CN116396235B - 一种异噁唑啉类杀虫剂及其中间体的合成方法 - Google Patents
一种异噁唑啉类杀虫剂及其中间体的合成方法 Download PDFInfo
- Publication number
- CN116396235B CN116396235B CN202310109519.2A CN202310109519A CN116396235B CN 116396235 B CN116396235 B CN 116396235B CN 202310109519 A CN202310109519 A CN 202310109519A CN 116396235 B CN116396235 B CN 116396235B
- Authority
- CN
- China
- Prior art keywords
- isoxazoline
- reaction
- substituted
- synthesizing
- trifluoromethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- WEQPBCSPRXFQQS-UHFFFAOYSA-N 4,5-dihydro-1,2-oxazole Chemical compound C1CC=NO1 WEQPBCSPRXFQQS-UHFFFAOYSA-N 0.000 title claims abstract description 22
- 239000002917 insecticide Substances 0.000 title claims description 10
- 238000010189 synthetic method Methods 0.000 title description 2
- 238000006243 chemical reaction Methods 0.000 claims abstract description 23
- 238000000034 method Methods 0.000 claims abstract description 17
- 239000000575 pesticide Substances 0.000 claims abstract description 15
- 239000013335 mesoporous material Substances 0.000 claims abstract description 11
- 229910000314 transition metal oxide Inorganic materials 0.000 claims abstract description 11
- 239000002131 composite material Substances 0.000 claims abstract description 10
- 230000002194 synthesizing effect Effects 0.000 claims abstract description 10
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims description 16
- 238000006352 cycloaddition reaction Methods 0.000 claims description 15
- 230000001590 oxidative effect Effects 0.000 claims description 14
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims description 12
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 12
- 239000007800 oxidant agent Substances 0.000 claims description 12
- 229910000684 Cobalt-chrome Inorganic materials 0.000 claims description 11
- DKGAVHZHDRPRBM-UHFFFAOYSA-N Tert-Butanol Chemical compound CC(C)(C)O DKGAVHZHDRPRBM-UHFFFAOYSA-N 0.000 claims description 11
- 239000010952 cobalt-chrome Substances 0.000 claims description 11
- CIHOLLKRGTVIJN-UHFFFAOYSA-N tert‐butyl hydroperoxide Chemical compound CC(C)(C)OO CIHOLLKRGTVIJN-UHFFFAOYSA-N 0.000 claims description 11
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 8
- 125000001624 naphthyl group Chemical group 0.000 claims description 8
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 8
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 8
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 6
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims description 6
- -1 aryl aldoxime derivative Chemical class 0.000 claims description 6
- 229910052731 fluorine Inorganic materials 0.000 claims description 6
- 238000006142 intramolecular cycloaddition reaction Methods 0.000 claims description 6
- 229910016507 CuCo Inorganic materials 0.000 claims description 5
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 5
- 238000006555 catalytic reaction Methods 0.000 claims description 5
- 229910052739 hydrogen Inorganic materials 0.000 claims description 5
- 239000001257 hydrogen Substances 0.000 claims description 5
- 229910052760 oxygen Inorganic materials 0.000 claims description 5
- 239000001301 oxygen Substances 0.000 claims description 5
- 125000002541 furyl group Chemical group 0.000 claims description 4
- 229910052736 halogen Inorganic materials 0.000 claims description 4
- 150000002367 halogens Chemical class 0.000 claims description 4
- 150000002431 hydrogen Chemical class 0.000 claims description 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 4
- 239000002904 solvent Substances 0.000 claims description 4
- 125000001424 substituent group Chemical group 0.000 claims description 4
- 125000001544 thienyl group Chemical group 0.000 claims description 4
- JAPGNSOHYWVLTE-UHFFFAOYSA-N 5-ethenyl-5-(trifluoromethyl)cyclohexa-1,3-diene Chemical class FC(C1(C=C)CC=CC=C1)(F)F JAPGNSOHYWVLTE-UHFFFAOYSA-N 0.000 claims description 3
- 229910052804 chromium Inorganic materials 0.000 claims description 3
- 239000011651 chromium Substances 0.000 claims description 3
- 150000001875 compounds Chemical class 0.000 claims description 3
- 229910052751 metal Inorganic materials 0.000 claims description 3
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims description 3
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 claims description 2
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims description 2
- PWHULOQIROXLJO-UHFFFAOYSA-N Manganese Chemical compound [Mn] PWHULOQIROXLJO-UHFFFAOYSA-N 0.000 claims description 2
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 2
- 238000007259 addition reaction Methods 0.000 claims description 2
- 125000000217 alkyl group Chemical group 0.000 claims description 2
- 229910017052 cobalt Inorganic materials 0.000 claims description 2
- 239000010941 cobalt Substances 0.000 claims description 2
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 claims description 2
- 229910052802 copper Inorganic materials 0.000 claims description 2
- 239000010949 copper Substances 0.000 claims description 2
- 229910052748 manganese Inorganic materials 0.000 claims description 2
- 239000011572 manganese Substances 0.000 claims description 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 2
- 125000001160 methoxycarbonyl group Chemical group [H]C([H])([H])OC(*)=O 0.000 claims description 2
- 230000035484 reaction time Effects 0.000 claims description 2
- 239000011701 zinc Substances 0.000 claims description 2
- 229910052725 zinc Inorganic materials 0.000 claims description 2
- 239000003054 catalyst Substances 0.000 abstract description 26
- 239000002699 waste material Substances 0.000 abstract description 7
- 238000006736 Huisgen cycloaddition reaction Methods 0.000 abstract description 4
- 125000003971 isoxazolinyl group Chemical group 0.000 abstract description 4
- 238000000746 purification Methods 0.000 abstract description 4
- 238000004440 column chromatography Methods 0.000 abstract 1
- 238000004880 explosion Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 description 25
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 18
- 238000000967 suction filtration Methods 0.000 description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 13
- 239000002244 precipitate Substances 0.000 description 12
- 230000015572 biosynthetic process Effects 0.000 description 11
- 238000004811 liquid chromatography Methods 0.000 description 11
- 239000000047 product Substances 0.000 description 11
- 238000003786 synthesis reaction Methods 0.000 description 11
- 239000008367 deionised water Substances 0.000 description 9
- 229910021641 deionized water Inorganic materials 0.000 description 9
- 125000001153 fluoro group Chemical group F* 0.000 description 8
- 239000007791 liquid phase Substances 0.000 description 8
- 239000012452 mother liquor Substances 0.000 description 8
- 230000003647 oxidation Effects 0.000 description 7
- 238000007254 oxidation reaction Methods 0.000 description 7
- JRNVZBWKYDBUCA-UHFFFAOYSA-N N-chlorosuccinimide Chemical compound ClN1C(=O)CCC1=O JRNVZBWKYDBUCA-UHFFFAOYSA-N 0.000 description 6
- 238000001035 drying Methods 0.000 description 5
- FZENGILVLUJGJX-NSCUHMNNSA-N (E)-acetaldehyde oxime Chemical compound C\C=N\O FZENGILVLUJGJX-NSCUHMNNSA-N 0.000 description 4
- 239000003513 alkali Substances 0.000 description 4
- 238000001514 detection method Methods 0.000 description 4
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- PMXISSFCMNQFSM-UHFFFAOYSA-N n-[(4-bromo-3-methylphenyl)methylidene]hydroxylamine Chemical compound CC1=CC(C=NO)=CC=C1Br PMXISSFCMNQFSM-UHFFFAOYSA-N 0.000 description 4
- 239000000843 powder Substances 0.000 description 4
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 description 3
- 230000003197 catalytic effect Effects 0.000 description 3
- 238000006735 epoxidation reaction Methods 0.000 description 3
- 239000011737 fluorine Substances 0.000 description 3
- NLKNQRATVPKPDG-UHFFFAOYSA-M potassium iodide Chemical compound [K+].[I-] NLKNQRATVPKPDG-UHFFFAOYSA-M 0.000 description 3
- 238000001228 spectrum Methods 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- 239000000273 veterinary drug Substances 0.000 description 3
- OGNSCSPNOLGXSM-UHFFFAOYSA-N (+/-)-DABA Natural products NCCC(N)C(O)=O OGNSCSPNOLGXSM-UHFFFAOYSA-N 0.000 description 2
- QPLDLSVMHZLSFG-UHFFFAOYSA-N Copper oxide Chemical compound [Cu]=O QPLDLSVMHZLSFG-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 229910002651 NO3 Inorganic materials 0.000 description 2
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Natural products C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 229960003692 gamma aminobutyric acid Drugs 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 description 2
- 229910000041 hydrogen chloride Inorganic materials 0.000 description 2
- 238000001095 inductively coupled plasma mass spectrometry Methods 0.000 description 2
- 239000013067 intermediate product Substances 0.000 description 2
- 150000002547 isoxazolines Chemical class 0.000 description 2
- 230000000737 periodic effect Effects 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 125000003011 styrenyl group Chemical class [H]\C(*)=C(/[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 241000238421 Arthropoda Species 0.000 description 1
- 241000282465 Canis Species 0.000 description 1
- 108010062745 Chloride Channels Proteins 0.000 description 1
- 102000011045 Chloride Channels Human genes 0.000 description 1
- 208000029639 Ectoparasitic disease Diseases 0.000 description 1
- 241000282324 Felis Species 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- AVXURJPOCDRRFD-UHFFFAOYSA-N Hydroxylamine Chemical compound ON AVXURJPOCDRRFD-UHFFFAOYSA-N 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 208000030852 Parasitic disease Diseases 0.000 description 1
- 238000006202 Sharpless epoxidation reaction Methods 0.000 description 1
- 238000010958 [3+2] cycloaddition reaction Methods 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 125000004429 atom Chemical group 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 150000001555 benzenes Chemical class 0.000 description 1
- 238000001354 calcination Methods 0.000 description 1
- 238000005660 chlorination reaction Methods 0.000 description 1
- GVHCUJZTWMCYJM-UHFFFAOYSA-N chromium(3+);trinitrate;nonahydrate Chemical compound O.O.O.O.O.O.O.O.O.[Cr+3].[O-][N+]([O-])=O.[O-][N+]([O-])=O.[O-][N+]([O-])=O GVHCUJZTWMCYJM-UHFFFAOYSA-N 0.000 description 1
- QGUAJWGNOXCYJF-UHFFFAOYSA-N cobalt dinitrate hexahydrate Chemical compound O.O.O.O.O.O.[Co+2].[O-][N+]([O-])=O.[O-][N+]([O-])=O QGUAJWGNOXCYJF-UHFFFAOYSA-N 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000007033 dehydrochlorination reaction Methods 0.000 description 1
- 238000006356 dehydrogenation reaction Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- DFBKLUNHFCTMDC-PICURKEMSA-N dieldrin Chemical compound C([C@H]1[C@H]2[C@@]3(Cl)C(Cl)=C([C@]([C@H]22)(Cl)C3(Cl)Cl)Cl)[C@H]2[C@@H]2[C@H]1O2 DFBKLUNHFCTMDC-PICURKEMSA-N 0.000 description 1
- 229950006824 dieldrin Drugs 0.000 description 1
- NGPMUTDCEIKKFM-UHFFFAOYSA-N dieldrin Natural products CC1=C(Cl)C2(Cl)C3C4CC(C5OC45)C3C1(Cl)C2(Cl)Cl NGPMUTDCEIKKFM-UHFFFAOYSA-N 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- MLBZKOGAMRTSKP-UHFFFAOYSA-N fluralaner Chemical compound C1=C(C(=O)NCC(=O)NCC(F)(F)F)C(C)=CC(C=2CC(ON=2)(C=2C=C(Cl)C=C(Cl)C=2)C(F)(F)F)=C1 MLBZKOGAMRTSKP-UHFFFAOYSA-N 0.000 description 1
- 229960004498 fluralaner Drugs 0.000 description 1
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 description 1
- JLYXXMFPNIAWKQ-GNIYUCBRSA-N gamma-hexachlorocyclohexane Chemical compound Cl[C@H]1[C@H](Cl)[C@@H](Cl)[C@@H](Cl)[C@H](Cl)[C@H]1Cl JLYXXMFPNIAWKQ-GNIYUCBRSA-N 0.000 description 1
- JLYXXMFPNIAWKQ-UHFFFAOYSA-N gamma-hexachlorocyclohexane Natural products ClC1C(Cl)C(Cl)C(Cl)C(Cl)C1Cl JLYXXMFPNIAWKQ-UHFFFAOYSA-N 0.000 description 1
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 230000000749 insecticidal effect Effects 0.000 description 1
- 238000011031 large-scale manufacturing process Methods 0.000 description 1
- 229960002809 lindane Drugs 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 229910001960 metal nitrate Inorganic materials 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 210000002569 neuron Anatomy 0.000 description 1
- 238000000655 nuclear magnetic resonance spectrum Methods 0.000 description 1
- 238000005580 one pot reaction Methods 0.000 description 1
- 150000002978 peroxides Chemical class 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 238000001308 synthesis method Methods 0.000 description 1
- 125000005424 tosyloxy group Chemical group S(=O)(=O)(C1=CC=C(C)C=C1)O* 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/04—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/584—Recycling of catalysts
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
本发明公开了一种异噁唑啉类杀虫剂或其中间体的合成方法,本发明采用介孔材料负载的复合过渡金属氧化物反应催化氧化1,3‑偶极环加成反应合成异噁唑啉环,合成路线缩短,且适合工业化规模生产,规避了原文献工艺的三废排放、氧化物不稳定易爆炸、产品需要柱层析分离纯化等问题。反应条件温和,催化剂相对的使用量极低,且可以多次循环套用。
Description
技术领域
本发明涉及化工领域,具体的说,涉及一种异噁唑啉类杀虫剂及其中间体的合成方法。
背景技术
异噁唑啉类杀虫剂是一类γ-氨基丁酸(GABA)门控氯离子通道的阻滞剂,对哺乳动物神经元和节肢动物神经元具有显著的选择性。类似的杀虫剂如林丹和狄氏剂已在世界范围内被禁用,相对而言,异噁唑啉类新型杀虫剂具有对哺乳动物安全、杀虫活性较高等特性。近年来,该药已被应用于犬、猫体外寄生虫病临床治疗。目前已上市的此类杀虫剂包括氟雷拉纳、阿福拉纳、沙罗拉纳以及洛替拉纳等。
异噁唑啉环作为此类杀虫剂的核心母核,一般通过1,3-偶极环加成反应构建,包括分子间和分子内的环加成方法,参见《中国兽药杂志》2020,54(11):72-78的相关文献综述及参考文献。环加成的工艺一般包括:醛和羟胺缩合成醛肟,醛肟经N-氯代丁二酰亚胺氯化,碱脱去一分子氯化氢,再用碱脱氯化氢,形成1,3-偶极子,和取代苯乙烯发生[3+2]环加成得到异噁唑啉环,如式3所示:
上述合成不仅仅合成步骤长,NCS及碱脱酸均造成大量三废。因此,有些文献采用了醛肟用氧化剂脱氢形成式3中的1,3-偶极子的方法,如专利CN113461653B中实施例4采用有机高碘化物-羟基(甲苯磺酰氧基)碘化苯为氧化剂,50℃氧化1,3-偶极环加成制备氟雷拉纳中间体,然而众所周知,有机高碘氧化剂存在巨大的安全危险,同时也产生大量有机物三废,原子经济性差,分离纯化不易。2017年湖北工业大学黄道友学位论文《新型兽药Fluralaner的合成工艺研究》报道了以碘化钾与过硫酸氢钾复合盐(Oxone)为氧化剂,目的同样是原位产生高碘化合物,室温氧化1,3-偶极环加成制备氟雷拉纳中间体,产物需要过柱纯化,反应收率及纯度相对较低。Oxone即使在干燥低温的条件下储存,每月都会有1%的活性成分损耗,分解生成氧气并放热,极易爆炸。因此反应同样存在巨大的安全危险,同时也产生大量无机物三废,原子经济性差。
发明内容
本发明的目的在于,针对现有技术合成异噁唑啉类杀虫剂及其中间体工艺中存在的缺点,提供一种新的异噁唑啉类杀虫剂及其中间体的合成方法,该合成方法为催化氧化1,3-偶极环加成方法。其技术方案如下:
一种异噁唑啉类杀虫剂或其中间体的合成方法,包括:
在介孔材料负载的复合过渡金属氧化物的催化下,芳基甲醛肟衍生物与1-三氟甲基苯乙烯衍生物在氧化剂的作用下进行分子间环加成反应,得到所述的异噁唑啉类杀虫剂或其中间体;或者
在介孔材料负载的复合过渡金属氧化物的催化下,1-芳基-3-三氟甲基-3-苯基丙烯酮肟衍生物在氧化剂的作用下进行分子内环加成反应,得到所述的异噁唑啉类杀虫剂或其中间体;
反应式如下:
其中,R1和R2独立地选自氢、卤素、三氟甲基或者C1~C6烷基;
Ar为取代或者未取代的苯基、取代或者未取代的萘基、取代或者未取代的五元杂环芳基;
所述苯基、萘基或者五元杂环芳基上的取代基为C1~C6烷基、C1~C6烷氧基、卤素、三氟甲基、C1~C5烷氧羰基或者中的一个或者多个。
以分子间环加成反应为例,反应过程如下,芳基甲醛肟衍生物在氧化剂作用下脱去一分子氢气形成1,3-偶极子,然后与1-三氟甲基苯乙烯衍生物发生1.3-偶极环加成反应,制备得到异噁唑啉类杀虫剂及其中间体。
作为优选,R1和R2独立地选自氢、F、Cl、Br、三氟甲基或者甲基;
Ar为取代或者未取代的苯基、取代或者未取代的萘基、取代或者未取代的呋喃基、取代或者未取代的噻吩基;
所述苯基、萘基、呋喃基或者噻吩基上的取代基为甲基、甲氧基、F、Cl、Br、三氟甲基、甲氧羰基或者中的一个或者多个。
作为优选,所述的异噁唑啉类杀虫剂为以下化合物中的一种:
作为优选,所述的介孔材料为SBA-15或者KIT-6;
所述的复合过渡金属氧化物所含有的金属元素为铜、铬、钴、锰、锌中的任意两种。
作为优选,所述的介孔材料负载的复合过渡金属氧化物为CoCr2O4@SBA-15、CuCo2O4@SBA-15、CuMn2O4@KIT-6或ZnCo2O4@KIT-6。
作为优选,所述的氧化剂为氧气、双氧水或叔丁基过氧化氢。
作为优选,所述的分子间环加成反应或分子内环加成反应的温度为20~30℃,反应时间为2~10小时。
作为优选,所述的分子间环加成反应或分子内环加成反应在以下溶剂中的一种中进行:甲醇、乙醇、异丙醇、叔丁醇、四氢呋喃或乙腈。
同现有技术相比,本发明的有益效果在于:
在介孔材料负载的复合过渡金属氧化物催化下,用相对绿色安全的氧化剂如氧气、双氧水、叔丁基过氧化氢等氧化芳基醛肟形成1,3-偶极子,和取代苯乙烯发生一锅法环加成反应,制备得到异噁唑啉类杀虫剂及其中间体。催化剂用量低,易于分离套用,而且可以多次循环套用。反应温度为室温,安全性高,两次获得诺贝尔化学奖的Sharpless在其首次获奖工作―Sharpless环氧化反应中明确指出,叔丁基过氧化氢是最稳定的过氧化物之一。氧气、双氧水氧化醛肟脱氢反应形成一分子水,而叔丁基过氧化氢形成叔丁醇和水,可以为环加成反应的溶剂,易于回收套用,工艺的三废排放少。对比实验证明,介孔材料负载的单一过渡金属氧化物催化效果不佳。本技术方案规避了原工艺采用NCS氯化/碱脱氯化氢产生的三废排放及合成路线长问题,以及有机高碘氧化物或者Oxone氧化环加成的三废排放和安全风险。同时产物纯化规避了Oxone氧化环加成的过柱纯化问题,易于放大生产。
附图说明
图1为SBA-15和代表性催化剂CoCr2O4@SBA-15的XRD谱图;
图2为代表性催化剂CoCr2O4@SBA-15的XPS全谱及Cr、Co元素的精细谱;
图3为实施例2氟雷拉纳中间体产物核磁氢谱;
图4为实施例2氟雷拉纳中间体产物液相色谱。
具体实施方式
参照下列实施例说明本发明的特定实施方案。这些实施例是用以阐明本发明,而非以任何方式限制本发明。
介孔材料SBA-15和KIT-6购自上海百化商城。制得的催化剂分别以CoCr2O4@SBA-15、CuCo2O4@SBA-15、MnCo2O4@KIT-6、ZnCo2O4@KIT-6表示,两个金属比例由ICP-MS检测确认。异噁唑啉类杀虫剂中间体的制备参考文献《中国兽药杂志》2020,54(11):72-78及其参考文献。
产品纯度的液相色谱检测条件:
仪器:Agilent 1260液相色谱仪
色谱柱:XBrige C18柱(4.6mm*150mm,3.5μm)
流动相:A:0.1%磷酸水溶液;B:乙腈。梯度表如下:
T/min | A/% | B/% |
3 | 20 | 80 |
10 | 20 | 80 |
10.1 | 80 | 20 |
13 | 80 | 20 |
检测波长:254nm
柱温:30℃
流速:1.0mL/min
实施例1催化剂CoCr2O4@SBA-15的制备
烧杯中称取九水合硝酸铬(0.8015g,2mmol)和六水合硝酸钴(0.2935g,1mmol),加入去离子水(2mL)溶解。SBA-15(1.8g)和正己烷(55mL)加入到单口圆底烧瓶中,快速搅拌10分钟,然后往烧瓶中加入两个硝酸盐混合水溶液,混合物充分搅拌4h后,抽滤,制备得到SBA-15负载混合金属硝酸盐中间体,在100℃的鼓风烘箱中干燥18h,以除去所有的水溶剂和大部分的硝酸盐结晶体水。然后将其装入敞口的焙烧槽中,以1.5℃/min的升温速率在管式炉中升温至600℃下空气中煅烧6h,得到墨绿色SBA-15负载双金属氧化物粉末,用CoCr2O4@SBA-15表示。称重,得到1.9476gCoCr2O4@SBA-15催化剂。催化剂经XRD、XPS和ICP-MS表征。
实施例2氟雷拉纳中间体分子间氧化环合成
在反应瓶中加入1,3-二氯-5-(3,3,3-三氟丙-1-烯-2-基)苯(0.1mol,24.10g)、4-溴-3-甲基苯甲醛肟(0.1mol,21.41g)、甲醇(100mL),室温搅拌溶解,再加入催化剂CoCr2O4@SBA-15(0.05g),室温搅拌6小时,液相色谱检测反应完全。抽滤去除催化剂,母液浓缩,加入总体积2倍的去离子水析出沉淀,抽滤,烘干,得产品42.23g,收率93%,液相纯度99.07%。
抽滤回收的催化剂经试验,可以至少循环套用30次以上,收率和纯度相当。
实施例3氟雷拉纳中间体分子间氧化环合成
在反应瓶中加入1,3-二氯-5-(3,3,3-三氟丙-1-烯-2-基)苯(0.1mol,24.10g)、4-溴-3-甲基苯甲醛肟(0.1mol,21.41g)、四氢呋喃(100mL)、30%双氧水(0.2mol,22.67g),室温搅拌溶解,再加入催化剂CuMn2O4@KIT-6(0.05g),室温搅拌2小时,液相色谱检测反应完全。抽滤去除催化剂,母液浓缩,加入总体积2倍的去离子水析出沉淀,抽滤,烘干,得产品43.65g,收率96%,液相纯度99.31%。
实施例4氟雷拉纳中间体分子间氧化环合成
在反应瓶中加入1,3-二氯-5-(3,3,3-三氟丙-1-烯-2-基)苯(0.1mol,24.10g)、4-溴-3-甲基苯甲醛肟(0.1mol,21.41g)、叔丁醇(100mL)、70%叔丁基过氧化氢(0.2mol,25.75g),室温搅拌溶解,再加入催化剂CuCo2O4@SBA-15(0.05g),室温搅拌2小时,液相色谱检测反应完全。抽滤去除催化剂,母液浓缩,加入总体积2倍的去离子水析出沉淀,抽滤,烘干,得产品42.87g,收率95%,液相纯度99.62%。
实施例4B氟雷拉纳中间体分子间氧化环合成(SBA-15负载的单一氧化铜催化效果对比实施例)
在反应瓶中加入1,3-二氯-5-(3,3,3-三氟丙-1-烯-2-基)苯(0.1mol,24.10g)、4-溴-3-甲基苯甲醛肟(0.1mol,21.41g)、叔丁醇(100mL)、70%叔丁基过氧化氢(0.2mol,25.75g),室温搅拌溶解,再加入催化剂CuO@SBA-15(0.05g),室温搅拌过夜(18小时),液相色谱检测反应显示原料残留64%。
实施例5氟雷拉纳中间体分子内氧化环合成
在反应瓶中加入氟雷拉纳中间体A(0.1mol,43.22g)、乙腈(100mL)、30%双氧水(0.2mol,22.67g),室温搅拌溶解,再加入催化剂CoCr2O4@SBA-15(0.05g),室温搅拌2小时,液相色谱检测反应完全。抽滤去除催化剂,母液浓缩,加入总体积2倍的去离子水析出沉淀,抽滤,烘干,得产品40.69g,收率94%,液相纯度98.74%。
实施例6氟雷拉纳分子内氧化环合成
在反应瓶中加入氟雷拉纳中间体B(0.1mol,55.63g)、乙醇(150mL),室温搅拌溶解,再加入催化剂ZnCo2O4@KIT-6(0.06g),室温搅拌5小时,液相色谱检测反应完全。抽滤去除催化剂,母液浓缩,加入总体积2倍的去离子水析出沉淀,抽滤,烘干,得产品48.29g,收率87%,液相纯度98.37%。
实施例7沙罗拉纳中间体分子间氧化环合成
在反应瓶中加入1,3-二氯2-氟-5-(3,3,3-三氟丙-1-烯-2-基)苯(0.1mol,25.90g)、4-碘-3-溴苯甲醛肟(0.1mol,32.59g)、异丙醇(100mL)、30%双氧水(0.2mol,22.67g),室温搅拌溶解,再加入催化剂ZnCo2O4@KIT-6(0.05g),室温搅拌2小时,液相色谱检测反应完全。抽滤去除催化剂,母液浓缩,加入总体积2倍的去离子水析出沉淀,抽滤,烘干,得产品52.68g,收率90%,液相纯度99.49%。
实施例8阿福拉纳中间体分子内氧化环合成
在反应瓶中加入阿福拉纳中间体A(0.1mol,43.22g)、甲醇(100mL)、30%双氧水(0.2mol,22.67g),室温搅拌溶解,再加入催化剂CuCo2O4@SBA-15(0.05g),室温搅拌2小时,液相色谱检测反应完全。抽滤去除催化剂,母液浓缩,加入总体积2倍的去离子水析出沉淀,抽滤,烘干,得产品46.08g,收率92%,液相纯度98.97%。
实施例9洛替拉纳中间体分子间氧化环合成
在反应瓶中加入1,2,3-三氯-5-(3,3,3-三氟丙-1-烯-2-基)苯(0.1mol,27.55g)、洛替拉纳中间体A(0.1mol,32.33g)、叔丁醇(100mL)、70%叔丁基过氧化氢(0.2mol,25.75g),室温搅拌溶解,再加入催化剂CoCr2O4@SBA-15(0.05g),室温搅拌2小时,液相色谱检测反应完全。抽滤去除催化剂,母液浓缩,加入总体积2倍的去离子水析出沉淀,抽滤,烘干,得产品52.97g,收率89%,液相纯度99.49%。
Claims (6)
1.一种异噁唑啉类杀虫剂或其中间体的合成方法,其特征在于,包括:
在介孔材料负载的复合过渡金属氧化物的催化下,芳基甲醛肟衍生物与1-三氟甲基苯乙烯衍生物在氧化剂的作用下进行分子间环加成反应,得到所述的异噁唑啉类杀虫剂或其中间体;或者
在介孔材料负载的复合过渡金属氧化物的催化下,1-芳基-3-三氟甲基-3-苯基丙烯酮肟衍生物在氧化剂的作用下进行分子内环加成反应,得到所述的异噁唑啉类杀虫剂或其中间体;
反应式如下:
1.分子间环加成
2.分子内环加成
其中,R1和R2独立地选自氢、卤素、三氟甲基或者C1~C6烷基;
Ar为取代或者未取代的苯基、取代或者未取代的萘基、取代或者未取代的五元杂环芳基;
所述苯基、萘基或者五元杂环芳基上的取代基为C1~C6烷基、C1~C6烷氧基、卤素、三氟甲基、C1~C5烷氧羰基或者中的一个或者多个;
所述的介孔材料为SBA-15或者KIT-6;
所述的复合过渡金属氧化物所含有的金属元素为铜、铬、钴、锰、锌中的任意两种;
所述的氧化剂为氧气、双氧水或叔丁基过氧化氢。
2.根据权利要求1所述的异噁唑啉类杀虫剂或其中间体的合成方法,其特征在于,R1和R2独立地选自氢、F、Cl、Br、三氟甲基或者甲基;
Ar为取代或者未取代的苯基、取代或者未取代的萘基、取代或者未取代的呋喃基、取代或者未取代的噻吩基;
所述苯基、萘基、呋喃基或者噻吩基上的取代基为甲基、甲氧基、F、Cl、Br、三氟甲基、甲氧羰基或者中的一个或者多个。
3.根据权利要求1所述的异噁唑啉类杀虫剂或其中间体的合成方法,其特征在于,所述的异噁唑啉类杀虫剂为以下化合物中的一种:
4.根据权利要求1所述的异噁唑啉类杀虫剂或其中间体的合成方法,其特征在于,所述的介孔材料负载的复合过渡金属氧化物为CoCr2O4@SBA-15、CuCo2O4@SBA-15、CuMn2O4@KIT-6或ZnCo2O4@KIT-6。
5.根据权利要求1所述的异噁唑啉类杀虫剂或其中间体的合成方法,其特征在于,所述的分子间环加成反应或分子内环加成反应的温度为20~30℃,反应时间为2~10小时。
6.根据权利要求1所述的异噁唑啉类杀虫剂或其中间体的合成方法,其特征在于,所述的分子间环加成反应或分子内环加成反应在以下溶剂中的一种中进行:甲醇、乙醇、异丙醇、叔丁醇、四氢呋喃或乙腈。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202310109519.2A CN116396235B (zh) | 2023-02-14 | 2023-02-14 | 一种异噁唑啉类杀虫剂及其中间体的合成方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202310109519.2A CN116396235B (zh) | 2023-02-14 | 2023-02-14 | 一种异噁唑啉类杀虫剂及其中间体的合成方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN116396235A CN116396235A (zh) | 2023-07-07 |
CN116396235B true CN116396235B (zh) | 2024-01-05 |
Family
ID=87011256
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202310109519.2A Active CN116396235B (zh) | 2023-02-14 | 2023-02-14 | 一种异噁唑啉类杀虫剂及其中间体的合成方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN116396235B (zh) |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101362097A (zh) * | 2007-08-09 | 2009-02-11 | 黑龙江大学 | 催化过氧化氢氧化苯到苯酚负载铜催化剂、制备及应用 |
JP2015221433A (ja) * | 2015-06-16 | 2015-12-10 | 公立大学法人首都大学東京 | 有機硫黄化合物の酸化触媒及び有機硫黄化合物を選択的に酸化する方法 |
JP2016121122A (ja) * | 2014-12-24 | 2016-07-07 | ダイキン工業株式会社 | 1−ブロモ−1−フルオロエチレン化合物の製造方法 |
CN112457267A (zh) * | 2020-11-27 | 2021-03-09 | 麦蒂辛生物医药科技成都有限公司 | 一种异噁唑啉杀虫剂的制备方法 |
-
2023
- 2023-02-14 CN CN202310109519.2A patent/CN116396235B/zh active Active
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101362097A (zh) * | 2007-08-09 | 2009-02-11 | 黑龙江大学 | 催化过氧化氢氧化苯到苯酚负载铜催化剂、制备及应用 |
JP2016121122A (ja) * | 2014-12-24 | 2016-07-07 | ダイキン工業株式会社 | 1−ブロモ−1−フルオロエチレン化合物の製造方法 |
JP2015221433A (ja) * | 2015-06-16 | 2015-12-10 | 公立大学法人首都大学東京 | 有機硫黄化合物の酸化触媒及び有機硫黄化合物を選択的に酸化する方法 |
CN112457267A (zh) * | 2020-11-27 | 2021-03-09 | 麦蒂辛生物医药科技成都有限公司 | 一种异噁唑啉杀虫剂的制备方法 |
Also Published As
Publication number | Publication date |
---|---|
CN116396235A (zh) | 2023-07-07 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
Orłowski et al. | Synthesis of corroles and their heteroanalogs | |
Cecchi et al. | Synthesis of 4, 5‐Dihydroisoxazoles by Condensation of Primary Nitro Compounds with Alkenes by Using a Copper/Base Catalytic System | |
Shiri et al. | A recent overview on the synthesis of 1, 4, 5-trisubstituted 1, 2, 3-triazoles | |
Maddila et al. | Efficient one-pot synthesis of benzoxazole derivatives catalyzed by nickel supported silica | |
Nguyen et al. | Heterocyclic reaction inducted by Brønsted–Lewis dual acidic Hf-MOF under microwave irradiation | |
Yamamoto et al. | Manganese‐Promoted Oxidative Cyclization of Unsaturated Oximes Using Molecular Oxygen in Air under Ambient Conditions | |
CN102442973A (zh) | 催化氧化伯醇闭环合成苯并咪唑和苯并噻唑化合物的方法 | |
CN115124465B (zh) | 一种二氯喹啉酸中间体的制备方法 | |
Banan et al. | Selective oxidation of secondary amines to N, N-disubstituted hydroxylamines by choline peroxydisulfate | |
Saha et al. | Reusable Palladium Nanoparticles Catalyzed Oxime Ether Directed Mono Ortho‐Hydroxylation under Phosphine Free Neutral Condition | |
Ou et al. | Highly efficient oxidative cleavage of olefins with O 2 under catalyst-, initiator-and additive-free conditions | |
CN116396235B (zh) | 一种异噁唑啉类杀虫剂及其中间体的合成方法 | |
Mondal et al. | Use of an efficient polystyrene‐supported cerium catalyst for one‐pot multicomponent synthesis of spiro‐piperidine derivatives and click reactions in green solvent | |
CN114736165A (zh) | 一种丙硫菌唑的合成方法 | |
Fu et al. | Synthesis of 3‐Nitroisoxazoles via Copper Acetate‐Mediated Reaction of Benzaldehydes with Nitromethane | |
Kuang et al. | Solvent free aerobic oxidation of alcohols with 1-methyl-2-azaadamantane N-oxyl as a recyclable catalyst through phase separation | |
Mamat et al. | A visible-light-induced thiol addition/aerobic oxidation cascade reaction of epoxides and thiols for the synthesis of β-hydroxylsulfoxides | |
CN107848965A (zh) | 4‑(三氟甲磺酰基)苯酚化合物的制造方法 | |
Karimian et al. | Methionine-Coated Fe3O4 Nanoparticles: An Efficient and Reusable Nanomagnetic Catalyst for the Synthesis of 5-Substituted 1 H-Tetrazoles | |
Nogueira et al. | Performance of a tetracarbonylmolybdenum (0) pyrazolylpyridine (pre) catalyst in olefin epoxidation and epoxide alcoholysis | |
Ramana et al. | An expeditious one-step entry to the tetracyclic core of integrastatins | |
CN111978162A (zh) | 一种芳香酮类化合物的合成新方法 | |
Forcato et al. | Effective oxidation of secondary amines to nitrones with alkyl hydroperoxides catalysed by (trialkanolaminato) titanium (IV) complexes | |
CN113717120B (zh) | 一种3-(2-甲基-6-硝基苯基)-4,5-二氢异噁唑的制备方法 | |
CN104628636B (zh) | 吡啶类杂环氮氧化合物的合成方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
GR01 | Patent grant | ||
GR01 | Patent grant |