CN116406373A - 工程改造的iPSC和持久性免疫效应细胞 - Google Patents

工程改造的iPSC和持久性免疫效应细胞 Download PDF

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CN116406373A
CN116406373A CN202180074553.XA CN202180074553A CN116406373A CN 116406373 A CN116406373 A CN 116406373A CN 202180074553 A CN202180074553 A CN 202180074553A CN 116406373 A CN116406373 A CN 116406373A
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cell
cells
car
receptor
domain
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B·瓦拉马尔
E·佩拉塔
张家伟
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Fate Therapeutics Inc
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Fate Therapeutics Inc
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CN202180074553.XA 2020-11-04 2021-11-04 工程改造的iPSC和持久性免疫效应细胞 Pending CN116406373A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063109828P 2020-11-04 2020-11-04
US63/109,828 2020-11-04
PCT/US2021/058118 WO2022098914A1 (en) 2020-11-04 2021-11-04 Engineered ipsc and persistent immune effector cells

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CN116406373A true CN116406373A (zh) 2023-07-07

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US (1) US20230390337A1 (https=)
EP (1) EP4240831A4 (https=)
JP (1) JP2023548467A (https=)
KR (1) KR20230098649A (https=)
CN (1) CN116406373A (https=)
AU (1) AU2021372975A1 (https=)
CA (1) CA3196545A1 (https=)
IL (1) IL302471A (https=)
MX (1) MX2023005029A (https=)
WO (1) WO2022098914A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN118909951A (zh) * 2024-07-05 2024-11-08 青岛华赛伯曼医学细胞生物有限公司 连续杀伤能力增强的工程化til细胞及其应用

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20250222029A1 (en) 2022-04-08 2025-07-10 Fate Therapeutics, Inc. Chimeric antigen receptor for tumor targeting
US20250228943A1 (en) 2022-04-08 2025-07-17 Fate Therapeutics, Inc. Cells having solid tumor targeting backbone and use thereof
EP4551692A1 (en) * 2022-07-01 2025-05-14 Fate Therapeutics, Inc. Enhancing effector cell durability and efficacy in adoptive cell therapies
AU2023315762A1 (en) * 2022-07-25 2025-01-30 Immunitybio, Inc. Treatment of mhc-i negative tumors with nk and t cells
WO2024097800A1 (en) * 2022-11-01 2024-05-10 Fate Therapeutics, Inc. Off-the-shelf therapeutic cells with multiplex genomic engineering for targeting kallikrein-2
WO2024097901A1 (en) * 2022-11-02 2024-05-10 Fate Therapeutics, Inc. Off-the-shelf therapeutic cells with multiplex genomic engineering for targeting cd79b
WO2025064822A2 (en) * 2023-09-20 2025-03-27 Factor Bioscience Inc. Cells and methods for engineering cells with persistent transgene expression
WO2026025087A1 (en) * 2024-07-26 2026-01-29 Dana-Farber Cancer Institute, Inc. Nucleic acids and engineered cells for treating cancer

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2861491C (en) * 2012-02-13 2020-08-25 Seattle Children's Hospital D/B/A Seattle Children's Research Institute Bispecific chimeric antigen receptors and therapeutic uses thereof
JP2021505131A (ja) * 2017-12-08 2021-02-18 フェイト セラピューティクス，インコーポレイテッド 増強されたｉＰＳＣ由来のエフェクター細胞を用いた免疫療法
EP3774866A1 (en) * 2018-04-13 2021-02-17 Ludwig Institute for Cancer Research Ltd Heterodimeric inactivatable chimeric antigen receptors
AU2019372673A1 (en) * 2018-11-01 2021-05-27 Gracell Biotechnologies (Shanghai) Co., Ltd. Compositions and methods for T cell engineering
MX2021006194A (es) * 2018-12-02 2021-06-30 Fate Therapeutics Inc Inmunoterapias mediante el uso de celulas efectoras potenciadas derivadas de ipsc.
KR20210139472A (ko) * 2019-04-11 2021-11-22 페이트 세러퓨틱스, 인코포레이티드 조작된 iPSC 및 면역 효과기 세포에서의 CD3 재구성

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN118909951A (zh) * 2024-07-05 2024-11-08 青岛华赛伯曼医学细胞生物有限公司 连续杀伤能力增强的工程化til细胞及其应用
CN118909951B (zh) * 2024-07-05 2025-05-13 青岛华赛伯曼医学细胞生物有限公司 连续杀伤能力增强的工程化til细胞及其应用
WO2026007776A1 (zh) * 2024-07-05 2026-01-08 青岛华赛伯曼医学细胞生物有限公司 连续杀伤能力增强的工程化til细胞及其应用

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US20230390337A1 (en) 2023-12-07
JP2023548467A (ja) 2023-11-17
AU2021372975A1 (en) 2023-06-15
WO2022098914A1 (en) 2022-05-12
IL302471A (en) 2023-06-01
MX2023005029A (es) 2023-05-16
EP4240831A4 (en) 2025-03-26
EP4240831A1 (en) 2023-09-13
KR20230098649A (ko) 2023-07-04
AU2021372975A9 (en) 2025-01-09

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