-28 | (주)아모레퍼시픽 | Masque en feuille de biocellulose multicouche revêtu d'hydrogel et son procédé de fabrication |
CN110787067A (zh) * | 2019-11-11 | 2020-02-14 | 青岛大学 | 一种不含防腐剂和增稠剂的深度补水面膜及其制备方法 |
CN111437221A (zh) * | 2019-01-16 | 2020-07-24 | 北京大学 | 一种祛螨虫的自由基水凝胶面膜 |
CN111658574A (zh) * | 2020-06-12 | 2020-09-15 | 青岛大学 | 一种含活性精华的干片式面膜及其制备方法 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002062312A1 (fr) * | 2001-02-08 | 2002-08-15 | The Procter & Gamble Company | Composition pour masque |
US20060104931A1 (en) * | 2004-11-12 | 2006-05-18 | Takeshi Fukutome | Cosmetic treatment article comprising substrate and gel composition |
JP5528022B2 (ja) * | 2009-07-13 | 2014-06-25 | ユニ・チャーム株式会社 | 吸収体及び吸収性物品 |
CN203885878U (zh) * | 2014-01-22 | 2014-10-22 | 珠海国佳新材股份有限公司 | 一种具有海藻酸复合凝胶纤维材料层的面膜 |
FR3060384B1 (fr) * | 2016-12-21 | 2018-12-07 | L'oreal | Composition sous forme d’une emulsion directe comprenant une resine siliconee, une huile siliconee non volatile et procede la mettant en oeuvre |
FR3067027B1 (fr) * | 2017-05-31 | 2019-06-21 | L'oreal | Derives de resorcinol pour leur utilisation cosmetique |
WO2019047954A1 (fr) * | 2017-09-08 | 2019-03-14 | L'oreal | Kit de soin de la peau |
IT201800007851A1 (it) * | 2018-08-03 | 2020-02-03 | Karys-Due Srl | Kit cosmetico multifunzionale |
CN209220694U (zh) * | 2018-08-29 | 2019-08-09 | 南京日光生物科技有限公司 | 一种透气性好的眼贴 |
PL238270B1 (pl) * | 2019-03-21 | 2021-08-02 | Artur Cyrych | Maseczka kosmetyczna |
CN110251450A (zh) * | 2019-07-12 | 2019-09-20 | 梁修剑 | 一种蒸汽冻干面膜 |
CN210673805U (zh) * | 2019-08-01 | 2020-06-05 | 厦门华博恒信信息科技股份有限公司 | 一种新型抗菌面膜 |
CN210991937U (zh) * | 2019-10-09 | 2020-07-14 | 上海科颜生物科技有限公司 | 一种海藻凝胶面膜 |
-
2020
- 2020-11-30 WO PCT/CN2020/132880 patent/WO2022110183A1/fr active Application Filing
- 2020-11-30 CN CN202080107573.8A patent/CN116568179A/zh active Pending
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2021
- 2021-02-12 FR FR2101348A patent/FR3116725B1/fr active Active
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20170022757A (ko) * | 2015-08-21 | 2017-03-02 | (주)진코스텍 | 하이드로겔화 알지네이트 부직포 마스크팩 |
WO2017034115A1 (fr) * | 2015-08-25 | 2017-03-02 | 충남대학교 산학협력단 | Hydrogel comprenant des zestes de mandarine ou d'orange raffinés à l'état humide, feuille de stratification associée et son procédé de préparation |
KR20180065849A (ko) * | 2016-12-08 | 2018-06-18 | 손주연 | 이중 베이스를 포함하는 마스크팩 및 그 제조 방법 |
WO2019059696A1 (fr) * | 2017-09-21 | 2019-03-28 | (주)아모레퍼시픽 | Masque en feuille de biocellulose multicouche revêtu d'hydrogel et son procédé de fabrication |
CN111437221A (zh) * | 2019-01-16 | 2020-07-24 | 北京大学 | 一种祛螨虫的自由基水凝胶面膜 |
CN110787067A (zh) * | 2019-11-11 | 2020-02-14 | 青岛大学 | 一种不含防腐剂和增稠剂的深度补水面膜及其制备方法 |
CN111658574A (zh) * | 2020-06-12 | 2020-09-15 | 青岛大学 | 一种含活性精华的干片式面膜及其制备方法 |
Also Published As
Publication number | Publication date |
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WO2022110183A1 (fr) | 2022-06-02 |
FR3116725B1 (fr) | 2024-03-08 |
FR3116725A1 (fr) | 2022-06-03 |
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