CN1163597A - 活性物质片儿童防护包装 - Google Patents

活性物质片儿童防护包装 Download PDF

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CN1163597A
CN1163597A CN95195944A CN95195944A CN1163597A CN 1163597 A CN1163597 A CN 1163597A CN 95195944 A CN95195944 A CN 95195944A CN 95195944 A CN95195944 A CN 95195944A CN 1163597 A CN1163597 A CN 1163597A
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packing
feature
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layer
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CN1168638C (zh
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R·科赫
F·穆勒
F·贝歇尔
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LTS Lohmann Therapie Systeme AG
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Abstract

活性物质片儿童防护包装形成主要包装，包括至少一层机械上坚韧的、特别是抗拉的层。

Description

活性物质片儿童防护包装
本发明涉及活性物质片儿童防护包装。
按照公知的原则，所有医药品要保持在儿童接触不到的地方。生活经验表明，如果好奇心强于禁令，则口头禁止不足以使儿童不拿他们够得着的范围内的医药品。为了发现一种药物和防止儿童接触有害材料，目前开发并引入在有害物质容器的螺帽上装儿童防护锁。
在最近几年内，对于各种疾病和/或控制机体功能，例如控制血压、戒除烟碱、计划生育等，活性物质片获得日益增长的重要性，进一步发展不能预见。
由于一些重要的原因，这样的片从生产到使用必须借助适当的包装保持密封，一方面确保其绝对隔离环境暴露，另一方面防止活性物质丢失，例如通过挥发性活性物质的升华、蒸发或扩散，这样对活性物质片提供保护性外部密封。
为此目的，开发了具体的包装材料。美国专利No.5,268,209描述了一种烟碱包装材料及其制备方法，它有多层组成，例如具有用丙烯腈-丙烯酸甲酯共聚物改性的腈橡胶制成的烟碱的屏障层。该专利提出较佳的烟碱屏障层是混有约70重量％丁二烯衍生物聚合物单元的约8-10重量份丁二烯-丙烯腈共聚物的约73-77重量％丙烯腈和23-27重量％丙烯酸甲酯的增强共聚物。该烟碱包装材料包括产生包装袋的密封层、铝箔和作为标签支持物的纸层。迄今形成了这样的活性物质片儿童防护包装，该片用适于活性物质性质的包裹物独立包裹，例如不渗透活性物质的包裹物，这种包装借助抗拉包装材料使其不被儿童抓、不损坏、不滥用。该双包装的缺点是导致涉及生产和材料方面相应高消耗的高包装费用。
因此，急需降低这些费用和相应的材料消耗而不降低儿童防护的质量。
结果，本发明的目的是提供可以低成本、低材料消耗生产、同时儿童防护作用特好的活性物质片包装。
在活性物质片包装上，用本发明达到这个目的，其事实如下：所述包装由具有多层结构并形成主要包装的包装材料组成，包装材料中至少一层具有足够高的机械负载力以满足儿童防护的要求，特别是抗拉，至少一层满足活性物质物理和化学的要求，至少一层对蒸气和/或活性物质不渗透。
一方面，按照本发明的活性物质片儿童防护包装最有益地具有机械强度特征，它有效地确保儿童用手，即不使用例如剪子、刀子等机械帮助，不能打开和接触该片。另一方面，包装材料的层状结构包括一层特殊的屏障层，以合适的和完全的方式密封活性物质，或保护包装材料不丢失到环境中。
该儿童防护包装按本发明独一无二地形成主要的包装，因而可省去迄今所需的双包装；因为这个原因，省去约50％包装工作，包括必要的机械使用和材料消耗。最有益的是这不仅节约费用，而且使环境减少废物和废物处置。
进一步的实施方案提供双轴向拉伸聚酰胺膜的抗拉层。然而关于选择合适的包装材料，本发明并不限于使用聚酰胺膜作为抗拉层；相反，大量高强度材料是适合的，如芳族聚酰胺纤维的材料(如KevlarR)。
抗拉层还可通过插入高强度纤维或织物来制造，例如插入细聚酯丝、玻璃纤维、钢织物，或适合于本发明的包装材料的层状结构的其它联合体。插入物或强化纤维可插在两层之间或整合成一层。
另一实施方案还提供纸制的材料或用印刷纸被覆的外层。
较佳的是将铝箔或镀铝塑料膜用作不渗透活性物质的层。最后，一实施方案提供塑料膜的最内层，它是用密封介质层压而成的或由密封材料组成。
包装材料的层状结构还可这样形成：重型、抗拉层位于层状结构的外部，适合于活性物质物理或化学要求并不渗透蒸气和活性物质的层位于层状结构的内部，或相反。
包装材料的层状结构以包括以下物质为佳：
-纸(1)
-层压粘合剂(2)
-铝箔(3)
-层压粘合剂(4)
-抗拉层(5)(聚酰胺膜)
-层压粘合剂(6)
-聚丙烯腈(7)
为了使儿童更难以损坏或破坏包装，借助滑动层(8)赋予纸层(1)外侧抗粘性，减少手指粘附于包装。
按照本发明所提供的活性物质片儿童防护包装所用的包装材料层状结构的实施方案见附图，该图显示层状结构断面，具有如下意义：
优质纸的纸层(1)，如涂层的或超滚压机压的未涂层纸层，
层压粘合剂(2)，如可热活化的胶，
铝箔(3)，
层压粘合剂(4)，
抗拉层(5)，如聚酰胺膜或芳族聚酰胺片，或用强化纤维强化的塑料膜，
层压粘合剂(6)，
聚丙烯腈内层(7)。
如果需要，可用滑动层(8)赋予纸层(1)外侧抗粘性，减少手指粘附于包装。这还使在包装上用力更困难。各层典型的重量标志(g/m2)以如下值为佳：
-纸(1)                     (40.0g/m2)
-层压粘合剂(2)           (2.0g/m2)
-铝箔(3)                 (24.3g/m2)
-层压粘合剂(4)           (2.0g/m2)
-抗拉层(聚酰胺膜)(5)     (17.2g/m2)
-层压粘合剂(6)           (2.0g/m2)
-聚丙烯腈(7)             (32.2g/m2)
儿童防护包装还可以是这样的：具有高机械负载力的层由两层膜和插入的强化材料组成或由一层膜和整合的强化材料组成。
此外，儿童防护包装可由两个重型表面部分组成；但还可采取措施使包装由高强度材料部分和低稳定性材料部分组成。
本发明提供制备方法，使片插入包装材料的两个表面单元之间，表面部分的边缘互相密封。
按照本发明，形成为多层结构包装材料制的主要包装的活性物质片儿童防护包装是不复杂的、实用的，并且与以前的双包装相比，可以很经济地制备，同时减少废物，减轻环境污染。由于这个原因，本发明以最适方式达到了上述目的。

Claims (13)

1.具有多层结构的包装材料的活性物质片儿童防护包装，其特征在于：所述包装形成片的主要包装，包装材料具有至少一层有足够高的机械负载力以满足儿童防护的要求，特别是抗拉层，至少一层满足活性物质物理和化学的要求，至少一层对蒸气和/或活性物质不渗透。
2.如权利要求1所述的儿童防护包装，其特征还在于：抗拉层是双轴向拉伸的聚酰胺膜。
3.如权利要求1所述的儿童防护包装，其特征还在于：抗拉层是芳基聚酰胺纤维的材料，如Kevlar。
4.如权利要求1所述的儿童防护包装，其特征还在于：抗拉层是具有至少一层高强度纤维或聚酯、聚酰胺、玻璃或钢织物插入层的膜样材料。
5.如权利要求4所述的儿童防护包装，其特征还在于：抗拉层由两层膜组成，其中插入强化材料，或由一层膜和整合的强化材料组成。
6.如权利要求1所述的儿童防护包装，其特征还在于：外层是纸制的材料。
7.如权利要求1所述的儿童防护包装，其特征还在于：不渗透活性物质的层是铝膜或镀铝塑料膜。
8.如权利要求1所述的儿童防护包装，其特征还在于：最内层是用密封介质层压起来的或由密封介质组成的塑料膜。
9如权利要求1所述的儿童防护包装，其特征还在于：包装材料的层状结构包括以下物质：
-纸(1)
-层压粘合剂(2)
-铝箔(3)
-层压粘合剂(4)
-抗拉层(5)(聚酰胺膜)
-层压粘合剂(6)
-聚丙烯腈(7)。
10.如权利要求9所述的儿童防护包装，其特征还在于：用滑动层(8)赋予纸层(1)外侧抗粘性，减少手指粘附于包装。
11.如权利要求1-9之一所述的儿童防护包装，其特征还在于：重型、抗拉层位于层状结构的外部，适合于活性物质物理或化学要求并不渗透蒸气和活性物质的层位于层状结构的内部，或相反。
12.如权利要求1-9之一所述的儿童防护包装，其特征还在于：其表面部分由具有机械上坚韧的抗拉层(5)的包装材料组成，其相对的表面部分由较少可负载性的包装材料组成。
13.如权利要求1-12之一所述的儿童防护包装的制备方法，其特征在于：片插入包装材料两个表面部分之间，表面部分的边缘互相密封。
CNB951959441A 1994-10-31 1995-10-26 多层包装材料在制备活性物质片儿童防护包装中的应用 Expired - Lifetime CN1168638C (zh)

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CN1946609B (zh) * 2004-03-26 2012-05-02 Csp技术公司 粘附有活性薄膜的柔性包装材料及其制造方法
CN107380497A (zh) * 2017-07-20 2017-11-24 广州易航电子有限公司 一种涂液包及其制备方法

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CN1946609B (zh) * 2004-03-26 2012-05-02 Csp技术公司 粘附有活性薄膜的柔性包装材料及其制造方法
CN107380497A (zh) * 2017-07-20 2017-11-24 广州易航电子有限公司 一种涂液包及其制备方法

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